Using Rapid-Acting Brain Stimulation for Treatment-Resistant Depression
Each month The Brain & Behavior Research Foundation hosts a Meet the Scientist Webinar featuring a researcher discussing the latest findings related to mental illness. In May, 2021, the Foundation featured Dr. Nolan R. Williams of Stanford University Medical Center.
Description: There is a widely acknowledged need for new, effective antidepressant treatments. Past research has demonstrated that a form of FDA-approved non-invasive brain stimulation called rTMS could be optimized to better treat depression as well as other psychiatric disorders. Our team has tested the hypothesis that the effectiveness of rTMS could be enhanced with a new treatment protocol involving multiple non-invasive brain-stimulation sessions at spaced intervals throughout the day delivered over the course of five consecutive days, providing patients with significantly more total stimulation, and targeted individually in each patient based on brain scans obtained prior to the start of treatments. We recently completed a randomized controlled trial to determine the antidepressant response of this novel protocol, called SAINT. As I will report in the webinar, we found that it had a profound and rapid effect in patients with treatment-resistant depression.
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Thank you guys for all you do. The bipolar depression can be extremely dehabilitating it's literally impossible to describe at times. And if a fix can be found for that it'd be life changing. However, I don't think taking a risk of putting electricity in your brain is a smart move to make..
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I've had ECT as well as TMS and other interventions like ketamine. I have treatment-resistant major depressive disorder. I work in a neurosurgery clinic, in which our surgeons among other things place electrodes in the brain for treatment of Parkinson's, with a battery implanted in the chest or side. The gut reaction or fear of these types of interventions is misplaced. It's definitely a natural fear, but your doctor can probably provide you with a lot of evidence that these things can be safe and effective. When I got ECT, it was helpful to reflect that many people live with epilepsy disorders and continue their lives--and when I felt the effect of ECT, it was as if I had a brain transplant. So many things I had hated about myself evaporated, and I could suddenly do things that became the basis of my self-respect. I still have depression, but I have a degree and a job because when I need it these treatments are available. I hope we see more of them.
Excellent.
If a person suffers from MDD and quality of life is non-existent, putting electricity where ever is going to be my choice if that person were me. Whether I respond by having improvement in mood and reduced depressive symptoms or have a fatal sentinel event as a result, relief will be had. Unless one comprehends the agony of living with MDD, that statement probably seems absurd.
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