NCCR Molecular Systems Engineering
NCCR Molecular Systems Engineering
Molecular Systems Engineering is a National Centre of Competence in Research (NCCR) funded by the Swiss National Science Foundation (SNSF), and headed by the University of Basel and the ETH Zurich. This NCCR combines expertise from chemistry, biology, physics, bioinformatics, and engineering. The overreaching aim is to develop tools and devices to monitor and manipulate off-equilibrium (bio)chemical systems. These may find applications in the synthesis of high added-value products, as innovative diagnostic tools and for the restoration of a desired cellular or organ function.
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Apart from my usual silly niggles, this was a great lecture. I love it when someone comes up with an original idea, even if mistaken. My silly niggles are, why can't any of these intelligent ppl sort out a pointer that the audience, live and on line, can see? Using the tiny triangle we use on PC's, or using a fancy laser pointer, is virtually useless. I have no qualifications but I'd suggest a stick with led lights along its length? Also the camera man should be told to get the best angle for reading the screen and stick to it, nobody needs 4 useless angles when the 1 decent one will do.
. and with what sir are You whacking
Hydrogen rich alkaline fluids. That must have something in common wit acidic Key Limes and their alkaline soil theyre growing on
Absolutely brilliant and fascinating
This very much compliments Dan Dennett’s book “From Bacteria to Bach and Back”, which is highly recommended reading
re: ATP. See Comings (2006) article, 'The Quantum Plenum: The Hidden Key to Life, Energetics and Sentience' which discusses bioenergetics incl. D. R. Wilkie's (1975) work on ATP.
re. timestamp 53:00 'Consciousness'. See Roeland van Wijk's (2014) work on biophotons in biology i.e. his book 'Light in Shaping Life: Biophotons in biology and medicine'.
re. timestamp 29:00 Excellent paper by James Shapiro (2008) on the intelligence of bacteria. www.researchgate.net/publication/5794057_Bacteria_are_small_but_not_stupid_Cognition_natural_genetic_engineering_and_socio-bacteriology
'Clays and the Origin of Life: The Experiments' by Kloprogge & Hartman (2022) www.ncbi.nlm.nih.gov/pmc/articles/PMC8880559/
Very profound ideas about the porous rock of the vents being a template. Life does tend to take the shape of its environment
im so happy right now. Thanks for the best presentation of this year. (shed a tear)
I remember Nick said something about the voltage gap between cells being like standing next to a lightning bolt if you scaled up the size. Does anyone know the timestamp he said it? Thanks
The Age of Life The ability to carry out actions differentiates inanimate matter from living matter. In turn, every action involves the management of Information. We do not know what Matter is or what Life is, and we assume that all life forms that currently inhabit the planet descend from a common ancestor (LUCA), an organism whose complexity is evident if we consider that it is attributed the ability to reproduce. Due to the above, it is reasonable to assume that “seeds of life” existed prior to LUCA. Assuming that the “seeds of life” emerged together with the Big Bang is a bold postulate, and as such requires a solid empirical foundation. When observing Evolution considering the information that our ancestors have managed, and that currently managed by humanity, it is possible to distinguish seven evolutionary milestones; Its analysis allows us to postulate that Life goes back to the origin of the Universe, and the existence of an “evolutionary pattern” is evident, which turns out to be the Golden Ratio. Evolutionary Milestones -Emergence of ”Seeds of Life”(1) (thirteen thousand eight hundred million years ago). -Emergence of LUCA (Last Universal Common Ancestor) three thousand eight hundred million years ago -Emergence of the brain (five hundred and fifty million years ago). -Emergence of what was the precursor of human language (2) (twenty-seven million years ago) -Emergence of the language that characterizes us(3) (around two hundred and twenty thousand years ago). -Emergence of “the information age” with the transistor (1950) -Evolutionary Singularity(4) proposed by Ray Kurzweil, who postulates that humanity will access a Singularity as a result of the exponential growth of information management (year 2045). Evolutionary sections Among successive evolutionary milestones we can distinguish the following six “Evolutionary Tranches”, with the duration indicated (in years): Tranche 1: 10,000,000,000 (13,800,000,000 - 3,800,000,000 = 10,000,000,000) Tranche 2: 3,250,000,000 (3,800,000,000 - 550,000,000 = 3,250,000,000) Tranche 3: 523,000,000 (550,000,000 - 27,000,000 = 523,000,000) Tranche 4: 26,780,000 (27,000,000 - 220,000 = 26,780,000) Tranche 5: 219,905 (220,000 - 95(5) = 219,905) Tranche 6: 95 (95 - 0 = 95) The particular variation experienced by the Evolutionary Sections over time suggests using the logarithm of said sections (LT) to analyze their behavior over time. The logarithms in question are as follows: LT1 = 10.0000 LT2 = 9.51188 LT3 = 8.71850 LT4 = 7.42781 LT5 = 5.34224 LT6 = 1.97772 The lines between two successive logarithms have the following slopes (P) P1 = -0.48812 (9.51188 - 10.0000 = -0.48812) P2 = -0.79338 (8.71850 - 9.51188 = -0.79338) P3 = -1.29069 (7.42781 - 8.71850 = -1.29069) P4 = -2.08557 (5.34224 - 7.42781 = -2.08557) P5 = -3.36452 (1.97772 - 5.34224 = -3.36452) After searching for an “evolutionary pattern” we will determine the variation between successive slopes, which is given by the Ratio (R) between them, that is, P2/P1; P3/P2; P4/P3; P5/P4, and is the following: R1 = 1.62538 R2 = 1.62682 R3 = 1.61586 R4 = 1.61324 The above values differ from the Golden Number (1.61803), a number also called the golden number, the number of God, the extreme and average ratio, the golden ratio, the golden mean, the golden ratio and the divine ratio, by 0.45%; 0.54%; 0.13% and 0.30%, respectively. In turn, the average of the sum of the ratios is 1.62032. This value differs from the golden ratio by 0.14%. The results obtained allow us to postulate that Evolution follows a pattern that is a function of Information and the golden ratio, and that Life goes back to the origin of the Universe. (1)The last universal common ancestor (LUCA) is the putative common ancestral cell from which the three domains of life, Bacteria, Archaea and Eukarya, originated. The complexity that LUCA is assumed to have does not give rise to affirming that it arose by “spontaneous generation”, it being valid to postulate the pre-existence of “seeds of life” prior to the emergence of LUCA; It is postulated that the origin of the “seeds of life” dates back to the moment when Matter arose in the Universe, that is, around thirteen thousand eight hundred million years. (2)“We find that the anatomical potential to produce and perceive sounds differentiated by their formants began at the latest by the time of our last common ancestor with Old World monkeys (Cercopithecoidea) about 27 Ma ago”; " Which way to the dawn of speech?: Reanalyzing half a century of debates and data in light of speech” (Science magazine) (3) The last change in the position of the hyoid bone in humans, which would have allowed access to the language that characterizes us, took place approximately two hundred and twenty thousand years ago, and its data is based on archaeological evidence and anthropological studies. There is no scientific source that records this change on an exact date. (4)Due to the exponential growth of information technologies, Ray Kurzweil postulates that a Technological Singularity will occur in the year 2045, at which time technological growth will be so rapid and so profound that it will be impossible to predict what its consequences will be. (5) It is the time between 1950 and 2045, the latter year in which Ray Kurzweil postulates that a Singularity will take place.
This is why I decided to skip because Michael levin and his team is beyond all this
Michael Levin is great but he’s not in the business of explaining the origins of life. Nick and Michael are correctly highlighting the importance of biolelectricity but they are focusing on different things.
@@ROBERTBROWN090564 yes and thank you for elaborating on that
What’s name of this device?
If he'd only not mentioned Humanity as a contribution to a fictitious climate change.
Have you published your "research" anywhere?
If metabolism is older than genes, then genes are just accessory to life. Is the definition of life shifting towards something like a self-reinforcing thermodynamic favorable process?
CO2 + Global Warming = moron
So…inorganic pore and autophtrophic cell are analogous in their respective structures😮 A very advanced version of Heschel’s embryos (which turned out to be a complete scam)😮 On this hypothesis we still have no account of: 100,000,000 -3,500,000,000 base pair operating instruction sets for early life (origin of polynucleotides like DNA and RNA) Any account of how 200 plus machines in the cell arose (that is testable) An account of chirality An account of selection of the right 20 amino acids out of over 80 to chose from randomly (origin if polypeptides) the origin of a stable energy source (polysaccharides) At least some sort of account for how the above elements self-assembled into a working early cell that could replicate and some sort of homeostasis But other than those deficiencies Nick had a great hypothesis. Is this why Harvard Origin of Life professor stated a year or two ago that OoL research is a scam?😮
Tell you your IQ is below 90, without telling us your IQ is below 90
Which origin of life researcher?
Who says the first cell had 200 plus machines?
WHICH HARVARD RESEARCHER?
What makes you think the first cell had 100 million to 3.5 billion base pairs of DNA or RNA? I take it you have never read a single science paper or book on the origin of life.
The thermal vent diagram reminds me of neurons. The way we have depolarization and repolarization(firing and resting states). We seem to find analogy everywhere when considering the likeness of life to non-life in this universe/earth. The concept of a mutual system rather than life is separate from environment is also fascinating. When we see how it works electrically, chemically, we see the boundaries we believe are there arent as rigid as we assume. There is exchange and communication, there is interaction. This lecture is awesome, inspiring. Thank you for posting this, I plan to check out this channel in more depth in the near future.
Hello sir can you make video on working
DR . LANE "In the realm of Particle Physics and Particle Chemistry, a captivating debate surrounds the fundamental constituents of matter, specifically focusing on the intricate building blocks of quarks, electrons, and gluons Can we unravel the profound essence of these particles and their interactions, which ultimately sculpt the very fabric of our universe? Delving into the heart of this discourse lies a fundamental question: What are the elemental particles that constitute quarks, electrons, and gluons, and how do their dynamic interplays delineate the fundamental architecture of matter? As we probe deeper into the subatomic realm, we unravel the mysterious dance of quarks, the elementary particles that make up protons and neutrons. Are they truly indivisible, or do they harbour deeper complexities awaiting discovery? Likewise, electrons, the enigmatic carriers of electric charge, stand as solitary entities, yet their behaviour perplexes even the most astute physicists. How do these particles, seemingly devoid of internal structure, exert such profound influence over the properties of matter? And then, there are gluons, the mediators of the strong force binding quarks together within the confines of atomic nuclei. How do these elusive particles govern the stability and structure of the very matter from which life itself emerges? In the grand tapestry of existence, proteins and sugars, the very building blocks of life, find their genesis in the intricate arrangements of these fundamental particles. Can we decipher the profound implications of these subatomic constituents on the macroscopic world, shedding light on the origins of life itself? Thus, the discourse unfolds, as we delve into the depths of particle physics, seeking to unravel the mysteries of existence through the lens of quarks, electrons, and gluons, and their profound implications for the nature of reality and the origins of life."
Just because the electric flow in a system can be described does not mean that it is organized by electric current; Just as in an electronic system of a telephone, the electrical flow builds the telephone.
It's crazy how many anti-science religious nutjobs comment on science videos, whether on the origin of life, evolution, the big bang. Then the religious people are dumb enough to turn around and ask, "If you don't believe in God, then why do you care what we believe?" Not to mention religious people trying to pass laws that impose their religious beliefs onto others, or religious people discriminating against marginalized peoples or people who are in the minority (gay men, for example), or making court ruling that say a cluster of 100 undifferentiated cells - with no nervous system at all, no brain at all, no neurons at all, no cardiovascular system at all, no heart at all, etc., with no ability to experience pain, or to have dreams, desires, and aspirations - is a child and deserves all the same legal protections as your newborn daughter does.
53:07 They arrange into octagonic & 12-gonic & 24-gonic structures.
The great Nick Lane. His recent fascinating book "Transformers" is worth a read or listen.
Alkaline Hydrothermal vents???, the only miracle to explain the origin of life???, I think you are going to need at least 100 more miracles!
Have you attempted to understand what he is saying?
Agora a biologia tem um novo paradigma como a física
A luta o que vence é o mais adaptado é contra as civilizações que o programa SETI procura e será travada através da viagem no tempo
Se eu não estou enganado na época dos dinossauros e a evolução humana o sol era uma estrela mais jovem uma estrela azul ou branca emitindo mais radiação ionizante que causa mutações no DNA
Mas Charles Darwin também está certo
Primazia pela criação de qualquer forma de vida
A luta pela criação da vida viagem no tempo
A origem elétrica da vida
We dont know what Energy is. Energy is philosophical predicate. We only know FORMS of energy (electric, magnetic etc)
Evolution=noi tu love. Genesis articulates the origin of all life but only those who are drawn to the Creator can comprehend it.
First you make the claim that the reality behind creation is dependent on the scientific community agreeing on how it took place if it was witnessed by all the members of the community. Just after mentioned climate change which explains the previous statement. You don’t get to vote reality into existence and denouncing reality when it doesn’t mesh well with accepted theories. A scientist denying clear evidence of an event doesn’t make them a scientist, a scientist reports on observations they make, they don’t fabricate affects in order to fit a hypothesis. On a larger scale, an entire group or community of people agreeing on false hypothesis’s and bearing false witness for personal gain doesn’t make them scientists, it makes them immoral and uncredible fools. False witness is not reserved only to clergy, and state authorities. It also applies to scientists. The mistake is there is a god and he’s returning soon.
A religious nut on the internet says what?
"You don’t get to vote reality into existence and denouncing reality when it doesn’t mesh well with accepted theories." This is a lesson the religious never learn. They claim to know as fact what they cannot know. Science is about discovery and adjusting to new information.
My beloved HEIR Nick thank you for attending...unto our OWN. Likewise thank you for thy visitation to comfort the COMFORTER! Love you my beloved HEIR!
Students what is an Observer? Thy Students from "Who am I an Observer"? Made NEW thy "i" AM an Observer! Indeed. How Students? From Thy shared Feet resting upon! Well said
Students shared "i" AM will say, gave something to talk about unto all the "Who Am I"? Keep watch!
Be still and know that I am, you are, we are - simply being aware of being aware - as Life at Large - eternally actualizing infinite potential, because only Eternity can fully embrace Infinity. To actualize potential: Dream it, Feel it, Do it. Living wholes are ever greater than the sum of their constituents.
Amazing talk! Thank you so much for sharing it with us.
Everything is made out of polarized light that turns into alternating current crystal light then it grows and is consummated back into direct current light. It exist in a light vortex matrix eddy and repetes continually. After many orbits of di-men-sions long ago a prior dimension discovered this and chose to create begotten di-men-sions in their image. God Almighty is real we are graven images and watched. Given law and if obedient the individual spirit of our continously resurrected soul can receive eternal life. But we live in a rebellious di-men-sion of evil spirits whom would rather YOLO their Names in ignorance out of the Book of life. This illusion of achievement of earthly wants and the ignorant belief that one is not subservient to thee glorious Most High is caused by rebellion. If You simply understand that all future generations believe that they are the best. You would finally realize that one di-men-sion will never achieve a greater knowledge that of the knowledge of all combined. 😞 Have a good day... Brothers and sisters of Adam.
Yikes! Is that supposed to be satire?
Best ever !!
This guy doesn't know what he's talking about.A scientist in Houston Texas named Doris Taylor creates internal human organs (including working human hearts) for transplant from peoples' stem cells and not that long ago Barbara Streisand had three clones made of her dog,Sammie.
So what part of the video do those examples supposedly refute? Give timestamps.
Euraĺotic process is a cure for the emeñt of body
That is the answer too hydrgen perikside reacting on a secondary of flesh of human species
Standing on the shoulders of midgets.
Was there a point you were hoping to make?
@@mcmanustony I can't unpack it. I had a lobotomy in the meantime and now it makes no sense to me whatsoever.
Johar 🙏💐Namaste 🙏🇮🇳💎🤝🙏💐😎🏁
schumann resonance cavity around 19:00. also when the Earth vibrates differently then our cells etc will too.