Why DMT works all the time and LSD won't - Tobias Buchborn

Ғылым және технология

It is known that serotonergic hallucinogens, such as lysergic acid diethylamide (LSD), produce profound alterations in human consciousness, which -when repeatedly applied- substantially decrease or completely disappear. The only exception to this rule seems to be the sHG dimethyltryptamine (DMT), whose psychedelic effect for reasons unknown even with multiple applications reappears.
As sHGs are thought to alter human consciousness by activation of serotonin (5-HT) 2A receptors, we here use an animal model of 5-HT2(A) activity (i.e. hyperthermia) and [35S]GTPγS binding techniques in rat brain homogenates to investigate whether differences in regulation of 5-HT2(A) receptors might account for the differential tolerance development noted for LSD and DMT in humans.
Tobias Buchborn is a German psychologist who does neuropharmacological research on serotonergic hallucinogens. He studied Psychology at the Otto-von-Guericke University in Magdeburg, Germany, and within his Diploma thesis investigated the antidepressant-like properties of LSD in an animal model of depression.
Currently, Tobias Buchborn concludes his Ph.D. thesis in Neuroscience at the Institute of Pharmacology and Toxicology in Magdeburg. His research addresses the behavioral and molecular biological correlates of tolerance to LSD, DMT, and DOB. In June 2016, Tobias Buchborn will start working as a Marie Curie Fellow at the Imperial College in London. Here, his research will be devoted to the relevance of 5-HT2A-glutamate interaction and cortical layer V pyramidal cells for the action of serotonergic hallucinogens. ***********
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Пікірлер: 184

  • @Tek_777
    @Tek_7774 жыл бұрын

    4:14 that inhale was intense

  • @eposntrix

    @eposntrix

    4 жыл бұрын

    Bahahahahaha Dude his inhales where the only intolerable thing in the video otherwise hella informational and worth a watch but still 😂

  • @bogotx1

    @bogotx1

    4 жыл бұрын

    💀💀💀💀🤣🤣🤣

  • @JeffCaplan313

    @JeffCaplan313

    4 жыл бұрын

    It's funny... I clicked play on this video and within ~0.5 seconds of Tobias starting to speak, I was like, "whoa, this dude is gonna speak fast." So next I paused the video to check the comments to see if this was gonna be the case and note my surprised face (😶) when I see the top comment has to do with his breathing...lol 😂 I suspect that Tobias might've benefited with a a little DMT from his own body's stash via breathwork, before he gave this presentation, eh?

  • @YogiNoGi

    @YogiNoGi

    3 жыл бұрын

    Kind of scared me lol Especially cause im on shrooms

  • @TeDoGBi

    @TeDoGBi

    3 жыл бұрын

    Man almost suck the oxygen out of that room

  • @Wickedstickyflowers
    @Wickedstickyflowers4 жыл бұрын

    I’ve been experimenting on myself which is a pity because I am not the best at data entry but I’m a long term opiate addiction dealing with paws . Good success if anyone cares

  • @sarahgeorge7786

    @sarahgeorge7786

    3 жыл бұрын

    Of course I care. Your important Everyone is Stay strong

  • @YogiNoGi

    @YogiNoGi

    3 жыл бұрын

    I’ve been dealing with opiate addiction for many years. And I can truly see the benefits of psilocybin beginning to take effect. I’m less drawn to taking pain killers and would prefer to get everything nice and cozy for a profound trip on this amazing medicine

  • @Wickedstickyflowers

    @Wickedstickyflowers

    3 жыл бұрын

    Ya I did I’m stuck on Kratom

  • @lobokath

    @lobokath

    3 жыл бұрын

    Good luck!

  • @wallybingbang4350

    @wallybingbang4350

    2 жыл бұрын

    Any advice on DMT for anxiety I’m not sure how to take it and the dosage I’m aware it will be broken down in the stomach so will probably try snorting or smoking it ?

  • @ded5630
    @ded56303 жыл бұрын

    Such a unique feeling of good can go bad and you can’t control it

  • @criscojesus4378
    @criscojesus43784 жыл бұрын

    I've tried DMT in just about every form you can ingest it in other than intravenously and ayahuasca. I cannot blast off. I've smoked the crystal form so much that my mouth had a coating. I've tried from many different sources and forms because I want the experience but it never works. I've smoked a DMT vape that all of my friends would draw in 1 hit and fallout, I took about 30 hits in a row until the flavor could no longer be tolerated. I don't know if the receptors aren't present for me or maybe they are damaged but I cannot have this beautiful profound experience that everyone talks about. I would like to see a study done on people like me. I haven't found anyone with the same issues. Edit: also lsd and psylosybin work very well for me. I have taken each of these molecules multiple times over many years and have always had an experience.

  • @theyeking7023

    @theyeking7023

    4 жыл бұрын

    You've been ingesting chalk Powder lol

  • @criscojesus4378

    @criscojesus4378

    4 жыл бұрын

    @@theyeking7023 strangest tasting chalk I've ever had.

  • @theyeking7023

    @theyeking7023

    4 жыл бұрын

    @@criscojesus4378 haha fair enuf

  • @criscojesus4378

    @criscojesus4378

    3 жыл бұрын

    @@danielcruzzz1427 not at all, the only prescription drugs I've ever taken are painkillers from a doctor after surgery and half of a xanax when I want to go to sleep after a long night of riding the psychedelic rollercoaster.

  • @diane257

    @diane257

    3 жыл бұрын

    Crisco Jesus you probably haven’t been inhaling properly

  • @soccerchris05730
    @soccerchris057305 жыл бұрын

    I would really like to know why DMT does not work for me. I tried DMT while on LSD as well and it actually gave me a calm, sobering effect and cleared my vision.

  • @beeennn12345

    @beeennn12345

    5 жыл бұрын

    john Michalala probably didnt vaporise it / get anough smoke in one hit

  • @soccerchris05730

    @soccerchris05730

    5 жыл бұрын

    @@beeennn12345 I've tried multiple times. Had people light for me. Even met a chemist who made a small batch, packed it for me and lit it. I'll still try again next time it comes around though.

  • @Pyrokittenx

    @Pyrokittenx

    5 жыл бұрын

    If you take acid dmt wont work

  • @XGaming1

    @XGaming1

    4 жыл бұрын

    You might be doing it wrong, you have to use an oil pipe to bubble your dmt, if you use a regular bowl or bong the flame will destroy your dmt.

  • @codyramseur

    @codyramseur

    4 жыл бұрын

    Ketamine potentiates DMT. Cannabis concentrate mixed with DMT can help with temperature. Avoid LSD for a month or more before DMT.

  • @JohnDoe-cl1wl
    @JohnDoe-cl1wl3 жыл бұрын

    You do build up a tolerance to dmt but it resets after about a couple hours, if you take dmt twice in a row the 2nd will be noticeably less intense unless you significantly up the dosage the 2nd time or something like that

  • @outlaw.2535

    @outlaw.2535

    3 жыл бұрын

    Every hour or so your tolerance hits 0

  • @EnygmaLabs

    @EnygmaLabs

    3 жыл бұрын

    I don't think so. At least for me, I never had to up the dose after the first blast off, and still had experiences just as intense, if not more.

  • @IchVillt

    @IchVillt

    2 жыл бұрын

    @@EnygmaLabs Cant confirm @Outlaw.253 cant confirm either, i can do about 4-5 trips in one day and need atleast 2 days break before im able to get the full effect again, if i do it again before i will get a way weaker experience with barely any visuals, i think it depends on how your seratonin level overall is, i have a pretty low seratonin level and i think people that have that issue have the same, im guessing obviously from my own experience, no science behind.

  • @EnygmaLabs

    @EnygmaLabs

    2 жыл бұрын

    @@IchVillt Sometimes, after months without smoking, occasionally, I might have no visuals at all, it is pretty much random. And I've already been through strong experiences right after the come down

  • @IchVillt

    @IchVillt

    2 жыл бұрын

    @@EnygmaLabs Yeah n,n Dmt is weird, its different for almost everybody but yeah saying that is no tolerance doesnt works, atleast not for me.

  • @coffeewithconvicts2851
    @coffeewithconvicts28513 жыл бұрын

    Amazing Work. You can blast off repeatedly. I am an author working on a book on Dmt and Dying

  • @EdgeMasterPro
    @EdgeMasterPro7 жыл бұрын

    Interesting paper. Some discussion of possible clinical implications for cross tolerance might be useful. It appears it would be possible to administer DMT then LSD and there would be no cross tolerance, whereas LSD then DMT would exhibit cross tolerance. If order dependent cross tolerance is not observed then you know you might have an issue with the use of DOB agonist binding on the 2A receptor.

  • @deplorableamerican9451

    @deplorableamerican9451

    7 жыл бұрын

    Francis Hemeter That would be so awesome to get research on that as well! 😊 Great idea, Francis!

  • @mokujin29

    @mokujin29

    4 жыл бұрын

    Interesting.

  • @coleburns5497

    @coleburns5497

    2 жыл бұрын

    Wait so DMT first, then LSD would make it more beneficial on the long run? I’m trying to see if I can reach the all the benefits of psilocybin, Mescaline, DMT & LSD. But of course separated & at different times, plus has anyone meditated during their trips?

  • @RhythmJunkie

    @RhythmJunkie

    2 жыл бұрын

    @@coleburns5497 , a closed eye ‘trip’ in the dark or with an eyeshade and lying down is basically advanced Meditation, and will eventually lead to Awakening, GOD Realization & Enlightenment if one keeps up with the practice ✨😉

  • @coleburns5497

    @coleburns5497

    2 жыл бұрын

    @@RhythmJunkie BTW, how do I avoid bad trips?

  • @alkeryn1700
    @alkeryn17002 жыл бұрын

    do you think it could be possible to make a lsd like RC that would not make you build up tolerance ?

  • @hypolaristic
    @hypolaristic7 жыл бұрын

    even youtube recognizes it as german lol

  • @sharank

    @sharank

    5 жыл бұрын

    How did you figure that out?

  • @agorist.boogaloo

    @agorist.boogaloo

    5 жыл бұрын

    Because the subtitles are German😂

  • @realbddy1921

    @realbddy1921

    3 жыл бұрын

    Genau... ähhhh 4:14 xD quickly switched to german lel

  • @chrisw5742
    @chrisw57422 жыл бұрын

    Look into mescaline also. It is AMAZING and VERY VERY HAPPY feeling and brings back long lost happy childhood memories.

  • @Anon-eq5hm
    @Anon-eq5hm Жыл бұрын

    I tried vaping DMT and only had a feeling of being lifted up and some ringing sound but nothing crazy. So it doesn't work all the time.

  • @Wickedstickyflowers
    @Wickedstickyflowers4 жыл бұрын

    Let me get this straight....are you saying if I’m tripping I can swim in ice water without getting cold

  • @RG-yz8ov

    @RG-yz8ov

    3 жыл бұрын

    If you melt dry ice you could swim without getting wet.

  • @iwannakillallmystupidfamil5910

    @iwannakillallmystupidfamil5910

    3 жыл бұрын

    @@RG-yz8ov w h a t ?

  • @barrygreen4849
    @barrygreen4849 Жыл бұрын

    well DMT does not do any thing o me now after using it every day couple times a day some days for about two weeks .for one thing it has wreacked m y lungs and cant hold a hit in and cough bad now all the time .

  • @canadianatheist3578
    @canadianatheist35783 жыл бұрын

    What about other tryptamines?

  • @rollbot
    @rollbot3 жыл бұрын

    so much information was said so quickly that I cannot understand please can you go through this information again?

  • @mistermistyc2219
    @mistermistyc22193 жыл бұрын

    I do dmt on lsd and Egyptian beings were in my trip.. the king tut death mask perfectly radiating in blue and gold... exactly what it really looks like too real . The message i got was the Egyptians are significantly profound to our existence they had to have known something. I didnr see Egyptian things for no reason...and i had no intent going into it. Im baffled...

  • @theprofessor3339

    @theprofessor3339

    2 жыл бұрын

    Some recommendations: Look into Tesla in his later years and how many of his inventions were classified upon his death, listen to Graham Hancock and Randall Carlson if you haven't already, Hermetisim, Kybalion.

  • @allisonb6182

    @allisonb6182

    Жыл бұрын

    bro same i would take like 2-4 tabs and the kaleidoscope shapes would morph into Egyptian looking hieroglyphics

  • @mistermistyc2219
    @mistermistyc22193 жыл бұрын

    Theres a video on KZread "groundbreaking info about dmt" they actually found it in human brains, the pineal gland and rats. If anyone cant find the video i can find the link

  • @outlawpotato8557
    @outlawpotato8557 Жыл бұрын

    Look up salvia reverse tolerance

  • @masteraugmentedproduction5828
    @masteraugmentedproduction58283 жыл бұрын

    DMT displaces time.

  • @colezitterkopf1895
    @colezitterkopf18952 жыл бұрын

    Will smoking dmt build a tolerance for acid? Can I smoke dmt then trip the next day?

  • @orsemcore

    @orsemcore

    2 жыл бұрын

    @Greg Daniellla you didn't answer his question properly

  • @mr.clutch5928

    @mr.clutch5928

    2 жыл бұрын

    @Christian Terrace I’ve taken lsd multiple times only once ever actaully “tripping” is the tolerance build up that quick

  • @colezitterkopf1895

    @colezitterkopf1895

    8 ай бұрын

    @Mrperkin much appreciated!

  • @Jacob.Weimar

    @Jacob.Weimar

    8 ай бұрын

    ​​@@colezitterkopf1895What was answer to this? SWIM smoked 50mg dmt 5 days ago. Does it affect my LSD trip what SWIM planned for tomorrow at all?

  • @user-hz3ii5qz9r
    @user-hz3ii5qz9r3 жыл бұрын

    the speed of his speech gave me so much anxiety, i couldn't finish the video, a shame because this topic is fascinating

  • @AdventureSlug

    @AdventureSlug

    3 жыл бұрын

    bro youtube gives you an option to slow it down :p

  • @Bhfvbji

    @Bhfvbji

    3 жыл бұрын

    Dummy knowledge isn’t gunna be handed to you on silver platter you have to concentrate and listen !

  • @chasedavis2358
    @chasedavis23583 жыл бұрын

    Both work all the time

  • @LuckyLondon62

    @LuckyLondon62

    3 жыл бұрын

    :( shrooms, lsd, and synthetic psilocybin don't work for me

  • @mofugga
    @mofugga3 жыл бұрын

    So there is no tolerance to dmt?

  • @RobertChris_Obi

    @RobertChris_Obi

    3 жыл бұрын

    No

  • @Name-bn3vo

    @Name-bn3vo

    3 жыл бұрын

    Only for like 20 mins then it's reset

  • @greentea4881

    @greentea4881

    3 жыл бұрын

    Add Johnsonl2019 on snap fam they reliable and fast got my gun from them

  • @IchVillt

    @IchVillt

    2 жыл бұрын

    Depends, some people do get one, i can do 4-5 trips in a day then need atleast a week break, i think its because of my alrdy low seratonin levels, im guessing it depends on your biochemistry. If i do it again the next day i simply wont get a full trip, like barely any visuals and the feeling of being one is just not the same

  • @maverick2246
    @maverick22463 жыл бұрын

    I'm not German

  • @maverick2246

    @maverick2246

    3 жыл бұрын

    Yeah

  • @TacoFiestaTime
    @TacoFiestaTime3 жыл бұрын

    So like.....how long should I wait in between acid trips??

  • @RobertChris_Obi

    @RobertChris_Obi

    3 жыл бұрын

    Stay safe about it, it take 2 weeks to fully recover serotonin levels

  • @o01chris10o

    @o01chris10o

    3 жыл бұрын

    I am an avid psychonaut. In my experience, you need to wait a week for a full reset, but if you go every other day, you will need 2-4 more each time on your streak.

  • @KasinaMedeis

    @KasinaMedeis

    3 жыл бұрын

    Definitely at least 2 weeks but I did this often and lsd lost it's magic for me :( and I mean I did it every 2 weeks sometimes just a week wait for like all of 2020

  • @MrFartboy79

    @MrFartboy79

    2 жыл бұрын

    @@KasinaMedeis Take a good month off… or longer, then drop a good dose.

  • @austfra1
    @austfra16 ай бұрын

    This is all wrong , dmt does not work everytime

  • @1122redbird
    @1122redbird4 жыл бұрын

    Could he talk any faster?

  • @jjhack3r
    @jjhack3r3 жыл бұрын

    *BREATH*

  • @austfra1
    @austfra16 ай бұрын

    Dmt doesn't work everytime stop .

  • @zyon3717

    @zyon3717

    4 ай бұрын

    DMT an other psychs are easily accessible from this dude i cop from. Super reliable ship's discreetly worldwide...

  • @zyon3717

    @zyon3717

    4 ай бұрын

    *On Instagram and telegram as*

  • @zyon3717

    @zyon3717

    4 ай бұрын

    *@Chequefibs1__*

  • @notawoke7531
    @notawoke75313 жыл бұрын

    DMT natural, LSD lab made. There's your answer.

  • @YokaiGotha

    @YokaiGotha

    3 жыл бұрын

    Nothing to do with being found in nature. 2CB is synthetic and it has less of a tolerance than DMT. Also you can synthesize DMT in a lab and can find LSD-like molecules like LSA in nature.

  • @notawoke7531

    @notawoke7531

    3 жыл бұрын

    @@YokaiGotha DMT in a lab is not the same as regular DMT you find in nature. 2cb However has less of a tolerance because it works on your serotonin receptors by binding to it unlike many other drugs using your neurotransmitter.

  • @langov3

    @langov3

    2 жыл бұрын

    @@notawoke7531 What's so unnatural about people?

  • @chill8865
    @chill88653 жыл бұрын

    Deems gimme that deeeeeeems!

  • @rocheburgers9859
    @rocheburgers9859 Жыл бұрын

    Is there no limit to the torture that animals are subject to. In the name of science. Why did you not use humans for this study, after all it only has significance to humans. We truly deserve the impending disasters that are awaiting humanity.

  • @rvansteensel420
    @rvansteensel4208 жыл бұрын

    the fuck u mean DMT works all the time

  • @trmdtv

    @trmdtv

    8 жыл бұрын

    If one takes LSD a few times in a row, the effect wears off. With DMT, it does not.

  • @hypolaristic

    @hypolaristic

    8 жыл бұрын

    +Tice Roose it'd be awesome if this is actually true

  • @deplorableamerican9451

    @deplorableamerican9451

    7 жыл бұрын

    extraxOne Really o:

  • @sharank

    @sharank

    5 жыл бұрын

    @@hypolaristic did you even watch the video?

  • @rvansteensel420

    @rvansteensel420

    3 жыл бұрын

    @@sharank who cares what some dude says , we have our own experiences ?!

  • @maverick2246
    @maverick22463 жыл бұрын

    You don't know anything about consciousness

  • @orsemcore

    @orsemcore

    2 жыл бұрын

    Maverick

  • @georgetheonlyporge
    @georgetheonlyporge7 жыл бұрын

    I can't listen to this guy. The German accent makes me cringe.

  • @Anthony-bz2xs

    @Anthony-bz2xs

    7 жыл бұрын

    LOL! youll miss out on alot of good shit with that attitude

  • @mrm4882

    @mrm4882

    6 жыл бұрын

    germany is full of people talking like that. strange if you think about it

  • @eXislander

    @eXislander

    6 жыл бұрын

    And thats why I'm sure you have a very shitty life!

  • @asad36360

    @asad36360

    5 жыл бұрын

    Are you a jew?

  • @musthaveV8

    @musthaveV8

    4 жыл бұрын

    incorrect use of cringe. u meant "hate his kind"

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