10. Glycogen metabolism- Glycogenesis and Glycogenolysis
Glycogen metabolism
Glycogen
Homopolysaccharide of glucose with alpha 1-4 glycosidic linkage in linear chain and alpha 1-6 at branching point
Branching make molecule more globular, compact and less space consuming
Metabolism includes
1. Glycogenesis
2. Glycogenolysis
Glycogenesis
Synthesis of glycogen from glucose
Key enzyme- glycogen synthase
Steps
1. Activation of glucose to UDP-glucose
2. Addition of glucose to primer/ glycogenin
3. Elongation up to 10 to 12 glucose units
4. Branching by forming alpha 1-6 linkage by branching enzyme
5. Elongation
6. Branching
7. Glycogen
Glycogenolysis
Synthesis of glucose from glycogen
Key enzyme- glycogen phosphorylase
Steps
1. Removal of glucose in the form of glucose 1 phosphate
2. Limit dextrin formation
3. Transfer of trisaccharide unit from branching point to linear chain by transferase
4. Breaking of alpha 1-6 linkage and liberation of Free glucose by debranching enzyme
5. Again removal of glucose in the form of glucose 1 phosphate
6. Conversion of glucose 1 phosphate to glucose 6 phosphate
7. Glucose formation
REGULATION
glycogen synthase active in dephosphorylated state
And
Glycogen phosphorylase active in phosphorylated state
Insulin favours the glycogenesis by decreasing cAMP and glucagon favours glycogenolysis by increasing cAMP
Glycogenesis is inhibited by Glucagon in Liver
Пікірлер: 270
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@gymnasticlover14
15 күн бұрын
Konsi clg me ho
@_life
15 күн бұрын
@@gymnasticlover14 SKIMS MEDICAL COLLEGE SRINAGAR
thank you sir....i am understanding each and every chapter of biochemistry very clearly by watching your lectures....u r really great sir
@bryantbarrett2657
2 жыл бұрын
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@bryantbarrett2657
2 жыл бұрын
@Vihaan Ayaan thanks for your reply. I found the site through google and im trying it out now. Seems to take a while so I will reply here later with my results.
@bryantbarrett2657
2 жыл бұрын
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@vihaanayaan2186
2 жыл бұрын
@Bryant Barrett you are welcome =)
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2 жыл бұрын
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@araishkhan9819
10 ай бұрын
Bhaiya, how was your result? How much did you study biochemistry before the university exam? My exams are in a month and I have not studied biochem whole year bcoz I hated it but now I am in a very scary situation so I want to know about your experience.😢
@iblish3247
8 ай бұрын
@@araishkhan9819Don't worry just read the pdf (notes) of jambhulkar sir u can clear your university exam easily
@brkabhi
8 ай бұрын
@@araishkhan9819micro 😌🌚
@asmitapatil1097
8 ай бұрын
Bhai Mera bhi hojay😢
@dangerous1014
Ай бұрын
@@araishkhan9819 u asking result too late that guy probably forgot
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@fearlesshim
22 күн бұрын
Passed.
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@user-lm1zd6mv8c
3 жыл бұрын
Do you know tamil
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@zainashorts
2 жыл бұрын
Which year of mbbs are you in ? I also want to give USMLE
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@AkashKS-dp6yg
Ай бұрын
Bams biochemistry??
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@snehamishra8554
9 ай бұрын
2x😂
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9 ай бұрын
Us oye
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9 ай бұрын
😅
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9 ай бұрын
Nobady
@gokuls4177
8 ай бұрын
Morning University exam at 9.30 am , now I'm revising At 4.35 am
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@swatimahapatra2841
3 жыл бұрын
Can you know any physiology youtube channels
@user-lm1zd6mv8c
3 жыл бұрын
@@swatimahapatra2841 Dr.Nazeeb lectures
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The glucose molecule released from glycogen through the action of glycogen phosphorylase yields 3 ATPs instead of 2 ATPs if directed toward Glycolysis. Explain? Thankyou
@4BIDDEN.SECRETS
4 жыл бұрын
Look ! In 1st step of glycolysis G is converted to G6P which require ATP, now in glycogenolysis we directly get G6P and this G6P undergoes glycolysis so there is no 1st step of glycolysis and we gain an extra net ATP the end
@4BIDDEN.SECRETS
4 жыл бұрын
And remember glucose is released in the form of glucose-1-phosphate from glycogen by glycogen phosphorylase enzyme
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