In this installment of the Synthesis Workshop Advanced Organic Chemistry course, we start our Synthesis module as Dr. Steven Crossley joins us to talk about retrosynthesis.
References (in order of appearance):
Corey, E.J.; Cheng, X.-M. The Logic of Chemical Synthesis, 1995 Wiley; Corey, E.J. Chem. Soc. Rev. 1998, 17, 111.
Chem. Rev. 2015, 115, 9465; JACS 2020, 142, 11376; ACIE 2020, 59, 13734.
Grossman, R.B. The Art of Writing Reasonable Organic Reaction Mechanisms, 2003 Springer.
Böttcher, T. Chem. Inf. Model. 2016, 56, 462.; Shenvi, R.A. & co. JACS 2020, 142, 18599.
Link to plug in SMILES code of molecule into a calculator (forlilab.org/services/bottcher/) to generate the Cm value.
For a recent demonstration, see: Yingfu Lin, Rui Zhang, Di Wang, and Tim Cernak. Computer-aided key step generation in alkaloid total synthesis. Science, 2023, 379, 453-457.
See Hutchinson, A.J.; Kishi, Y. JACS 1979, 101, 6786; Baran, P.S.; Corey, E.J. JACS 2002, 124, 7904.
Wei, H.; Qiao, C.; Liu, G.; Yang, Z.; Li, C-C. ACIE 2013, 52, 620; Hughes, J. 2018, Thesis Part I. I. A Total Synthesis of (−)-Virosaine A, McGill University.
Haelsig, K.T.; Xuan, J.; Maimone, T.J. J. Am. Chem. Soc. 2020, 142(3), 1206.
See Shenvi, R.A. & co. JACS 2020, 142, 11376; Maimone, T. & co. Chem. Rev. 2017, 117, 11753.