In this recorded talk, David MacMillan, James S. McDonnell Distinguished University Professor of Chemistry and 2021 Nobel Prize Laureate in Chemistry, talks about his path to chemistry and the important role his brother played in this process. He learned early on that despite the knowledge, science and chemistry doesn't care about what you know or think, it's going to do what it wants to do, and you have to be ready to grab the reins and hold on tight and let it lead you where it wants to take you.