Mohit Jolly (Rice U.): Circulating tumor cell cluster: A model for cancer metastasis
Ғылым және технология
www.ibiology.org/human-diseas...
Despite major advances in cancer biology, we do not fully understand the molecular cues that trigger metastasis. Cancer cells need to leave behind the organ of origin and travel through the blood or lymph node system. This requires cancer cells to leave the epithelial (non-mobile) characteristics of the original tumor and acquire mesenchymal features of mobile cells (e.g. red blood cells). Dr. Mohit Jolly developed a model combining theoretical math and molecular biology that predicts cancer cells with both characteristics, epithelial and mesenchymal, have higher tumor-initiating potential. Jolly and colleagues experimentally showed that this hybrid state allows cancer cells that travel in clusters to have higher chances of survival. This work highlights the value of using theoretical math to provide new insights on how to treat cancer metastasis and progression.
Speaker Biography:
Dr. Mohit Jolly earned his Bachelor and Master degrees at the Indian Institute of Technology Kapur. Here he began to recognize the promise of theoretical mathematics to understand complex biological systems. He joined Dr. Herbert Levine at Rice University in Texas for his PhD to study the intrinsic characteristics of cancer metastasis. During his PhD work he became a key contributor to the scientific community leading initiatives for outreach and science communication, including co-founding Notes on Engineering Research and Development (NERD), a quarterly campus science magazine.
Пікірлер: 26
Great presentation, and very accessible to a biology "novice" like myself. Thank you!
@mkjolly15
7 жыл бұрын
Thanks very much Mike for your words of appreciation. I am glad you liked the presentation.
Very nice! So impressed by your work and conclusions. Thank you for sharing.
@mkjolly15
7 жыл бұрын
That's an excellent suggestion, Nicole. Thanks a lot for your appreciation! I will definitely explore adding this to my Google Scholar page.
Really helpful, thanks!
great work,
Wonderful talk Mohit!
@mkjolly15
7 жыл бұрын
Thanks very much Dr. Hyde! Coming from you, this appreciation means a lot to me :)
Brilliant work..nice presentation
He is a genius with humor.
Beautiful lecture!
@mkjolly15
7 жыл бұрын
Thanks a lot Sonam!
This guy is brilliant, great presentation
@mkjolly15
6 жыл бұрын
Thanks so much for the encouragement!
very well explained!
@mkjolly15
7 жыл бұрын
Thanks very much Milind !
Good work! Nice and easy to understand for people without biotech background(like me)!
@mkjolly15
7 жыл бұрын
Thanks a lot Mudit :) Glad to learn I was clear enough.
WoW Mohit...... Splendid job :)
@mkjolly15
7 жыл бұрын
Thanks very much Sumit :) Glad you liked it!
Impressed to see conditions described with linear algebra and easy to comprehend graphs. It's like learning about physics all over again. Will the 21st century be the heyday of medical science?
@mkjolly15
4 жыл бұрын
Many thanks Stephen for your kind words!
If only this video could be added to your Google Scholar profile
I would have liked to know how mathematical model was drawn
@mkjolly15
6 жыл бұрын
Thanks Amrita! I'd be more than happy to talk more about it. Please let me know any questions you may have.