If anybody told me I needed to retry statins I would just refuse to take them. I've already tried 4 of them. The last one was pravastatin. I was in PT two different times due to the pain. My back, legs and knee hurt so much. I couldn't walk down the stairs, put my shoes and socks on, can't clean my house, can't do the yard work, go for a walk. Heck it hurt to stand there and do the dishes. My Dr's office is just working on getting approval for repatha. Not sure if my insurance will approve it but if not I will live the rest of my life pain free with no statins.

@bansheeclan4119

Жыл бұрын

Whats your experience with Repatha? Have you taken it?

@mariopolnyc6683

Жыл бұрын

I had the same symptoms with the least amount of all the different statins. Repatha has worked like a charm. I also take Zetia. Good luck!

@karimaogden3875

11 ай бұрын

​@@mariopolnyc6683Do you have diabetes? I ask because I have read that Repatha could cause an increase in Blood Sugar (among others like runny nose, sore throat, flu and flu-like symptoms) which would be counterproductive in that case, especially if the Cardio Vascular problems are related to diabetes as in my husband's case. His doctor suggested Repatha depending on the results of his Apo B test which he had today.

@mariopolnyc6683

11 ай бұрын

My diabetes was diagnosed 7 years before I started Repatha. At the time my A1c was 15.3. At that level most likely more than half of my Beta cells were wiped out. Because of the super high blood sugar my Trigs were in high hundreds. The combo of very high Trigs and high cholesterol accelerated atherosclerosis and culminated in heart bypass the following year. So because of advanced heart disease I have to lower my cholesterol with Repatha. Given these conditions it's impossible for me to determine if Repatha was responsible for my BG increase and to what extent. I wish good health to You and your husband.

@Melanie-ix4nq

11 ай бұрын

I just looked up the side effects of repatha and one of them is getting diabetes. I have the same problem with statins also. I just tried Zetia, and that is making things worse without going into details. I am so done with all of this trying cholesterol crap. The treatment is worse than the disease. Why fix one thing and get another, I do not want to be diabetic.

You did not talk about glucose rise because of statins.

While there was a 59% reduction in LDL in the Fourier study, there was only a 0.1% difference in mortality benefit . Hardly an endorsement. You may want to look at absolute risk reduction rather than the relative risk reductions paid for by the pharmaceutical industry. Just a though.

@emsea1658

Жыл бұрын

In the 30 year Follow up to the Framingham study, those with higher LDL lived the longest. And lowering LDL was associated with INCREASED mortality. Yet when the Framingham study first came out, they used it as justification that everyone's LDL must be lowered while being totally ignorant of the inflammation markers that the latest science indicates actual accurate risk prediction. It's stunning how how much the AHA is owned by the food industry. They are the ones writing the checks for the AHA

@williewonka6694

Жыл бұрын

BINGO

Her approach to people who can't take statins, tell them they're imagining the side effects

What about the meta analysis with CoQ10 at 200mg/day resulting in significant reduction in SAMS?

Sobering as she discusses the 51 yoa patient and there's no alarms to TG of 231, HDL of 32, and a1c of 6.6. As if these markers are ok as long as the LDL is 95. And most likely will be added a second cholesterol lowering drug to bring it LDL to 50 Would love to see this patient labs as far as available

@jimmyg3855

Жыл бұрын

You took the words right out of my mouth !!!! Extremely alarming!!!! I’m shocked your comment does not have more likes or comments heck! Even a respond or rebuttal.

@franciscoadolfo5805

Жыл бұрын

​​@@jimmyg3855 Don't expect one hahaha I am part of the little people

@williewonka6694

Жыл бұрын

His BMI was 32!!! Cholesterol is the least of his problems at this point, I would say. And apparently no concern whatsoever about increasing blood glucose in this patient.

does diet and exercise work as well in familial hypercholesterolemia cases? and which statin works best for this group? and which is also safe for already prediabetic cases?

I do give her credit for mentioning the fact that some studies pre-eliminated all patients that couldn’t tolerate statins from the study pool.

You would think that, in a presentation by this title, she wouldn’t just say “it’s difficult to lower Ldl-C using diet,” but would perhaps give just a LITTLE attention to who is doing it, how they are doing it, what peer-reviewed research supports it, and the fact that it’s so effective that Medicare and insurance companies are now paying for Ornish’s training in doing it. Because you think something is “difficult”-for you-doesn’t mean you get to ignore it.

What are side affects of bempedoic acid. What are side affects of repatha.

Trying Crestor… known to have the least side effects. ? 2.5 mg to 5 mg effectiveness? Or qod or even once a week? I always develop muscle pain. Looking for options

@janerogers2395

Жыл бұрын

I am Female/77 yo

@janerogers2395

Жыл бұрын

My muscle aches develop within 2 weeks… from 1-10 I would be a 6

@williewonka6694

Жыл бұрын

I'm going back to try it after adopting low carbohydrate lifestyle in October 2022. Crestor is supposed to have lower side effects to the muscles and brain. I was concerned about the higher blood glucose buy didn't notice any other problems.

Hello Dr Cho. You mention that there is such great data showing that it is really important for those who have had a heart attack or bypass surgery to get a LDL-C level of less than 70. Please let me know what this data is. I had a heart bypass 13 years ago and my typical LDL-C level is 155. I haven't had any angina for many years so your statement is a trifle odd. But I would be interested to examine the data to which you refer.

Interesting that none of the studies consider the assigned dose for the patients. Patients with the maximum dose are accorded the same weighting as patients with the lowest dose. As someone prescribed the maximum dose for simvastatin, Pravacol, Lipitor and Crestor I experienced muscle problems and brain problems with the first three. I became concerned with the risk of developing diabetes from statins. So, which is worse; high cholesterol or diabetes and its effects? I no longer trust pharma studies of their own "blockbuster" products. These studies repeatedly bias the data sets to get the results that support FDA approval of the product.

solely focusing on ldlc when science shows heart disease risk factors like insulin resistance diabetes etc are way more important in cvd seems illogical

@jimmyg3855

Жыл бұрын

Fun fact diabetes is a risk factor for heart disease. Though that was a blood sugar problem not cholesterol hie strange?

@Michael-4

Жыл бұрын

I have gone full circle with this. The elephant in the room is that the majority of adult Americans are IR and is a massive accelerator of chronic disease including heart disease. I have been keto for 6 years bringing my IR into remission. However, the idea that you can have high LDL C and be immune to ASCVD if pumping out ketones has yet to be shown in decent studies. The ideal diet, I think is low carb but relatively low saturated fat and make up the difference with monos, oily fish, PUFAs from whole sources and adequate protein from real food.

@williewonka6694

Жыл бұрын

Well, don't upset big pharmas cart while they have a blockbuster drug.

@jobrown8146

10 ай бұрын

I'm looking forward to the LDL LMHR study/ies being published by Dave Feldman. I saw a video recently where he talks about getting some results already and they are planning on publishing some findings very soon. I'm a non-lean LDL hyper-responder after changing to low carb with LDL of 300 (good trig/HDL ratio). I am metabolically healthy and even with a CAC of zero (65 yo F) the cardiologist recommended low dose statin to which I said no thanks. @@Michael-4

The Hell with Statins

You forgot to mention hair loss with taking stains

if PCSK9 is so effective, why not start with that alone?

@Michael-4

Жыл бұрын

Probably the cost.

@georgecav

18 күн бұрын

Effective at what? Cardiologists and doctors get excited at cholesterol reduction it brings yet the best reduction in mi cv deaths I have seen is a miserable 2% in absolute terms and the worst analysis says it does a little more harm than good. It just shows how such smart people are brainwashed in groupthink. Objectively its a laughably poosr outcome esp given possible side effects

How to take statins: Dump whole bottle in water and flush 🚽

@jobrown8146

10 ай бұрын

There are some people saying that statins should be added to the water. I don't think they meant toilet water ha ha!!!

Ali, please work on your voice. You speak much too rapidly and it needs to be at a lower pitch. These changes will improve your audiences' comprehension and comfort in listening. Also, the presenter only addressed pharmacological approaches in the studies. Although lifestyle change was mentioned multiple times, not data comparing it to drugs was shown.

@davidburt6659

Жыл бұрын

I WOULD AGREE WITH YOU...AHE SPEAKS TOO FAST AND PITCH IS TOO HIGH

And of course talking to elderly people on the phone will accurately measure their cognitive function and prove beyond debate that the statins don't make a difference 🙄

blindly lower LDL is wrong. cholesterol is needed by our body! blindly lowering LDL may cause lack of cholesterol and may kill one faster. If plaque is formed by LDL is true, everyone in the earth should have plague in one's body since everyone does have LDL! and LDL level and plaque should be in proportion that means higer LDL must have more plaques but there is no evidence that this is true. Besides, higher LDL and lower LDL level has similar risk factor of heart attack! Also LDL alone will never form plaques! seems doctors over-Simplified the plaque formation process

@jobrown8146

10 ай бұрын

From what I've been listening to it seems more likely that the cholesterol forming the plaque is the body's way of dealing with damage, which seems to be caused by inflammation; the fireman at the fire, not the fireman causing the fire. My doctor is still using the TC/HDL ratio not the trig/HDL and being a non-lean LDL hyper-responder (LDL 300 with good trig/HDL ratio) she and my cardiologist recommend statin treatment (I've said no). However they both seem to be ignoring that fact that I am now metabolically healthy after changing to low carb in Oct 2021. Even with all my other numbers being in the so-called "normal" range (which is possibly based on the majority of people eating SAD and possibly metabolically unhealthy), with a recent CAC of 0 after a lifetime of bad diet (I'm 65 yo F) my doctor (graduated in 2018 so she is still following the "script" touted by pharma) told me that I am at a high risk of heart disease. When I said that there are studies indicating that statins can cause or worsen diabetes she said there are new studies coming out saying that they can help with diabetes. My thought was, which is it? Doctors get their information about drugs from the pharma reps and of course the pharma companies are going to use the studies that suit them to sell their drugs.

I LOATHE the smugness about the study where they tricked the people. It's gaslighting to tell people they aren't expecting what they're experiencing and I don't know why the smugness is always part of it. Also, was it possible those people weren't actually taking the medicine and saying they were? And btw, that's what people do when you treat them like an idiot. They'll just take it a few days before the blood work and that actually works btw.....so keep being smug and relying on this ' study' and keep making enemies of your patients.

How about these propaganda ‘experts’ actually show they are up with modern knowledge and talk about dealing with LDL-P rather than C. And far more importantly, why aren’t they focussed on lowering CV events rather than ldl which is obviously not the root cause as some of these new meds move ldl down heaps but barely move the dial on CV events occurring. Its all so unintelligent at the end of the day.