Welcome to Science With Tal!
In this video, we will cover some basic sleep physiology, what & where orexin neurons are as well as what function do they mediate. We will also consider some clinical implications of orexin signaling and how it relates to sleep disorders such as narcolepsy and insomnia
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TIMESTAMPS
0:00 Introduction
0:50 Polysomnogram & Hypnogram
2:54 Sleep Circuit In Brain (Wake/Sleep-Promoting)
4:40 Molecular Mechanism Of Orexin
6:00 Orexin Influence On Sleep Circuit
6:51 Orexin & Narcolepsy
8:14 Orexin & Insomnia
9:04 Conclusion
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Eric Kandel: Principles of neural science (6th edition)
- Meir Kryger: Principles and practice of sleep medicine (7th edition)
- Ayumu Inutsuka: The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions
- Timothy Quinnell: Narcolepsy, idiopathic hypersomnolence and related conditions
- Chunmei Wang: The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower (kzread.info/dash/bejne/k6OAwcWMhZS-pNo.html)