What if we could predict-and cure-all diseases? | Albert-László Barabási
Ғылым және технология
This network scientist is creating a map of the human genome, and it could revolutionize the future of healthcare.
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The Human Genome Project was a major breakthrough in medicine, but according to network scientist Albert-László Barabási, simply having a list of genes is not enough to fully understand how they interact, and crucially, how our bodies work. Barabási believes network science - which studies complex patterns and interactions between our cells - can fill in this gap by creating a biological map from which we could develop new cures, and even predict diseases.
He explains that disease genes often have mutations that result in a missing interaction within the sub-cellular network, which then causes problems in the functioning of a cell. Traditional medicinal interventions can lead to unwanted side effects, as they also affect other cellular processes in the network; network medicine has revealed that these complex systems, though robust, are also fragile to attacks, and removing a few major hubs can break the network into tiny pieces.
Understanding the structure of the network within our cells can allow for precise interventions that cure the problem without causing other issues. For Barabási, the ideal future of medicine would involve individualized network diagrams being adopted as a standard tool for doctors to show patients where mutations are, how they impact the rest of the cell, and how interventions can stop their effects.
Read the full video transcript: bigthink.com/the-well/the-cur...
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Пікірлер: 57
I think that this branch of medicine tends to forget that most of the disease burden in today’s world actually comes from causes external to the individual. Poverty has a lot more impact on health than a group of genes.
@prodtaKaN
Жыл бұрын
Poverty impacts human health through mechanisms that follow the same sort of network that is talked about in this video. While things like this won't solve the impacts of poverty, we should be able to better understand why poverty causes such outcomes.
During my master's, I came across the research by this guy...changed my perspective of things. Great video.
@The-Well
Жыл бұрын
Cool to hear! Hope you're doing cool stuff yourself now :)
@cadethompson3622
10 ай бұрын
Yzzu i
The progress of AI and computing power is key to advancing in this area
Could not agree more!
This guy's amazing!
@The-Well
Жыл бұрын
Glad you liked it!
If all diseases can be cured, then will the body be able to live much longer? 200 Years? 1,000 Years? Will the retirement age for government benefits still be the same age as today?
@ozymandiasultor9480
Жыл бұрын
No. The aging process is not really connected with illness. Our body is made of cells and those cells have to die out after a certain time and new ones be created... But the process of creation of new cells is not perfect, that is the essence of getting old. A good analogy is if you have a Xerox machine and you start to copy the original then copy the copy, and then copy the copy of a copy, etc...After a certain time mistakes will be visible and more of them will appear. The same happens with human beings and almost all living organisms, and some cells are so complicated that replication is almost impossible like neurons.
@ozymandiasultor9480
Жыл бұрын
Of course, our ancestors lived shorter lives because of many reasons, lack of medicine, lack of enough good food, tooth decay, eyes get weaker... Today humans live much longer but the aging process will continue even if we can cure all illnesses. It maybe ca be stopped if we find a way to correct mistakes that appear in our DNA, if we get so good in biochemistry to intervene in the process of making new cells or even create better cells than we had before.
@FairnessIsTheAnswer
Жыл бұрын
@@ozymandiasultor9480 Keep telomeres long! Long live telomeres! Telomeres forever!
@ozymandiasultor9480
Жыл бұрын
@@FairnessIsTheAnswer Sure, it would be good (and bad) if we can keep telomeres long.
@jd-xe4rn
Жыл бұрын
@@ozymandiasultor9480 have you ever read or heard of Dr. David Sinclair's work on aging? His book Lifespan is a great read if you haven't checked it out. Your Xerox analogy reminded me of his work because I believe he uses the same analogy within the book as well.
Although the speaker completely disregarded somatic mutations, it is still something worth pursuing. However, I don't think there will be a replacement of organ system specialist with "networkologist", rather this new "specialty" will be incorporated as a "general" course in each specialty curriculum.
@OsvaldoBayerista
Жыл бұрын
Somatic mutations?
@therealb888
Жыл бұрын
@@OsvaldoBayerista ya mutations of non gamete cells like skin cells.
My cardiologist treats me for a neurological problem, actually. 😅
@The-Well
Жыл бұрын
Well, good luck!
@johnnyearp52
Жыл бұрын
@@The-Well That is common for my problem (POTS). The neurologists tend not to want to treat it so the cardiologists step up.
Reminds me of Aldous Huxley Island
Maybe someone will invent a device to detect our individual conciousness collect it then store or transfer
@aq1sw2qas3qd
Жыл бұрын
God I hope not. I was born a creature and as one I should also die.
@The-Well
Жыл бұрын
Both of these perspectives have their own appeal, honestly 😅
@OsvaldoBayerista
Жыл бұрын
@@aq1sw2qas3qd Nobody said it's for you. You can choose to not use it, and other can choose to use it. Why do you want it to no be invented if others want it? It doesn't affect you.
@society_for_praising_appli6261
Жыл бұрын
It is easy to be distracted by the spectacle and forget that we are creatures. Our lives are a gift. Our conscious awareness is a gift. We are from the void/source and to the void/source we will return. But I'm awake NOW! Alleluia for coffee and its Creator!
If we cured all diseases and everyone died only due to old age, can the environment handle that many human beings?!
@serenityssolace
Жыл бұрын
Yes, as long as people like Bill Gates doesn't pollute the world like 1000000 people would. And if we stopped spending trillions of dollars in the war industry and put that money in space and science we would also find new solutions and planets to habitate
@FairnessIsTheAnswer
Жыл бұрын
No, the environment can't handle the number of people we have now. The way that world population control has worked for a long time is that there was a lot of attrition (death by various means), so living things needed to produce lots of offspring to keep from dying out. That system has been overridden by people finding ways to increase survivability. Some people argue that we have enough food to support an even bigger population, but food isn't the only issue. Enough space to house all the people is also not the issue that will kill us. If all the forests are cut down then it won't matter if there is enough food or housing. The consequences of global warming and pollution may kill enough people to bring the population down. Look at what is happening in Pakistan. The world situation could get a lot worse. Mass starvation could be coming even with the technical capability to grow enough food.
@supayambaek
Жыл бұрын
That's why space exploration is in development.
@AmanSingh-lv9qp
Жыл бұрын
Elon Musk already began finding a solution to that
@serenityssolace
Жыл бұрын
@@FairnessIsTheAnswer Sounds like climate fear p*rn to me. Elon Musk says one of our greatest threats right now is population collapse. Housing, nature and food shouldn't be a problem. Especially with radical science advancements. Floating cities, ocean cities, underwater cities, space travel. It can all be done
If screw does not goes into nut just eliminate the nuts and bolt just use snap in like snap and twist and new human had no sexual organ is future of evolution