In-situ multiomics is revolutionizing research in oncology, immunology and neurobiology. However, speed and throughput are major bottlenecks for these critical studies. Here, we present data from a novel in-situ sequencing system, with sub-micron resolution and ultra-high throughput capacity, employing rapid 4-color SBS chemistry to profile RNA transcripts and proteins in FFPE tissue. The system also generates virtual H&E images, producing multi-modal spatial images of 40 cm2 of tissue in less than 24 hours.