Thank you Brian for the superb production quality, despite the guests being remote. Zero lag, zero glitches, beautiful background.. Really top class.

@azztecar

Жыл бұрын

Couldn't agree more. 👏

Love these conversations with experts in their field, the format is perfect to present the latest developments of ongoing investigation into the various fields of science!

@gertabare

2 жыл бұрын

Just let us go and if I

Who doesn't love to hear David Sinclair talk. Great conversation, first time discovering the other three geniuses on your panel. Everyone up there ,collectively, offer information that could change our human race , our future, our world as we know it and that is too cool!! A big thank you to all!!

I knew Sinclair was going to be on this even before he was introduced. Naturally!

This is bar none the best "TV show" on the market today. At this time of writing, those 42k views are the select lucky ones. I'm so glad to have educated material and conversations to watch. It's an inspiration, for sure.

More people need to watch these videos than TikTok. It's really sad to see how people spend their free time.

@Vlado709

2 жыл бұрын

This is the point of TikTok. The age reverse technology will be only accessible for the "elites" The rest will watch TikTok!

@aeonproelium

2 жыл бұрын

Couldn't agree more

@gyozakeynsianism

2 жыл бұрын

It's sad how much time people waste complaining about TikTok.

@geigercourtier

Жыл бұрын

Ok China

@woocash2526

Жыл бұрын

It's evolution's foult - we have full spectrum of people.

One hallmark is a symptom of another. They're not separate from each other. David is right!

I have watch many of your broadcasts, Brian. This must be one of your best. You seemed to bring the best out of the expert panel. Well done and thank you an interesting and compelling discussion.

Awesome discussions. Brian is a revolutionary. And so is David. From the talks of David it appears people will soon start to have a life span of 500 years..and we need people to have longer lives particularly brilliant minds like Brian and David and Einsteins of the world to invent new things and take human civilization to further advancements.

When it comes to mortality as a choice, delivering equality is paramount and world wide peace in simultaneity

@communitycollegegenius9684

2 жыл бұрын

Do it now.

@kevinblackandwhite8273

2 жыл бұрын

Since when is the CCP against equality? Lol. Just work on your social score and you can shop anywhere you like!

I love watching these videos! Great job guys and gals! Big hugs to you all, and the hard work you do for us as humans. We all could agree that we want to stop the aging process! We know what happens as we age. Thanks again for taking your time for us!

In the building industry we are always crying about loss of information and lack of information transfere that makes projects go longer and cost more money and resources. Having older human stock on the planet will help us be more efficient in our projects.

I live 1 mile from (Ponce) DeLeon Springs in central Florida. Yes, we are very young old folks here!!

15:08 "Where are they on the chromosome?" I understand that he knows perfectly well where telomeres are on a chromosome. But he interjected the question for our sake. A true educator.

@SpiritsBB

Жыл бұрын

It's for the prepared graphics

A notification from World Science Festival just makes the day. Excellent discussion. Missed Aubrey de Grey's beard.

If we have the ability to reverse aging we should do it. Arguing semantics of calling it a disease or not is a waste of time. You make the treatment, people will take it, if it works it will become popular, and it will spread regardless of what you call it.

I am eighty three years plus. I hope the developments in longevity happen sooner than later and I can also enjoy the benefits of longer healthy my life for longer time .

@jagjitpunjrath5887

2 жыл бұрын

Sure the scientists would find a way to deal with problems of population, environments as happened earlier.

Thank you Brian for putting this together and for making it so accessible. More please! And more David Sinclair. He's the rockstar of this topic!

Age is just a number. The key to life is: live it to the fullest; work hard and play harder, that is. The end of the day, you take nothing to the grave. Not even your memory.

The important thing is HEALTHspan instead of lifespan

That's a great talk I'm glad the topic of poverty was brought up. One issue I think we all do fear is that regardless of population expansion, anti aging treatments, and any health benefits that come with it, will be relegated to the rich and maybe the middle class. I do hope in 500 years, if not sooner, we start to see significant social growth to include all people, or I feel we well may actually be doomed.

@JimBob1937

Жыл бұрын

This becomes a question of philosophy of prioritization. Such a thing does create a population expansion, this is something that is at the core of how you apply such technologies, once developed. Hence, while I think most would certainly want to help as many people as possible, ideally all, that rubs up against the reality that such a thing isn't viable unless other measures are taken to reduce or eliminate the negative side effects. These are where one should be focusing, not just hoping it can be given to all at some point.

Seriously, a fantastic conversation. Such sober but encouraging thinking on this topic.

I love that the question about "is it wise to extend life past 100-150 years" was brought up. I'm not a scientist or anything, but once people start artificially living longer (not living longer because of medicines that treat disease, rather bc we are manipulating natural processes to get more years), what are the actual stresses on the economy, environment, etc. Are we creating problems that we are hoping future generations can solve, just for the sake of 'science'. What is the purpose of living longer (again, what feels like artificially longer to me) if the standard and quality of living on the planet will be more strained for everyone? I feel like there is a reason the human body taps-out around 115yrs. If this technology is used to treat or mitigate diseases, I think that's one thing. But it didn't sound like that's what they were advocating for. Plus, we see it today with lifesaving care in general: the people who have the money and access are going to have better outcomes. What makes us think this won't follow suit? When companies see the $$, I honestly don't have faith that they will broaden access to all and keep costs low just for the sake of it. Sorry for the novel. Just my thoughts on this.

@JBPVFL

Жыл бұрын

So I'm by no means an expert on the topic, but I do love listening to this stuff and it intrigues me greatly. The question about living to 150 would also have to come with how would that look? Would our age at 60-80 still look the same, but we would just be stuck in that very frail form for just another 50 years? Or, would 100-120 be the new 60-80? I don't think anyone would want to just extend the end of our lifespan to 150 if the middle wasn't also extended. So about availability to everyone and the benefits of it economically. First off, this is not the same as rich people getting big boats or mansions. If the rich would attempt to horde something like this, you would quite literally see them be ganged up on like times in the past. But, I don't think they would with something like this in the first place. Imagine if everyone could "extend" their working years from 18-66 to 18-120. Imagine the money saved by companies if their employees could work that long and the experience each individual would be able to bring to the table. It will no doubt come at a cost, and it would also depend on how much could be produced. But, if there was something that could extend life by 50 years, it would be one of the most valuable things you could get your hands on. Because if a tech or pill could do that, would would come out in the time that 50 years bought? Many of the scientists working on longevity think that if you are middle age by the time 2030 comes along, you will most likely experience the term they coined longevity escape velocity. Basically saying that enough life extension medicine and technology will be coming out extending lifespans that it will basically go into infinity until we would no longer die of old age. Of course you could always get hit by a vehicle or killed. But they think they could eliminate death due to natural disease and aging in general.

after seeing the title i knew David will sure be in this..

Great conversation! Thank you so much to everyone that made it possible!

Thank you - high quality talk! Something changes direction at middle age (where we go from growing to declining) - if we can only move understand what kicks off this change - and delay it.

@hearyou4203

2 жыл бұрын

@Bizpo Very interesting. Been thinking about that myself. I will soon be 57, but personally to me it feels like middle age is just starting (the decline you mention and I mean only physical, and not very significantly). On an intellectual and cognitive level, I personally feel I have gained a lot and keep "evolving." I firmly believe in good health by prevention, being conscious about your intake of food, exercise, sleep, etc. For the rest, life is just a journey, I'd like to keep the mistery up, no need to delay anything, in my honest oppinion. I enjoy life, try to make the best of my day, have no rush to check out, but wouldn't want to prolongue my life any further than for example my parents, who left in their late 60's and 70's respectively. But this of course is, and should give way to a more philosophycal discussion.

@JimBob1937

Жыл бұрын

@@hearyou4203 , my dad has said something similar. Age really only started to hit him in his late 50's, so you guys may already be experiencing the shift in 'middle' age due to health advances and a healthier living with increased exposure to health knowledge and means (access). My grandfather was similar, when he was 80, he felt intellectually in his late 20's he said. Time caught up with him a bit after that, but something to be said for sure about keeping your mind and body active.

1:05:20 “Life expectancy for 10s of thousand of years was between 25 and 35” isn’t that just the average life expectancy due to infant mortality? I was under the impression if you made it to adulthood you could expect to live quite a long life. It dipped later when we started to live closer together in towns and villages due to the spread of disease.

@jennifermcdonald5432

Жыл бұрын

I’m not a scientist, but I am pretty sure that, back then if you made it to 50-60. you were considered rather remarkable. Of course, there we’re many exceptions, people who reached 80 or over, I’m only talking averages. Again it’s only my understanding, but they had very little knowledge about food and diet and it’s actual effects on our systems, they also worked extremely hard, ( compared to us) mostly physically work, along with using very harsh chemicals in very unsafe ways, ect ect.

A really excellent discussion with a great panel! - they hit all the right notes from my point of view - despite the relatively minor differences of philosophy . .

Please Brian, continue with sharing your extremely high content. You are a gift to the entire World, Universe.

Thank you professor for a great interview, love it!

Seriously, a fantastic conversation. Such sober but encouraging thinking on this topic. Very well done!

Another great talk which was much appreciated. I’ve been watching these conversations for quite a while, Thank you many times over for these important conversations. ⭐️

Thank you for bringing these experts together with their different views. I find Dr. Epel's ability to integrate so many factors and views astonishing. When listening to some of the claims made, I fear the claimants have forgotten the basics she referred to: socio-economics. Additionally, the one example cited of the holocaust survivor was striking. Why do academics repeatedly forget that there will always be the 10% outliers residing in the nether regions of the bell curve who will always beat the odds? In my opinion, holding those figures up as heroes, and or villains, negates the hard work and challenges of the remaining 80%.

What a great conversation!! I loved the reflections raised by Nir Barzilai =)

It’s not the length of your telomere that matters, it’s how you use it.

These are always so wholesome and enlightening. Thank you 😊

at 27 years old, the idea that i would get to see the year 2100 is both astounding and so enticing i want it more than anything else i've ever heard. to exist in three centuries, to see what all could come of that. to imagine the next hawking or einstein could have triple or quadruple the time on this planet to contribute to humanity... absolutely breathtaking implications in this discussion. man, i'm stoked for the future!!

Been waiting for this. I'm a huge fan of Dr. David and Brian Greene 🥰

This was such a great conversation to hear.

Imagine you turn 50 and lose your job or marriage, and instead of suiciding you have enough time and vitality to realistically "restart your life"

Love the strong disagreements

Wonderful discussion thank you world science festival and all scientists.

This video was so good that I sent it to one of my Doctors hoping that they will tap into the continued research.

Amazing conversation! Enjoyed every bit of it!!! Looking forward to your next editions!

I think the concept of “reverse ageing” is a misnomer. We should instead think of it as “how to elongate cell renewal” . IMO, the solution wouldn’t be necessarily to destroy sescescent cells but to keep creating the production of new cells. Something that could be akin to accelerated healing. And imo that is related to the pineal gland and the thyroid…

@hrgwea

Жыл бұрын

The secret is somewhere between normal cells and cancerous cells. Normal cells can only reproduce a limited amount of times whereas cancerous cells can reproduce without limit. The trick is to achieve unlimited reproduction but without producing tumours.

another great panel and topic - absolutely loved it

Loved it, Thank you BrainGreene. David Sinclair will succced.

Thx Brian for making this. Yeah we don't fear death but we also don't appreciate death! Make the world a better place by the knowledge we have and will discover.

Really enjoyed this,thank you 🙏😊

Excellent conversation, thank you so much for the video!!

If everyone is health and wealth we need the logivity concept.I love the concept..we will correct the economy system..hopeful no body will be poor forever .we will rejuvenation for every thanks to the almighty God. ..

It’s De Lion Springs, just north of DeLand, Florida!!

Definitely a rewatch!

best channel on KZread, as always. Thank You Professor

Has research been done on people with progeria? Do they find the same cellular patterns?

Brian is a great moderator

27:15 i really like this analogy

It seems that the differences is ageing between species can be measured by the rates at which they accumulate genetic mutations over the species typical lifetime, and that correlates very well with their expected lifespan. So now I know why my beloved Beagle is ageing so much faster than I am 8-(

@hrgwea

Жыл бұрын

And what determines the rate of mutations in a species?

@leighedwards

Жыл бұрын

@@hrgwea Honestly I don't know. But it seems all species do it but at different rates and higher rates correlates with lower life span.

@hrgwea

Жыл бұрын

Maybe the rate of mutation is directly correlated to the rate of celular reproduction. A faster metabolism should result in a greater rate of cellular reproduction and, therefore, more mutations.

@JimBob1937

Жыл бұрын

@@hrgwea , was just about to say this. Metabolism is seen as an indicator of lifespan. The more a cell reproduces the more chance there is for mutations. This same thing applies to things like viruses, which is why vaccines can (sometimes, it's complex) have an impact on mutation rate, since they can stop the reproduction of viruses sooner, reducing the chance of mutations. Although, of course, one can't ignore that the longer a cell exists in time, the more chance it has to be exposed to mutagenic factors.

Thank you for sharing it ❤

Great video. Thank you

Professor Greene from the perspective of pure biology as a science is key in the structure of telomeres and there is physics stronger, in fact at the same time not because the transfer of information during the evolution of reality the best solution is genetics or awareness of existence we call life ♾️

Good job David Sinclair .

I really agree with the woman arguing about extending lives cause there is a cost on earth and its definitely classiest issue as well

Regarding the purpose of life, I think it's meaningful if there's not mortality because continuity allows the all span to be differentiable.

@aeonproelium

2 жыл бұрын

I believe you're over complicating my friend. Understanding the "purpose of life" is quite simple. Living organisms breed, interact with their interfaces and evolve. Simple as that. Everything else is just occupied time between.

@barcoyou5976

2 жыл бұрын

@@aeonproelium Thank you for your reply. I was understanding the meaningness of life from consciousness perspective, which relies on continuity (differentiable calculation) I believe.

@aeonproelium

2 жыл бұрын

@@barcoyou5976 I understand your perspective, however consciousness doesn't over rule the basics of the particular organism and organisms need adversity to continue to simply maintain and certainly to evolve. That being said continuity needs to come from heritage and not the lack of mortality. But again, I do understand your perspective and will agree that longevity is preferential.

@barcoyou5976

2 жыл бұрын

@@aeonproelium good points.

@newbleppmore7855

2 жыл бұрын

@@aeonproelium actually historically most males did not reproduce, the small high quality group of men had most of the women, so for the majority of men reproduction was not their purpose

There is no bigger curse than immortality, no one will be interested in a story that never ends. We should appreciate our short stay in this universe and leave way for the future generations. We are precious because we are mortal.

@nargacuga4597

Жыл бұрын

Way too dramatic and cringey lol. Life extension doesn't mean immortality. Depends on your definition of immortality of course. May I remind you that you can choose to end your life anytime. I can assume that when we get that aging reversal tech, euthanasia would also be legalize as long as you're in a healthy state of mind. That way, you can choose the time you're going to die; happy, without regrets, healthy, and painless.

@ekaterinavalinakova3945

Жыл бұрын

Maybe for you, but the goal is for people to make choices for themselves. That is the goal. Also ending aging is not the same as immortality. You can still die from various other things.

I'm also not scared of dying but there are things I need to know because I feel like I'm the most powerful human. So I get to overthink and take extra precautions whether or not I'm the Amun Ra. Or, am just blind or deaf? Or everybody is? 🙄

Maybe an entirely different approach should get discussed. E.g. Science just told the world "hey peeps, we got some things wrong and from what we can tell everything actually is possible" Crispr is already the genome Rockstar tool, I'm very curious if consciousness research will soon prove that emotional and mental good health is the key to youth and adaptation.

@kevinblackandwhite8273

2 жыл бұрын

The best predicter of longevity is the quality of your relationships. This has been proven in study after study and so it is strange that David and Mir didn't really touch on it. In so much as good relationships are linked to good mental health and a positive outlook, I think you are spot on.

@JimBob1937

Жыл бұрын

@@kevinblackandwhite8273 , I think it is because that is just the side effect of the same underlying causes they already discussed. If you have good relationships, your mental well being is higher, which will tend to have less stress and less stress hormones, and less inflammation...etc.

These genuinely brilliant researchers can imagine humanity with no ageing, but not humanity with no capitalist exploitation.

Thanks Brian

i am all for the acclimation of meaning when it does happen

I find it hard to believe that over 50% of the over 100year olds in his study were overweight or obese. I would be interested to see the numbers and know what is considered obese.

@kevinblackandwhite8273

2 жыл бұрын

No doubt! The stats he gave were scary. Was it 30% smokers, 50% obese, majority sedentary.. wtf??

@spindoctor6385

2 жыл бұрын

@@kevinblackandwhite8273 Yeah, The smoking percentages were that the people were heavy smokers "at some stage" in their lives. So who knows what that means? You would assume that a sedentry life would kill you, no matter your genetics. The overweight one really gets me though. While I have never asked an old person how much they weigh just from visual impressions, I do not see a lot of fat people who are 80 let alone 100.

@kevinblackandwhite8273

2 жыл бұрын

@@spindoctor6385 I agree. Really weird. Gotta get hold of the original study I suppose, to make any judgements.

Dear scientists, how do I get involved in clinical studies to slow aging. I live in Vero Beach, FL. USA. I'm about to become 66 years old. Was vegetarian for 33yrs. I just went back to meat ,etc eating .low sugar diet. Have been athletic all my life. I've retired. Take anti allergy shots, asthmatic, inflammation etc.. But I'm show signs of aging. Please direct me how to go about involved in studies. Anxiously waiting for your reply.

on the ills of poverty with regards to the creases of aging makes for a great saga 🍿🍿🍿

Great stuff!

Besides The Okinawa diet book which mentions many centenarians from that city who mainly consume fish, shellfish and veggies. There is a book which I have started reading, is right now in my moving boxes but the title is something like Reaching a 100 healthy and happy! There they mention that besides Japan and China that are known for having many citizens reaching more than 100 years old, also the Scandinavians eat a lot of fish and vegetables. In the book it is mentioned that in the coastal cities where fish is easily available, there are centenarians who did not smoke or drank heavily and exercised besides having a healthy diet mainly of fish, seafood, grains, vegetables and fruits.

This is a story for developed advanced countries but not for most people in the world, not to mention overpopulation and climate crises. That doesn’t mean that we don’t continue advanced biological research, it is a must .

It is something that we can and must combat ageing immortality is the key we want to be young and live forever

We will have to completely reform society before this can be released, if ever.

Now it's guns... A gun I used to stop an attack when I was 21 saved me to live to 66!

I found the "Fountain of Youth". I was swimming in all these local springs, Deleon, Blue, Rock, Indian, Gemini, Salt, etc...I did not DRINK spring water until 5 years ago. Naturally Occurring Electrolytes ARE THE KEY ! I drink it everyday and I just turned 50. Yet I look and feel like I'm in my 20's. Have you ever wondered why "Spring Water" is SOOO EXPENSIVE when it comes out the ground For Free? Doctors only get paid if WE GET SICK...right ? I drink Iridium, Gold and Platinum too. We are sentient "Organic Computers"...right ? I invite you to explore these claims.

Excellent production quality... Wow wow

Please! If Sean Caroll (Mindscape podcast) can adjust music volume levels then so can you. End credits OUT OF THE ROOF or what ABSOLUTE MINDBLOWINGLY LOUUUUUUUUUD

Freedom improves the quality of life.

Sounds like a great idea. All the world leaders never get old.

“Die of old age” … you don’t die of old age.

David's and Nir's suggestion that technology and "the market" allow infinite growth on a finite planet is pretty cargo-cultish.

for the lady, when you know yourself you are balanced,and that in itself creates balance globally

This is great but there is only one way to get the Showdown at OK corral effect.

The oldest person on Earth just died a couple of days ago. She was 119, they didn;;t say how many days, that's important b/c the oldest to die was 122 I forget how many days but she was French and smoked united she was 90. The 2nd oldest was also 122 but the only thing I remember about her is that she ate 3 eggs for breakfast every single day since she was a teenager. The 3rd oldest was 119 and since I dont know the amount of days lived past 119, Im not sure if she is still in 3rd place or if she got bumped to number 4 instead. The only thing I remember about her is that she was another smoker.

Can somebody name the song playing in the outro? Thanks :)

Fantastic. Loved it.

Gracias Brian

I liked Nir Barzilai views.

Incredible production quality! Fitting for an absolutely fascinating conversation on one of the most interesting and important topics in science today.

anyone know the names of the drugs and supplements they are taking?

Resveratrol is widely known for its renowned beneficial biological effects, namely involving its chemopreventive and antioxidant properties. However, some studies have documented that it may behave as a pro-oxidizing agent.Thus, paradoxically, it may also have implication in pathology of several diseases.

Fantastic conversation.

Only those who have the character and a mindset of a beast, can and will live longer and healthier for at least a century.

On the point of environmental impact. I think a society with a higher average maturity level will be better at making decisions and electing officials that make long term decisions. If I might live forever I’m going to want to live on a better planet (and that’s probably going to have to be this one for a very long time)

@JimBob1937

Жыл бұрын

That assume age correlates with correctness... I think evidence of history proves this wrong. History almost exclusively favors progressives. Changes also occur largely due to transition from one generation to the next. If societal problems are problems to be solved, and the solution space are the various ideas for solving these problems, then more variation is needed to explore this space. If you created a magical pill that suddenly stopped all aging for the entire world, the world would be far more stagnant than it is now. I wouldn't think it would entirely stop the exploration of the solution space, but it would slow it down drastically.

Is fesetin the same as the supplement fisetin?