Parkinson’s Disease Education
Parkinson’s Disease Education
#parkinson #parkinsonsdisease #parkinsonseducation #parkinsonsawareness
This channel is dedicated to helping Persons with Parkinson's Disease to become Parkinson's Warriors fighting their disease wielding the weapon of knowledge about PD and the impact that it has on daily living.
You can get detailed answers to your questions with a Parkinson's Disease Expert here: clarity.fm/pdeducation
Contact us:
Parkinson's Disease Education
P.O. Box 1678
Broken Arrow, OK 74013
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I m suffring trigeminl nurelgea and parkisans 😢😢
I’m so sorry you are having to deal with each of these conditions. Lots of pain. :-(
im taking my medication levodopa i wish that it.helps.
Levodopa is certainly a good place to start. Something like Nrf2 and other supplements can also be a great addition to treatment
Thanks!
Wow! Thank you so much Kurt!! Not expected, but much appreciated.
GDNF increase dopamine levels. Optimal Level of GDNF Overexpression: GDNF Promotes Dopaminergic Phenotype, Dopamine Turnover, and is Excitatory in Cultured Midbrains Cells. The first published literature on GDNF showed dopamine uptake increased 2.5 to threefold per cultured midbrain neuron. What are the benefits of GDNF? GDNF (glial cell line derived neurotrophic factor) Early lab studies showed that GDNF has powerful effects on dopamine-producing cells grown in a dish. It can help dopamine cells survive and regenerate, and further experiments suggested GDNF can rescue the brain cells lost in Parkinson's in animals. How does acetylcholine affect serotonin? Previous research has shown that acetylcholine (ACh) can interact with serotonin (5-HT) at the hippocampal level, which may have consequences for cognitive functioning. However, little is known about the exact nature of this ACh and 5-HT interaction as well their possible interactive effects on novelty processing. Is GDNF a hormone? THE MOLECULE. Glial cell line-derived growth factor (GDNF) is a glycosylated disulfide-bonded homodimer which is distantly related to the TGFβ superfamily. GDNF is a neurotrophic factor that promotes the survival of dopaminergic neurons, and has been implicated in their morphological and functional differentiation. Is GDNF a growth factor? Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. How to increase GDNF naturally? Calorie restriction - Significantly increases GDNF (along with other neurotrophic factors such as BDNF and neurotrophin-3) in the brain and gut nervous systems. Exercise - Exercise increases GDNF in the spinal cords of both young and old rats.
Does coffee boost BDNF? Top 10 Foods to Boost Your BDNF | Amos Institute Blog The caffeine in coffee has been shown to increase your BDNF, but you have to be careful to choose a coffee that is not contaminated with heavy metals, mycotoxins, or mold. Does vitamin C increase BDNF? Additionally, vitamin C has been found to induce the expression of brain derived neurotrophic factor (BDNF) - a component of several survival pathways (Grant et al., 2005). Alongside vitamin C, a number of nutrients have been shown to affect cognitive function (Gómez-Pinilla, 2008). Does creatine increase BDNF? Creatine treatment increased PGC-1α, FNDC5 and BDNF mRNA in the hippocampus as well as BDNF immunocontent. What increases brain derived neurotrophic factor? Exercise Exercise, is a well-known strategy to increase BDNF brain levels, so it has been proposed as a non-invasive way to mimic the effects of direct BDNF administration over chronic stress. Radahmadi et al. (2016) found that the hippocampal BDNF increases in response to exercise after a chronic stress protocol.
What causes the biggest spike in dopamine? Which Behaviors Cause the Biggest Spikes in Dopamine? Sex is likely to cause a 100 percent spike. Amphetamines, a class of drugs that includes meth, will trigger dopamine to surge above baseline at about 1,000 percent.
Does too much dopamine cause Parkinson's? Scientists believe a lack of dopamine causes Parkinson's disease. That deficit, they say, comes from a disorder of nerve cells in the part of the brain that produces the chemical. However, dopamine isn't the only neurotransmitter affected in Parkinson's disease.
You’re right. Acetylcholine and serotonin are also effected negativity, among others
That’s very interesting. Thanks for sharing these details.
Do another video on this Keep it short and simple Get to the conclusion
Not much point in doing another one. This is around 13 minutes, have you seen how long videos from Parkinson’s Foundation, Davis Phinney, etc are? Typically they are recorded webinars that are like an hour long on a single topic.
@@parkinsonsdiseaseeducation OK it's just that my attention span is short All the best
@garyc9908 I can sympathize with that. I’m not sure it’s been done yet, but often KZread will automatically add “chapters” to videos that you can skip to based on the topic being discussed. This upload is brand new so it probably doesn’t have that yet
@@parkinsonsdiseaseeducationk
Replay
Club #replay! Thanks for watching Rose!
Your baby is so darn adorable.
Aw thank you. She’s turning two next month!
Stiff person syndrome. It's the same thing I guess but the correct is person
Yes that’s the current preferred term
Need help finding a “Dopamine Agonist” that doesn’t have the side effects like C/L. What else is out there to stimulate Dopamine - without the mania, constipation and nightmares? Mucuna and B1 ( maybe not taking enough) don’t seem to be doing enough and the C/L causes other awful, debilitating ( nightmares, etc) side effects in my HWP.. But w/o the Dopamine Agonist, they aren’t as active and not wanting to do as much.. Anyone have experience w / Selegiline? Doing Mucuna, L-Dopa, L- Theanine and B1- but not making a dent yet. Am I not giving right iteration or dosage? Thanks in advance🙏🏽
Hey Shayna! First of all, we need to clarify terms. Dopamine agonists are not the same as C/L. C/L converts to dopamine in the brain while dopamine agonists stimulate dopamine receptors in the brain (they “act” like dopamine) and can help with symptoms that way. Have you seen all of the medication videos on the channel? Each type is detailed along with examples. Selegiline is an MAO-B inhibitor and is not a dopamine agonist or the same as C/L. Keep up the mucuna and B1, but it not likely that there is a way to avoid medication completely. I’m also sorry to report that they all have side effects, so be very discerning before making any changes. Better yet, don’t make changes unless a neurologist advises. Here’s more information on MAO-B inhibitors such as Selegiline: Managing Parkinson’s “Off Times” with MAO-B Inhibitors | PD Medications, Purposes, and Mechanisms #2 kzread.info/dash/bejne/hK6op8-tmti9Y6g.html
Thank you for the tips!
It’s not a slam dunk for everybody, but these can certainly be helpful
may father is taking madopar he is PD for 12 y , he suffers from this day time sleep since , i hope you can give advice on how to help him live his life most normal possible , in Morocco it's the only medicine available
Hello there! Thank you for your comment. Short advice I can offer: 1) He needs to do his best to exercise physically every day. 2) Relying on medications won’t work. While madopar may be necessary it isn’t the only answer. 3) Use supplements as able to help with oxidative stress, such as Glutathione, CoQ10, and more. Creatine is important for energy and could help with the daytime sleepiness and overall energy.
@@parkinsonsdiseaseeducationthank you so much for your replay ,can u give me some insights on how to take these supplements during the day how much he should take.... like dosage and is it after madopar or before i really appreciate it
Hi again Abdeljalil, happy to help in whatever means that I am able to help. The supplements I mentioned (there are more) are not considered prescriptions so the instructions on the bottle are the best place to start. I am doing a series on supplements right now on the channel, I’ll link some of them here if that’s helpful to you. As far as when to take in relationship to the Madopar, I would not change the schedule of medication, but would rather look into taking the supplements as recommended with the first meal of the day or at bedtime, whichever is recommended on the bottle. Some substances absorb better with food and some it will be better on an empty stomach. In the case of Madopar your father will absorb more dopamine if taken at least 30 minutes before eating
@@parkinsonsdiseaseeducation thank you so much
Is there any medicine that can help us get to sleep?
Hi Richard, sleep medication is often NOT recommended for PWP due to the issues of reducing deep sleep and it can increase fall risk. I’d ask your physician about supplementing with melatonin and I’ve heard that magnesium infused lotions or magnesium capsules may help as well.
Congratulations!!
Thanks Dr Josh!
Is ok to take a SSRI when on dopamine agonists
I’d best leave that advice to the physicians. I’d ask your MD, DO, NP, or PA. I do not prescribe medication or offer specific medical advice on the channel.
I was diagnosed with Parkinson’s disease in February my neurologist put me on pramipexole any feed back on this medication ,
Thanks for your question Steve. Yes, this is not uncommon. Carbidopa/Levodopa has limited effectiveness and the longer you have PD the more you have to take for it to manage symptoms. The side effects are also often negative depending on the amounts (dyskinesia, nausea, increased sleep issues, fatigue, etc). Sometimes neurologists will prescribe Pramipexole or similar dopamine agonsists as a first line of treatment as it can stimulate dopamine receptors without the negative effects of C/L. Be sure to watch this video too to find out more about Dopamine agonists: How Dopamine Agonists Improve Parkinson’s Symptoms | PD Medications, Purposes, and Mechanisms #6 kzread.info/dash/bejne/aH2ZtJpsgqzggdo.html
Stop the background music
Too late for this video
www.ncbi.nlm.nih.gov/pmc/articles/PMC7458523/
Since January a portion of my autonomic has failed. I don't have natural BMs. It's just one of the effects of PD.
Among many, sadly
Finally a really good explanation of this problem. Thank you !
That’s high praise, thanks!
I asked a neurologist at Jefferson hospital and she said coq10 does nothing for parkinsons and has been founded to do nothing. Not sure who to believe here.
Physicians rarely put any stock in supplements and tend to only focus on medications. I had a patient who was told by her neurologist that exercise wouldn’t make any difference with her Parkinson’s. You can’t trust everybody in a white coat.
@@parkinsonsdiseaseeducation thank you for your response
@sergiosantolupo8780 my pleasure
Are you still active on this channel. I need advice so I typed in what symptoms I’m having and your video popped up
Definitely still active, just posted a new video yesterday!
nothing new .There is no proof that it works.
Good grief. Nobody said it was new. Why do you always feel the need to negate all of the information about supplements that we are sharing on the channel? Some people benefit from this even if you may not
@@parkinsonsdiseaseeducation we need facts
@@parkinsonsdiseaseeducationHey Michael 👋👋 Ignore these type of comments it's obvious they are just bullying and trying to demean your channel. Someone special to me told me once years ago when you have an issue with someone to just smile and move on. 😊
Mistergreen Michael comes highly recommended from another Physical therapist in Ohio He puts serious effort into his work and many here on this channel with Parkinson's have benefited from Michael. It's ok to disagree but what is the point in trying to cause trouble for people?
Nothing shared on this video is not factual. I shared the facts that I have available.
My mom, who has Parkinson’s, gets vitamins c and b via iv along with a glutathione “push” once per week. On the same day, she also gets HBOT. I’m wondering if they are “canceling” each other out since one type of treatment is an antioxidant and the other causes oxidation. What are your thoughts on this? Should she be staggering these treatments? I also wonder if she should be getting HBOT every day for a month or so and then taking a break before starting up again? I’ve come across those types of recommendations also. It’s so difficult to figure out. 😢
Initial thoughts… hyperbaric oxygen does increase oxygen in the body, increases blood flow in the brain, etc. Oxygenation is NOT the same as oxidation. In other words, HBOT should not result in oxidative stress. Glutathione, or any other antioxidant, should not result in cancelling out the effects of HBOT. The key question is, how is she feeling after the combination of HBOT and glutathione? Is she wiped out and fatigued? More energetic?
Initially, she was feeling a bit more energetic and she said she had a bit less brain fog. Now it seems to be wearing off, maybe? She can’t really describe it very well. But she continues to get treatments to slow down any progression of the disease, which I believe seems to be helping. Her neurologist always seems surprised that her condition isn’t worse. However, when we’ve asked the neurologist about HBOT, glutathione, etc., she’s very dismissive of it…so we stopped mentioning it.
@unknownorigin9517 well, that’s a typical physician for you. If it’s not medication they tend to brush it off. Keep doing what you feel is making a difference. There’s something to it if she’s feeling better and seems like progression has slowed.
Well that’s a typical physician for you. They tend to dismiss anything that’s not medication. If it’s helping her to feel better and it seems to be slowing the progression then keep it up. It’s worth it if there’s any benefit.
Hey Doc. Im now experiencing peripheral neuropathy in my hands, which has been linked to PD. I DO HAVE PD, I do not have diabetes. I state the later for clarification regarding neuropathy. What do you know about PD and neuropathy?
Hey there CBU! Well… Can Parkinson’s Disease Cause Peripheral Neuropathy? kzread.info/dash/bejne/ZnZhscevmKS2fco.html In addition to what was talked about on this video I linked here, it is also likely that alpha-synuclein aggregates in the peripheral nerves are a big part of the issue.
@@parkinsonsdiseaseeducation thanks Doc. Found your video just after leaving my comment. THANK YOU!!!!!!
Hi Mike watching replay
Hey, thanks for watching Rose!
B6 ruined my life. A doctor put me on 100mg which I took on and off for a month and I was covered from head to toe in neurological problems almost immediately after taking it. 8 years later, I still have neuropathy from that. They need to take this stuff off the shelves. It is completely toxic and not safe to be buying it over the counter.
I’m sorry this happened to you.
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤❤️.
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤❤️.
Recent blood tests showed I have high levels of Vitamin B6 (about 30% that higher end of range) and the supplements I was taking had only 0.85mg of Vitamin B6, just 50% of RDA (have taken them for about 2 years but neuropathy symptoms started 3 months ago).
Hi Guillermo. Were the supplements you were taking specifically B6 or was it a multivitamin or B complex of some kind?
@@parkinsonsdiseaseeducation It was a Multi Vitamin (sells in Amazon under Brad Stanfield Multi Vitamin) but none of the vitamins have RDA levels suggesting mega doses. I also take 1150 mg Omega-3 but I assume that doesn't include B6.
@guillermofuentes151 wow, that’s pretty scary
It works well for people with Parkinsons, but there is a high morbidity rate from pneumonia after 10 years.
Did you mean high morbidity rate among persons with PD who contract pneumonia? DBS and pneumonia wouldn’t have a direct correlation to my knowledge, but the former certainly does
Thank you
Glad this was helpful Richard!
Hello! My husband has lived with Parkinson Disease 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now…All thanks to Dr.Madida on KZread…
Hello! My husband has lived with Parkinson Disease 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now. All thanks to Dr.Madida on KZread.
Hello! My husband has lived with Parkinson Disease 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now. All thanks to Dr.Madida on KZread.
Hello! My husband has lived with Parkinson Disease 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now. All thanks to Dr Madida on KZread.
DBS has worked well for one I know, zero results for another I know. I'm on the fence whether I'll try it or not.
It’s definitely a gamble, though if it pays off it could be life changing, in a good way
I definitely find creatine helpful but I don't find it raises my off-time score. What I mean by that it doesn't seem to help my off times like other things do.
That makes sense. Thanks David, I’m glad to hear that this is helping PwP with their energy.
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤
www.ncbi.nlm.nih.gov/pmc/articles/PMC4573899/
Well that’s good to know! Wow
I have PD and I take 3grams of creatine everyday! It definitely helps give me a boost of energy and less fatigue!
Its biggest benefit for me is definitely helps me recover faster from my rigorous workouts!
This is awesome thank you for your feedback!!
@@Lions_Forever71❤
The comments below are so helpful!!!!
Stop the background music.
🤷🏻♂️
Why do people make videos like this? Where one person is down at the bottom of the screen watching a video and you’re watching that person watch a video? Like, what is wrong with people? Seriously? Do people really want to be seen that bad? Are we that desperate for attention? I just don’t get it. Social media is in a sad state right now!
It’s called a reaction video and it’s abundantly common. In this case it’s to bring attention to what this individual (John Pepper) is claiming about fast walking “reversing” his Parkinson’s Disease. It’s not something that should be taken at face value so I thought it was important to highlight that.
Hes a sweet man. Wish him the best of health
Hello! My husband has lived with Parkinson Disease 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD 🦠symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now… All thanks to Dr Madida on KZread..
Mega benfotiamine and magnesium threonate back helped me. C/L I dcd' as it did nothing for me except side effects.
C/L is sometimes not the answer as you point out. Supplements are great and also if meds are necessary at times dopamine agonists and MAO-B inhibitors are helpful early in diagnosis
From someone that has suffered from B6 toxicity, STAY AWAY FROM EVERY SUPPLEMENT CONTAINING B6 - even if it’s only 1 mg. Trust me, it’s not an easy fix and a hell of a ride.
Hello, ive been taking 600mg for two weeks, is it reversable or how long would take the cure?
600 mg of B6??? Cmon! You’re literally poisoning yourself. I won’t take 1 mg of that poison after what it did to me 12 years ago. I still suffer from symptoms of B6 toxicity. Stay away from it!
That does seem like a high level
I have no way to answer your question objectively because I don’t know any of your history. Do you have B6 toxicity? Why are you supplementing and why so much? Who advised you to take it?
I just took b6 while ago and now I’m nervous and haven’t heard of this. It’s 100mg but will I be fine?
I wouldn’t worry, I’ve seen varied numbers of folks having toxicity with supplementing. Doing it once isn’t likely enough unless you’ve had some past issues with metabolizing B6. To be on the safe side I would contact the folks at understandingb6toxicity.com They also have safe products for B6 on their site
@@parkinsonsdiseaseeducation very helpful comment
I’m glad it was helpful.