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  @slmerts99555 күн бұрын

  thank u

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  @user-ev6zu7yq6c15 күн бұрын

  Thank you Dr. ❤

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  @dolomuse18 күн бұрын

  What is the implication of IDC without DCIS? Does this imply a lack of local, clonal cellular evolution and suggest breast reseeding from a distant metastatic locus? Thanks so much for this excellent channel!

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  @mariodelemos450019 күн бұрын

  Great presentation, particularly on how the social conditions lead to differences in diseases supposedly based on biological race.

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  @mariodelemos450019 күн бұрын

  Thank you for such great presentation on a very important topic. As an oncology pharmacist, your presentation makes me rethink how useful (or NOT) it is to look at the pharmacokinetics or drug metabolism data that supposedly vary in different races. Medline MeSH still have white people, Asian, etc. as well.

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  @kamongankanza890219 күн бұрын

  Thank you

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  @mariodelemos450021 күн бұрын

  Thank you Dr. Deyrup I know that pathologists often describe the gross pathology in food terms, but this description of the histology is so helpful that I will never forget it the difference again. I am an oncology pharmacist and I am systematically going through your videos, including the non-oncology subjects because I found that so educational and engaging.

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  @selmgfan22 күн бұрын

  thanks this was amazing

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  @victorialeigh571123 күн бұрын

  Thank you for these videos. I was looking for detailed videos to follow along with my Robin's book (I am using the 10th edition of Basis of Disease). I am interested in the Path A direction, and I want to learn as much as I can about pathology before I apply. Your videos have helped a lot.

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  @beatricevaillant510824 күн бұрын

  Greetings from Germany! I love your lectures. I am a medical student and I use your lectures to prepare one of my exams. In German medical schools also we are thought only caucasion do get MS for example even though there are so many cases contradicting it. There is even a German study showing that if immigration was before the age of 15 the risk of having MS is similar to the national average. The average time needed to diagnose MS in Germany is over 2 years and when one belongs to the "wrong" community it takes even longer to get a diagnostic.

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  @obedarmah740226 күн бұрын

  You are so good

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  @viswadevr.j229326 күн бұрын

  Thank u for this amazing class. Simple and precise ❤

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  @sannpwintaung1224Ай бұрын

  Thank you sir great explanation

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  @cabsouthАй бұрын

  Excellent presentation

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  @dylansolomon3423Ай бұрын

  Awesome lecture. To the point, concise, and deeply understandable.

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  @adreamanapron299Ай бұрын

  It’s super useful mam ❤ Thanks 🤩

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  @ozguromak2 ай бұрын

  That was so interesting, thank you so much !

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  @thibo33232 ай бұрын

  Was just diagnosed with Clear Renal Cell Carcinoma...thanks for the interesting explanation. I have worked in a hematology lab for 41 years but have always been interested in pathology.

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  @mariodelemos45002 ай бұрын

  I assume most cells in human body are dormant (permanently differentiated, senescent, quiescent) and therefore not taking up labelled glucose in PET scan?

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  @royaledits_12 ай бұрын

  Gate keeping this channel! You r the best!!

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  @mariodelemos45002 ай бұрын

  Thank you Dr. Deyrup for such an engaging and clear presentation, particularly in pointing the relevance of various new information. As an oncology pharmacist, I find it challenging to remember the genes and proteins involved in carcinogenesis, many of which have become targets for drug therapy. Knowing what the do in normal cells give me a better framework to learn about them.

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  @jugnu3612 ай бұрын

  Thanks

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  @dudethatsbad85412 ай бұрын

  I’m being %100 honest, your explanations are just a masterpiece This need more attention fr

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  @melon88702 ай бұрын

  you are the best thank you doc :)

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  @melirj2 ай бұрын

  Thanks 🤩 It is so understandable 👏🏻

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  @MariaVargas-uw1kn2 ай бұрын

  Fantastic Content !!!!! I've just discovered your channel and I loved it !!!! Thank you for this high standard lesson❤

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  @EternianIrish2 ай бұрын

  Brilliant, thank you. I've started working in ENT as a Physio and this is a terrific resource

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  @ruwiem93673 ай бұрын

  this really helped me thank you

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  @mariodelemos45003 ай бұрын

  Thank you Dr. Deyrup for the excellent lecture that helps me appreciate the RB more clearly than how I learned it and the two-hit hypothesis through Cancer Biology lecture

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  @elijahsmith56833 ай бұрын

  Nursing student here and I found this helpful. I’m trying to wrap my head around DIC and HELLP syndrome because my instructors are burnt out lol

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  @mariodelemos45003 ай бұрын

  Thank you Dr Deyrup for a great short lecture. I am an oncology pharmacist with some basic general basic pathology and oncology pathology training as part of my postgraduate studies. Your opening slides of why we need to histopathology are similar to what I have been telling my pharmacy colleagues of why oncology pharmacists need to know about pathology. More than other therapeutic areas, pathology report is the central part of oncology, and not knowing it well deprives me from communicating not only with the physicians and other healthcare disciplines, but also with the patients who usually know a lot about their pathology. Over the past decade, more and more drugs are more targeted with specific histology so it's no longer enough to know NSCLC vs. SCLC, I also have to know NSCLC other than squamous cells, etc. Now we have to know about ER-low positive, HER2-low positive, and how that fits into triple negative breast cancer. Having an appreciation of the challenges in differentiating different intensity of ICH staining for ER is so important, when trying to understand the therapeutic decision. I hope you can do more oncology pathology and if possible molecular pathology related to cellular targets due to gene mutations or overexpressions, and PD-1 staining for the checkpoint inhibitor immunotherapy.

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  @nickname82463 ай бұрын

  Can we mention that p53 gene is located at chromosome 17 p arm, so deletion of 17p is associated similar problems as p53 mutations

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  @mariodelemos45003 ай бұрын

  Thank you Dr. Deyrup for the excellent lecture, both in contents and presentation. I feel such a privilege to have discovered to access to your lectures, which further increased my interest in cancer pathology. I am a clinical pharmacist practising in oncology for the past 25 years. I have always been interested in pathology, initially because no retake exam was allowed for the basic medical pathology course during my postgraduate PharmD program, and then because pathology plays such an essential part of cancer care, that cancer pathology was mandatory for my MSc in Oncology program. For the past 15 years I have been trying to understand more in-depth because more and more new oncology drugs are targeting the molecular pathology of the tumours.

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  @OluRow3 ай бұрын

  Thank you for being a proper scientist.

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  @gurushree20153 ай бұрын

  Thank u madam very clear information

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  @user-nh4xs2wz5c4 ай бұрын

  Thank you so much for this very important discussion. I have two reasons, one professional and one personal, that makes this information incredibly relevant to me. Professionally, I work in the biotech industry and am trying to help our company prepare to comply with the draft guidance from the FDA regarding diversity action planning for all of our pivotal and phase 3 trials. It has been a very interesting process to listen to people's responses when I talk about the need to have more solid, scientific data regarding efficacy and safety in under-represented populations and people struggle to understand the why. This is an example of why, it is so important. We need to be sure that people preparing to become medical providers have science and fact-based information about any condition that is accurate and peer reviewed. The personal reason this is compelling to me is that I am a female with severe hemophilia A due to extreme x-inactivation of my mother's non-mutated X chromosome leaving me with the activated X of my father who also had hemophilia. I clearly have 0-1% clotting factor VIII in circulation, yet doctors keep telling me that I don't have classical hemophilia because women don't get hemophilia. They have said this while looking at a lifetime of factor VIII assays. I am always shocked and angry that these physicians anchor so strongly to what they have been "taught" in medical school they cannot set that aside and actually look at data and listen to me describe my medical history and clinical manifestation of the condition. Luckily, one cannot keep arguing with a person with 0-1% factor viii levels and i do get treatment. It is the huge group of women who have a partial x-inactivation who suffer. These women have factor levels, that in men would be classified as mild or moderate hemophilia yet, because they are women, they will not be prescribed treatment for potential internal bleeding. It is 2024 and the story has not changed much from when I was told as a little girl that my mother was wrong, that I did not have hemophilia and that I should only listen to him. Ugh! Thank you so much for your excellent work and making it available on you-tube.

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  @cheriseobino4 ай бұрын

  Appreciate🙏

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  @jeelo564 ай бұрын

  Dear Dr. Deyrup, I thoroughly enjoy your lectures. Just wanted to point out at 13.00 minutes - there is a minor error - the slide says immune complex mediated vasculitis (Goodpastures), I note that Goodpastures is a type 2 antibody mediated hypersensitivity. Keep up the great work! Jay

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  @ameeshaehelamalpe59044 ай бұрын

  Thank you for this informative video. 4th year med student here and this gave me a concise and well round idea of the concept. Grateful ❤

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  @rakanalyami53394 ай бұрын

  With the polyol pathway, I think glucose to sorbitol is the NADPH consumption step. Sorbitol to fructose would be an oxidation reaction by polyol dehydrogenase coupled to a reduction of NAD to NADH. Great content, thank you,

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  @salomonscheepers63314 ай бұрын

  Thanks, great presentation!

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  @prasanthchakrapani81054 ай бұрын

  Very useful information on Myeloid neoplasm

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  @ahmedsiro16564 ай бұрын

  Thank you so much for uploading these video's. Its really helpful to use as a supplemental notes for pathology

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  @abbyhose73115 ай бұрын

  If fasL is expressed on self reactive T cells is it part of autoimmunity?

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  @LEARNING-MEDICAL-EDUCATION5 ай бұрын

  does MS involve cranial nerve nuclei and cranial nerves. i think they are part of PNS, so, MS wont involve cranial nerve nuclei and cranial nerves

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  @CarlosGomz706 ай бұрын

  Thanks for this. Very explicit and didactic 😊

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  @muksinhamza97826 ай бұрын

  🔥🔥

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  @PathologyCentral6 ай бұрын

  Thank you!

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  @MaybelAninonBalansag6 ай бұрын

  Hello doc I always watch your videos, your videos are very helpful aside from reading the Robin patho. Thank you so much

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  @PathologyCentral6 ай бұрын

  Thank you for the feedback!! It means a lot to me!

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  @Saed76306 ай бұрын

  5 star presentation

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  @PathologyCentral6 ай бұрын

  Thank you! I appreciate the feedback!!

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  @Saed76306 ай бұрын

  What a great presentation!

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  @PathologyCentral6 ай бұрын

  Thank you! Comments like yours are why I do this!