What is Amyloidosis? | Symptoms, Diagnosis, Treatment | Visual explanation
This video covers the pathophysiology, presentation, diagnosis and treatment of amyloidosis. This video aimed at helping medical students and junior doctors learn hematology.
In short:
- Amyloidosis is a rare disease characterized by a buildup of abnormal amyloid deposits in the body. Amyloid deposits can build up in the heart, brain, kidneys, spleen and other parts of the body.
- The most common types of amyloidosis are: AL (Primary) Amyloidosis, AA (Secondary) Amyloidosis and ATTR (Familial) Amyloidosis.
- Amyloidosis isn’t curable. Treatment aims to slow amyloid protein production and reduce symptoms.
Timecodes:
0:00 Introduction
0:23 What is Amyloidosis?
0:33 Causes
1:08 Types
2:09 AL - Primary Amyloidosis
3:22 AA - Secondary Amyloidosis
4:02 ATTR - Familial Amyloidosis
4:29 Symptoms
5:21 Diagnosis
6:38 Treatment
8:18 The end
#Amyloidosis #hematology #medstudent
Пікірлер: 125
Thank you for watching my video. If you liked it, please consider giving it a thumbs up 👍. Feel free to let me know if you have any questions, I'd be happy to help you ☺.
@NISHAnisha-sh6ig
Жыл бұрын
Mam plz help me
@dr.paulinemoyaert
Жыл бұрын
@@NISHAnisha-sh6ig I'm not your mom, but can I help you? ☺
@Mikesworld777
Жыл бұрын
Do you know what percentage of patients are vaccinated against sars 19 vs not and if this is a factor worth noting. Their has been a high increase in “Sudden deaths” in the last 2 years and the embalmers at multiple funeral homes have noted amyloid protein blockage through the body. They have pulled 1’-2’ long pieces from the carotid arteries
@johnblas651
Жыл бұрын
Any relationship in an elevated igg4 and positive amyloidosis?
@klujics123
9 ай бұрын
Doctor, ❤ Would potentially someone reducing the amount of protein they consume (I believe one only needs a few ounces for a healthy diet anyway), help reduce the effects of Amyloidosis?
I lost my husband to ALamyloidosis in November. Looking back he had symptoms for around 3 years. About a year before he died he started experiencing fatigue then the symptoms spraled. Initially he was tested for ATTR amyloidosis. All tests were negative. He didn’t have bone morrow test until around the first of November. Once he tested positive for AL amyloidosis he was told chemo was his only hope. He had his first treatment on November 13. His heart couldn’t handle the chemo and passed away on the 14th. He went from an extremely healthy 72 year old to barely able to walk across the room in 6 months.
@noorizza4756
3 ай бұрын
Stay strong! ❤️
@scottwatson8836
2 ай бұрын
🙏🏽
@dennisbbb
2 ай бұрын
My mom currently is going thru treatment for AL Amyloidosis. She undergoes Daratumumab infusions with positive response and her lighchains are back to normal level; however, she is still bed-bound with severe fatigue and level 4 Edema due to heart failure and low eGFR. Not sure how long she can live like this. 😢
Very clear explanation thank you Doc !
Could Covid booster shots cause amyloid TTR?
This is very well explained
Well explained,thank you Doctor
Thanks for the info I really appreciate it very much
Next level 🔥 explaination ma'am
Im 41 and have been trying to get a diagnosis for years. I was convinced i might have MS but id never heard of amyloidosis so this is pretty terrifying.
beautifully explained.
@dr.paulinemoyaert
Жыл бұрын
Thank you, Mapheko 😊
Gracias! explicas muy bien
@dr.paulinemoyaert
Жыл бұрын
Thank you Alexei!
Great explanation!
@dr.paulinemoyaert
6 ай бұрын
Thanks!
Thanks a lot dear doctor for a very informative video in a very easy way. God bless you.
@dr.paulinemoyaert
Жыл бұрын
Thank you, Arjumand! 😊💛
Merci beaucoup.
Thank you very much🎉🎉🎉🎉🎉🎉
Nice presentation!
@dr.paulinemoyaert
Жыл бұрын
Thank you, Robert! ☺
Thank u sooooooo much for this beautiful presentation , if u could please make the video longer it will be cool ❤️❤️❤️❤️❤️❤️❤️
@dr.paulinemoyaert
Жыл бұрын
Thank you, Abo! 😉
This is scary. I was recently diagnosed with hypothyroidism. No other tests were done, but I have multiple organ issues, heart, brain, kidneys, liver, nerves. I have had every symptom of this disease except for the swollen tongue. I started Levothyroxine 6 months ago. This treatment hasn't helped any of my organs that I mentioned. I read that Hypothyroidism is often triggered by Amyloidosis.
@dr.paulinemoyaert
Жыл бұрын
Hi Venom, it is true that systemic amyloidosis can compromise thyroid function and lead to hypothyroidism (pubmed.ncbi.nlm.nih.gov/7672976/). It could also explain why you have multiple organ problems. I recommend going to your doctor (endocrinologist? Family doctor?). You can explain to him/her why you think you might have amyloidosis. If it eventually turns out to be amyloidosis, it can be treated and it will hopefully reduce your heart - brain - kidney - liver issues. Good luck. If you have any other questions, feel free to ask.
@Mikesworld777
Жыл бұрын
Did this by chance happen after vaccination?
@venomx4093
Жыл бұрын
@@Mikesworld777 Here's the story. In 2015, my liver failed. Non alcohol fatty liver. During the massive blood test, my TSH was already elevated. Nothing was said or done. I began self treating the fatty liver by detoxing my liver. I had no issues until 2021. In June of 2021, I got vaxxed. 2 weeks later, I caught covid. My wife caught it too and almost died. Weeks in the hospital on oxygen. That stressed me out. 2 days after my vax, I developed a pin point pain in my chest. This continued for months. Then in October, I went to my doctor with severe kidney pains. My white cells were elevated as was my absolute neutrophils. My dr suspected cancer. I refused to hear that and demanded a full thyroid test. He refused. The pains got worse each week. April of 2022, I found a doctor that would listen. I handed him 7 years of blood work from 2015. He immediately said my thyroid is in trouble. He ordered a thyroid test and it hit. Overt Hypothyroidism. I believe either my hypothyroidism was either at a stand still or slowly creeping up until I got vaxxed or covid and that set it into a rage. I am getting better, but it's slow going.
@MrEvtmazda
Жыл бұрын
Caused by the vax. So in other words vax injury. Good luck
@Mikesworld777
Жыл бұрын
@@venomx4093 thank you for sharing that. Are you doing hyperbaric o2 treatment or laser/light therapy?
Thank you for this video. When diagnosed with ATTR is reducing your protein intake helpful?
@dr.paulinemoyaert
Жыл бұрын
No, that won't have any effect, unfortunately.
@lss8568
Жыл бұрын
There is a test for Amyloidosis that the peptide used for it binds to the amyloid and sugar molecules present in the deposits, so a diet low in sugar or 0 sugar will help a lot.
@SeaFlower38
Жыл бұрын
Krill oil
Hi. Very informative video. Thank s for a clear explanation. Can you please share the references for this video?
@dr.paulinemoyaert
9 ай бұрын
Hi! I'd love to share the references, but I no longer have access to them. I recently purchased a new computer, and unfortunately, I lost the text of this video along with the references. I do recall that I sourced all the information online, primarily from Google, Google Scholar, and PubMed, without referencing any books. I apologize for the inconvenience.
My oncologist has given me a diagnosis of Mgus following longterm use of sertraline, an SSRI.
Hi. So if im a dialysis patient, how can i reduce the AL. Does it work if i change dialyser to Theranova or HDF. Will it reduce the AL to reduce the risk of heart failure or liver failure?
@dr.paulinemoyaert
Жыл бұрын
Hi Fared, I'm sorry. I cannot give any medical advice. I don't know your medical history, your drug regimen. I can't tell you based on this information if you should change your dialyser. I'm sorry. I hope someone else can help you find answers. Good luck.
My father has been diagnosed with Systematic Amyloidosis AL type with multiple myloma, doctor said chemotherapy is the only hope for this desease, his heart condition is also poor, should we start the chemo?
My mom was recently diagnosed with Primary Al Amyloidsis. She has multiple organ issues heart, kidney, gastrointestinal. I noticed she has very dry mouth and constantly drinking water. Also, noticing she forgets things when we talk and I help fill in the blanks. She stays in the lower and only goes up to the kitchen to eat. She is independent person but should she be living alone? Or driving Thank you! Clayton from Maryland
@saikumar4470
6 ай бұрын
Hello, by what test doctor's have confirmed about AL Amyloidsis...please help me your information helps me lot🙏
@icouldntthinkofaname.1188
6 ай бұрын
@@saikumar4470 My mom was diagnosed this past July and died in Aug17 th she was stage 4. She died at Georgetown hospital of heart arrhythmia. I believe they found it with bone marrow biopsy. My mom explained that the doctors discovered light chains. The interesting part was she had a bad kidney infection two years prior and her white and red blood cells where as low as someone as HIV. They wanted her to have bone marrow biopsy back then. I read catching it early with chemotherapy can put it into remission for years. Lastly, given improvements to treat the disease people are living longer and could managed like HIV in the future.
@abhishekpateriya7773
5 ай бұрын
Bone marrow biopsy and myloma penal test will be helpful@@saikumar4470
@sachinjain3739
3 ай бұрын
Iska kya tatment hai yr koyi to batao
@icouldntthinkofaname.1188
3 ай бұрын
@@sachinjain3739 My mom passed away August 2023. My mom died of heart arrhythmia. I hope in the future medicine can cure this type of cancer.
My mom diagnoses Al amyloidosis 2022 of December and treat of dexamethasone during taking dexamethasone my face makes round and my tongue have a canker sore and not have good taste for food and my skin become dry..it is the symptoms of having amyloidosis? I'm in chemotherapy session and I have a done a 1st cycle of 8 cycles sched ( bortezomib, cyclophosphamide at dexamethasone is my treatment
@dr.paulinemoyaert
Жыл бұрын
I'm sorry, I don't know the answer to this question.
@saikumar4470
6 ай бұрын
Hello, by what test doctor's confirmed Al amyloidosis, please help me. Your information helps me alot. Please 🙏
@IrfanKhan-ww9ot
2 ай бұрын
Moon face is a common side effect of chronic administration of dexamethasone. Taste is lost when administered chemotherapy. Dry skin is a side effect of cyclophosphamide. These are common side effects of the drugs you take
how about MACULAR AMYLOIDOSIS, R/O TINEA VERSICOLOR? is this connected?
@dr.paulinemoyaert
Жыл бұрын
I'm sorry, I don't know this. 🙁
My father (they said about 10-15years ago) has lungs amyloidosis. I don’t know is it genetic type or not?
❤❤❤
@dr.paulinemoyaert
Жыл бұрын
💛💛
My wife daignosied amyloidosis AH type through kidney biopsy. She is having creatine 2.5 blood urea 84 .she treated with lenolomide 5 mg along with bortiter inj for 1 year. Now she is treated with Endoxin 50 since last 9 months. She is not taking food intake properly due to vomiting sensation. Recently immunofixation,serum electroflorisis tests done Igg,iga,igm are normal.no m band. B2 micro globulin is high. Is there any better treatment to survive my wife. Kindly advise me Madam
@dr.paulinemoyaert
Жыл бұрын
Hi, thank you for your comment. Unfortunately, I can't give any medical advice. I don't know the patient, I don't know her medical background, I don't know your health care system. I'm sorry, I wish I could do more.
@sudhakararajuchitraju2996
Жыл бұрын
Thank you very much madam For your reply
@klujics123
9 ай бұрын
I hesitate to ask, but how are things going, and did you find any treatments which were beneficial? My Brother-in-law 48yrs old was just diagnosed through a biopsy yesterday. He has swollen lymph nodes in his chest. And has lost 35 to 40 lbs in the last few months.
@saikumar4470
6 ай бұрын
Hello, by what test doctor's confirmed about Amyloidsis AH. Please help me, your information helps me alot🙏
@saikumar4470
6 ай бұрын
@sudhakararajuchitraju2996
tttttttttttttttthanksssssss
@dr.paulinemoyaert
Жыл бұрын
yyyyyyyyyyyyyou're wwwwwelcome
Hi Team My mom is suffering from Amylodosis, please share contact of Indian doctor who can help in treatment , doctors are saying there is no treatment for this
@sukhwinderKaur-vp4gr
2 ай бұрын
My mother is also suffering with amylyodsis. She is on chemotherapy coz she is above 65 yrS si stem cells transplant is not possible
My Father @ 84 has 'A' & received 5 shots of Chemo in the stomach 1x week, for 6 months. So when do they know, at what point, Chemo is not effective in his case. 3mo 6mo, never.
@dr.paulinemoyaert
Жыл бұрын
Hi S P, they usually evaluate the effectiveness of the chemo after a few months (+- 3 months).
How to contact you?
@dr.paulinemoyaert
Жыл бұрын
Why would you like to contact me? I don't give any personal medical advice.
@B710Music
Жыл бұрын
@@dr.paulinemoyaert I need a clarification regarding the results about amylodosis
Sir i have litchen amylodisis on leg forearm Heavy itch doctor tried all medicine not worked my question whther skin amylodisis have any impact on heart kidney liver ?
@dr.paulinemoyaert
Жыл бұрын
You just called me sir?
@nagarajarao.k.v.8761
Жыл бұрын
Pl let know lichen amyloid on skin leg affect heart kidney any other internal organ jagannath Bangalore india
@ZoZo-fh4yz
6 ай бұрын
هل لقيت جوابا للسؤال
Buyers remorse?
هل لديك واتس اب
@zozansinde9610
9 ай бұрын
الله يشفينا هل لقيتي علاج
@user-vp8pg8qd9i
9 ай бұрын
@@zozansinde9610 اي
@user-vp8pg8qd9i
9 ай бұрын
@@zozansinde9610 كريم اسمو ايزيراكس بتخلطيه مع كريم تاني اسمو هيدروكينون اتنين بالمية وبتدهني مكان الاصابة لمدة شهر واحد الدهن يكون مساء
@user-vp8pg8qd9i
9 ай бұрын
@@zozansinde9610 بعد الشهر بتدهني ايزيراكس مرتين فقط اسبوعيا وبتدهني هيربيووايت مرة يوميا لمدة تلت اشهر كمان بتخليطي كمية من هاد وكمية من هاد وبتدهني مرة مساء كل يوم
@user-vp8pg8qd9i
9 ай бұрын
@@zozansinde9610 مارح اشفي بشكل كامل لكن تحسن كبير
Maam can you share your email id so that I can share my test report to you...
@dr.paulinemoyaert
Жыл бұрын
No, sorry. I can't give any medical advice.
Main Planet Ayurveda ka dhanyavaad karta hoon, kyunki unki herbal medicines ne meri umra ko bhi badhaya hai.