This video from 4 years ago came up on my site. I have been doing a little "research" since I was diagnosed with ET several months ago. I had been feeling very weak and they tracked it down to a JAK 2 mutation. i can see and hear the emotions you have gone through. How are you now? My situation is different as I am 80 years old. However, it feels like a big loss to me because up till last year I was hiking in the mountains and swimming in the ocean. Now I have to really push myself to walk and swim in the gym pool. I must sound ungrateful because I have had a lifetime of being active and able, and yet I get pretty depressed at times because it was not a gradual loss from aging. I am taking hydroxyurea and it has helped the platelet count but I suspect some of the side effects are similar to the disease symptoms. I do have some good days when I think I have conquered it, but it always comes back. which can be very discouraging. Thank you for letting me share this. I would love to hear how you are doing.. Fran