I realize this is meant to be an introductory video, but I think it would be worth noting that VWF is present in multiple components of the blood and the vessel wall in multiple forms. It is present in both the Weibel-Palade bodies of endothelial cells as well as platelet granules. On top of that, large VWF multimers flow freely within the plasma. Immunostaining has also shown VWF is stored in the subendothelium (presumably bound to collagens), which further primes the exposed vessel wall to be pro-adhesive. Lastly, fibrin tends to accumulate closest to the vessel wall and decreases toward the lumen, effectively preventing total vessel occlusion by the hemostatic plug.

@adamjones1780

8 жыл бұрын

Alex, thank you for your comments. You are right, it is difficult to get all the science across and still create a good narrative of the processes for the student who is new to the subject. I think clotting is particularly challenging in this regard!

Those who are confused: Adhesion = vWF - Gp Ib Aggregation = vWF - GpIIIa/IIb

This is genius! Thanks❤

Clear as distilled water!!! Thank you!!

I think its "Gp 1b ix-v" receptor on the platelets which binds von willebrand factor and "gp IIb/IIIa" receptor which binds fibrinogen! Any correction will be appreciated!

@hakanozduran7534

4 жыл бұрын

von wilibrand tip 2b

@swatipatel8948

2 жыл бұрын

It is both actually. Vwf binds Gp 1b ix v and helps in cell adhesion to vessel wall. Gp 2b 3a, is in resting state, when Vwf binds to it, it gets activated and vwf forms a bridge between two gp2b3a receptors on two platelets. This helps in aggregation ( along with fibrinogen)

Is it not the glycoprotein Ib that binds to vWF and IIb-IIIa that binds to fibrinogen?

@kapulachifunda2011

7 жыл бұрын

noticed too

@Abbasbaby-girl

6 жыл бұрын

Daniel Caamaño no. He is right.

@Andr295

6 жыл бұрын

No, he is not right. Gp IIb/IIIa is a receptor for fibrinogen. Gp Ib is a receptor for vWF.

@lybomanolov5054

6 жыл бұрын

GP Ib => VWF GP IIb/IIIa => fibrinogen

@boredtodeath741

6 жыл бұрын

yeah you're right. i was freaking out cuz i thought i memorized it wrong.

great👍👍👍👍

Thank you for the excellent explanation.

Awesome 👍👍👍👍👍👍

Great video! Thanks!

this video is veyr clear and informative, very easy to understand. thank you so much

What a nice explaination Sir ❤

Incredible 🌹🌹🌺🌺🌺🌺🌺🌺

it was very useful!! thank you sir! 😊👏

🙏

nice video, thanks a lot

Thanks mate

thanks

Thanksss💕💕💕

❤

merciii

The background music was distracting.

@kapulachifunda2011

7 жыл бұрын

very distracting!!!

Does paracetamol also inhibit cox pathway...I think it doesn't...it is centrally acting drug

mint

Great video and a great addition to my notes, but please get rid of the music in the background!!

HOW COME VWF IS NEVER BROUGHT UP WITH ENDOMETRIOSIS PATIENTS?

This is a great video, but the music is too loud and distracting, making it harder to follow.

Why don’t you have a billion followers? The world is mad

nice

this guy is HOT

I couldn't understand the accent because of loud music

thanks