The doctor spends at least ten minutes describing how to lessen side effects with shorter ADT duration, intermittent ADT etc. At the end he is asked about exercise and says, 'we'll talk about it later'. That may be, but regardless it is typical of a doctor to make no mention of exercise in this type of presentation. Weight bearing exercise in particular is the single greatest intervention for ADT side effects by far. Far more important than the pharmacological elements he describes. Good luck finding a MO who will do more than gloss over the critical importance of exercise.

ADT puts men at risk for osteoarthritis, heart attacks.

Thank you for sharing this.

Are Prostate cancer cells, that do produce their own testosteron, targeted by ADT ?

What about men with naturally low testosterone sub 200. And have aggressive pc ...how good is adt then ?

@jimo50

11 күн бұрын

Very good. The lower the better. Under 10ng/Dl is standard today.

How do you do intermittent ADT CASTRATION when the original ADT term leaves the patient with sub- castrate level of testosterone?? Maybe that's the case for Orgovyx daily pills, but men are reporting that even that medication leaves then with castrate levels for many months.

@jimo50

11 күн бұрын

Everyone is different. Patient age, time on ADT, baseline testosterone at diagnosis and overall health greatly affect T recovery. Some men recover theirs within weeks after stopping Orgovyx. Even recovery from Lupron can be 3-5 months. Sometimes longer. Others never recover beyond castrate levels or slightly above. They don't know until they try. Always worth a shot.

I am aged 66 . My PSA is 4.1 The MRI prostate w wo contrast RAD showed 4 and the biopsy report from 12 samples showed one RA , biopsy 3+3 and one RMPZ biopsy 4+3 . The bone scan showed no spread . Am i considered as Intermediate Risk Prostate Cancer ? Should i do Radiation therapy with or without hormone therapy ?

How do you explain why long term ADT results in a two year reduction in overall long term survival??? Or is this a big secret that big pharma doesn't want exposed.

@jimo50

11 күн бұрын

ADT is hard on the body no question. It exacerbates every co morbidity and health issue. It shouldn't be given to most men, unless they are committed to exercising more and eating less. The average older man is not fit to withstand it. That's why they get picked off so much.

Instead of taking away the testosterone... block the testosterone input on the cancer cell..we need ai bad..humans are to slow

@jimo50

11 күн бұрын

Drugs which do just that have been around for 15 years. They are called second line anti androgens. They sometimes work well alone, more often both are needed. We don't need AI as much as humans to stop calling each other slow. Especially the brilliant minds working on this stuff every day.

@jabster58

11 күн бұрын

​​​@@jimo50 humans Are slow compared to AI.. It saved humans a billion years on folding proteins..that's a hard cold fact. Alpha fold 3 will save us a 100 years on new drugs.