Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology
Multiple Myeloma - Malignancy of Plasma Cells - Bone marrow - Hematology & Oncology
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►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Multiple myeloma is a plasma cell dyscrasia.
Multiple myeloma (MM) is characterized by the overproduction of plasma cells.
Bone marrow fibroblasts, as well as myeloma cells, produce interleukin-6 (IL-6) which stimulates osteoclasts to break down bones, that's why bone pain is the most common symptom in multiple myeloma.
Since osteoblasts were not stimulated:-
1) Nuclear bone scans are useless to diagnose multiple myeloma.
2) Alkaline phosphatase (ALP) will NOT be elevated.
The anemia in multiple myeloma is normocytic normochromic (normal mean corpuscular volume "MCV").
Neurological symptoms include neuropathy as well as radiculopathy.
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In brief, multiple myeloma is a plasma cell dyscrasia characterized by overproduction of plasma cells. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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I can definitely say this is the best series on hematology in the entire Universe. THANK YOU VERY MUCH. Love from Nepal.❤
@MedicosisPerfectionalis
5 жыл бұрын
Wow! That’s an extraordinary complement 😊
@sncnutrition7118
3 жыл бұрын
@@MedicosisPerfectionalis can u do a video if someone's cbc w diff and CMP is all normal. ... yet their NRBC is 1 ... normal is 0 so its considered HIGH. your thoughts...? Thanks
You are easily one of the most talented and brainy teacher with a superb sense of humor. Thank you so much for putting out such excellent quality content. I literally wake up with a lighter heart knowing that you may have a video on any of the topic that has been kicking me. Kindly keep sharing your knowledge . One request though is to absolutely ignore the peabrains who whine about your voice or accent or whatever else that their insecure nitpicky anti social personalities want to water drip on. You keep doing you. We want more vieeos whenever time allows for you! Thank you with all my gratitude.
@MedicosisPerfectionalis
5 жыл бұрын
Best comment ever...Thank you, dear...I truly appreciate all of your kind words. Can you-please-share my videos with others? It really helps me :)
🩸 Hematology Playlist: kzread.info/head/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq
1. Bone pain 2. Bacterial infection 3. Uti and pneumonia 4. Staph, strep, ecoli, klebsiella 5. Ecoli staph? 6. Normal 7. High anion gap? Thank you so much!!!
@Leoantonio13
4 жыл бұрын
I guess normal AG, because it causes RTA (a normal serum AG acidosis).
@aymenkamal9488
3 жыл бұрын
Anion Gap is decreased.
@MedicosisPerfectionalis
3 жыл бұрын
Anion gap is usually low in multiple myeloma
@carolweaver3269
3 жыл бұрын
Thank you for placing this in order.
@lafurselfsik
3 жыл бұрын
"In addition to displacement of sodium-containing water from serum by large amounts of non-sodium-containing paraproteins, some paraproteins (eg, IgG in multiple myeloma) can have a net positive charge at physiological pH. This leads to an increase in unmeasured cations and a low anion gap"
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
Found the perfect page for hematology. Waiting for more subjects.
@MedicosisPerfectionalis
5 жыл бұрын
Coming soon...Thank you!
the most powerful lecture about multiple myeloma on youtube platform
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 🙏
1. Due to hypercalcemia fatigue,weakness including bone pain 2. Infection mostly bacterial 3. Pneumonia ,uti, pharyngities etc 4. Ecoli,staph,step,kleb 5. Ecoli 6. Normal bec no osteoblast activation 7. Due to acidosis anion gap is low
can i just thank you "63 thousand times". you are so helpful. thank you so much. big help. watching your video a day before my deadline for my coursework. life saver. thank you. thank you . thank you.
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
If I had a teacher like you during my medical school,I would have been gold medallist
This channel is seriously underrated and below the radar. Dude, you are going to outrun more famous channels if you continue like this ;)
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊 I really appreciate it! Can you please help me by sharing?
Hands down best medical channel, pure quality man, really appreciate the effort 💯
i want to thank you for making this video. i had a project on multiple myeloma and i kept reading and reading facts about it from multiple and different resources and i was a bit confused with how the one info connects with the other, but your video helped me understand the whole thing! again thank you so much! bless your soul
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 Good luck 🍀 Can you please help me by sharing?
There is simply no better way to explain things, such a great job!
@MedicosisPerfectionalis
Жыл бұрын
Thank you 😊
I was admitted 4 days ago to the hospital. Diagnosis Multiple Myeloms. Tuesday my bone marrow biopsy test will provide more information. I watched the entire video, will watch every video in your library related. Im am so grateful for your documentation.
I swear to god I learned soooo much from you compared with what i learned from classes (med student here) thank you for doing this!!!!
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much! I am honored. There are 600+ medical videos on my channel...I hope you’ll enjoy them.
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@MedicosisPerfectionalis
4 жыл бұрын
Thanks a ton, bro All the best! Can you please help me by sharing?
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@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 Can you please help me by sharing?
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@MedicosisPerfectionalis
4 жыл бұрын
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@MedicosisPerfectionalis
2 жыл бұрын
Thank you 🙏
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@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much, dear :) I am so happy you liked my videos!
@MahendraKumar-fh1do
11 ай бұрын
Can u suggest any channel for pediatrics and surgery too....
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@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊
Thanks professor.Such an awesome presentation..Very clear,detailed and good visuals.It motivated me to learn more..(Nurse working in hematology department).Also going to help so many patients since it gave explanation in an excellent way.God bless you Sir.
@MedicosisPerfectionalis
3 жыл бұрын
God bless you too!
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@MedicosisPerfectionalis
2 жыл бұрын
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@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊 I appreciate it!
YOU ARE THE BEST TEACHER EVER !!! many many thanks
@MedicosisPerfectionalis
4 жыл бұрын
You’re very welcome 😊
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@MedicosisPerfectionalis
5 жыл бұрын
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@breakinankles92
5 жыл бұрын
@@MedicosisPerfectionalis already have!! That's how awesome you and your work are!
@MedicosisPerfectionalis
5 жыл бұрын
Thanks 🙏
Thank you a lot for your videos! 🙂 In my opinion, your videos are the best! You help me to take my specialist exam in Hematology! 🎉✨I want to study every day and be a good doctor!
@MedicosisPerfectionalis
4 жыл бұрын
Awesome 👏 You can do it 👍 When you have time, please help me by sharing!
When he said “buy you have the memory span of a fish”😭😭😭 you’re absolutely right I do
@MedicosisPerfectionalis
Жыл бұрын
😊😊
Birds with feathers flock together Stacked rbcs quickly sink together 👏😂awesome,Thank you so much for these wonderful videos.Your humour is simply superb
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
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U r such a great teacher, making things so easy, thanku so much sir, u r great .... Love uuu sir😍😍 keep uplaoding such great videos and increase ur knowledge...
OmG. I'm in soooo much love with the way u teach 🤩🤩🤩🤩🤩🤩 Keep upload more videos for medicine docs pls.. Thanks a lot. I appreciate ur work. May u stay healthy
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 Thanks for your kind words! Please help me by sharing my videos with others!
I could never forget about multiple myeloma, its really perfectly presented crystal clear concept which makes us understand logically and conceptually .thank you so much medicosis perfectionalis ❤
@MedicosisPerfectionalis
3 ай бұрын
You’re very welcome!
Awesome and very funny teacher ! Thankful! Can't seem to find the answers to the questions at the end tho :(
I first skipped the video because it was 28 mins long but I ended up watching the whole lecture. Amazing lecture 👍
@MedicosisPerfectionalis
2 жыл бұрын
Wow! Thank you so much 😊
Thank you for your videos, your channel is very helpful !
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
Finally medical videos that are not boring lectures. Thank you!
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇 I am honored! Can you please help me by sharing?
@mokeiramokuamm
4 жыл бұрын
@@MedicosisPerfectionalis Definitely
What a hell of easy learning! Fab!
@MedicosisPerfectionalis
2 жыл бұрын
Thank you ☺️
My only regret is finding about this channel, quite late😅😅... You've changed my perspective of medicine. Massive respect bro!!
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much ☺️
U r amazing ! Thank you 🙏🏻 ♥️
Dude imma about to cry! May Allah protect you and bless you
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊 You too!
U r such a great teacher, making things so easy, thanku so much sir, u r great sir..... Love uuu sir😍😍
Thanks alot medicosis for ur grt wrk in hematology
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure :) Please help me by sharing!
Your videos are so rich. And byt the way, I love your sense of humour
Nice explanation of Multiple Myeloma, Thanks sir
@MedicosisPerfectionalis
5 жыл бұрын
You’re welcome 😉
perfect!!! thanks for everything you r excellent
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure 😇...I am glad you liked my videos!
The best medical channel .
The best so far ❤️
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊
I wish i could travel back in time and tell my past self abiut this channel 😅 Loving all of your videos its a shame that my 2nd year is ending now but I'll still watch your videos nevertheless ❤❤
Many thanks, good teacher. In fact, excellent teacher.
@MedicosisPerfectionalis
4 жыл бұрын
The pleasure is mine :)
Awesooome amAzing lecture..so thankyouuuu to you...😍😍👏👏👏👏👏
All i want to say is Thank you very much for making my life less miserable 😘😘.. And keep doing more of those awesome content.. Love from Sudan 🇸🇩
@MedicosisPerfectionalis
Жыл бұрын
Thank you so much 😊
even after 5 yrs coming across this video, still it made me master this topic god bless u ur videos r great but alot of information crowded on a single slide...this panics me😅
Thank you bro that was so helpfull
You are extremely amazing! Thank you soooo much♥
@MedicosisPerfectionalis
Жыл бұрын
My pleasure 😇
amazing love this video i had to subscribe except when i went to click the button it sead im already subscribed. thankyou
@MedicosisPerfectionalis
4 жыл бұрын
😊😊😊😊😊😊😊😊
Dude you're amazing! Very thanks!
@MedicosisPerfectionalis
Жыл бұрын
I appreciate you!
Best teacher.
Thank you very much
I am watching your all videos and I can say your explanation is very nice and clear. Thanks
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure 😇....Welcome to Medicosis.
@doctornsn3548
5 жыл бұрын
@@MedicosisPerfectionalis How I can buy your videos with pdf?
@MedicosisPerfectionalis
5 жыл бұрын
My videos are on KZread, but the illustrations that are used for them are available on www.patreon.com/medicosis/ organized in pdf forms...I would be happy to give them to you 😊...Thanks!
@doctornsn3548
5 жыл бұрын
@@MedicosisPerfectionalis I see.. Thanks!
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure...Let me know if you need any help!
Excellent .much interesting and valuble to all of ..
I have already watched lots of your videos. Thank you so much. Love 💚 from Guwahati, India.
@MedicosisPerfectionalis
4 жыл бұрын
Thanks 😊
oh my... astonishing!
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 😊
thank you very much sir !!
@MedicosisPerfectionalis
5 жыл бұрын
You’re very welcome 😊
Thank you. . Respect from. INDIA ❤️
@MedicosisPerfectionalis
5 жыл бұрын
Thank you, dear :)
Just perfect explanation ☺️
@MedicosisPerfectionalis
2 жыл бұрын
Thank you 🙏
Are lymphocytes elevated in multiple myeloma?
I love your videos !!! thank you
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
Simply great!
@MedicosisPerfectionalis
Жыл бұрын
Thank you 🙏
Thanks really to your work u really help us❤❤❤🌹
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
Amazing Thank you so much
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
Tq for this elaborate lecture...
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
very helpful thanks
@MedicosisPerfectionalis
5 жыл бұрын
My pleasure 😇
I'm glad I found your channel. Thank you for your videos. Can you make a video about myoma? Thank you in advance
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much!
Great work ,thank u
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
great lectures easy to understand
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊
24:22 why are you calling me out like that XD. awesome vids btw.
@MedicosisPerfectionalis
2 жыл бұрын
I was joking 🙃 Thank you so much 😊
VERYYYY NICE 😁 LOVED IT
@MedicosisPerfectionalis
5 жыл бұрын
Thanks 🙏
I love you for this😭❤ I will share your videos to my friends😭 This is the minimum i can do for you😭❤
super job!!!
@MedicosisPerfectionalis
3 жыл бұрын
Thank you 😊
Thank u so much.
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
I have an exam i’ll make sure to update you about my answers since you helped me alot 💜💜💜💜
@MedicosisPerfectionalis
2 жыл бұрын
Good luck 🍀
Thank you for putting up such a good lecture videos. Your videos are really informative, where do you gather your resources from? Whats your references? Is it Harrison and Wintrobe or something else. If you could share your references would be really grateful.
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊 I use Harrison’s, Davidson’s, Goldman-Cecil, Goljan and Medstudy.
So amazong explanation .
@MedicosisPerfectionalis
Жыл бұрын
Thank you 😊
I might forget everything but I'll never forget that M proteins and BJ proteins are nasty and they are everywhere! I LOVE all the vids.. working for my exams rn and this is the only thing that's keeping me motivated rn 🙏😭
Your instruction is superb!
@MedicosisPerfectionalis
3 жыл бұрын
Thank you 🙏
@Livinggud
3 жыл бұрын
@@MedicosisPerfectionalis chiropractic student here BTW! You really made all the information finally *click* into place for me!
@MedicosisPerfectionalis
3 жыл бұрын
I am honored!
plz upload more pathology videos ur the best ♡♡♡
@MedicosisPerfectionalis
5 жыл бұрын
I sure will ❤️
Thank youuu @Medicosis perfctionalis you saved me From Algeria 💙
@MedicosisPerfectionalis
Жыл бұрын
Thank you!
hi, can you elaborate more why ALP is unaffected in MM?
Dude ur a legend
@MedicosisPerfectionalis
4 жыл бұрын
Thank you 😊 I am blushing ☺️
I have a question that why only light chain get excreted not the heavy chain bcozz of bigger size?? Plzz tell
) Which of the following cytokines is intermediate in the pathogenesis of MM ? IL6 OR IL1? I HAVE Exam please reply?
Great video as always, my boy never disappoints. I have a question though you said we get proteinaceous tubular casts which may consist of albumin in the cast in urine but then in the bullet point u said glomerular function is nearly normal thus no albuminuria. care to explain?
thank you
@MedicosisPerfectionalis
Жыл бұрын
My pleasure 😇
@medicosis perfectionalis Great lecture!! but isnt viruses reactivation are related to B-cell and antibody immunity? @7:17