In this sneak peek, we discuss: 00:00 - Intro 00:10 - Importance of metabolic health and a primer on metabolic disease 05:05 - How poor metabolic health increases one’s risk for other chronic diseases 09:39 - How useful is body weight and BMI for estimating metabolic health? 12:12 - Overview of various tests and metrics used to understand metabolic health 15:10 - Traditional biomarkers and how Peter’s point of view may differ from the guidelines In the full episode, we also discuss: -Lactate: insights into metabolic health through fasting and resting lactate levels; -Zone 2 output: an important functional test of metabolic health; -Cardiopulmonary exercise testing (CPET); -Visceral adipose tissue (VAT): what is VAT and how does it impact health?; -Oral glucose tolerance test (OGTT): how it works and why it is such an important metric for assessing metabolic health; -The utility of a continuous glucose monitor (CGM); -Liver function and NAFLD; -Sleep as an intervention; -Exercise as an intervention; -Diet and nutrition; -How reducing stress can improve metabolic health; -Much more

Hey Peter, truly appreciate the format you designed for your premium / non-premium memberships. I believe it is absolutely fair - even generous - and also appealing. The information level and quality for "non-premium members" is great, so your can ensure the 80/20 impact for the largest share of your listeners (who probably wouldn't have their priorities or resources straight to become premium members). Thank you once again for teaching me so much, and asking so little from me in return. And also, for being a role-model in a range of dimensions, from more ethical (i.e., integrity, truth-seeking, honesty) to more technical (i.e., pragmatic thinking, structuring, communication) spheres. Hope all the best for you and for your community.

0:20: 📊 This AMA focuses on metabolic health and its impact on aging and disease. 4:29: 📊 The video discusses the definition of metabolic syndrome and its key components. 12:39: 💡 The speaker discusses the metrics used to understand metabolic health at an individual level, including functional tests, imaging tests, regular biomarkers, and special tests. 8:11: 🧠 Abdominal obesity may have a protective role in reducing the risk of Alzheimer's disease, but there is a higher risk for other forms of dementia. 16:01: 💡 The video discusses the benefits of becoming a premium member and the exclusive content and benefits offered. Recap by Tammy AI

@SpLUrGe85

9 ай бұрын

Wow ai is on point

@IntegrityMeansAll

7 ай бұрын

Thank you🙏but why is the other guy whispering like this?🤔 it’s a little creepy/inappropriate 😅

I have a few health gurus. Pete is one of them

I love Ayrton Senna’s helmet in the background!

Thank you for this valuable information.

Really appreciate the guys like Attia and Huberman who cover this important material so well. I also enjoy Barbara O’Neill and Sam Bailey for holistic natural health. Sinclair Kenalley and others really take you into the liver health etc You tube and platforms like it allow a lot of information making it easy for busy folks to still learn

I’ve listed to a lot of podcasts from Peter on this topic but the question of how to lower your apoB level non pharmacologically, especially when you are in your 30s and still have a chance of affecting it, is never approached. I know a ton on how cholesterol works and how it kills people but nothing on how to prevent it from killing me. It would be great to make an episode on that topic and related to that on how your diet affect your apoB level.

@HEARTANDSOULOFMINE

7 ай бұрын

Try listening to Dr. Ford Brewer on ApoB.

@curious_boy9092

6 ай бұрын

all you can do , reduce saturated fat and raffined carbohydrates

I’m so addicted to this channel

Have listened for a while. Was an endurance athlete. Age65 and rampant arthritis. ( jt replacements looming ) can make a lot of his workout recs impossible for me. Wish there was more in between for the mere aging mortal

@cherylh4688

8 ай бұрын

Oh, Cindy!! A year ago I could not only not walk anywhere anymore without having to hold onto something because of severe pain in my feet, but I could no longer dress myself either because of the arthritis-like pain that had spread to my shoulders! And I say "arthritis-like" because it hasn't been diagnosed. But then, my doctor never diagnosed my gout, metabolic syndrome, venous insufficiency or lymph edema either! I had to do it and only then did she confirm it! But she hasn't confirmed the arthritis, however, because I have managed to reverse it so much with diet! And today I can do almost anything with my arms (not pull ups tho', lol) and am almost pain-free in my feet and building back muscle to start a walking program again! And how did I do it? By putting myself on a "carnivore" diet of only animal protein foods: in my case, red meat, poultry and seafood, which I rotate. And altho' I started with keto and only gradually eliminated suspected plant foods, it was only when I finally had eliminated them all that I got my best results, altho' just eliminating plants with lectins & oxalates reduced my pain by about 80-90%%. And it was the plants high in oxalates that were the biggest culprits. Yet even after removing them, I still had to remove everything else to reduce edema, etc. And now, after several months on strict carnivore, I am at last able to add back a few plants again: Broccoli, asparagus, artichoke, celery, romaine and olive oil so far, none of which contain lectins or oxalates. So please, please start watching some carnivore doc videos as well (Drs Berry, Chaffee, Cywes, Baker, Boz to start) and read the comments. I promise you will see many testimonials to healing arthritis. And also check out Michaela Peterson for her story (diagnosed with arthritis at age 2, needed joint replacements at 17, etc). She, too, put her severe condition into remission on a carnivore diet, altho' hers has to be even stricter than mine. Her father's, too. (Jordan Peterson) And if you want some guidance on how to make the transition, pls don't hesitate to ask me. I would be thrilled if I could help you also find some relief!🤗

@Mary_QQQ

8 ай бұрын

​@cherylh4688 great. For longevity, have as much plant food as you can tolerate and as little red meat

@cherylh4688

8 ай бұрын

I forgot to mention the GAPS diet, Cindy. It has a protocol for healing arthritis too, which is much like my own, and I can highly recommend it. The book is called "Gut and Physiology Syndrome," by Dr. Natasha Campbell- McBride.

The best, even if he is an over achiever as he labeled himself, he is so authentic and true to himself and very honest with others. Very credible not only because he is an MD…

What is the physical mechanism of fatigue? Like from sleep deprivation etc.

What a coincidence! Just yesterday I was reading Jerry Reaven's 1988 Banting lecture.

It seems that American versus Canadian medical testing is a bit more broader and deeper. Never had my blood oxygen levels taken until going to the US during a typical examination. Maybe that's due to cost cutting, controlling the amount of time? .....

@kddidit08

10 ай бұрын

I've tried for a while (I live in BC) to get a breakdown of my LDL cholesterol. My family doctor is receptive to conversations about this stuff and said he would be willing to order the test, but he's never heard of it and has no idea where I can get it. I asked at my local hospital's lab and at the corporate lab and they likewise have no idea what I'm talking about. BC's medical recommendations seem to focus on reducing total LDLs and total cholesterol (which is weird, since we want higher HDLs, part of "total cholesterol"). I'm not sure it's about cost-cutting as much as widespread adherence to a set of standards that will likely increase the prescription of statin (not that statins are the devil, but not necessarily necessary).

It's just a shame the life insurance companies place more emphasis on BMI than true measures of health.

@cherylh4688

8 ай бұрын

Apparently, insurance cos give the greatest importance to a liver measurement called "GGT", which when high is "the greatest predictor of all-cause mortality" and "linked to ALL major diseases"! And yet, my doctor has never even had any liver panels done for me!

I don’t know if Dr. Attea answers questions but I am a 70-year-old woman with FHS muscular dystrophy. I had my hip replaced at 59 from my car accident. I fell on May 14 of this year just pre-my 70th birthday and dislocated my hip I subsequently had three more hip dislocations (spontaneously) I have had hip reconstruction. The down time was quite hard on my muscular dystrophy, but I am working hard to regain all my mobility. I’ve got a rebounder and have started exercising on it. I do seated yoga and strength training five days a week I don’t think I’m fooling myself, but I have not lost any mobility walking. I do use a cane or a walker, but I was pre-falling. Anyway is there anything that you know about as a physician that would help my muscular dystrophy. Significant muscle loss is in my shoulders and my hip girdle my leg seem to be hanging in there, thank you.

Does anyone know if you get the numbers - the optimal readings for these bio markers - if you become a premium subscriber? And what that costs? Thanks in advance!🤗

Is that helmet in the background Senna's? 🤔

Love to see Ayrton Senna helmet ❤ luv from Brazil

Many of my metabolic readings are pretty much a mess except for two (possibly three): HDL (@50), bilirubin (2.98 or Gilbert's Syndrome), and high (but not quite gout territory) blood uric acid (@6.50). Gilbert's is something you might want as unconjugated bilirubin has antioxidant properties, and high uric acid has been shown in some studies to protect against neurodegenerative conditions. Blood full of piss and bile, who'd a thought!🤣 Six years ago, I sustained my first heart attack. During my catheterization, dye injected into my heart's vascular system revealed a remarkable absence of atherosclerosis except for just one spot: a 95% blockage mid-LA. The surgeon fixing my heart said he only saw this occasionally in young women and rarely in men who exercise maybe too hard. (When men have their first heart attack after 60, they almost always come to the realization that there's plaque all over the place.) It's called SCAD. It's more dangerous in that the affected artery can rip open like a zipper, unlike the usual circumstance where a blood clot forms over a solidly planted ruptured plaque. Therefore, a stent was inserted to open up the blockage (consisting of ripped up endothelial tissue and blood) and to seal the rip. I had been on a statin for five years until it seemingly exacerbated another chronic condition, in addition to Syndrome X, that I have (MCAS: Mast Cell Activation Syndrome) during the winter of 2011. My abdominal scan revealed a hyperechoic liver and a proximal colon (caecum, ascending, and transverse) squirming like a worm lost on a hot sidewalk. My symptoms (intense RUQ and RLQ abdominal discomfort, slight POTS, brain fog, fatigue, and pruritis) slowly subsided for over a year after discontinuing the drug. Back to 2017: at the ER, the attending doctor told me that my lipid profile was "deranged", and he wanted me back on a statin. However, my family doctor and my cardiologist thought I'd probably be alright on Ezetimibe in lieu of my angiogram, HDL, bilirubin, and athletically competitive attitude without pushing things further. Also, my optometrist was very surprised when I told him that I was recovering from my first heart attack (my retinal scans revealed nothing except a nevus). Also, my morning wood is as hard as ever. I still exercise regularly, get sufficient sleep, and eat a much more Mediterranean Diet (with under 40% carbs). In the twentieth century, my triglycerides got over 500 (my serum looked like chicken soup, not apple juice) on a "normal" Western Diet (with 60% to 70% carbs); they now straddle the fence (135 to 175 on average). Finally, my Dad lived into his mid-nineties without diabetic complications even though his fasting glucose (144) was well within the diabetic range. He didn't exercise and continued eating the way most eat (i.e., a "normal" Western Diet).

@cherylh4688

8 ай бұрын

Wow! That's a lot to share without a question anywhere in it, lol. Interesting, tho' (and I loved the description of the colon😂). Have you had your Lipoprotein (a) [aka Lp(a)] tested to see if you carry the heart attack gene? I did ..and do.😢 I just wanted to share that my mother's boyfriend lived to be 98 on a typical American diet, altho' NOT high in sugar but did have a slice of white bread at every meal. My mother would complain all the time about his "terrible" diet, but all I could say was, "It seems to be working for him," lol, bc he didn't take a single med! BUT he walked outdoors for at least 3 hrs every day throughout his retirement, and only passed away when he had to stop bc of a fall. So I think that must have been his secret to longevity! Maybe you could add that? OTOH, just a note that altho' my LDL did go up to around 156, my TTL chol went down slightly, to 229 from 256, on a carnivore diet that is heavy in seafood. And my trig finally dropped to only 76, while my HDL finally went above 50, to an optimal 65! And so that was with almost zero carbs for a little less than a year, altho' I have currently added back in a cup or 2 of greens per day (broccoli, asparagus, artichokes, celery, romaine) but no other carbs. So perhaps you could try that for about 6 months, to see how your numbers might improve. Worth a shot, maybe?

@rdbm-uo5zt

8 ай бұрын

@cherylh4688: Yeah, my gut was on 'fire'! Mast cells were releasing their mediators (including histamine) in amounts similar to those having inflammatory bowel disease flares. I was feeling just as miserable, yet there was no actual attack of my immune system on my bowel. The pain was described as "unexplained" as result. Still, since I was over 55, they finally agreed to do a colonoscopy. At my cardiac rehab, a guy mentioned Lp(a), but the therapists didn't use it. I don't think OHIP (I live in Ontario, Canada) covers it. I was told that exercise is the strongest 'pill' you can take to offset the effects of Syndrome X. I try to walk 10,000 steps per day, cycle moderately to vigorously for 30 minutes, three times per week, and lift weights three times per week. I was advised to follow a 80:20 Mediterranean Diet (80% pure, 20% Western) on a 16:8 intermittent fasting schedule (16 hours fasting, 8 hours eating). So far, I can manage that without cravings. On a wholly Western Diet, my trigs were over 400, and on my new diet, they went down to about 135. LDL went from 135 to 160 and then down again to 125 with Ezetimibe. It's quite surprising the differences that can be seen in omnivores such as humans! Some are much more vegetarian than others and vice versa. Some, like your mother's boyfriend, do best on a Western Diet (even one loaded with sugar!). Others, like Dr. Shawn Baker, do best eating like a lion. I think more fitness programs should acknowledge individual differences, unlike most cookie cutter one-size-fits-all systems and guides.

I think the guy with the cap is tired.

I don’t get why is LDL never mentioned even though it’s allegedly the predictor or heart disease? My ApoB is kinda high of 100 and high LDL but every other thing is super good, low blood pressure, low triglycerides, narrow waist, high HDL low fasting glucose etc.

@SZD06564

9 ай бұрын

Because they’re just talking about metabolic health, not heart disease. Poor metabolic health is associated with higher risk of heart disease but if you’re in great metabolic health you can still get heart disease if your apoB is high.

@Cass-gi4kk

9 ай бұрын

@@SZD06564 why they chose those markers and not include LDL though?

@itsmano22

9 ай бұрын

What's your diet like? Carnivore/animal based?

@Cass-gi4kk

9 ай бұрын

@@itsmano22 I eat animals because I need high protein diet for skeletal muscle. However I rather eat fish and low fat meats if possible since I have high cholesterol. I’ve had it already at least 20 years.

@cherylh4688

8 ай бұрын

​@@SZD06564 And/or if your Lp(a) is high as well. But thank you for the reminder that they were only talking about metabolic syndrome, because I was also wondering why they hadn't mentioned certain tests, like an NMR panel and CAC, lol!

Why the paywall peter

fell asleep twice... must be tired but the conversation was also monotonous and too many %