Prostate Cancer and Androgen Deprivation Therapy

As part of the 2024 Prostate Cancer Patient Conference, Dr. Eric Small reviews Androgen Deprivation Therapy, including choices of agents, side effects, considerations in timing, duration, intensity of therapy, and discusses interpretation of clinical trial results.
Recorded on 03/09/2024. [Show ID: 39756]
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Пікірлер: 16

  • @jimo50
    @jimo5011 күн бұрын

    The doctor spends at least ten minutes describing how to lessen side effects with shorter ADT duration, intermittent ADT etc. At the end he is asked about exercise and says, 'we'll talk about it later'. That may be, but regardless it is typical of a doctor to make no mention of exercise in this type of presentation. Weight bearing exercise in particular is the single greatest intervention for ADT side effects by far. Far more important than the pharmacological elements he describes. Good luck finding a MO who will do more than gloss over the critical importance of exercise.

  • @janetw9430
    @janetw94309 күн бұрын

    ADT puts men at risk for osteoarthritis, heart attacks.

  • @larryparis925
    @larryparis92524 күн бұрын

    Thank you for sharing this.

  • @bell1095
    @bell109512 сағат бұрын

    Are Prostate cancer cells, that do produce their own testosteron, targeted by ADT ?

  • @RH-xd3nx
    @RH-xd3nx24 күн бұрын

    What about men with naturally low testosterone sub 200. And have aggressive pc ...how good is adt then ?

  • @jimo50

    @jimo50

    11 күн бұрын

    Very good. The lower the better. Under 10ng/Dl is standard today.

  • @robwells230
    @robwells23018 күн бұрын

    How do you do intermittent ADT CASTRATION when the original ADT term leaves the patient with sub- castrate level of testosterone?? Maybe that's the case for Orgovyx daily pills, but men are reporting that even that medication leaves then with castrate levels for many months.

  • @jimo50

    @jimo50

    11 күн бұрын

    Everyone is different. Patient age, time on ADT, baseline testosterone at diagnosis and overall health greatly affect T recovery. Some men recover theirs within weeks after stopping Orgovyx. Even recovery from Lupron can be 3-5 months. Sometimes longer. Others never recover beyond castrate levels or slightly above. They don't know until they try. Always worth a shot.

  • @maxstyle3286
    @maxstyle328612 күн бұрын

    I am aged 66 . My PSA is 4.1 The MRI prostate w wo contrast RAD showed 4 and the biopsy report from 12 samples showed one RA , biopsy 3+3 and one RMPZ biopsy 4+3 . The bone scan showed no spread . Am i considered as Intermediate Risk Prostate Cancer ? Should i do Radiation therapy with or without hormone therapy ?

  • @robwells230
    @robwells23018 күн бұрын

    How do you explain why long term ADT results in a two year reduction in overall long term survival??? Or is this a big secret that big pharma doesn't want exposed.

  • @jimo50

    @jimo50

    11 күн бұрын

    ADT is hard on the body no question. It exacerbates every co morbidity and health issue. It shouldn't be given to most men, unless they are committed to exercising more and eating less. The average older man is not fit to withstand it. That's why they get picked off so much.

  • @jabster58
    @jabster5824 күн бұрын

    Instead of taking away the testosterone... block the testosterone input on the cancer cell..we need ai bad..humans are to slow

  • @jimo50

    @jimo50

    11 күн бұрын

    Drugs which do just that have been around for 15 years. They are called second line anti androgens. They sometimes work well alone, more often both are needed. We don't need AI as much as humans to stop calling each other slow. Especially the brilliant minds working on this stuff every day.

  • @jabster58

    @jabster58

    11 күн бұрын

    ​​​@@jimo50 humans Are slow compared to AI.. It saved humans a billion years on folding proteins..that's a hard cold fact. Alpha fold 3 will save us a 100 years on new drugs.