NEW FDA Approved CRISPR and The Future of Hair Loss Treatment
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Timestamps:
0:21 Introduction: FDA Approves CRISPR Treatments The Future of Medicine is Here
5:12 What is CRISPR? CRISPR To Treat Androgenetic Alopecia
9:08 CRISPR IN PRACTICE Removing an Androgenetic Alopecia Gene
11:16 Conclusion Looking at the future....
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Sources:
Adhikari, P., & Poudel, M. (2020). CRISPR-Cas9 in agriculture: Approaches, applications, future perspectives, and associated challenges. Malaysian Journal of Halal Research, 3(1), 6-16. doi.org/10.2478/mjhr-2020-0002
Casgevy (exagamglogene autotemcel). (n.d.). CenterWatch. www.centerwatch.com/directori....
CRISPR in Nature - CRISPRpedia. (2022, September 14). Innovative Genomics Institute (IGI). innovativegenomics.org/crispr...
LYFGENIATM (lovotibeglogene autotemcel) | Now FDA Approved. (n.d.). www.lyfgenia.com/
Office of the Commissioner. (2023, December 8). FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease. U.S. Food And Drug Administration. www.fda.gov/news-events/press...
Ryu, J., Won, E., Lee, H. a. R., Kim, J. H., Hui, E., Kim, H. P., & Yoon, T. (2020). Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy. Biomaterials, 232, 119736. doi.org/10.1016/j.biomaterial...
Shetty, A., & Matrana, M. (2014). Renal medullary carcinoma: a case report and brief review of the literature. PubMed. pubmed.ncbi.nlm.nih.gov/24940141
Wikipedia contributors. (2023, December 18). Beta thalassemia. Wikipedia. en.wikipedia.org/wiki/Beta_th...
Wikipedia contributors. (2024, January 11). Sickle cell disease. Wikipedia. en.wikipedia.org/wiki/Sickle_...
#crisprcas9 #crispr #Casgevy #Lyfgenia #sicklecelldisease #betathalassemia #androgenicalopecia #androgeneticalopecia #malepatternbaldness
Пікірлер: 51
*Noncarcinogenic not nonmutagenic 0:21 Introduction: FDA Approves CRISPR Treatments The Future of Medicine is Here 5:12 What is CRISPR? CRISPR To Treat Androgenetic Alopecia 9:08 CRISPR IN PRACTICE Removing an Androgenetic Alopecia Gene 11:16 Conclusion Looking at the future....
I’m just praying for verteporfin at this point
@Kyle_Bu
5 ай бұрын
Verteporfin has some great news. Looks like it's working to some extent to regenerate hair follicles. More people and hair transplant doctors need to be open to using it.
@_yuri
5 ай бұрын
so is it like infinite hair glitch ? if you have the money ?
@__j20
5 ай бұрын
@@_yuriif it works how it’s supposed to, it basically means you would be able to do unlimited hair transplants.
@_yuri
5 ай бұрын
@@__j20i saw the 5 month update by feller and bloxham hair transplant and it barely preserved 2% 😢
Thx for the reschedule ❤
@Kyle_Bu
5 ай бұрын
:P
As always, impressive and easy to understand content
@Kyle_Bu
5 ай бұрын
Much appreciated!
Awesome vid. Such a shame that crispr itself is expensive and only for people that can afford it. I think realistically the "cure" for regular people would be verteprofin or just strong enough treatments that make the consition easy to manage. What are your thoughts on that?
@Kyle_Bu
5 ай бұрын
I think with more research, manufacturing and cost effective means will be created. I can see a future crispr hair loss treatment that's at least the cost of a high quality hair transplant procedure performed in the west.
@danielurbanski8855
5 ай бұрын
@@Kyle_Bu Agreed, I do hope that the very least its something we can experience somewhat soon, I do hope that with future treatments such as SCUEB3, GT20029, HMI-115 (tho I dont have much faith in this treatment compared to others), JAK/FAK inhibitors, and Verteprofin, and also future hair transplant procedures can make Hair transplants themselves cheaper and easier to do, as well as far more affordable, even higher quality ones being on the same boat. Also on a unrelated note would love to see advancement so i can at least see my Norwood 7 dad (starting to borderline a 8 if that makes sense) have his hair growback haha.
Moneyman, this paper was 5years away i think its gonna take o good while at least for the us and europe to accepct crispr to treat comsetic stuff. But i have some hopes that it will be available in south korea earlier. Although its prolly gonna be damn expensive.
@Kyle_Bu
5 ай бұрын
I think there will be a trial that shows that it DOES work for AGA. But in terms of commercialization...yeah not for a while
Hey, bro. Do u think is possible change human hair from the follicle? With crispr/cas9?! I mean curly hair to straight? We know that a protein makes hair curly. Do u think is it possible? Thank you Very much.
@Kyle_Bu
Ай бұрын
Hi. Go talk to the doctor. I'm not a doctor.
👍🏽👍🏽 money man
@Kyle_Bu
5 ай бұрын
🧬
Can it regrow miniaturized hair? When hair gets miniaturized to a point where hair doesn’t grow anymore is the hair follicles then dead or gone? If just dead could something like this perhaps regrow it?
@nathan87
5 ай бұрын
Who knows. If we're open to complete speculation, maybe we can find a gene that, for example, gives scalp hair whatever beard hair has and grows stronger in the presence of DHT. Or that stimulates neogenesis/regeneration, or whatever. Maybe you can make the right cells pump out scube3 and treat themselves. However, if we're sticking with normal scalp hair, maybe not. The hair follicle is created early in life, and beyond that does not seem to have any natural regeneration mechanisms to bounce back from androgen attack. There is nothing to suggest that non-balding people have such repair mechanisms; their follicles just aren't getting attacked. If it's a process that is irreversible with "normal" biology, switching out the genes to those of non-balding people isn't going to do anything.
@ytsux9259
5 ай бұрын
If remained dormant for a long time, they're pretty much dead.
Is there a medicine that contains Dutastreid 2.5 in one pill?
@Kyle_Bu
5 ай бұрын
Unfortunately no. But I have a video on this coming soon
@douglasfarris8493
5 ай бұрын
No there isn’t. But most compounding pharmacies can make it for you. You just have to have a dermatologist willing to prescribe it for you
oh, cool! I happen to have thalassemia minor, and it causes tiredness and fatigue, so it's really cool to hear that there is a gene cure on the pipeline. Honestly, I live in EU, so probably that treatment wont be available in many many years. Now about the gene therapy for hair cloning. If single gene threapy session for a disease costs 2.2 million dollars and insurance companies are hesitant to cover that, I'm guessing the gene therapy is going to cost millions of dollars as well, and there is no chance that insurance will cover any of it. So this might be a cure for hair loss in the future, but only for the wealthy who have the money to pay millions of dollars for a single gene therapy session.
@Kyle_Bu
5 ай бұрын
Hope the treatment gets to you soon. I'm assuming you guys are single payer healthcare which ever part of the EU you're in. Hang in there, the future is already looking brighter
I'm waiting for the X-Men.
12:11 That would be great to do, but keep in mind that is dangrous game to talk about stocks and money. Maybe a great alternative would be to talk about companies in this hair lose / gene space instead and which product they are developing / researching
no way bro scheduled it 18 days before
@Kyle_Bu
6 ай бұрын
😂
@Kyle_Bu
5 ай бұрын
It's out now 😂
Sorry to ask disturbing questions, but when you think that there will be new (and hopefully better) treatments on the market, talking about stem cells, hair cloning or a shampoo that can help you help preserve what you have. . I read that by 2030-2035, baldness could be a thing of the past... is my hope justified or are we doomed to dubious promises and hair systems?? Thanks
@Kyle_Bu
Ай бұрын
Maybe in the 2030s. Technology, especially quantum computing and regenerative medicine is rapidly picking up.
@GorillaGreg-f5x
Ай бұрын
@@Kyle_Bu thanks for responding, what is quantum computing, is that AI can help developp new drugs and pinpoint bad genes ? Or something completely different ? For the regeneratihe medecine you probably think about scube3... Gosh I hope that in the 2030's we will be able to grow as much hair as we want...
Ever since Moogene got shut down, that killed any dream of Crispr for another like 15 years
@Kyle_Bu
5 ай бұрын
I feel you
Money man 💰
@Kyle_Bu
5 ай бұрын
💸💸😎
Money Man
first
Money Man $$$$
@Kyle_Bu
5 ай бұрын
🦀💸
Hello ! Do you know anything about treatment for alopecia areata?
@Kyle_Bu
5 ай бұрын
Yeah one came out a year ago. LITFULO™ (Ritlecitinib) . It does have some potential sides. Do your research. I plan on doing a video about all alopecias and their treatments
Science, shmience. Yes hair or no hair?
@Kyle_Bu
5 ай бұрын
You can use the timestamps.
@nathan87
5 ай бұрын
You can't have your hair, until you've had your science. How can you have hair until you've had your science?!
@Kyle_Bu
5 ай бұрын
I'm gonna ban his finasteride now...😈
*Slowest progress ever in the history of humanity.*
@Kyle_Bu
2 ай бұрын
Have hope 🕊️