Nephrotic and Nephritic Syndrome | Causes Symptoms & Treatment🩺

#NephroticSyndrome #NephriticSyndrome #Nephrology
Nephrotic and Nephritic Syndrome | Causes Symptoms & Treatment🩺
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Glomerulopathies
00:00:56 Basic Structure Of Glomerulus
00:10:00 Grade I Injury
00:11:40 Grade Ii Injury
00:12:49 Grade Iii Injury
00:15:36 Liver Role
00:18:30 Clinical Manifestations Of Glomerular Injury
00:24:45 Anasarca
00:26:29 Why Edema Is More In Preorbital Area
00:28:00 Concept About Pitting And Non Pitting Edema
00:39:01 Activation Of Renin Angiotensin Aldosterone System
00:41:50 Adh Effect
00:42:53 Triangle Of Clinical Features
00:43:43 Hyperlipidemia
00:48:30 Nephrotic Syndrome
00:54:13 Thrombus Formation
00:56:26 More Chances Of Infections
00:58:02 Nephritic Syndrome And Mechanism
01:13:25 Recap
01:14:14 Differences In All The Glomerular Injuries
01:27:13 Chronic Renal Failure
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Nephrotic & Nephritic Syndrome-Causes, Symptoms & Treatment-Nephrology Basic anatomy of a Glomeruli; Fenestrated Endothelial cells, Filtrations slits; Significance of these structures as size barriers, charge barriers; Albumin. Injury to Glomeruli; Albuminuria, Explanation of terms: Selective Proteinuria & Non-selective Proteinuria. Proteinuria less than 3.5gm/day; Catabolism of large number of proteins in PCT before they end up as Proteinuria; Hypoalbuminemia. Consequence of Hypoproteinemia (mainly hypoalbuminemia); Reduced Osmotic Pressure, Severe Generalized Edema [Anasarca], Periorbital edema. Pitting and Non-pitting edema; Oncotic and Osmotic Pressures; Clinical Implications; Breast Cancer; lymphatics involved or not. Heavy Proteinuria (Hypoproteinemia); Significance of decreased blood volume & resulting low renal perfusion; activation of RAAA; salt-water retention; Hyperosmolar blood, Release of ADH; causing further retention: Triangle of Heavy Proteinuria, Hypoproteinemia and Generalized Edema. Liver: Increased Lipoprotein synthesis resulting in Hyperlipidemia/Dyslipidemia; Lipidurea; Defining Nephrotic Syndrome; Nephrotic & Sub-nephrotic Range Proteinuria. Additional protein losses through urine: Transferrin loss in long term/chronic proteinuria; Iron Deficiency Anemia. Antithrombin-3 loss; Procoagulant blood (Increased Thrombotic tendency). Complement loss in proteins; weakened immune system; increased susceptibility to pneumococcal infections. Nephritic Syndrome: Advanced injury to Glomeruli; Leakage of all types of proteins, even RBCs; Hematuria (of glomerular origin) Dysmorphic star shaped RBCs, Cylindrical RBC casts Nephritic Syndrome continued: Inflamed, clogged glomeruli; Decreased Renal Blood Flow, Reduced GFR; Oliguria. Proteinuria paradoxically decreased; clinical; need to differentiate from an improving Nephrotic Syndrome. Nephritic Syndrome continued: Urea, Creatinine levels rise; Azotemia. Powerful stimulation of RAAA axis; Hypertension. Triangle of Hematuria, Oliguria and Hypertension. Recap. Rapidly Progressive Glomerulonephritis/Crescent Glomerulonephritis: Very intense injury to Glomerular Membrane: Fibrin leaks; Macrophages arrive, Growth Factors released, proliferating epithelial cells & macrophages; Cellular Crescents. Clinical features of (Acute) Renal Failure develop; High K; Arrhythmia, Uremic pericarditis & encephalopathies.
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  • @HarunKhan-in2tx
    @HarunKhan-in2tx4 жыл бұрын

    I used to think myself totally zero in nephrology but after hearing u'r this lecture I think myself hero in nephrology.it erases my all the confusions and misunderstanings. I am just only a health assistant from NEPAL and understood u'r full lecture.just think how simple the lecture is?subhan Allah.

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    sir thank you so much for all ur lecture.. plz upload lecture on anti epileptic drugs

  • @RitaSharma-jm1hd
    @RitaSharma-jm1hd2 жыл бұрын

    Your lectures are blessings to every medical student!! 🙂🤗 thank you for teaching with such a dedication ❣️💜 you really inspire us🌼🌼

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Pleasure to have such great students like you. Stay blessed 💕💕

  • @kareemabdelkhaleq1438
    @kareemabdelkhaleq14383 жыл бұрын

    Thank you so much Dr. Najeeb, Amazing explanation! Crystal Clear.

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Hope it cleared the concepts. Stay blessed.

  • @sabasaba3117
    @sabasaba31173 жыл бұрын

    Excellent informative description

  • @alaaelshiekh3064
    @alaaelshiekh30646 жыл бұрын

    thnx from Egypt if u read this u helped me so mush

  • @maimunabano9873
    @maimunabano98733 жыл бұрын

    Jazakalllah khairan kathira 💕 💕 sir you are very excellent in your work may get bestest in both life,💕❤️❤️❤️💗💗💗🤩🤩🤩🤩

  • @I_love_BTS_2025
    @I_love_BTS_20253 жыл бұрын

    Thank you very much sir! for your wonderful lecture.I didn't understand this topic well before in the college, but once I listened to you here it's amazingly everything becomes crystal clear!

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    You are most welcome. Keep sharing your feedback. Stay blessed. ✨✨

  • @sijdahasan9592

    @sijdahasan9592

    2 жыл бұрын

    @@DoctorNajeeb sir aap Hindi main lecture upload kijiye n plz

  • @lalanto341
    @lalanto3414 ай бұрын

    Brilliant lectures as always, Dr. Najeeb. Thank you for being passionate in teaching!

  • @DoctorNajeeb

    @DoctorNajeeb

    4 ай бұрын

    Thanks for liking

  • @zahraafrough5487
    @zahraafrough54874 жыл бұрын

    Really wonderful teaching. Allah save you.

  • @tshegofatsoserala9843
    @tshegofatsoserala98433 жыл бұрын

    Thanks, ur teaching are very clear and helpful

  • @HenryAme-iv1ic
    @HenryAme-iv1ic Жыл бұрын

    Dear Dr. Najeeb, Thank you for making me the best Dr. You still remains the best Lecturer and role model in the global 🌎

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Thank you for your kind words❤️ Keep supporting ❤️

  • @DavidJones-ie1qp
    @DavidJones-ie1qp4 жыл бұрын

    Simply outstanding!!!! Just to say, every teacher is doing there best to teach their students the subjects they have decided to teach... However, just like in every aspect of life - within every subject or profession on the planet, there are those that stand out from the rest. He's like the Usain Bolt of running the 100 meter race, or Gordan Ramsey in cooking food. Much respect Najeeb. Respect from Oxford England.