In this video Alex Trombley, Business Development Manager North America, presents the Syntegon Xelum R&D continuous manufacturing system. The Xelum R&D is built around our renowned Hüttlin fluid bed technology. We paired it with a unique feeder/blender module that dispenses exact aliquots of material, so-called X-keys of powder that are individually fed, blend and processed throughout the system.
We have eliminated the need for scale-up by pairing one blending module with up to 5 fluid beds and a TPR tablet press.
It is the best of both worlds, combining the positives of continuous manufacturing such as batch size flexibility, reduced footprint and PAT with the aspects of batch manufacturing that are just too valuable to leave behind - such as formulations with sub 1 % material concentrations, ability to adjust any dispensing issues, and a clear control strategy of a firmly defined aliquot of powder.
There are several different technologies out there for oral solid dosage continuous manufacturing, but they all are largely reliant on powder feeders dispensing an exact flow rate and concentration of material. Truly continuous powder unit operations are heavily influenced by throughput and the nature of pharmaceutical manufacturing does not allow for fluctuations in dispensed concentrations. Syntgon Xelum R&D avoids these issues altogether by feeding to a target X-key mass with no dependence on time. There are also several benefits to fluid bed granulation over other truly continuous options on the market.
Syntegon has announced strategic partnerships with pharmaceutical giants like Bayer and Shanghai Pharmaceuticals, as well as several North American installations at a BlueChip Pharma company.
To find out more about the Xelum R&D, visit Syntegon’s website at: www.syntegon.c...