Two posters with opposing points of view both allowed to post their opinions on Twitter is excellent. If it were FB or ewe-toob some 'moderator' with an arts degree would ask the govt who was right and the other would be told their post was 'fact checked' ... and deleted. 🤓🇦🇺 Progress.

@machinethesun9243

Жыл бұрын

Arts degree here, and not asking the government anything, thanks.

@LTPottenger

Жыл бұрын

lol

@dilligafwoftam985

Жыл бұрын

@@machinethesun9243 ... and hopefully not pretending to be an informed science moderator. (Science PhD and DSc here)

@machinethesun9243

Жыл бұрын

Why pick on artists, what is so bad about us? Go pick on weapons manufacturers, war profiteers, big pharma and their corporate schills.

Happy for the battle, at least they allow debate now! Without debates, there's no real science!

I’ve been on Oncology Nurse Educator in big pharma for a decade….love Dr V. I have nothing of import to add I just want to help monetize his efforts!

Way to go, Dr. Prasad! I love watching your videos. A cousin of ours was asymptomatic for multiple myeloma and immediately began treatment, which lasted several years and was an extreme hardship for him. Toward the end, when covid happened, he was so afraid of catching the virus that he didn't allow visitors, and practically starved to death all alone in his apartment. His close family members finally discovered his emaciated state and rushed him to the hospital, where he died several days later. Quality of life--what a "novel" concept in these times.

"this isn't 2022 okay, this is back in the diggity and by the way by 2042 the studies you're using now are going to look like horseshit they're too small and the end point is too stupid".... I love this channel.

This also reminds me of the limitations of twitter/online communication. I would love to see such a debate held between these two guys both in the same room. Much easier to have a good faith disagreement.

I love being served up chemo drug ads while watching this video.

I've been a follower of yours for some time and given that my dad has MM (dx'd with HR SMM in q4 2018, progressed to active MM in q4 2019), I watched this with great interest. I love that MM is getting more attention as it seems like the treatments are just a few steps behind some of the more breakthrough options for leukemia and lymphoma patients.

well commented. thanks

❤ that was helpful! Currently my hematologist broached the topic of chemo, I am awaiting appointment with MM Specialist. I am on a sharp learning curve prior to the appointment.

Problem with treating smoldering MM is that you burn up a key agent, lenalidomide, and you possibly impair future stem cell collection. Also, no established ethics about transplant consolidation therapy in these patients. I would argue it's unethical do to HCT on a smoldering MM patient, too much mortality risk for the given situation. Rd is great in the short term, but the long game is much more problematic. Nice video!

My good friend has this disease and we were just discussing at the other night.i ask her if she was going to do chemo.she said she would wait and see so I was very interested in this posting thank for doing this

*best part is **_"if you cant easily power a study for your "caper"; aint much of a caper."_* [paraphrase] . & it doesnt mean it isnt important, and rare items have to be treated separately. but for most topics & pts nearly all of the time: it's a con. gr8 fight. _JC

I worked with Barlogie for years and when he retired the doctor I worked for and an APN inherited most of his patients so I got to do a historical audit on all the charts plus my 11 years treating 1000s of Myeloma patients. He often times would give zometa. I can think of several patients that had a very small lesion on MRI and with Zometa alone the lesion resolved and 5-10 years later still didn’t need Myeloma treatment. I am just not a fan of treating smolders even if they are high risk. They of course need to be watched closely. The quality of life is so important, and the copays for Revlimid is not insignificant. I have had patients who have had to mortgage their house or couldn’t buy a vehicle because of the cost.

It seems to me that the 3 historical studies seem to suggest not only that it's reasonable to delay treatment, but that it's in fact better to delay treatment, because if they're not seeing an OS difference, then why pump your patients full of toxic chemo? You'd have to demonstrate a pretty hefty OS benefit to justify treatment. It also seems to get things the right way round, your default reaction should be not to do anything you can't back up, unless and until you have data that supports a benefit, not to treat just in case and subject your patient to toxic therapies that reduce lifespans on their own. The only reason we're okay giving anyone these drugs is because the cancer is gonna kill em faster than the drugs

If the QuiRedex study is underpowered for OS, then aren’t the null results from the diggity also incapable of ruling out an OS benefit? Doesn’t that cut both ways? I agree the null hypothesis is still that early treatment doesn’t improve OS and it must be proven otherwise, I’m just pointing out that too little power affects the null studies as well

"Do no harm!" Unless..........

@janeteddddd

Жыл бұрын

Unless you get big incentives $$$$$$

Haha this needs sound effects. Ting dingding🔔🥊

Sadly seems like wait for progression is still the tactic

Vinay - is there a way to ask you a question about your chart as compared to some results I received? I tried using your contact me form but I haven't heard back. I want to have a consult with you if I can. Or someone you recommend.

Vincent got owned and he knew it and raged quit.

Rajkumar is like a GOAT of MM.

So weird. It’s not Multiple Myeloma, but it’s not MGUS. Idk I’m just a med student who keeps confusing CLL and CML- how embarrassing 😂

Devil's in the details.... consider: change the terrain instead