Renin Angiotensin Aldosterone Sysytem - Renin Pathway easy Explanation

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/ medsimplified
When the plasma sodium concentration is lower than normal or the renal blood flow is reduced, the juxtaglomerular cells in the kidneys convert prorenin (an intracellular protein) into renin, which is then secreted directly into the circulation. Plasma renin then cuts a short, 10 amino acid long, peptide off a plasma protein known as angiotensinogen. The short peptide is known as angiotensin I.[2] Angiotensin I is then converted, by the removal of 2 amino acids, to form an octapeptide known as angiotensin II, by the enzyme angiotensin-converting enzyme (ACE) found in the lung capillaries. Angiotensin II is a potent vaso-active peptide that causes arterioles to constrict, resulting in increased arterial blood pressure.[3] Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex.[3] Aldosterone causes the tubular epithelial cells of the kidneys to increase the reabsorption of sodium ions from the tubular fluid back into the blood, while at the same time causing them to excrete potassium ions into the tubular fluid which will become urine.
RELATED TOPICS
renin
catalysis
protein
chemical compound
organic compound
endocrine system
polymer
blood pressure
angiotensin
enzyme
Renin-angiotensin system, physiological system that regulates blood pressure
Renin is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys (the renal capillary networks that are the filtration units of the kidney). The renin-secreting cells, which compose the juxtaglomerular apparatus, are sensitive to changes in blood flow and blood pressure. The primary stimulus for increased renin secretion is decreased blood flow to the kidneys, which may be caused by loss of sodium and water (as a result of diarrhea, persistent vomiting, or excessive perspiration) or by narrowing of a renal artery. Renin catalyzes the conversion of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via receptors in the adrenal glands to stimulate the secretion of aldosterone, which stimulates salt and water reabsorption by the kidneys, and the constriction of small arteries (arterioles), which causes an increase in blood pressure. Angiotensin II further constricts blood vessels through its inhibitory actions on the reuptake into nerve terminals of the hormone norepinephrine.
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Пікірлер: 222

  • @thatfishbreeder
    @thatfishbreeder7 жыл бұрын

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    4 жыл бұрын

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    @Jmont.4 жыл бұрын

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    @aneekaak2 жыл бұрын

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  • @isabellearrowood210
    @isabellearrowood2103 жыл бұрын

    Wow thank u so much for that elaborate, yet easy explanation. I was curious to know about renin aldosterone pathway, since I learnt very briefly about it in school, this lesson made it all very clear for me. Thanks again:))

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    @taylora78027 жыл бұрын

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    @kabirchoudhary7062

    3 жыл бұрын

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    @al-ew5rp5 жыл бұрын

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    @juanzilla64362 жыл бұрын

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    @durefatima89823 жыл бұрын

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    @sukhrajsingh88893 жыл бұрын

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    @edufuaeduful32813 ай бұрын

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    One of the best videos on RAAS Mechanism

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    @frenyvaghela29327 жыл бұрын

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  • @MEDSimplified

    @MEDSimplified

    7 жыл бұрын

    +Freny Vaghela Thank you Freny

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  • @B3bita1215
    @B3bita12153 жыл бұрын

    I am grateful for this video. ONE MINOR CORRECTION though. Angiotensin II (MAINLY acts of the EFFERENT arterioles) although angiotensin II constrict both, AAAfferent and EEEfferent, it preferentially constrict Efferent arterioles. One way I remember the mechanism of action of ACE inhibitors, is by remembering "A"-->Angiotensin II "C"--> constrict "E"--> Efferent. Other than that, Thank you very much for this easy to grasp explanation. Have a lovely day! :)

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    3 ай бұрын

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    @mashfikatashnim19385 жыл бұрын

    Very easy to understand. Thanks

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    @chololhey3 жыл бұрын

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    @erdisagjyshka12386 жыл бұрын

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  • @MEDSimplified

    @MEDSimplified

    6 жыл бұрын

    +erdisa gjyshka you are most welcome 😊

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    @aaishatabassum22566 жыл бұрын

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    @mithukarmakar5702 жыл бұрын

    The most clear lecture on raas mechanism

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    @janethisip55444 жыл бұрын

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    @alighanem93587 жыл бұрын

    sehr gut Danke

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    @yashpawate13064 жыл бұрын

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    @minaltaunk88884 жыл бұрын

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    @minatachkanlouei62387 жыл бұрын

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    @snehababu51384 жыл бұрын

    Nice expansion

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    Thanks so so much

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    @sureshsavithri012 жыл бұрын

    Well clear explanation💚🌟👏

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    @arsalanmerchant69085 жыл бұрын

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    @ranaabdulrahman77882 жыл бұрын

    very helpful! Thanks

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    @maddies7575 жыл бұрын

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    @vikrampinto7 жыл бұрын

    very well explained. thank you! what software do you use to animate your videos?

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    @rishiraj2548 Жыл бұрын

    Thanks a million

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    @WaseemAkram-cc1sd7 жыл бұрын

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    @Poojagupta-dc8sx3 жыл бұрын

    Best explanation 👌

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    @sabaha83965 жыл бұрын

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    @Nicenice1276 жыл бұрын

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    @joymumo81733 жыл бұрын

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    @GigglePoot233 жыл бұрын

    awesome, thank you

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    @aneenasanthosh9215 жыл бұрын

    Superb explanation

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    @sumehrajawed38003 жыл бұрын

    Thank you!!

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    @fatimasohail12143 жыл бұрын

    Superb explanation 👌👌👏👏

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    @fathimafathima4509 Жыл бұрын

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    @junczhang6 жыл бұрын

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    @sanchit50866 жыл бұрын

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    @vijaytagadiya93817 жыл бұрын

    Best Explanations

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