Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, discusses optimizing induction chemotherapy for acute myeloid leukemia (AML). Combining venetoclax with azacitidine (AZA+VEN) has shown effectiveness, despite lacking FDA approval. Trials incorporating anti-CD123 agents like tagraxofusp or pivekimab sunirine with AZA+VEN have improved measurable residual disease (MRD) negative rates and response duration. Another approach involves adding targeted agents for specific mutations, such as menin, FLT3, or IDH 1/2 inhibitors, to AZA+VEN. Longer randomized trials are needed to assess the impact on response depth and durability in chemotherapy-based treatments. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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