10. Glycogen metabolism- Glycogenesis and Glycogenolysis

Glycogen metabolism
Glycogen
Homopolysaccharide of glucose with alpha 1-4 glycosidic linkage in linear chain and alpha 1-6 at branching point
Branching make molecule more globular, compact and less space consuming
Metabolism includes
1. Glycogenesis
2. Glycogenolysis
Glycogenesis
Synthesis of glycogen from glucose
Key enzyme- glycogen synthase
Steps
1. Activation of glucose to UDP-glucose
2. Addition of glucose to primer/ glycogenin
3. Elongation up to 10 to 12 glucose units
4. Branching by forming alpha 1-6 linkage by branching enzyme
5. Elongation
6. Branching
7. Glycogen
Glycogenolysis
Synthesis of glucose from glycogen
Key enzyme- glycogen phosphorylase
Steps
1. Removal of glucose in the form of glucose 1 phosphate
2. Limit dextrin formation
3. Transfer of trisaccharide unit from branching point to linear chain by transferase
4. Breaking of alpha 1-6 linkage and liberation of Free glucose by debranching enzyme
5. Again removal of glucose in the form of glucose 1 phosphate
6. Conversion of glucose 1 phosphate to glucose 6 phosphate
7. Glucose formation
REGULATION
glycogen synthase active in dephosphorylated state
And
Glycogen phosphorylase active in phosphorylated state
Insulin favours the glycogenesis by decreasing cAMP and glucagon favours glycogenolysis by increasing cAMP
Glycogenesis is inhibited by Glucagon in Liver

Пікірлер: 270

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    @araishkhan9819

    10 ай бұрын

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    8 ай бұрын

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    8 ай бұрын

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    8 ай бұрын

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    Ай бұрын

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    @fearlesshim

    22 күн бұрын

    Passed.

  • @vrindhacm3387
    @vrindhacm33874 жыл бұрын

    thanku sir...actually i was fed up with this glycogen metabolism..and i searched in youtube and found ur class....awesome..... well understood....thanku soo much

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    @premroy83123 жыл бұрын

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    @179sanjeevmandavilli65 жыл бұрын

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    3 жыл бұрын

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    @FarmanAli-tw6ou4 жыл бұрын

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    2 жыл бұрын

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    9 ай бұрын

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    8 ай бұрын

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    @RohitSaini-yt3zh3 жыл бұрын

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    @swatimahapatra2841

    3 жыл бұрын

    Can you know any physiology youtube channels

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    3 жыл бұрын

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    @shubhamkumar639511 ай бұрын

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    @beingmusical78683 жыл бұрын

    Thank you so much sir 🙏🏼

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    @taniasarkar49093 жыл бұрын

    Legendary lecture sir👍👍👍

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    @Ankit.malyaj10 ай бұрын

    Thank you so much sir❤❤😊😊

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    @learnteachlt53774 жыл бұрын

    U make it simple sir

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    @Bio159 Жыл бұрын

    Thank you My Spiritual daddy ❤️.Very easy and conceptual explanation...

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    @user-mu3bw9ss3cАй бұрын

    Thankyou so much for your clear cut explanation sir❤️

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    Nice lecture sir I can understood well after watched this video

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    Thanks u sir ..... It very useful for the exam I am from Chennai ...kmc medical College

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    @shalaka65023 жыл бұрын

    Simply awsome sir ty

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    @_sidhantbansal_3 жыл бұрын

    Thank you so much sir!!!!

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    @anshitajham82245 жыл бұрын

    Nice explaination sir...

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    @sweetathegreat3 жыл бұрын

    Very clear Thank you sir 😁

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    @bhavanangowda8073 жыл бұрын

    Great lecture 👍

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    @kirubhahari91655 жыл бұрын

    thank you so much sir

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    @kajaldodiya5622 жыл бұрын

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    @drmanojgupta7635 Жыл бұрын

    Awesome lecture Thankyou

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    @rashidsworld55364 жыл бұрын

    Thnqu sir...osum lecture

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    @hanumanthuanjali2985 Жыл бұрын

    Thank u soo much for ur video sir. It helped me to understand in a better way. This is the best🙏🙌

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    @harshdeep2854 Жыл бұрын

    thanks sir u help us to get good marks in b pharma bio chemistry

  • @saikirankongalla7036
    @saikirankongalla70365 ай бұрын

    Thanks for your time sir

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    @vishnumohanan9473 жыл бұрын

    Very good teaching👍👍

  • @nslfbass6235
    @nslfbass62354 жыл бұрын

    The glucose molecule released from glycogen through the action of glycogen phosphorylase yields 3 ATPs instead of 2 ATPs if directed toward Glycolysis. Explain? Thankyou

  • @4BIDDEN.SECRETS

    @4BIDDEN.SECRETS

    4 жыл бұрын

    Look ! In 1st step of glycolysis G is converted to G6P which require ATP, now in glycogenolysis we directly get G6P and this G6P undergoes glycolysis so there is no 1st step of glycolysis and we gain an extra net ATP the end

  • @4BIDDEN.SECRETS

    @4BIDDEN.SECRETS

    4 жыл бұрын

    And remember glucose is released in the form of glucose-1-phosphate from glycogen by glycogen phosphorylase enzyme

  • @shurtz8058
    @shurtz80582 жыл бұрын

    I can add subtitles for your videos ....as while taking lecture...sometimes we are not able to understand what word you said ....

  • @aratijadhav9305
    @aratijadhav93054 жыл бұрын

    Sir please make a video on Kreb's cycle as well

  • @CHANDRAKUMARCHENNAMSETTY
    @CHANDRAKUMARCHENNAMSETTY8 ай бұрын

    Thanku sir for this wonderful lecture

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    @chaitanyareddy67054 жыл бұрын

    Excellent 👌 lecture

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    @muhammedanas9714 жыл бұрын

    Very helpful thankyou sir

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    @bidyadharadash1829 Жыл бұрын

    Very very helpful sir ☺

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    @sanghamitrasamanta62633 жыл бұрын

    Thanks a lot sir...

  • @user-wk2gp3tu8h
    @user-wk2gp3tu8h3 жыл бұрын

    Thank you sir 👍🏻👍🏻☺️

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    @sauravpurushothaman48083 жыл бұрын

    Love from Kerala

  • @sonam268
    @sonam2683 жыл бұрын

    Thank you sir 😌

  • @AyubKhan-bz4yr
    @AyubKhan-bz4yr3 жыл бұрын

    Thank you sir 🙏🙏

  • @siddharthsid4525
    @siddharthsid45253 жыл бұрын

    Perfect 👍

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    @kunikachauhan22902 жыл бұрын

    Sir you're awesome

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    @amalantovarghese35544 жыл бұрын

    Sir you are massss🤗🤗

  • @pavanyadav1691
    @pavanyadav16913 жыл бұрын

    Sir plz up load the notes to Google Drive and give link that will be most helpful for the students

  • @69-sunayanamitra40
    @69-sunayanamitra40 Жыл бұрын

    very good explaination sir

  • @amit37715
    @amit377154 жыл бұрын

    Excellent

  • @gaddimohalledi6053
    @gaddimohalledi60533 жыл бұрын

    Thank you sir ☺️😊

  • @abheemishra
    @abheemishra2 ай бұрын

    Being biochemistry student sir is God 🙏🏼

  • @hussainzuhajamz1420
    @hussainzuhajamz14204 жыл бұрын

    Thnku so.much sir.

  • @jainilshah576
    @jainilshah5762 жыл бұрын

    Thank you sir.