I studied for two days and this video has more answers than all of those days combined! Thank you

Who's here after the 2021 Nobel for Medicine announcements! Congratulations to David Julius, Ardem Patapoutian.

I've been looking an explanation for a some time. What I find fascinating is how these receptors are perfectly calibrated so to speak.

Thank you sooo much. You guys are brilliant at explanations. Keep things flowing as we really do appreciate your kind work.

Is it a coincidence; we just learned about those receptors and you uploaded a video about the same subject really interesting :-)

It's interesting how the cell contents of certain plant species (the capsaicin molecule) are natural analogs for the molecules detected by the body's own pain receptors. (I expect there is an evolutionary connection to account for it.) When you stick your toe under sub-scalding temperature water at a precise temperature (about 54C) it actually 'feels' like chilled water instead of hot. Can this observation be explained from the interactions of the different thermoception signals?

Thank You very much

thank you

Sorry, but all the sources I use suggest that "A Beta fibres", (the really fast ones), are NOT involved in the nociception. Aside of that, beautiful explanations!

@Andrew-kh7rz

5 жыл бұрын

en.m.wikipedia.org/wiki/Group_A_nerve_fiber

@inshi22

4 жыл бұрын

For thermoception, A beta is involved and you're right; it's A alpha fibres that are involved in nociception, not beta :)

Are the fast, medium, and slow fibres the same as the fast-adapting, slow-adapting, and non-adapting receptors discussed in the somatosensation KA video?

@harkirtansingh495

5 жыл бұрын

No , they are fibers and adapting is property of fibers. Fast adapting needs constantly changing stimuli to remain active ( like in case of fine touch ( meissner corpuscles(fast fibers) ) but slow adapting and non adapting can respond to sustained stimuli (like in case of deep static touch (merkels discs) (fast fibers).

Can’t believe this video was uploaded 7 years ago..😅😅

You talked about A beta fibres sensing pain but that's incorrect. A beta fibres only sense non-noxious stimulus. Due to faster transmission they can actually be stimulated to to flood the relevant T cell that the A delta fibres are crossing acting as a pre synaptic inhibitor and thus relieving pain.

For 3yrs I've been dealing with this issue of pain & temperature on my LEFT side of my body - pretty much from the bottom of my skull down to my toes & only the left side. I can't feel heat & cold on the left side! I feel PAIN instead. "Warm" seems to not bother me. I also have a decreased sense of touch on my left side. My left hand doesn't seem to be as affected as the rest of the left side of my body. Maybe because my hand is always touching things? But I still have the decreased sense of touch in my left hand & the increased pain but I can sense some temperature in my left hand, but it isn't as it should be. So when I'm getting a bath ready for my kids, I have to use my right hand to see if it's too hot or cold. No doctors have been able to tell me what this is or why this is happening. :-( Why is this happening?!?!

@nathane6740

7 жыл бұрын

Gwenelle Trivette Did you find out whats wrong with you

Saw

How to block capsaicin for chronic nociceptive pain

Not really a question that contributes to the content. But I really can't figure out of which food you're talking about ;) I suppose that it is a sort of chili pepper, your "holopaynio"?

@philtrem

8 жыл бұрын

+Jeroen Colon Jalapeño

makes sense that chili peppers effect these receptors in our body. Chilis are spicy to eat (pain) and they make us feel warm. (Scoville heat units)

your example of how pain activates trpv1 is way too specific, you give the mechanism for chemesthesis but not overall pain activation of trpv1

but i only feel it at the nerves, not my cells

@user-cw8vt3zc8t

Жыл бұрын

and i feel it at the hand, not the brain

@user-cw8vt3zc8t

Жыл бұрын

am i 'the thing'?

Pain does not equate to nociception. This is the Cartesian model of pain and has been thoroughly disproven. Very disappointing. Google "biopsychosocial model of pain" if you really want an explanation of how pain works.