KREBS CYCLE MADE SIMPLE - TCA Cycle Carbohydrate Metabolism Made Easy
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The citric acid cycle - also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats and proteins into carbon dioxide and chemical energy in the form of guanosine triphosphate (GTP).
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In addition, the cycle provides precursors of certain amino acids as well as the reducing agent NADH that is used in numerous other biochemical reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.
The name of this metabolic pathway is derived from citric acid (a type of tricarboxylic acid) that is consumed and then regenerated by this sequence of reactions to complete the cycle. In addition, the cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the TCA cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.
In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria which lack mitochondria, the TCA reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion.
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Hi "MED simplified " ..Your videos are excellent and of great help !thank you so much they helped me a lot for my exams ☺😊
@prakashguhe5020
6 жыл бұрын
yes
@babitachauhantanwar8833
5 жыл бұрын
Recent created by a brilliant mbbs student.
@binobino2425
4 жыл бұрын
yes... It really helped my friend and I.
@itstraveller25
4 жыл бұрын
Plzz make a video on fomation And utilisation of ketone bodies ;ketoacidosis
@wildfire7268
3 жыл бұрын
acetylco a is a two carbon compoIJnd in b©i
you did a good job. Still gonna fail my test tho Edit: thanks for the support. I did in fact fail. Goodnight. Update: now I'm in my doctoral program. Don't give up!
@MEDSimplified
6 жыл бұрын
How did the test go
@sheikhzabir4405
5 жыл бұрын
Same
@goldmedal67
5 жыл бұрын
Ryan G I have a test tmmr and I have to label the whole process of cellular respiration and photosynthesis... school is honestly bullshit and a waste of my time cause who tf needs to know this stupid shit unless you’re gonna major in something with biology
@ashleydaniels8792
5 жыл бұрын
loooool i feel that
@OrganicallyLuxeLife
5 жыл бұрын
Hope you guys passed your tests
Who has exams tomorrow? Hahahaha
@Faisuspeaks
3 ай бұрын
Today ½hour left 😂
@Gujjarji302
3 ай бұрын
Tomorrow
@user-vl5yk5vz8b
3 ай бұрын
Legends are present.tomorrow is my exam 😂
@sahanargowda
3 ай бұрын
Today I have internals 😂
@Comebackstory955
3 ай бұрын
Neet ha bhai kal 🥲👍🏻
Legends watching one day before exam 😂
Me: I need help in college Some Indian guy on KZread: I got you, fam
@samfatima4426
4 жыл бұрын
Relatable
@samfatima4426
4 жыл бұрын
All these Indians teaching me biology and physics ,chemistry even cuz my college is bullshit
@garymarkow7005
3 жыл бұрын
Exam tomorrow for me :(
@shishirmaharana4022
3 жыл бұрын
@@garymarkow7005 How did it go?
@garymarkow7005
3 жыл бұрын
@@shishirmaharana4022 It actually helped; I got a B!!!
when ever i look up a certain video about a topic for my exams , i'm so happy when i see this channel on top result , u know the video will be short and sweet and straight to the point . thank you , u're really making a difference
Thank you. I have watched several tutorials on the the Krebs Cycle (cellular respiration) and this is the most clarifying one. Thank you for keeping it simple yet informative. I was able to keep my focus on the main aspects of the Krebs cycle and have a much better understanding. Keep posting!
I loved this video so much! You made all the different intermediates and enzymes so easy to understand and remember, my professor didn't spend sufficient time explaining this concept and your video was extremely helpful.
Considering how complex this is, i'm pretty sure i took a lot of information on-board. Thank you so much for your awesome video!
This video is incredibly helpful. It's a detailed explanation of all the processes involved in the Krebs cycle, yet it doesn't get caught up in the minutiae and is simple enough to commit to memory. Thanks!
I'm inlove with the way you drop words from your mouth.
This video is so good. But he forgot to mention one thing. Like he said Qh2 becomes FADH2 same ways that GTP gets converted to ATP, hence kerb cycle produces 2 GTP meaning it produces 2 ATP. thank me later. Keep studying, peace out
@ngminphin8818
6 жыл бұрын
correct, the conversion of GTP to GDP will facilitate the formation of ATP from ADP
@fathimakhadri9211
5 жыл бұрын
Thanks for the information.. I was thinking about the same...does GTP enters ETC or directly get converted... Then I thought of its a substrate level phosphorylation so obviously it won't enter ETC.. You r a keen observer like me 😃
@drsamadlaghari
5 жыл бұрын
Yeah
@iamyes731
4 жыл бұрын
thank you! this saved me. :)
@muhammadaqibmemon2718
4 жыл бұрын
Thank you
nice visuals make it even easier to understand. thankyou!
hello!! med simplified. your videos are just amazing .💟 and had saved my time a lot !!! thank you for such a great service . please keep it up and looking forward for more amazing stuff like this👍😄❤
Today was my assessment test and I scored highest marks in class . All credit goes to you sir . You did a great job . Thanks 💕😊
@heart_x_damka
Жыл бұрын
Oooo
@Unic_subrat
Жыл бұрын
Noiccee
That was just perfect. Please keep doing this... You have a gift for clarity and concision. Thank you.
Wow, I really feel like I learned something here. This helped me so much in understand the flow of the kreb cycle. Thank you
there should be some corrections 1. its succinyl-CoA synthetase not synthase 2. during above reaction occurs the produced GTP is turned into GDP and using that energy release one ADP molecule is converted into ATP
@rajatmeshram426
Жыл бұрын
Synthase hi hai
i usually don't comment on videos, but your videos are really well made and i think you are really underrated. thanks for the video
Thank you so much MED Simplified! Keep uploading these videos you deserve everything sir!
Bless you. I have a quiz today and nothing helped until your mnemonic. Your channel has saved me so many times.
Hi! As a medical student myself, I very much appreciate your videos! They were very beneficial for my biochemistry exam. Can you please make more videos?
@muzahirjaffery3887
3 жыл бұрын
kzread.info/dash/bejne/apyAuc-vqNrToKw.html
@anurimakarmakar2525
2 жыл бұрын
Are you a doctor now?!
@lanjarashid5308
2 жыл бұрын
@@anurimakarmakar2525 Yes! I graduated this July thankfully!
@anurimakarmakar2525
2 жыл бұрын
@@lanjarashid5308 Congratulations!!! I am in second year of MBBS 😅
@flaminmongrel6955
2 жыл бұрын
@@anurimakarmakar2525 you have biochem in second year of MBBS?
Of all videos I have watched, yours is the one that finally helped my idiot mind understand this stuff. Thanks.
@reenajericajohnson1829
3 жыл бұрын
😂
Thank you so much! Loved being able to pause and draw step by step! Best video yet.
After two weeks, i finally found a video that explained the cycle clearly and simply. Thank you so much, great video.
@MEDSimplified
8 жыл бұрын
+Summaya M. U are welcome summaya
@MEDSimplified
8 жыл бұрын
+Summaya M. U are welcome summaya
@sheikhahsanahsan5843
3 жыл бұрын
U are write since last two months I am going to tusion and when I study the Krebs cycle in tusion I dot under stand anything so then I can search on u tube and seriously I understand every concept
@harimailedme5651
3 жыл бұрын
after 4 years youtube recomended this...
Simple, to the point, efficient. Thanks a lot mate!
Wonderful, short specific and straight to the point. I was looking for help with a tutorial and this helped a lot.
Just what i was looking for short, simple, clear and straight to the point
U r explaining great and this’s helping me to understand the cycles even more better .. thanks a lot 😇
This is so far so good. Keep it up , am enjoying your videos. Continue making more videos because your videos are well simplified and easy to understand. Wow wow wow.... May God continue Blessing you....🙏🏾🔥🙏🏾.
you have no idea how helpful your videos are! truly saved me for my bio exam
This format of presenting the information is fantastic! Thanks for all the detail, clarity, and quickness!
@MEDSimplified
6 жыл бұрын
I am very glad to hear that you liked the video.
You actually made it look so easy to memorize and the drawing is also comfortable for the eyes hahahah thank you for your wonderful work
Like howwww do you do this .... I was just watching and now I’m ready for my finals ❤️😍 man you are amazing
This is too good. Explained it with great ease. Thank you.
i love how you explain and compound about krebs cycle :) thank you so much
thank you for simplifying complicated concept.
That was made super easy , after surfing KZread for hours I could finally understand it Alhamdllah , thanks 💖
@MEDSimplified
7 жыл бұрын
+Asmaa Fathy Glad it helped you
Really informative and a brief description of each and every point.
This is amazing. Keep up the good work bro.
arrest situation - SO GLAD I remembered KREBS CYCLE. It helped me so much... said no one - ever.
I missed 2 weeks of university because of my visa issues and I was worried about catching up with biochemistry work. I'm no longer worried now because I found your videos. Thanks a lot!
@alfiyaaaa4154
Жыл бұрын
Same thing is happening to me
Your videos are SO clear!
Thank you for making this man! Be blessed
Awesome I was reading Harpers and must say you smoothen it out :) thanks
@MEDSimplified
5 жыл бұрын
Thanks for the appreciation 🙏
woooooooooooow was worried about this cycle.......yeah surely it is made easier here.....................THANK YOU SO MUCH
Thank you for getting right to the point! Clear and concise.
This is so awesome!! thank you so much for such a simple explanation
I have a biochemistry exam in 2 days and I'm so glad I found your videos, only wish I found them sooner! ✨💕
@tulipa5171
3 жыл бұрын
how was ur exam?
@lolalove1208
3 жыл бұрын
@@tulipa5171 I passed the practical part of the exam😌✨ however we went into another lock down and I'm doing the second theoretical part this April 😊🤞 hopefully it goes well! 🍀✨😭😅
My exams in 20 minutes 🤧 will update y’all
@poornimamaurya5876
4 ай бұрын
Pass hua bhai ?
@dbcooper.
4 ай бұрын
What happened?
@itsaayushyadavbesubscribin4385
4 ай бұрын
Lagta h fail ho gaya AUR MUMMY NE PHONE LE LIYA😂🎉😅
@dhairyakapoor8246
2 ай бұрын
Zinda hai??
@ayeshashaikh8313
2 ай бұрын
????
I just loved it ... the way you explain simple short and crisp
THIS IS THE BEST VIDEO I HAVE EVER SEEN ON THE KREBS CYCLE
This video is really helpful.thanks alot
@MEDSimplified
8 жыл бұрын
+Buland Iqbal You are most welcome iqbal
@MEDSimplified
8 жыл бұрын
+Buland Iqbal You are most welcome iqbal
@MEDSimplified
8 жыл бұрын
+Buland Iqbal thank you so much your appreciation
DUDE!!! I FREAKING LOVE YOU MAN!!!! SUBSCRIBED!!!! YOU ARE THE BEST!!!!
@MEDSimplified
6 жыл бұрын
+Omer Khan thanksssssss soo much. Btw my name is omer too! 😇😇but its spelled umar. Thanks so much for all the appreciation. Much love
Thank you so much! Excellent video. Very straight forward. Much easier to remember and understand
this is the most easiest way to break down Krebs cycle. Thank you so much for the video !
hi bro you did my exam tomorrow
thank you so much for this video! I've been having a lot of trouble understanding this on my own, but after watching your video i feel better! keep it up :)
@MEDSimplified
7 жыл бұрын
+Aileen Flores i am glad it helped
@mohdashrafali7711
2 жыл бұрын
R u a doctor now??
oh I feel like I'm released from so much pain and street cause I was super worried about how Iam going to remember and understand Krebs cycle. thank u so much! God bless u
This was very helpful! thank you so much, very much appreciated :)!
I didn’t expect to learn this in high school lol.
hey! thanks! please keep it up!!!
This really helped me big time. Thank you!
ive been trying to understand this for two weeks thank you so much
thanks bro you just made my life easier
@MEDSimplified
7 жыл бұрын
+Yousef Murad u r welcome sir
@yousefmurad5254
7 жыл бұрын
do you have video for electron transportation chain ?
Thanks a million, you have made it easy for me.
Short and to the point. Very well done.
Thank you so much. The krebs cycle was really simplified.
you are the best
I study in Maharashtra state of India. In the biology textbook, the krebs cycle is not shown at all, yet we have been given this question in the textbook. This is extremely weird. This video helped me a lot and understood the Krebs cycle. I am studying in grade 10th and this video helps a lot. Thank you medsimplified!
Great job with the videos, simple, fast, and clear :D
These videos are awesome. Thank you.
wow.. this calligraphy makes me stare at the screen
Hey "med simplified" we are appreciating your work ...kindly upload videos on rest of the metabolic pathways (glycogen synthesis , its regulation ,degradation ,) as well please.
@MEDSimplified
5 жыл бұрын
Yes surely. The work on these topics is in progress 👍
Yes, I am going to subscribe because it helps me alot, thanks MEDSIMPLIFIED
You just got yourself a new subscriber ,thanks a ton!
Thank you for this video. However, I would just like to correct fumrase into fumarase and the succinyl CoA synthase into succinyl CoA synthetase. Nevertheless, this video is excellent.
@MEDSimplified
4 жыл бұрын
Thankkk you
succinyl coA converted to succinate. The enzyme is succinyl coA SYNTHETASE not SYNTHASE. SYNTHASES and SYNTHETASES are different 1st one is class 4 & 2nd one is class 6.
@Anonymous-cc3ql
6 жыл бұрын
Dark master yes you are right... synthetases require ATP or GTP but synthases do not.
@rishithavarikuti8641
5 жыл бұрын
Yeah you are right
@srilathareddy1317
5 жыл бұрын
In my book the enzyme given is succinate thiokinase. Is it the same ?
@princessbre
5 жыл бұрын
also it is fumarase instead of fumrase
Finally after so much of research i finally found a good video
This is so clearly explained... thanks a lot!
Wth we have to learn this in our second month of IB Biology...
@teresa4940
7 жыл бұрын
I feel ya. And to make it worse, our teacher doesn't teach a thing!
@Zetsuke4
7 жыл бұрын
Tresia Lol GG.
@teresa4940
7 жыл бұрын
Rip us all D: Also, John Green's crash course on this helps too
@muhammadsattar1454
7 жыл бұрын
Zetsuke4 same... im not even in ib tho. Plus my teacher told us to do this to do this on our own and made the unit final open book but... no one is prepared for the final exam now
4:12 "So this forms the SHORT description of the Krebs cycle".... bro
@sipstea7865
3 жыл бұрын
🤣🤣🤣
@hudamazharuddin9369
3 жыл бұрын
*sips tea* Do I spot an ARMY? taste👌🏽
@Aman-qr6wi
3 жыл бұрын
Yes, he skipped some rxn to make it little easy.
Thank u so much 😇finallly find best video on krebs cycle after 4 hours🙃 its very helpful and needed video😇
This video is very clear...I watched many videos to understand this Krebs cycle...finally I found your video...it is great...thank u very much💖
brother please give a video glycolysis cycle please please please please please
@MEDSimplified
7 жыл бұрын
+Munna Munna Glyu can find the video on Glycolysis on our channel
@munnabrucelee7278
7 жыл бұрын
brother give a video of about our eye please please please please please please please please please please
@himanshuchauhan9177
6 жыл бұрын
Munna Munna
@rameshdeshmukh7566
5 жыл бұрын
L
dont understand =( #Pathophysiology
@Angelxbaby88
7 жыл бұрын
watch this video several times.. I am sure You'll understand understand =)
@ASlamKhan-zc7pp
5 жыл бұрын
what Jo IU you so very usurious I have a great day and I will be more HP hi Jo hi Jo Jo
Thank you. This was a beautiful explanation
God bless you. This is fantastically explained. Even the way it eventually links to the Electron Transport Chain. I finally understand.
thank you for helping us!! I am a visual learner, so this is amazing
awesome video man really helped out a lot.
Best lecture listened so far. Thanks
I love it. thank you!
So helpful! Thank you so much!
You made it sooooooo much simpler than the other med school channel.
Thank you! This really helped!
If this is the Krebs cycle simplified, I don't want to even imagine what the krebs cycle unsimplified is lol. Thanks for all the awesome vids!
Thank you..!! Simple and to the point.
Excellent video I just loved it
This is so helpful. Thank you so muchhhh for this videooo. :)
You explain it very well thank you so much