The best explanation so far!!!‼️💯‼️💯‼️💯‼️ Because eveyone just saying that dopomine is blocked, it doesn't mean anything. The question is, where it is blocked? Besides, nobody mentions that also histamine, acetylcholine, norepinephrine is blocked as well. Here a doctor speaks. And this video explains it beautifully!!!

I was on Venlafaxine XR and Quetiapine for major depression and BPD. Diagnosed in early 50's. 7 years later im off the venlafaxine and reduced quateipine. Since being off the medication ive lost weight and am not so hungry. I didnt realise until stopping the venlafaxine how numb it had made me. I can feel now and its brilliant. Ive been fortunate to get therapy to learn coping skills to help my BPD. I needed the antidepressants and the larger dose of quateipine when i was most poorly. Quateipine doesnt help motivation which is hard. I feel like i lived that time in a dream. Knowledge and insight helps too.

I've been asking for help with my jittery muscle movement and tardive dyskinesia for 5 YEARS! Ive always been told there's nothing a mental health specialist can do for them. Why am i finding this out from KZread! This is invaluable to me, thank you so much!

@annipsy2185

8 ай бұрын

because you care more than the doctors about yourself 😅just how it is. always research the things youre taking imo

I got Tardive Tourettism from antipsychotics, it causes vocal and motor tics. I also gained more than 70lbs, got restless legs syndrome and sedation among other side effects. It's been awful.

@Mogwai-fk4bf

7 ай бұрын

I feel you man. I've been forced to take Abilify for the last 2 years. I don't feel joy for anything in life anymore and it feels like my creativity has completely gone.

@rustymotionstudio4717

6 ай бұрын

I’m so sorry this has happened to you

@TheLolzatyourfacemoo

4 ай бұрын

​@@Mogwai-fk4bf same here but I took Respridone and Invega. Antipsychotics are dangerous and should not be prescribed to people.

@Mogwai-fk4bf

4 ай бұрын

​@@TheLolzatyourfacemoo 100% agree with you

My mom has the parkinsonism symptoms from antipsychotics. She has lost the ability to walk, move, emote etc. She has been tapering down on the meds but I don’t know how to help her get her movement back. Managing her care has been so difficult.

@mobee9181

Жыл бұрын

that stuff can be permanent and I really hope its not. It should a crime to prescribe these to people.

@kareendeveraux1847

10 ай бұрын

I read several times, that ex patients have been able to resolve some of the movement issues with alpha lipoic acid. My mom was harmed, too. (No mental illness, got booty juiced when told about my dad's death.) I got rid of her brief psychotic breaks (caused by the brutally overdosed haloperidol injections a few decades ago and also her incapability to process the death) by supplementing her with omega 3. After 3 decades and I figured out what happened back then and why she's behaving this way. She had no movement problems so, but issues with the digestion system. Sorry, that it happened to your mom. Maybe it helps. I highly doubt you'll get any help from psychiatry that doesn't cause further harm.

@ThomasConover

9 ай бұрын

The only thing that can repair such damage is Rick Simpson Oil. And it’s a nightmare to go through. You’ll have to chug down enormous amounts over many months and it’s extremely expensive.

@BL-sd2qw

6 ай бұрын

I have them too. Have you checked asking in Surviving Antidepressants, Inner Compass Initiative, Ashton Manual of Beyond Meds: Alternatives To Psychiatry website?

@cagedheat3

6 ай бұрын

For anyone following this I have good news. We took her entirely off of anti-psychs and all of her symptoms resolved. The bad news is that her paranoia, ocd and delusions are back. They seem to be somewhat manageable at the moment but I worry about another psychotic break. I am looking madly for alternatives.

Dr. Sill, your videos are incredibly informative and have been a tremendous help as I navigate the complexities of antipsychotic medications. Your insights into the side effects are invaluable, giving me a clearer understanding of what to expect. Thank you for emphasizing the importance of communication with doctors to manage side effects effectively. I appreciate your breakdown of the different receptors affected, shedding light on the intricacies of the medications. It's fascinating to see how drugs like Clozapine, while effective, come with unique challenges. Your dedication to educating us is commendable. Looking forward to more enlightening content. Cheers to a wonderful day ahead! 👏🌟

Very nice video, thanks for your effort. I enjoyed it thoroughly. I could tell you really read up on your psychopharmacology. One small, but important thing 2:55 - "Blocking dopamine receptors reduces psychotic symptoms". That's true, but it's a NON-SPECIFIC reduction of said symptoms. It reduces all thoughts, drive, desires, imagination etc not just the psychotic thoughts. Induces a sort of psychological parkinsonian state. It's why in the old days the drugs were called neuroleptics and/or major tranquilizers. Non-psychotic patients will react and become similarly sedated on the drugs, which is why the drugs have application in dementia induced agitation, organic delirium etc etc. Non-specific

Constipation is the worst for me. I just had an abdominal X-ray and my intestines are full of clumps. It's really bad and I don't yet know what intervention will be required.

Im pleased someone who sounds caring is going to be a psychiatrist. Ive been on lots of different anti psychotics and anti depressants and monitoring and blood tests etc weren't routine for me for alot of the 34 years i was being medicated at high doses in the public psych system. Definantly no patient input into treatment options back then.

I watched that documentary with that girl who’s sister died from antipsychotics from sudden death and it scared the shit out of me. I haven’t taken mine now for two weeks, I feel better but I’m not sleeping and my partner isn’t happy with how I’m behaving. Wish there was an alternative.

@mobee9181

Жыл бұрын

altered behavior could be from withdrawal from the medication. Give yourself time.

Outstanding, most informative!

Thanks, doctor. As someone taking antipsychotics, I found this video very good and informative. Also, I was wondering if you could do a video on the side effects of taking Ritalin/Concerta because I'll start to take it soon and I'd like to know your opinions on it, please.

Thank you Dr. Syl. Your channel is so informative, helps me to understand the world around me

@DrSyl

Жыл бұрын

Thanks so much. It helps me out if you have any suggestions for content you’d be keen to watch!

Great video again Syl. What would be your treatment of choice for frail elderly with late stage Parkinsons disease having psychosis (hallucinations), BPSD ? Goh

If antipsychotics reduce psychosis itself, why didn't Deniker or Delay report this effect? Seeman's research supports the notion that dopamine is implicated in certain hightened states of agitation, but its not clear that this alone is psychosis. Blocking dopamine can in the short term reduce the apparent excitement but it's not clear that it's superior to other sedatives, or that it's anything other than a sedative effect. What about the issue of prophylaxis? What even is it? Does it only apply to drugs with a disease modifying effect? If I had a headache and I took panadol and it releived the headache, should I continue to take panadol to, as Kraepelin said of sodium bomide, "ward off future attacks"? Isn't the effect of antipsychotics that Seeman described similar to panadol? It's temporarily muting a down stream response. So if I have an over excitment, I take the dopamine blocker and there is a reduction in excitment, but is it advisable to continue taking it? Probably not. Typically drugs that have a downstream effect on some symptom will eventually loose there effect or cause a sensitivity to the symptom. Regarding the research, what do you think of the enrichment and the use of multisite clinics in the developing world or the tiny effect sizes? Do rating scales prove an "antipsychotic" effect? Imagine a world were no one could describe the experience drinking alcohol in plain language. Imagine if you asked someone what drink six cans of beer "feels" like and they said "well, you'll have less symptoms of social anxiety". Or, imagine if they said "well, it's different for everybody". You did well talking about "effects". The effects of antipsychotics are not really so very mysteriouos but for some reason plain language about their effects has become obscured by a sort sceintific double speak. I think psychaitry is suffering from some called Kuhn loss. Kuhn loss is when a new sceintific theory replaces and old one, but certain things about the old theory that gave us "insight" and "understanding" are lost. It's a bit like when a simpler theory, though perhaps wrong, is easier to understand, and the new theory is hard to understand, so much so that people with a poor understanding of the new theory get things wrong more than they did operating under the old theory, even though it was technically not as accurrate. I think when you go back before 1980 there is this much plainer descriptions and I think some of the earliest observations offer the best insights, even if they are not the most sophisticated. It's worth tracing how the ideas formed from their beginning and see what the hot take was when the new drug first hit the scene. What did people observe before they knew what they were "supposed" to be observing?

I love how this is actually educational and not in baby language. Thank you!! Sure may require googling certain terms for the layman, but it gives us a real place to refer to.

Very helpful.

Thank you dr.Syl for this informational video. I have a question, I read that olanzapine causes memory issues and it’s like 1 out of 100 people experience this, so what memory issues do they go through?

I feel like cursing people when I pass them and I feel like trying to jump out of a moving car I don't want to but it keeps coming back to my mind all day long The time is spent in all these thoughts, after going to the doctor, the doctor has given the medicine, there are many side effects after taking the medicine, talked to the doctor about it, but there is no solution, I am feeling hopeless, I feel there are not treatment option available and it will never be cured, I feel like committing suicide, because of this I am not able to study properly, please give me any solution, what should I do?

I’m curious. (Don’t worry I know you wouldn’t want to say anything about specific cases… I’m curious from a sciencey perspective…) someone I know has the tardive dyskinesia effect from her antipsychotic. What I’ve noticed is even without any increased dosage of meds , the twitches get more dominant when she’s getting a bit manic. It seems odd to me. I might have expected the opposite?

how much is this medication affecting the nervous central system?

I’m I screwed I went of my antipsychotic to fast will my dopamine receptors ever recover or am I brain damaged?

Thanks Syl. I see APs as being an amazing subset of drugs. I am so glad I now work in psychiatry after the discovery of these drugs. Whether or not it is a “side effect” in of itself is pedantry to me, sorry to say, as that’s what our patients describe them as being and are the very good reasons for non-compliance or non-concordance, whatever phrase we use. I hope that further research can create more targeted and efficient APs in the future.

That's very high tech like to hear in simple terms

@GEN-

Жыл бұрын

@@snafu22 Tvrzenou chemickou ne/rovnováhu mozku prý neumí zatím nikdo na živých lidech přesně, prokozatelně změřit. Tohle se musí změřit komplexně, protože hladiny se během 24 hodin stále mění.

The medication sounds as brutal as the disease can be

@a56wildkat

7 ай бұрын

Yes, it is.

@aj5424

7 ай бұрын

@a56wildkat I have taken Abilify before it cancelled out my feelings, inttuition, and spirituality.

@kathyfrancis9229

6 ай бұрын

It's crap. If I don't take it I can't sleep. If I do take it I put on weight. A lot of weight. I've put on approximately twenty five kgs. I am really careful with what I eat. Damned if you do and damned if you don't.

@aj5424

6 ай бұрын

Sorry for your struggle Kathy sending you love and good wishes from Bingley@@kathyfrancis9229

@dionysusapollo

5 ай бұрын

That's the awful catch 22 we are in 😢

I there any antipyvhotic which cold help in BPD? Borderline Personality Disorder? With high Anxiety

Tell me please the constipation story to control it

If I took two doses and then didn’t take any more, will I be fine?

you forgot not being able to stay motivated. ( no motivation) because of te drugs

Is taking 2.5 mg Aripiprazole daily causes weight gain and diabetes .Plz reply.

What about blepharospasm?

Could someone please tell me the name of the drug that helps with weightgain?

@brenarose8647

6 ай бұрын

Metformin

Weight gain!!!! Do you Vraylar . Apparently the side effects profile is mild. Why do metabolic syndrome,stroke and weight gain the common side effects of all the psychotropics

I've got a bad speech disorder and sexual dysfunction from depixol depot.

I want to know about the abdominal pain, mine has been so severe on quetiapine I nearly got sent to hospital so im not taking it, and none of the normal doctors know anything about it. Psychiatrist visits are so far apart you are kind of left alone to deal with this stuff. Since I got tardive dyskinesia symptoms in my jaw too, i got spooked because you can get it in your diaphragm and abdomen too and the pain was going up to an 8. Dont want to be permanently afflicted with this.

The atypical antipsychotics have a better compliance rate than hypertension meds, in fact the compliance rate is about the same as people with epilepsy.

@aethylwulfeiii6502

3 ай бұрын

Also no one tells you these things, when you take them no one. Maybe be honest for better compliance, they pretty much just screen for safety for themselves no matter the patient’s complaints.

Amisulpride helps me with the negative symptoms of schizophrenia but I get insomnia and akathesia!

Smoothness in movement sounds like you're talking about pooping xD

Been taking them for 5 years barely any side effects

Can you please point side effects of this drugs on normal person

Doctor, I lost my imagination due to antipsychotics. I stopped taking antipsychotics 5 and half months ago. Despite of that I didn't get my imagination back. When do I get it back?? How long does it take to get back???

@Mogwai-fk4bf

9 ай бұрын

How long have you been on them and what was your dosage?

@user-ud7oj5xi5p

9 ай бұрын

@@Mogwai-fk4bf been on them for five months. My dosage : For three months Zyprexa 10 MG Stellasile 5 mg Quitapex 100 mg ...... For 1 month Flounixal 40 mg Faverine 100 mg ...... For 2 months Abilify 5 mg Apexidone 2 MG Olapex 5 mg ..... For 3 weeks Clozapex 15 MG

-talks about how awful antipsychotics are, citing deadly depressive symptoms, -wow people don’t stick to these, we can’t believe it

7:52

@smallisbeautiful2808

9 ай бұрын

and 9:03

As a North American, it's so weird to hear an adult say 'weeing' (especially a doctor lol).

@matthewthompson6455

Жыл бұрын

Common phrase in the us,

Vraylar is a partial antagonist /agonists

I get sexual dysfunction, constipation, weight gain and high prolactin levels on anipsychotics (and god knows what else). This medication sucks. The worst part is when the doctor says my psychosis is chronic and there is no cure, i'd rather live with the psychosis and without the medication.

Is anyone getting a super low key daddy vibe of this look? Very charming and becoming. He's smart, handsome and stylish?!?! The world isnt ready!!

@bopperette7260

Жыл бұрын

Back off!! He's mine 😂😋

@WouldntULikeToKnow.

Жыл бұрын

This is a pretty inappropriate comment. If someone wrote a comment with this tone about a woman it could be perceived as creepy. Stay on topic with the content of the video.

1. Every single person who takes antipsychotics will experience the main effects which are all adverse in nature, even if they may not complain about them. 2. "Work with your doctor" - well what if your doctor is gaslighting you or simply unwilling to work with you. You need to draw the line somewhere. 3. Good analysis on the adverse effects and neural circuits. 4. Ozempic is a terrible drug with a litany of adverse effects and some long lasting. 5. Abilify is NOT a 'good' drug. It has ruined many people's lives and has much more adverse effects than the college guidelines show. Just because it is not as bad as clozapine, let's say, that does not make it a 'good' drug.

Are you familiar with the plant kratom? I’ve been taking it for about 10 years now, mostly for digestive issues but also general mood issues. My brother disappeared from our lives a few years ago after a sudden bout of paranoia. I still don’t know what happened to him, but piecing together everything from odd experiences I recall to facts I’ve gathered from various family members - such as him hearing voices from a young age, having sudden religious conversion experiences that petered out later, and more - I personally suspect he either developed bipolar w/psychotic features, or schizophrenia. Anyways. Between that mystery and my own shaky mental health these past few years, I’ve become fascinated with psychosis and psychotic disorders. So, imagine my surprise when I recently learned a study came out last year positing kratom may have potential as an alternative antipsychotic! The study demonstrated that the main alkaloid in kratom has effects similar in mechanism to both typical and atypical antipsychotics, and nearly comparable in efficacy too. They compared it (in rats) to clozapine for negative symptoms and haloperidol for positive symptoms. But best of all, kratom provides the relief without any of the extrapyramidal side effects! It’s also been shown to both increase dopamine in some areas of the brain/at lower doses of kratom, while lowering dopamine in other areas of the brain/at higher doses, so this complexity makes sense imho. I know a plant is not exactly something a dr could prescribe, but since you seem to be that rare gem of a medical professional who’s genuinely fascinated by your field, I recommend you check it out!!

Thank you for this video. I am on antipsychotics for bipolar I disorder, and have had a hell of a time finding something that does not trigger an acute dystonic reaction and/or tardive dyskinesia. Interestingly, I do not experience EPS with olanzapine. I would love to see a video in the future where you explore the neurobiology of weight gain and fluid retention associated with some antipsychotics. Thank you for your dedication to the mental health/psychiatric community. Your patients are lucky to have you, and so are we!