This is positively the BEST introductory explanation to tolerance and withdrawal that I have EVER seen. The rest of the videos in this series are also good, and would be appropriate for use in family education/treatment centers and graduate and undergraduate settings (I was an Assistant Professor at UF)...It is THAT good. I am not affiliated with the Khan Academy in any way. I came across their stuff while homeschooling my kids. Take a moment and watch the video and you will see what I mean...phenomenal.

@dejanmarkovic3040

3 жыл бұрын

It's ok, but not the most comprehensive..can you then answer my question? It's in the comments.

"May cause irreparable damage to other parts of your brain..." - key phrase

Awesome video on mechanismof neurotratransmitters in the brain. Understanding tolerance and withdrawal would be the key to treatment addictions, mechanism of drug action. I look forward for next video.

this is totally helping with my meth addiction.

@dmitryduryagin6980

3 жыл бұрын

how?

@gc8972b

2 жыл бұрын

@@dmitryduryagin6980 logic helps manage emotions

This video helped me define addiction for me. It's good to know that I'm not addicted to porn/masturbation. I may feel a little more irritable and lethargic lately, but I don't feel abnormal or lower than my baseline of happiness

Orgasm addiction is the worst. It's free and very accessible. Only thing you need is a hand. It's an addiction you can never really beat.

@bashar375

6 жыл бұрын

hahahahah

@addmenow7454

5 жыл бұрын

I've quit many drugs and alcohol multiple times to lay off drugs for a while.. To gain back my tolerance.. But with masturbation, that's the only thing I've never took a break on because that shit is super hard to stop 😂ya hand is always available, true

@dimkacracker

4 жыл бұрын

@@addmenow7454 just cut it off.

Why are adult brains more resistant to drug addiction than younger people's brains? A nicely done video btw! 🤗

Very impressive I like the voice of the girl as well as lecture too ❤ great style

Thankyou, very easy to understand.

Fantastic lady. Thank you.

What if i develop total tolerance for realising emotions after workout (training for 5 yrs now) and tolerance after good lunch or any other healthy or less healthy activity, almost zero emotions released..any suggestions???

This is an excellent overview of addiction, and these principles apply to many drugs that replace the brain's normal production of the feel-good chemical serotonin. Once the drugs start to control the brain's production of serotonin, it takes a long time for the brain to take back over serotonin production once the drug is discontinued. Good job.

Nice explanation

I would wonder, or maybe there is a video on how the different drugs affect the brain unless they are all very similar in effects.

also love the voice!

Can't drugs also lead to an increase in receptors, which also results in withdrawal symptoms? Eg. too many drugs, brain or cells compensate by creating more receptors, due to there being more drugs, then when there are no drugs you get withdrawal. Just did some research, seems to do with agonist/antagonist molecules, but tolerance and withdrawal can also be related to an increase in receptors (i.e. not just due to receptor desensitisation).

@davidnelson3388

6 жыл бұрын

It’s actually the opposite. The cells respond to exogenous drugs by down regulating receptors. For example, in a simplistic view... an opioid receptor is an inhibitory receptor in the G-coupled receptor family. When you add an external agonist to the inhibiting receptor it inhibits the response to pain by decreasing the amount of cyclic AMP produced. The cell responds to the inhibiting agonist by reducing the number of receptors available at the cell surface and creating the need for more agonist (opioid) to get the same response.

who else is here from treatment of substance abuse class at USC?

Wait, if the dendrite shuts down receptors in response ti a superstimulus of dopamine, how does a higher dose still get you high? Does it get crammed up through those receptors that are left open? I don't get it...if our brains are so smart to develop this thing called hedonic adaptation, why...oh, I see...adaptation...touche. Ok, then how do multiple superstimuli affect the process of withdrawal? If you're kickin a drug, but you keep drinking, gambling, fucking, eating sugar, whatever...does it then alleviate the absence of that dug and make it easier to endure? Oooor....does it just reinforce your weak nucleus accumbence's habit of overindulging, eventualky ending up in a relapse? I don't know what region is responsible for what we call willppwer, but I imsgine it's somewhere in the pfc...so...do we spare it the pain, like an overworked muscle, or do we exercise it by every harmful habit that feels good? I don't get how it works and my ignorance manifests as this cyclic behavior because I don't know what the hell I'm supposed to do during abstinence...god damn it.

I don't think this video is very accurate. One, meth incites release of dopamine from the presynaptic neuron, not coke. Coke, afaik, blocks reuptake. Secondly, tolerance isn't simply fewer active receptors, but also a myriad of other changes: higher CRF, lower dopamine secreted by the VTA, etc. I like her previous video though on the mesolimbic reward pathway!

@beingfor1825

6 жыл бұрын

Did you even watch the video completely or in a hurry to regurgitate your knowledge?

@Beastosterone

5 жыл бұрын

Thank you the information

@kamomandy25

2 жыл бұрын

Thanks for this x

@Kgucken1104

2 жыл бұрын

I agree, this example is more is more conducive to opiates rather than cocaine.

The science is definitely wrong. She starts out by saying that tolerance is such that you need more of the chemical for the same "effect", keyword being the same. I've never met an addict who says their first time could be replicated. From personal experience, the "effect" your looking for will never be achieved. Tolerance, addiciton, withdrawal are more nauanced and complicated than can be given in 5:32. I feel like this video is equivalant to: "learn how to solve PDEs with no math knowledge in 5 minutes". Science is far behind on addiction, is that because of the underlying politics of racism and tyranny? I know the DEA(drug enforcement agency in America) has a policy that says, "regardless of science, illegal drugs will never be legalized". SO maybe when it comes to the science of addiction, even scientists have their hands tied by the government.

We could be this infinite divine creatures if our brain naturally made us feel euphoric and intense well being to begin with but for some reason our brain makes us naturally feel like shit? And the argument that if we did feel this way we wouldn't want to do anything is invalid since our brain could just simply increase the reward of this euphoric feeling even higher when we take action on a task. Here is what i mean in math explaining how we naturally feel vs how we could feel better and still be even more effective: *Feeling pretty shitty as a normal human being *Feeling extremely happy and euphoric to begin with Did god purposelyfully make us feel like shit when he could just make us these more happy creatures?

@bryanjaramillo2789

4 жыл бұрын

twacked the fuck out

@SERGE_Tech

4 жыл бұрын

it all ready works this way if you feel like shit theres something wrong going on and you need to address it. nature through natural processes made the brain work this way. Your base level of happiness is determined by dna some people are super happy all the time. its either genetics or your environment that needs changing

@fitsumgarredew9624

Жыл бұрын

@@bryanjaramillo2789he’s asking a legitimate question you dipshit

@fitsumgarredew9624

Жыл бұрын

@@SERGE_Techso you feel euphoric all the time?

@SERGE_Tech

Жыл бұрын

@@fitsumgarredew9624 like 45% of the time the rest is pure pain, thats the biology of bipolar which is probably what I have with maybe some bpd because mostly if you have a normal brain you shouldnt see as big mood swings because euphoria suppose to be rare but some people can trigger it with caffine or they can trigger it with exercise, you do have powers you might not be aware of just about your brain and it should all make more sense.

Well im just here. Smoking weed. Stick to weed, no one has died directly from weed in any form.

@ShezzLuvsShadow

3 жыл бұрын

Don't underestimate the psychological side effects and dependency...weed is safer than most drugs but isn't "safe".

@kamomandy25

2 жыл бұрын

Weed can cause schizophrenia

So boring.. please make it clear your words when you are saying.. be motivated and fast, I listened it twice and yawned.