🎯 Key Takeaways for quick navigation: 01:04 *🩺 Acarbose: Mechanism of Action and Clinical Applications* - Acarbose inhibits enzymes involved in carbohydrate breakdown, preventing glucose absorption. - It primarily acts on postprandial glucose, making it useful in various types of diabetes. - Versatile usage includes type 2 diabetes, type 1 diabetes (in India), pancreatic diabetes, hypoglycemia in pregnancy, and hypoglycemic syndromes. 08:23 *📊 Glycemic Variability and Diabetes Management* - Glycemic variability, alongside fasting and postprandial glucose, is crucial in diabetes management. - It's assessed through metrics like standard deviation and coefficient of variation, with values above 36% indicating high variability. - Case studies illustrate the impact of glycemic variability on patient outcomes and the role of acarbose in reducing it. 14:25 *💡 Acarbose in Reducing Glycemic Variability: Case Study* - A case study demonstrates acarbose's efficacy in reducing glycemic variability and hypoglycemic episodes. - Combining acarbose with basal insulin shows significant flattening of the glucose curve, improving overall glycemic control. - The strategy of fixing fasting glucose first, followed by monitoring and adjustment, showcases effective diabetes management. 18:09 *📈 Clinical Cases: Acarbose in Various Diabetes Conditions* - Clinical cases highlight acarbose's effectiveness in type 2 diabetes management when combined with insulin and other medications. - Acarbose demonstrates utility in pancreatic diabetes, showing improved glycemic control in patients with chronic pancreatitis. - It can be utilized in hypoglycemia, including reactive hypoglycemia, expanding its applicability beyond conventional diabetes treatment. 21:43 *🩸 Treatment of Reactive Hypoglycemia* - Reactive hypoglycemia mainly occurs in early or pre-diabetic patients due to delayed and blunted first-phase insulin secretion. - Patients experience postprandial hypoglycemia due to a mismatch between glucose and insulin levels. - Acarbose can be effective in treating reactive hypoglycemia by delaying glucose absorption to match insulin secretion. 24:35 *🍽️ Mechanism of Action of Acarbose* - Acarbose delays glucose absorption, preventing postprandial hypoglycemia by blocking alpha-glucosidase enzymes. - It works in the oral cavity and intestine to inhibit carbohydrate breakdown, delaying glucose absorption. - Acarbose is versatile and can be used in various clinical situations, including type 2 diabetes, pancreatic diabetes, and pregnancy. 27:42 *🛑 Side Effects and Management* - Common side effects of acarbose include abdominal pain and gastrointestinal discomfort. - Side effects reduce over time as the gut microbiota adapt to the presence of unabsorbed carbohydrates. - Reducing carbohydrate intake can help minimize side effects associated with acarbose treatment. Made with HARPA AI

Very good teaching,I have learnt valuable information.Thank you.

@EndocrinologyIndia

29 күн бұрын

Thank you

Cannot thank you enough for all the valuable information given by you in your videos. You are an inspiration sir. Thank you.

@EndocrinologyIndia

2 ай бұрын

Thank you

So overall take home messege is 1. Review fasting, pp and Hba1c 2. Fix fasting first 3. Switch to gliclazide if glimepiride is used 4. Monitor with cgm 5. Add acarbose if pp is persistently high.

@EndocrinologyIndia

Ай бұрын

Yes

Thank you very much sir for all of your educational videos.

Sir All you lectures are very informative. Please make a video on saroglitazar and its use in diabetics.Apart from treating dislipidemia is there any benifit on insulin resistance and glycemic control.

@EndocrinologyIndia

Ай бұрын

Thank you Yes it does improve glycemia as well

Acarbose, doesn't have long term safety data, for its usage in DIP. Are you comfortable with its usage in DIP

I’m really your fan and follow all your videos But here I respectfully disagree Acarbose have lots of GI side effects and our patients are never happy on acarbose

the problem is its unavailable and extremely expensive in my country otherwise i would prescribe it too

@drmetroyt

Ай бұрын

It's good add on drug , but patient compliance is low to moderate because of GI side effects

By chewing a significant proportion might be absorbed in systemic circulation and little left to act on bruh boarder . what is your take on this issue

@EndocrinologyIndia

Ай бұрын

No that is not true

A obese Female PT already on Metformin 2g/day, how to start Acarbose in this case? HbA1c is 6.2

@EndocrinologyIndia

2 ай бұрын

If the HbA1c already is 6.2 - acarbose is not required But if you do need start 50 Mg TDS

@nadirabbas8114

2 ай бұрын

@@EndocrinologyIndia can we lower the Metformin dosage in this case and start Acarbose?

@drmetroyt

Ай бұрын

​@@nadirabbas8114no acarbose is an add on drug , metformin should be continued .

Ultimatel sir 👌👌👌👌👌