Addisons Disease Made Simple - Primary Adrenal Faliure
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Addisons Disease Made Simple
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Addison’s disease, also known as primary adrenal insufficiency, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones.[1] Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss. Darkening of the skin in certain areas may also occur. Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness. An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection.[1]
Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly aldosterone are produced,[1] most often due to damage by the body's own immune system in the developed world and tuberculosis in the developing world.[2] Other causes include certain medications, sepsis, and bleeding into both adrenal glands.[1][2] Secondary adrenal insufficiency is caused by not enough adrenocorticotropic hormone (ACTH) (produced by the pituitary gland) or CRH (produced by the hypothalamus). Despite this distinction, adrenal crises can happen in all forms of adrenal insufficiency. Addison's disease is generally diagnosed by blood tests, urine tests, and medical imaging.[1]
Treatment involves replacing the absent hormones.[1] This involves taking a corticosteroid such as hydrocortisone and fludrocortisone.[1][3] These medications are usually taken by mouth.[1] Lifelong, continuous steroid replacement therapy is required, with regular follow-up treatment and monitoring for other health problems.[4] A high-salt diet may also be useful in some people. If symptoms worsen, an injection of corticosteroid is recommended and people should carry a dose with them. Often, large amounts of intravenous fluids with the sugar dextrose are also required. Without treatment, an adrenal crisis can result in death
The signs and symptoms include fatigue; lightheadedness upon standing or difficulty standing, muscle weakness, fever, weight loss, anxiety, nausea, vomiting, diarrhea, headache, sweating, changes in mood or personality, and joint and muscle pains. Some patients have cravings for salt or salty foods due to the loss of sodium through their urine.[8] Hyperpigmentation of the skin may be seen, particularly when the patient lives in a sunny area, as well as darkening of the palmar crease, sites of friction, recent scars, the vermilion border of the lips, and genital skin.[9] These skin changes are not encountered in secondary and tertiary hypoadrenalism.[10]
On physical examination, these clinical signs may be noticed:[8]
Low blood pressure with or without orthostatic hypotension (blood pressure that decreases with standing)
Darkening (hyperpigmentation) of the skin, including areas not exposed to the sun. Characteristic sites of darkening are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa); also, old scars may darken. This occurs because melanocyte-stimulating hormone (MSH) and ACTH share the same precursor molecule, pro-opiomelanocortin (POMC). After production in the anterior pituitary gland, POMC gets cleaved into gamma-MSH, ACTH, and beta-lipotropin. The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin pigmentation. In secondary and tertiary forms of adrenal insufficiency, skin darkening does not occur, as ACTH is not overproduced.
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Excellent. ER Physicians need to watch this in the US. I know from experience they are clueless when Addison's Crisis presents.
@howtomeetwomen-
4 жыл бұрын
I'm here because an *endocrinologist* just tried to take me off prednisone. I told her I'm pretty sick from being on only 6.5mg, and think I need more. She said I'm fine and don't even need a follow-up! Thing is.. she's my 6th endo and one of the best I've found. Why is it like this? And yeah, in the ER they usually try to withhold steroids, disregard my Medicalert bracelet, it's a mess. I've had to sneak my own hydrocortisone out of my bag.
@brahimimoustafa6390
4 жыл бұрын
Realy I think they are excellents
@tammyl1646
4 жыл бұрын
@@howtomeetwomen- I understand completely! It's not only frustrating, but dangerous. I carry an article with me that I printed to try to open their eyes. Even my PCP said she knew practically nothing about Addison's. Very disheartening.
@atheistleopard618
4 жыл бұрын
Doctors don't know everything, ffs. lol.
@tammyl1646
4 жыл бұрын
@@atheistleopard618 F U atheist idiot.
* Firstly, am sorry for my bad English because English isn't my primary language. Great video. I've been suffering with all the addison's symptoms (Not fully diagnosed yet) for quite a long time. I'm craving salt, losing a lot of my weight, hypotension problem and more... Well, I also have Type 1 Diabetes (currently using an Insulin Pump) and Thyroid Disease. So, this video has opened my eyes about other autoimmune disease that probably manifest in my body. Thanks for the video because it's gonna save my life.
Thank you so much! I love how easy this was to follow. 💕
Good information. My wife was diagnosed about 6 months and we are still researching and learning about Addison's Disease. It would be nice to find a place to print out what was in the video for our research.
Brief and straight to the point. Well explained. Thank you.
Fantastic explanation. This was very helpful. Thank you so much.
youve made it so easy to understand, thank you!
Thank you so much. This has helped me greatly. I appreciate
thank you! very well explained and organised video :D
Great video. Made it very simple to understand without wasting too much time. Great explanation skills too. Well done and thank you again.
amazing. Great help. Thanks
APPRECIATE. Precise but to the point. And tests required.. thanks
Brilliant!! explanation, well describe and clear, thanks.
Very helpful and informative, thank you
Thank you so much! It helps
My teacher has this, I will send this to her when she feels better. Can you do a video on hydrocephalus?
Great video!
thanks, wonderful talk!
Very helpful. Thank you!
Thank you so much.. You made it so simple to learn
You have a beautiful voice and clear enunciation. Thank you for a clear presentation at a good pace. 🙏🏻
Great information thank you
Very helpful, dude thank you
Thanks so much it s very helpful😊
Good job explains the subject
This video is very helpful tq
really helpfull for medicos thanks sir
Excellent work! Although is a very rare disease it’s important to know about it. Thanks
Good explanation.
Thank you - great over view!
@MEDSimplified
7 жыл бұрын
+Sarah Louise u r welcome sarah
Thank You sir ✨️
Thank you
This is so interesting - THANKYOU
@beckhamhenderson9827
3 жыл бұрын
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I couldn't focus while watching this cuz I was wondering, is this your hand writing or did you use an application/program to make this .. I loved it. great vid, thank you.
@MEDSimplified
7 жыл бұрын
+SajoOo92 Sir, all the material in this video is first hand made with a digital pen and tablet. And then converted to necessary formats for an animation software. Thank you for ur kind words btw
thank you sir
Super video! You are very good at explaining! This really helped, thank you.
Thanx
Thank u sir ❤️
Thank you. I'm sharing this with my adrenal insufficiency support group. It answers many of the questions that are posed by members of the group with PAI on a fairly regular basis.
@nataliea9829
4 жыл бұрын
This was two years ago but my two year old just got diagnosed. I’m looking for a support group but can’t find one for children
for the causes... one was left out. Failure of the pituitary. It creates a secondary adrenal failure. Great video!
@nicolaventuri5229
6 жыл бұрын
This video is tituled Primary adrenal deficiency.
Good description sir but I d like to point out one minor mistake if u don't mind...U said androgen deficiency produces loss of libido in both sexes but actually it affects only females because males have other sources of androgens like testes so they are not affected... Thanks
Most times 1.5 tab of Hydrocortisone is not enough. Summer time is increased to 4 TAB a day or during high stress. My question is how many patients have a DEFIB or what is the standard?
thank you sir ; its very useful video
@MEDSimplified
7 жыл бұрын
+Rasha Tariq U r Welcome Rasha
thnx
Great video. Thanks for the upload. I've had Addison's for over 20 years. I believe the dosages for medication is different for every patient. My dosage is not as shown in this video. And I do very well. It is also important. To take more fludrocortisone before any medical procedure even dental work
@joelmakelly3584
2 жыл бұрын
Pw.
Hi, my father has low cortisol but normal level of ACTH. What does that mean?
Do video on congenital adrenal hyperplasia, cushing syndrome, liddles, bartter and gitelmann and gordons syndrome pls... Sorry for longlist😳
Plz make more videos on medicine
I was diagnosed with Addison's about 7 years ago and wasnt suffering one of those symptoms. I was told by the Dr is was a stress management condition and I was having a few panic attacks at the time so just believed it. I have been taking hydrocortisone and fludrocortisone for the past 7 years every day. I think im going to get a second opinion.
@bradcampbell5766
3 жыл бұрын
Check out Pam Popper. She can help clear up the medical hype, so you don't get sucked into the medical mill again.
@Poonams586
2 жыл бұрын
Can you please share about the dose ? And your age?
@d.indira7548
2 жыл бұрын
Iwant know more medication about addissones.alsohow toprotect repeat.fenideslone raising bp
@sparko2012
2 жыл бұрын
@@d.indira7548 when I am ill and by body of fighting an infection then I am required to double my daily dose of hydrocortisone. This drives my blood sugar levels up so it is very difficult to manage my type 1 diabetes when I am doubling my steroid dosage.
very nice, simplified, to the point for quick review, good job well done
tqq u
Best👌👌
Good explanation though I would Suggest correcting the spelling errors. E.g. Failure not faliure.
if it's autoimmune, take immunosuppressants and/or immunomodulators.
Opoids can also cause adrenal fatigue. Wish my doctors explained this!!
Beside short synacthen test what other test should be done to diagnose addison disease.
your video is really helpful! one thing i noticed, though - for the ACTH stimulation test, you should give 250 micrograms (0.25mg) of ACTH, not 250mg, that's so much! also, i believe cortisol is usually measured in micrograms/deciliter.
@MEDSimplified
7 жыл бұрын
U r absolutely right Kelly. It was 250 micrograms. MY mistake
@fernsader9261
4 жыл бұрын
Lol huge correction. Difference between life or death in a patient due to malpractice
My Father passed away from Addison's in 1975
great video guys ..keeep it up ....also made videos on cardio diseases
I had a blood test that shows I have anti adrenal anti bodies with a titer of 1.10. I was tested since I have a lot of the symptoms minus the skin stuff. My cortisol was actually high at 23.1... could I still be feeling symptomatic of Addisons? It’s very confusing
sry ...i think the dose of exogenously acth should be 250 micro gram....not milligram.....thanku...if m wrong plz inform me...
Sucks !! It’s taking a long time to get better .
I was diagnosed with addisons disease when i was 4
@tawnyglo13
4 жыл бұрын
So sorry to hear this. How are you doing? Does medicine control it pretty good
can you please upload some cardiac videos? Also diabetes. thx
@MEDSimplified
7 жыл бұрын
+Freny Vaghela Sure. We will try our best
I take medications constantly twice a day. Yet sometimes like now im on my way to a hospital. I can very little keep food down.
@MEDSimplified
6 жыл бұрын
+Hidden-Pride-Gaming i m really sorry about your condition sir. I hope u get well
@bradcampbell5766
3 жыл бұрын
Check out Pam Popper.
Hi, Thank you for the great video! Just wondering how does cortisol deficiency (less gluconeogenesis, ^ insulin activity) lead to weight loss. Thank you
@Roon864
4 жыл бұрын
First maybe bc of loss of fluid Second bc cortisol causes high glucose level in blood >high insulin > target adipocyte to accumulate more fat molecules with time this will cause glucose intolerance >insulin resistance No Gluconeogenesis means no glucose in blood no insulin
Please more information in Spanish 🙏
The loss of adrenaline is very important. How could you miss that?
Hi can i make a question
what is the treatment for addisons w/defective adrenals vs adrenals that have been removed
@MEDSimplified
5 жыл бұрын
Adrenal hormones given artificially
@stephan2796
3 жыл бұрын
Indeed, I actually have this disease and I need to take hydrocortisol as a medine 3 times a day. Since I have started taking the hormones, starting 3 weeks ago, I have felt healthier than ever. Of course, I cannot say yet how it will develop.
very clear presentation. thank you.. am on hidrocortisone replacement. since i got this illness so late in life, am hoping it will be temporary.. this disease is awful and is affecting many of my systems and has caused weight gain. still not sure if cause was over use of steroid injection or severe head trauma, perhaps affecting pituitary.
@MEDSimplified
6 жыл бұрын
Thank u so much for the appreciation
@shaek6820
2 жыл бұрын
Can you get Adrenal fatigue from head trauma? And have weight gain? Because this has been my experience but no diagnosis. In fact, the endocrinologist told me there’s no way I could have adrenal fatigue or failure because I was overweight. I think I was overweight because I couldn’t move for years and ate to feel better. (Which didn’t work ) Now I take adaptagenic herbs,Cordyseps mushrooms, vitamins and freeze dried cow Adrenals (found at the health food store) and I can at least function on some level. But without these I can’t function at all. The Video was very helpful though. Thanks
@jovanimorales3411
2 жыл бұрын
@@shaek6820 No such thing as Adrenal "Fatigue". Ask your Endocrinologist to perform a morning ACTH Stimulation test. Have an Addison's antibody test done. Get imaging done of your Pituitary & Adrenal Glands. Yes, u can develop Adrenal Insufficiency if your Pituitary or Adrenals were damaged by trauma/hemorrhage/infection. These tests will confirm whether u have Adrenal Insufficiency (AI) or not and need lifelong steroids. It will also differentiate whether u have Primary or Secondary AI.
Font is too small
My mom was been treated pituitary adenoma by surgery and then radiotherapy. Several years later her pituitary gland seems to shrink in function , not able to secrete ACTH , and cortisol level is too low . She got the symptoms of heaviness in chest, sometimes stomach and is not feeling fresh and energetic . She was initially taking prednisone with dose of 5 mg in the morning and 2.5 mg in the evening . Since the symptoms does not subside, or increase more , doctor prescribed 20 mg in morning and 10 in morning for a week . And now she is having moon face and. Still not fresh and energetic. Please help those who knows
@sivasan4399
Жыл бұрын
My mother also a Addison patient ... she has same problems...
is an Addinson disease a addernal disease ????
clinical features 3:09
😊
Thanks for the video it's great , but please change the intro, the chalk sound made me cringe so bad.
@MEDSimplified
7 жыл бұрын
+rawan naj HaHa. Thank you raj for bringing it to notice..
Omg this is what's wrong with me...
I have primary Addisons disease I've had it since I was 14 I am now 65
@tannerplays6656
4 жыл бұрын
I have Addisons Disease since I was 9 years old and now I am 11 It was a hard time.
@itsminal4638
4 жыл бұрын
Are you recover and you have any disability
@barbarakoeppe2623
4 жыл бұрын
Mi ma mi vlogs there is no cure for Addisons disease but i am thankfull i have lived a normal life just in the last few years i have a few more problems but i still work full time at amost 66
@itsminal4638
4 жыл бұрын
@@barbarakoeppe2623 my son 18year old he is leg payralize .my son have last year fever and vomating and after 2days urine block .after 1month he is stable but both leg have no power and not walking plz any suggestions for my son
@barbarakoeppe2623
4 жыл бұрын
Mi ma mi the only thing we can do is pray and ask God to heal him if not ask God to help him through it or give him strengh. Im sorry to hear about your son
it can't be fully cured??? i mn rest of d life patient need to be under medication?? plz reply..its urgent
@princesspentagram3458
7 жыл бұрын
Atindrila Dey There is no known cure unfortunately and a patient can lead a relatively normal life but this is achieved with various medications it stops adrenal crisis from happening which can be fatal I hope this helps you with your question
@ekop1778
7 жыл бұрын
there will be a cure SOMEDAY IVE HAD IT FOR ALMOST 19 YRS NOW READ ALL KINDS OF STORYS ABOUT CURES I THINK THERE WILL BE
@affinitylivingriverside3053
3 жыл бұрын
@@ekop1778 thanks for sharing your story. What is your quality of life if you don’t mind me asking? Also has it affected your vision?
adrenal insufficiency presents with irregular or absent menstrual period in women
@MEDSimplified
7 жыл бұрын
It depends upon the Severity of adrenal faliure. Also different females have different response
@bradcampbell5766
3 жыл бұрын
@Margo Lockweeze Feelings about our health are subject to manipulation. Doctors are not scientists, and science has become politicized. Doctors probably use an arbitrary standard to make you a regular customer once you are a believer. It's not their fault... Good Will Hunting
nice... but speaking style is not consistently fast a bit as is the writing .. but thanks anyway
After 15 days of prednisolone corse...can the pt suffer from addison symptoms?
@MEDSimplified
6 жыл бұрын
+opium latex i don't think so
Hindhi m dalo koi vdo
in my country Norway we are 5 million people i read that there is only a little bit more than 1000 addison's damn yeah the sleep is true i sleep 4 to 6 hours and i struggle to fall asleep as quick as my parents : P they fall asleep within 1 hour i can spend up to 3 hours before i fall asleep
my boyfriend died of this... it was terrible
@MEDSimplified
3 жыл бұрын
Very sorry for your loss
@alllisun5298
3 жыл бұрын
@@MEDSimplified thank you :)
@lunam7249
Жыл бұрын
Rip
I have addison's disease
@michealcheng2949
3 жыл бұрын
thank you DR Rorpopor herbal on KZread for helping me to cure my herpes totally, thank you DR Rorpopor herbal on KZread
*failure
Packed with typos 😂😂
No sex hormone replacement?
@MEDSimplified
7 жыл бұрын
Nuwanda usually sex hormones are not affected
@syednadeemahamed706
5 жыл бұрын
Adrenal gland is not the primary source of sex hormones.Testes and ovaries are the main source.So even if adrenal gland is insufficient the ovaries and testes compensate the losses of sex hormones.
I have Addisons Disease and I got it when I was 9 years old...
@bradcampbell5766
3 жыл бұрын
Don't get too attached to labels, and don't be manipulated by so-called "authority figures". Do your own research, and heal yourself. You don't want to be a regular patient in the medical mill. Check out Pam Popper. I realize she's a little older, but oh well, think of her as a loving grandmother with a lot of wisdom. Good luck.
@affinitylivingriverside3053
3 жыл бұрын
Hi, if you don’t mind me asking how old are you now? Do you lead a normal life? Has this affected your vision? Are you on a medication? Sorry I’m asking all these questions but thank you and wish you all the best
why did you say anorexia as a symptom. anorexia is a MENTAL disorder in which the patient doesn't want to eat to control food, to feel better about their bodies and keep control. I don't see how anorexia is related at all. you mean low appetite?
@chriswilkinson1250
6 жыл бұрын
Medically anorexia just means loss of appetite. 'Anorexia nervosa' is the mental health condition where people dont eat due to perceived body image issues, but we have come to refer to that as just anorexia in daily life.
@lunam7249
Жыл бұрын
Please..read medical books...there are millions of causes or anorexyia and catchexia.....besides mental, physical
@lunam7249
Жыл бұрын
Some " anorexics" are suffering from a form of addisons disorder....try to keep up...the class is starting now