Non-Hodgkin's Lymphoma

Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/non...
** Correction at 1:09:30 - 1:10:51: **
The Ann Arbor Staging looks at the position of involved Lymph nodes on the SUPERIOR and INFERIOR positions regarding the diaphragm, not the left or right hemidiaphragm. In other words, Stage II would have 2+ LN’s above OR below the diaphragm, but can only be on one of those sides. Stage III would have 2+ LN’s both above AND below the diaphragm.
Of note, the Ann Arbor staging has fallen out of favor for NHL and was recently replaced with the Lugano classification.
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Non-Hodgkin's Lymphoma. Non-Hodgkin Lymphoma (also known as NHL, or sometimes just lymphoma) is a cancer that starts in white blood cells called lymphocytes, which are part of the body’s immune system.
NHL is a term that's used for many different types of lymphoma that all share some of the same characteristics. There is another main type of lymphoma, called Hodgkin lymphoma, which has been discussed in our Hodgkin's Lymphoma lecture: • Hodgkin's Lymphoma
NHL usually starts in lymph nodes or other lymph tissue, but it can sometimes affect the skin. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Non-Hodgkin’s Lymphoma Introduction
0:50 Lymphocyte Pathway
16:22 Causes of Increased Neoplastic Lymphocytes (B-Cells)
32:36 Effects of Increased Neoplastic Lymphocytes (B-Cells + T-Cells)
53:22 Diagnostic Approach to Non-Hodgkin’s Lymphoma
1:06:14 Staging of Non-Hodgkin’s Lymphoma
1:13:05 Treatment
1:19:31 Comment, Like, SUBSCRIBE!
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#ninjanerd #nonhodgkinslymphoma #lymphoma

Пікірлер: 163

  • @Delatta1961
    @Delatta19619 ай бұрын

    Great presentation. I was diagnosed with MZS Lymphoma, Stage IV (low grade) in 2005, only 5 years after retiring from the Army as a Aviator. I was 43. The one thing I think is very important for diagnosis is how my symptoms presented themselves. Dry cotton mouth, severe itching (mainly where my clothes touched my skin tightly), night sweats, periodic fevers with no infection, and very severe fatigue. I never contributed any one of them to be part of the collective issue. I like to think I’m educated and informed, but there was no way I could have connected them all to NHL. Even the doctors were baffled. I was admitted to the hospital, and for a week I was the Guinea pig for about a dozen residents. There’s nothing more concerning when it comes to my health then watching doctors scratch their heads and not have answers. It took a bone biopsy to find the truth. After my enlarged spleen was removed, I went through CHOP (I wouldn’t wish it on anyone), and maintenance treatment for 4 years. I’m still in the fight, and the key for patients is to stay aggressive and informed in your treatment. Including the PET scans and labs as often as possible. What you presented here really helped me understand the process of how it progressed. Thanks

  • @Katie-vy5rd

    @Katie-vy5rd

    6 ай бұрын

    Thanks for sharing your story. The cotton mouth is perhaps the first I've seen where listed on any stories of lymphoma symptoms but makes so much sense. I have a enlarged lymph node but haven't taken the order in to have the ultrasound yet. Waiting g for insurance to kick in. In the mean time I've been going batty with the dry mouth for about 3 weeks, lozenges don't even help and have been wondering whats going on.ive got the severe fatigue too so hanging onto my job by a thread. I hope I don't have lymphoma but answers would help ease my worries. The treatment for yours sounded harsh. Hope you're doing well now. 😊

  • @canbarosomali4757

    @canbarosomali4757

    4 ай бұрын

    Are you still fighting or you win I hope you are doing okey

  • @carriesmotherman2273
    @carriesmotherman22737 ай бұрын

    I live vicariously through you. Before I was struck by lightning, I tutored physics, chemistry and calculus. I discovered you exploring Hodgkins lymphoma as I have many symptoms and am trying to get referred to an oncologist. Your videos are amazing! I miss teaching so very much.

  • @vetnet100
    @vetnet100 Жыл бұрын

    Best medical and physiology videos anywhere on the internet! Thank you for your dedication!

  • @atiqrahman6427
    @atiqrahman64278 ай бұрын

    I have non-hodgkin mantle cell lymphoma. Going through RBAC chemo after 7 cycle of Retoximab and acalabrutinib. Not sure why RCHOP shows everywhere to tackle the cancer. Presentation was mind blowing, the best so far in YT. Thank you!!

  • @elinaparkkonen517
    @elinaparkkonen517 Жыл бұрын

    Once again a huge THANK YOU Ninja Team💕 for all your hard work. Team work makes the dream work. All my love to you all. Happy midsummer from Finland 🇫🇮👋!

  • @mopthefloor9131
    @mopthefloor9131 Жыл бұрын

    I’m so glad you are making haematology videos because I have an exam in a week and these are the only thing that makes sense to me. Thank you !!!!

  • @georgebashour4333
    @georgebashour4333 Жыл бұрын

    Thank you .. This video is on time for my last semester in medical school ...having Hematology in a month! ... This surely made everything way easier

  • @maristhelatgalian9366
    @maristhelatgalian936611 ай бұрын

    I am overflowing with knowledge 🧐 Love this stuff, please do some more!!

  • @yeikalarrinaga3656
    @yeikalarrinaga3656 Жыл бұрын

    Amazing lecture! Thank you very much for your dedication

  • @destaebisa6216
    @destaebisa6216 Жыл бұрын

    I have been waiting for this lecture. Thank you sir!

  • @sedatesmeray2437
    @sedatesmeray243711 ай бұрын

    Thank you very much, great explanation from start to finish. You first talk about physiopathology and until you finish to treatment. We are grateful.

  • @WhyNot-si4pj
    @WhyNot-si4pj11 ай бұрын

    1:00:46 Correction = " Follicular cell lymphoma " is associated with chromosomal segment translocation between chromosomes 18 & 14 ; t(14,18) NOT chromosomes 11 & 14 ; t(11,14) .

  • @elcancerynosotros.7036

    @elcancerynosotros.7036

    5 ай бұрын

    Correction: It is t(14;18) not t(18;14)

  • @manojkahar7242
    @manojkahar72422 ай бұрын

    One of the best lecture ever attended on Non Hodgkin Lymphoma ever attended or learnt in my life...too too good...no words to describe the marvellous way in which the concepts are given by the presenter...hats off to you sir

  • @cathyzeller4987
    @cathyzeller49874 ай бұрын

    Brilliantly explained & presented! Thank you!

  • @elcancerynosotros.7036
    @elcancerynosotros.70365 ай бұрын

    Thanks a lot! Excellent presentation! Zack, you have a natural uncanny set of skills to teach!!!

  • @deannaclark1359
    @deannaclark13599 ай бұрын

    You really are a great teacher! ❤️

  • @mrsamandabernier
    @mrsamandabernier10 ай бұрын

    Great video, as always. Thanks!

  • @samruddhimahadik4054
    @samruddhimahadik40546 ай бұрын

    Absolutely the best explanation I have ever received on this topic,even paid platforms fail to give such detailed and understandable explanation ❤

  • @MegaGrownFolks
    @MegaGrownFolks7 ай бұрын

    Perfect presentation…very inspiring….Great instructor

  • @whelmersantos4564
    @whelmersantos45647 ай бұрын

    Thank you for your dedication!

  • @eternitystudent
    @eternitystudent5 ай бұрын

    Excellent. As an oncologist I can say that this lecture is so true and important for common understanding

  • @ClassicB3bituh
    @ClassicB3bituh9 ай бұрын

    Thank God for Dr. Zach!! 🙏🏼❤

  • @anvisaini789
    @anvisaini7897 ай бұрын

    This should be paid. THANK YOU SO MUCH

  • @shahiramohammadi7284
    @shahiramohammadi7284 Жыл бұрын

    Thanks for this content I don't realize this much in class❤

  • @kingsleychinedu252
    @kingsleychinedu252 Жыл бұрын

    Thanks for all you DO🙌🙌. Zach! A video on Renal tumours won’t be a bad idea🙂

  • @marywakefield3472
    @marywakefield34724 ай бұрын

    Awesome presentation- thank you

  • @humanicgenes8825
    @humanicgenes8825 Жыл бұрын

    Thanks a lot Professor Zac from 🇿🇲🇿🇲🙏

  • @moongakampoli3533
    @moongakampoli3533 Жыл бұрын

    And we had this same lecture in class a day ago. Coincidence!!

  • @Sugi_Ruyeew
    @Sugi_Ruyeew Жыл бұрын

    I love your video so much, thank you for giving us such useful information

  • @kennethmanzanares4073
    @kennethmanzanares4073 Жыл бұрын

    I am 1yr in remission from diffuse large B cell lymphoma. Thank you for helping me understand my disease.

  • @kennethmanzanares4073

    @kennethmanzanares4073

    Жыл бұрын

    @1Alchemist420I was stage 2E. Did 3 cycles of R-CHOP chemotherapy followed by 21 treatments of radiation.

  • @UsRanger
    @UsRanger9 ай бұрын

    Wow, you're an amazing teacher.. Thank you so much for doing this... Now, I can talk to my doctor and know more what he's talking about. 🙏

  • @lubababukhari6794
    @lubababukhari679410 ай бұрын

    Amazing!!!!!!!!! Loveee it!!!! Thankyou so much, you're extremely good mentor

  • @michaeldonaldsherida
    @michaeldonaldsherida9 ай бұрын

    Rockstar! Very informative and I didn’t die of boredom!

  • @venusdarkside4350
    @venusdarkside4350 Жыл бұрын

    I was diagnosed with hodgkins lymphoma a year ago my chemo is complete and excited to study the hodgkin and non hodgkin as a med student

  • @ShiraKadosh
    @ShiraKadosh Жыл бұрын

    You are awesome!!! Thank you so much! 😊❤

  • @tadelleyohannes9400
    @tadelleyohannes94006 ай бұрын

    great lecture ..thank you

  • @marinaschiavi5442
    @marinaschiavi544211 ай бұрын

    thank you Zach!

  • @alejacarrasquillo1291
    @alejacarrasquillo12915 ай бұрын

    amazing as always

  • @ahmedmohamedhussein7993
    @ahmedmohamedhussein799311 ай бұрын

    HUGE THANK YOU , AMAZING

  • @mishkalmujjalla8286
    @mishkalmujjalla8286 Жыл бұрын

    thanks for this class❤❤❤❤❤

  • @user-cf5cz4yj3y
    @user-cf5cz4yj3y10 ай бұрын

    Huge respect for u guys❤

  • @qayoommemon3436
    @qayoommemon343611 ай бұрын

    Great work,,,, Very easy to retain now,,,

  • @jannatulferdaus6777
    @jannatulferdaus67779 ай бұрын

    Excellent presentation

  • @nadiakhan1612
    @nadiakhan16122 ай бұрын

    Can’t thank you enough Dr.Zach😊

  • @Shahrzad3360
    @Shahrzad33605 ай бұрын

    Perfect as always ❤

  • @jeanpaulrukabyarwema1972
    @jeanpaulrukabyarwema1972 Жыл бұрын

    I have been looking for this after watching Hodgkin lymphoma

  • @mehranhashemian5170
    @mehranhashemian51702 ай бұрын

    Great as always Thank you سپاس فراوان

  • @ariosmondaca
    @ariosmondaca4 ай бұрын

    excellente, thanks

  • @suzanazlateva7423
    @suzanazlateva7423 Жыл бұрын

    Great videos! Absolute the best. Could you please add normal histology prep of the different NHL next to histopathology. It is difficult for me to know what to look at If I don’t have anything to relate to... Thank you for your interesting videos!

  • @SamuelMwene-hu4sw
    @SamuelMwene-hu4sw11 ай бұрын

    Okay but ninja nerd uli chi pondo..👌 From a mad scientist to a Ninja nerd. I salute

  • @chombachama4841

    @chombachama4841

    6 ай бұрын

    Zambia ku caalo😂... I just had to like your comment

  • @saaaaaa1129
    @saaaaaa112919 күн бұрын

    I love your videos, you help me so much!

  • @user-co4jd7sb8v
    @user-co4jd7sb8v10 ай бұрын

    Thanks Mr Zac ❤❤

  • @anushaaamir3522
    @anushaaamir35224 ай бұрын

    very well explained

  • @abrightonreign758
    @abrightonreign758 Жыл бұрын

    A BIG THANK YOU FROM UGANDA.

  • @rawanalmansouri
    @rawanalmansouri Жыл бұрын

    Thank you!

  • @Biomaan
    @Biomaan Жыл бұрын

    Thank you sir 😊😊

  • @okorobepascalmathew420
    @okorobepascalmathew42011 ай бұрын

    Genius . saved my time instead of cluelessly staring at the text books

  • @user-zv1dm2gy7p
    @user-zv1dm2gy7p28 күн бұрын

    Thank you so much.

  • @atifraza421
    @atifraza421 Жыл бұрын

    Thank you so much sir❤❤

  • @nexus3736
    @nexus37368 ай бұрын

    Thank you!😊

  • @saraasif2372
    @saraasif23727 ай бұрын

    Your lectures are too good

  • @joadmagezi4778
    @joadmagezi47783 ай бұрын

    Amazing presentation❤

  • @hasane982
    @hasane9828 ай бұрын

    Excelent video you really helped to me as a med student

  • @0111vramj
    @0111vramj8 ай бұрын

    I had NO symptoms other than a almond sized lump in my neck. Thought it was an infection. 1 month turned into several lumps that started pressing on my windpipe. I was lucky I had a DR that LISTENED to me and took me seriously.

  • @tadelleyohannes9400
    @tadelleyohannes94006 ай бұрын

    u r great abd dedicated teacher. thank you

  • @catherinew.asiimwe
    @catherinew.asiimwe2 ай бұрын

    Thanks Prof👏

  • @MalakAhmedd___
    @MalakAhmedd___8 ай бұрын

    thank you!!

  • @idrisahmed588
    @idrisahmed5885 ай бұрын

    i was watch this awesome lecture from ninjanerd web page, had to come to youtube just to give BIG THUMBS UP.. what awesome way of teaching.. one little suggestion if ninja nerd team could rearrange the web page lecture's in order. thank you again

  • @kamaldinmiya8062
    @kamaldinmiya80627 ай бұрын

    Thank you❤

  • @khaoula7389
    @khaoula7389 Жыл бұрын

    thank you so much

  • @chisulochisanga7809
    @chisulochisanga78096 ай бұрын

    Excellent

  • @AbuSadatMdSalehAries
    @AbuSadatMdSalehAries2 ай бұрын

    Thank you

  • @chamchamz98
    @chamchamz98 Жыл бұрын

    Thanks for the lecture ❤ Haematology is hard for me to understand and memorise😅 this lecture is so helpful ❤

  • @khaoula7389
    @khaoula7389 Жыл бұрын

    thank you so much

  • @rachidksyar6810
    @rachidksyar68105 ай бұрын

    Excellent presentation. The only thing that I am not ok with is the classification of Ann Arbor: sides of the diaphragm means sub and supra diaphragm and not left to right of the body. Please correct that

  • @Sadhana661
    @Sadhana661 Жыл бұрын

    Ur work is amazing!! I love everything u do... i hv a very humble request... i went thru ur entire channel but couldnt find a section on obstetrics and gynaecology... pls pls can u upload those or make a basic video of it?? I hv exams coming up and would like to hv ur vudeos before it.. thanks in advance @ninja nerds

  • @jawadabo-tabik4035
    @jawadabo-tabik40354 ай бұрын

    As always, you are the best! I appreciate your work and dedication. I'm a MD and I really enjoy and learn a lot from your video. I'd love to know you in person, that would be a huge PLUS! :D

  • @jaspersilver1055
    @jaspersilver10553 ай бұрын

    Good information

  • @bonniehuang8696
    @bonniehuang869611 ай бұрын

    Thank you so much for your lectures on Hodgkin’s and non-Hodgkin’s lymphoma! Learned so much. Can you talk about HLH next?

  • @Imusama90
    @Imusama90 Жыл бұрын

    thanks

  • @mazatv3438
    @mazatv3438 Жыл бұрын

    Please upload two lectures in a week.

  • @akshatgautam964
    @akshatgautam964 Жыл бұрын

    Thanks from India 👍

  • @tenmanina2468
    @tenmanina24682 ай бұрын

    Thank youuuu ❤

  • @zaidsallam2365
    @zaidsallam2365 Жыл бұрын

    best medical videos at all

  • @alfredlincoln2407
    @alfredlincoln2407 Жыл бұрын

    Please kindly make a video on BIOSYNTHESIS OF ELCOSANOIDS🙏🙏🙏

  • @1Itsyasr
    @1Itsyasr Жыл бұрын

    Love it❤

  • @MesutTgloglu-lq1bx
    @MesutTgloglu-lq1bx Жыл бұрын

    You are really awesome , great lecture ..Multipl Myeloma please 🙏only you can do it properly and perfectly

  • @sajiruddinsk8129
    @sajiruddinsk81298 ай бұрын

    You are great.donot compare.

  • @kawtheralb1742
    @kawtheralb17427 ай бұрын

    Impressive 🤩

  • @tenzrinz8222
    @tenzrinz8222 Жыл бұрын

    Thank u

  • @sivajinidarmendra2250
    @sivajinidarmendra225011 ай бұрын

    Thanks dear Prof, Please explain GIST

  • @cozettalandry3429
    @cozettalandry34295 ай бұрын

    Had severe EB mono in my 20’s. At 62 had DLBC lymphoma from taking Humira for 10yr. Crohns Disease. Remission 5 years. RCHOP and Methotrexate intrathecal

  • @user-wg5xl9vo8u

    @user-wg5xl9vo8u

    10 күн бұрын

    Biologics can kill. I was on Remicade for nine years, it gave me NHL. It wasn’t worth it.

  • @AboobiadaAlmohager
    @AboobiadaAlmohager Жыл бұрын

    U R the best always 😘 ❣️

  • @liamleffler1515
    @liamleffler151510 ай бұрын

    love you big dawg

  • @sorooshho5111
    @sorooshho5111 Жыл бұрын

    awesome

  • @hopeworld9515
    @hopeworld9515Ай бұрын

    Im literally only passing my exam because of your videos. Forever grateful ❤

  • @LUX711
    @LUX7119 ай бұрын

    @NinjaNerdOfficial please explain what you mean here 1:10:23 when you are discussing staging in relation to nodes being on the “same side of the diaphragm “ or “different sides of the diaphragm.” The diaphragm is drawn on your figures it splits the thoracic region from the abdominal region. But when you are explaining it in real time you draw a dotted line down the middle of the figure like a Sagittal section. For ex. Stage 3 is 2+ nodes on “different sides of the diaphragm,” but are you really trying to say it’s 2+ nodes on different sides of the mediastinum?

  • @kittensgalore.5444
    @kittensgalore.54447 ай бұрын

    Need a lecture on Dendritic cell neoplasm

  • @maraeaquibtaea9465
    @maraeaquibtaea946511 ай бұрын

    You are gem❤️❤️❤️❤️❤️❤️❤️

  • @troll1801
    @troll1801 Жыл бұрын

    Uploaded right after my hematology exam😭 passed though thanks to the other hematology videos🙏