Pharmalytical Summit 2021: A Virtual Forum presented by Rigaku is happy to present Aya Takase.
X-ray computed tomography (CT), especially when combined with low energy radiation and high-resolution geometry, can image the 3-dimensional structure of tables non-destructively. This technique can be used to analyze non-uniform mixing of API, aggregates, cracks, and voids in tablets and coating thickness and delamination distributions. X-ray CT analysis can provide insight into why some tablets have a short shelf life, how and why the dissolution process does not have as designed. The level of microstructure detail revealed by X-ray CT can be considered to be a critical aspect of pharmaceutical equivalence for final dosage forms. Basics of X-ray CT and a number of application examples will be presented.
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