Why are AI and AN children recommended to receive RSV preventive antibody for their 2nd RSV season?

Welcome to Immunize.org’s Ask the Experts resources. This Ask the Experts question is presented by Immunize.org’s Kelly L. Moore, MD, MPH.
Question:
Why are otherwise healthy American Indian and Alaska Native children recommended to receive a dose of long-lasting RSV preventive antibody to protect them during their second RSV season?
Answer:
Some American Indian or Alaska Native (AI/AN) children experience higher rates of severe RSV disease than the general population. A recent study found that the incidence of hospitalization due to RSV among some AI/AN children in their second year of life was four to ten times higher than that of similar-aged children in multiple study sites in the United States. Also, some AI/AN communities live in remote regions, making transportation of children with severe RSV to obtain medical care more challenging. Although the available data are limited and may not apply to all AI/AN children in all settings, ACIP recommends nirsevimab for AI/AN children entering their second RSV season.
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