Despite undergoing all of the latest and greatest medical interventions, the patient survived. - Tolstoy

@sliglusamelius8578

5 ай бұрын

TBF, Tolstoy lived at a time when medical care was still pretty young. The distance between then and now is many many light years in terms of quality of healthcare.

@bwalker4194

5 ай бұрын

@@sliglusamelius8578And yet, the infancy of modern medicine and the corruption of today’s medicine hold many parallels. His quote has stood the test of time.

@jevans8909

5 ай бұрын

@@sliglusamelius8578 have we really come “light years”, or are they just making us think that………

@nicole2828

5 ай бұрын

what is source for this quote please?

@warnerchandler9826

5 ай бұрын

​@@sliglusamelius8578I would posit that there is also a wide gap between, on the one hand, currently known/understood medical and health care, and on the other hand, treatment and outcomes that are manifested.

The art of medicine consists of entertaining the patient until the body heals itself - Voltaire

@barnabusdoyle4930

4 ай бұрын

No, treat the symptoms while ignoring the cause and most of the time give medications that make the cause worse.

@bobthrasher8226

4 ай бұрын

@@barnabusdoyle4930 Making things worse is part of the "entertainment." "Do you feel worse? That means it's working!"

My late Dad suffered from being put on so many different medications, and I'm convinced that it decreased his quality of life, and then ultimately led to dementia. Some of those medications are mentioned in this talk. Dad was good about following doctor's orders by taking the prescribed meds, but instead of improving the first condition he sought medical help for, that condition worsened and eventually dozens of others cropped up, each one resulting in yet another prescription being added to the cocktail. After 10 or 15 years of this, I ended up having to take guardianship. Btw, that was just months before COVID lockdowns, and I'm furious about the inept, inhumane response.

@knolls9499

5 ай бұрын

If a person is taking more than 4 medications, regardless of for what conditions, there will be drug interaction effects. As you describe, MDs then often prescribe another med to deal w/ a side effect. I worked for years as medical consultant for SSA's disability program and was shocked (at first) seeing lists of 24 meds cited as currently taken. Bottom line: we are responsible for our selves and not sheep. Many/most physicians are under so much time pressure to produce that the patient who protests can be seen as irritating. If one has a concern or does not fully understand, ask anyway. Many clinics now have nurses to whom the MD or PA can defer for the time to explain.

Just a carpenter who stumbled across this lecture. I really enjoyed it. Thx.

@elloohno1349

5 ай бұрын

I love listening to him talk, a flow of clear thoughts and logical thinking.

@warnerchandler9826

5 ай бұрын

There is a story about another carpenter that is applicable given the nature of this presentation by Dr. Prasad. Mark 5: 25-34 (KJB) [25] And a certain woman, which had an issue of blood twelve years, [26] And had suffered many things of many physicians, and had spent all that she had, and was nothing bettered, but rather grew worse, [27] When she had heard of Jesus, came in the press behind, and touched his garment. [28] For she said, If I may touch but his clothes, I shall be whole. [29] And straightway the fountain of her blood was dried up; and she felt in her body that she was healed of that plague. [30] And Jesus, immediately knowing in himself that virtue had gone out of him, turned him about in the press, and said, Who touched my clothes? [31] And his disciples said unto him, Thou seest the multitude thronging thee, and sayest thou, Who touched me? [32] And he looked round about to see her that had done this thing. [33] But the woman fearing and trembling, knowing what was done in her, came and fell down before him, and told him all the truth. [34] And he said unto her, Daughter, thy faith hath made thee whole; go in peace, and be whole of thy plague.

@leewilson1368

4 ай бұрын

Subscribe to this Doctor and continue to learn and share his knowledge!

We're a pill popping society, for the most part. If you can take a pill, it's the easy answer for most ppl, instead of doing the necessary research and work - So sad!!!

@garrettkajmowicz

5 ай бұрын

Pills take advantage of all of our ability to do large-scale manufacturing. We can produce a month's worth of pills for the cost it would take someone to step into a hospital room, merely confirm you aren't dead, leave, and then chart that interaction. Services cost a lot of money. So, yeah, pills are frequently going to be preferred if they are comparatively safe and effective. Because they are cheap and easy.

@kennethg9277

5 ай бұрын

​@@garrettkajmowiczha! If only that were true for surgeons who preferred performing harmful spinal fusions for years. If only it were true for pharmaceutical companies, whose entire business model depends on people NOT being satisfied with the current safe and effective remedies, but preferring new and more expensive ones.

@swangirl63

3 ай бұрын

All with terrible side effects. Just listen to the TV ads with the long list of awful outcomes.

The catcher on my son’s baseball team complained that his mitt needed tightened up. The coach took his glove and said he’d work on it but never did. When he gave it back the kid said it was better. Placebo has efficacy even in baseball! Who knew!

@sdrc92126

5 ай бұрын

There was a studied maybe 10-20 years ago that showed the more expensive the placebo, the more effective it was.

@KenJackson_US

5 ай бұрын

Though perhaps the kid just didn't want to appear ungrateful or to make his coach unhappy.

@aprilhancy7277

5 ай бұрын

Same as Retail.@@sdrc92126

@debravictoria7452

5 ай бұрын

​@@KenJackson_USOr maybe his hands grew.🤷🏻‍♀️

@marchhair01

5 ай бұрын

@@sdrc92126 I read an article similar to that in NYT. Basically said that the more elaborate the placebo the better the efficacy.

Ads for antidepressant drugs with suicidal thoughts listed as a " side effect " . Does anyone see something wrong here or is it just me ?

@mr.giggles4995

5 ай бұрын

The way I see it thre's no such thing as "side-effects". A drug can produce various effects, some good and desirable and some bad, or adverse. I've been on quite a few of these BS psychiatric drugs and they come with a lot of adverse effects, some life-threatening such as suicidal thoughts, organ damage, obesity and diabetes...

@mariecurie7491

5 ай бұрын

And migraine pills that can provoke migraine 🤔

@RpMcMurphy_

5 ай бұрын

You don’t understand the progression and nature of depression. In short, very often this “side effect” you mentioned occurs as one gets better. When they get better enough to have energy and cognitive abilities to plan. This is indeed a dangerous time, however they will likely continue to improve. It’s very likely we over prescribe unnecessarily such meds.

@kennethg9277

5 ай бұрын

​@@RpMcMurphy_ lol, very confidently presented narrative friendo, but actually those who understand the literature (you obviously don't) are aware that the available evidence indicates a vastly increased risk of suicidality overall among younger SSRI recipients, for instance. This simultaneously with the fact that pharma companies own published data indicates that the benefit of SSRIs- if it exists at all- is negligible, should prompt one to be highly suspicious of grand pronouncements regarding pysch drugs.

@aleyabellydance2

5 ай бұрын

All of it is wrong thats why only USA and new Zealand do it. Two nations who want their people dead. BTW most active shooters are on psych meds!

for years i have contended that the history of science is mostly a history of error. am so glad to hear this discussed. if science is conducted correctly, it is self correcting, but people and money really throw a wrench in this process, so often it takes much longer than it should. more education should emphasize this. science is a wonderful tool. it should not be turned into something more akin to religion-trust the science. science is not a matter of trust

Thank you Dr. Prasad. May you continue to wake people up. What in the world...when medical prescriptions are mind bending and dangerous.

Fascinating. I have learned so much from watching your videos! Thank you for another informative lecture! I teared up at the end when you were talking about your view of the policies during covid being human rights violations. I couldn't agree more. Thank you for speaking about it!

I so agree with you about the baseless rules that people, children and families, were forced to endure apart from each other in hospitals and long term care. Thank you so much for your bold and honest communication.

My friend’s grandmother had a different cancer/depression combination. It wasn’t that she was depressed because she had cancer, the cancer was actually causing the depression, and the doctors were prescribing meds for the depression instead of looking for a cause. Apparently in this 5’6 60 year old, there was a tumor the size of an american football that was altering her brain chemistry and causing the depression and they only found it because one day she pressed on her stomach and felt the hard patch. When they doctors cut this thing out, her depression was gone almost within the month, her bathroom trips were less frequent, she could go from the car to the house without becoming out of breath, and she had her appetite back. That’s how big this thing was that the doctors completely ignored the symptoms of, KNOWING she had previous issues with ovarian cancer.

@idunsgarden

5 ай бұрын

Yeah, I’m not surprised. I had a tumor the size of an egg on my thyroid and I kept pointing it out to doctors. I got told I was bipolar (turns out it’s Hashimotos) and ignored. Didn’t even offer me anything for the supposed bipolar. 😂 the third or fourth doctor finally helped and got it cut out.

@Asptuber

4 ай бұрын

@@idunsgarden So sorry that happened to you. I am (or was) the opposite. Every psychiatrist wanted to look at my thyroid! They haven't found anything in decades, now it is just a routine test every few years.

The one thing that our current sociaty actively fights against, let's five them drugs instead of Most studies report a positive association between religiosity and spirituality (R/S) and aspects of mental health

I'm a retired Licensed Clinical Social Worker and I think the DMS is bogus. Psychiatric diagnoses are just a collection of patient reported symptoms. The medications are awful and stigmatize the patient with this disease or malady. It's particular terrible when it's children who are put on stimulants because they are not compliant in school or kids who are termed hyperactive because they are naturally energetic. Even depression is largely a reaction to a difficult situation and the SSRI or worse the atypical anti-psychotic is a terrible response to a hurting person.

@paulbarclay4114

5 ай бұрын

the causes are disruption of the gut microbiome in 80-90% of people, and the ensuing problems the body has as a result 10% more is nutritional deficiencies and related issues maybe 10% is "genetic" or caused by the environment

@groove9tube

5 ай бұрын

Psychiatry ruined ten years of my life. Outpatient treatment was like being in some kind of prison camp. My problem was undiagnosed sleep apnea with insomnia. Many to blame including my primary physician.

@kennethg9277

5 ай бұрын

​@@paulbarclay4114spare us the new age digestive faith-based assertions, kiddo

@kennethg9277

5 ай бұрын

​@@groove9tubesadly, a common story

@kennethg9277

5 ай бұрын

You, OP, are correct

Yes! I fear that many people are getting antidepressants to blunt normal human emotions. It’s OK to be sad if circumstances are sad!

Having a compassionate doctor is absolutely essential to effective treatment. I had an improved labor and delivery anecdotally when having a trained midwife working alongside an obgyn. Neither of which I had a previous relationship with. I had given birth in a different hospital system than the one I was getting prenatal care with. I thought that was extremely intuitive of the hospital to broaden their scope of care so to speak by providing this combined care approach.

@Sunlightsam24

5 ай бұрын

I had midwives for both my kids and that was 28-31 years ago

Use a more objective outcome to evaluate SSRI and SNRI meds, such as reversal of sleep pattern disturbance or appetite disturbance rather than depression scores…

@rachaelvaccaro3420

5 ай бұрын

I agree. Sleep, appetite, eye contact, interactions and pain level all improve with better mood,

Thanks Doc. Excellent video. Very sharp mind

thank you for the commentary on visitor restrictions, although my children are adults, the times that i have been hospitalized and they have stayed by my bedside for extended periods helped me immensely, it took away so much of the stress of being there. there is a case to be made for volunteer or paid visitors who spend time with patients talking to them, holding their hand, brushing their hair, etc. dont know about clinical outcomes, but it would lessen the burden of being hospitalized

WHERE !!!?, do you store all that hi-tech info !!!, you are incredible brother !⭐️⭐️⭐️⭐️⭐️

I've been subscribed to your channel for 3 years and I watch most of the videos. Some go over my head, but I can follow along well enough to know that the concerns you raise "should" and "need" to be addressed. Our current Healthcare system is potentially doing more harm than good. I will continue to follow your career and it is my hope that your platform continues to grow to a place that, if you are up to the challenge, you advance to a position where you can influence policy on a national/global level.

@swangirl63

4 ай бұрын

You are right, we must use our own judgement about medical advice and not accept everything. The third leading cause of death is medical mistakes, after cancer and heart disease.

Time, bedside manner, safe.. and affordable....massage and bodywork are excellent protocols for support.

Thank you for your analysis! We're all losing our minds and need to be reminded of the basics - DO NO HARM . Absolutely critical to review these practices and for shining a light on how to improve trials especially requiring standard of care for the control groups. It's not a long list - safe, cheap and not replacing beneficial treatment. Re long-covid... there has to be some biological marker of long-covid or else why wouldn't you try psychological treatment. Maybe an indicator of long-covid is increased levels of IGG4?? And/or the abnormal proteins that are occuring?? What a mess. Thank you for your help. And please... we need your help and clear thinking re prescribing ivermectin here in NZ.

Wow 😮. I'm totally blown away. Thanks for putting out this information.

As a psychiatrist, I enjoyed the discussion on psychiatric medications. Would be happy to see more related content.

The mind is very powerful!

@ohsweetmystery

Ай бұрын

The mind is not healing anyone in these instances, it is simple delusional in believing something happened.

Yeah you know there's a problem when the Placebo group does just as good as the drug being tested. They do not want people to focus on the Placebo Problem. It would empower too many people.

Excellent doctor!!

Screen for T3 levels in post partum depression

I’m a hard working doctor and an admirer of Vinay. I could use more of his brains.

You're spot on about psychology. General anxiety is not the same as surviving or going through true, life altering, and possible fatal trauma/experiences.

Same with chronic pain and or illness and antidepressants/ anxiety. We’ve lost touch w/ human emotions and feeling or working through them.

Vinnay, thank you! This is really brilliant exposition. And I agree, sham placebo arms are required if at all possible.

An informative and sobering presentation. Reminds me of Mark 5: 25-26 (KJB) "And a certain woman, which had an issue of blood twelve years, And had suffered many things of many physicians, and had spent all that she had, and was nothing bettered, but rather grew worse,"

Fantastic! Midweek Edification Hour with Dr P! Pull up a chair pass the bong! Time to learn something! “on air”

Just came across this channel, no topic is off limit for your analysis. Great❤

Thanks for this lecture Dr. Prasad from a 4th year medical student!

Very much enjoyed your bad hospital visitation practices, we need better practices, not more pills. The quality food activist Calley Means made the same statement in different words: "if your fish are dying from a dirty tank, you don't medicate the fish, you clean the tank"

thank you, dr.prasad.

Love your hair, Dr. Prasad!

im always amazed shams get thru IRBs. & it gives me hope. =). fine entry. _JC

VP is a gem.

Thanks Doc.

I agree but also disagree. We need much ,much better research. One thing about pain is that it isn't so black and white. Let us know exactly when the pain starts. Well, yes, if you are anticipating pain you yell before anything happens, and if you think you won't have pain you don't notice it until it overwhelmes you, but in real life what is the pain level and how often does it happen? My husband has had RA for many years. He yells in pain before anything happens. Now, his heart is involved. I got so upset with his complaining after being checked out by a cardiologist. One night I had had it, told him that he had to stop, he was making himself sick by thinking he was sick, the cardiologist said his heart was fine. So we were sitting in the living room, next thing I know, he's unconscious with only agonal breathing. My point is that pain is a big clue that something major is the matter and people usually know it. Just because this study found 16 seconds different while doing a stress test means nothing. None of us spend every moment trying to analyze if we are in pain. However, when pain overcomes every other thought on our mind, then it is significant.

@gilianrampart8514

5 ай бұрын

Much before thay!

Long covid is mostly just a byproduct of the depression and anxiety caused by the covid response.

totally agree with your views on long covid!

This is an important topic.

Brilliant thank you

As a practicing neuropsychiatrist in the US, SSRIs can definitely cause suicidal ideation when given to bipolar patients suffering from bipolar depression. Since most docs use the incredibly faulty DSM criteria for diagnosing MDD vs bipolar, you end up with a lot of patients with clear bipolarity that get enrolled in MDD trials as they don't hit the arbitrary criteria set forth by the DSM. This also lowers the response rate for unipolar depression meds in the trials. Using classical Kraeplinian criteria for manic depressive, I have had incredible success treating my patients who have been misdiagnosed and mistreated for years.

Loved the last part - about making a bone marrow transfer better instead of thinking of pills as the solution❤

Ketamine improves depression when you know you take it because who doesnt like to get high with depression

*23:00** i actually love Jo Moncrief in this space (if you havent crossed paths yet.)* she just made full prof too im pretty sure, not too long after you. _JC

In addition to vaccination, I would like to know if there is linkage between long covid, sun block, and Vitamin-D. Ignoring politics, under what circumstances where do you think Ivermectin should be used?

@paulbarclay4114

5 ай бұрын

both the mrna injection(its not a vaccine) and the covid infection cause the same types of damage, but generally speaking the mrna injection is FAR worse, and becomes more detrimental with every injection.

@paulbarclay4114

5 ай бұрын

as far as a connection, low vit d levels correlate with everything bad. ivm is incredibly safe and there is no reason not to take it, since "they" wont allow it to be studied in a manner that actually proves whether or not its effective.

Yes, PAIS. Had it myself long ago after mono and eb hepatitis. Took damn near a year to recoup - something like cfs.

Errors and judgment is a euphemism for unbridled greed in this case.

@kennethg9277

5 ай бұрын

If only it were just greed. In my country doctors make little or no money for these kinds of "errors"... but they make them anyway! Much of this is based on arrogance, ignorance and hubris as well as some greed.

I find it fascinating that current science still clings to the mind/body duality when in reality we are dealing with the mind/body/SPIRIT triad. Factor in energy, and the placebo effect and so much more, including the so called "bed side manner effect," not only makes sense but becomes perfectly logical.

I was put on gabapentin for nerve issues to do with my skin by my dermatologist, and i am pretty sure the only reason it was effective was because it knocked me out 😂. Of course I’m not going to have neuralgia if I’m out cold.

Dr Prasad, that was fantastic as usual. I wish the attendance had more questions! The one thing that frustrates me is when doctors use the humanities lingo of "gender" instead of the proper biological term which is SEX. The type of woman who asks for a doctor or nurse of the same SEX is NOT asking for a male impersonating a woman in the "gender" woowoo, she wants a FEMALE. I don't know if male patients/clients make such requests at the same rate as female patients/clients. The medical field needs to stop using euphemisms and stick to using biological terminology. There are two sexes, male and female, nothing else.

what about the Amsterdam University study with muscle biopsies? this is now presented as THE evidence of long covid. but this could also be post viral, like post every otjer virus or other infection?

Neuropsychiatrist here. For the ketamine trial, we need to look at what the other anesthetic was. There was an earlier trial showing that ketamine's antidepressant effect was blocked when administered with an opiod receptor blocker. Basically, was the "placebo" anesthetic also affecting opioid receptors, confounding the result?

‘There was a benefit when the medications were stopped…but you can’t just stop giving people their medicine.’ Oh, the quackery of ‘medical science’.

The horror of knowing that many dementia patients died alone and confused with no way for anyone to explain to them what was going on is one of the many horrors that haunt me about hospital procedures during covid 19. Utterly heartbreaking to think what they endured while in the UK our politicians partied and travelled up and down the country or met up with lovers breaking all the measures they put in place and buying a nice new fridge to store all the wine for the parties.

The part about ketamine for depression interested me. I was given it as an aesthetic, after I broke my arm when a car knocked me of my bicycle. It had the opposite effect. When I woke up, I felt so depressed I didn't want to carry on and was begging the doctor to put me to sleep. Fortunately it was temporary and I felt much better the following day.

Wish I could have heard the questions

OMG....I have been talking about active placebo effects in psychiatric drugs for years......thank you. Until we have a placebo that has relatively the same side effects, but not the primary drug effects all the studies are IMHO invalid.

I agree with so very much of this but did want to comment on the ketamine study. While I completely concur that it is almost impossible to accomplish any blinding in a study on a substance that has such distinct psychological effects, the only thing I think this study shows is that there is not an effect on brain chemistry itself and its impact on depression. I think that this ignores other factors such as what is going on in the mind during the ketamine experience. I worked in a Spravato clinic for a while and, while I absolutely think that the placebo effect is very real, I also saw patients whose minds were locked in the powerful thought loops that are a part of depression begin to come to new insights, establish different thought patterns, and find healing because of things they were able to let go of and things they were able to understand in a new way due to the dissociative and mind-opening effects of the drug. I think if we only focus on physiology this study is damning, but I think that in the case of a treatment like this there are additional variables at play also.

@kennethg9277

5 ай бұрын

God of the gaps. When a proposed mechanism for a drug's action is shown to not work, people are always ready to pop up with the "but it might still work via this other method/pathway!". But the null hypothesis is that any given remedy DOESN'T work, and it's up to you to demonstrate with concrete evidence that it does.

@cayterivera6076

5 ай бұрын

@@kennethg9277 I think you are reading quite a bit into this comment - my point was that there are more variables at play in evaluating the efficacy of ketamine than simply its effect on brain chemistry. I’m not sure how “God of the gaps” applies unless this observation borders too much on the social sciences than you’re comfortable with? The entire scientific process is based on exploring observations - if it is generally observed that ketamine may have antidepressant effects and one theory (brain chemistry only) appears to have no foundation, how is it fallacious to explore other variables at play? Failing to evaluate a study for other possible variables is, in fact, the less scientifically rigorous position.

Great video by the way. Blame YT for me posting many comments, rather than one. It often gets removed and I would rather it just happen to a short post, rather than a long one.

I would put forth a challenge to your point at 19:00 with an example. Did you know that roughly 30-40% of paternity tests come back negative? Are a third of children the result of infidelity? Obviously not. The reason is because the tests are generally only done when there is suspicion. I would expect a similar filter for medical tests. So 30% of practices for which there is enough suspicion to fund a follow-up study are found negative. That's not nearly as bad as your point makes it sound.

@swangirl63

4 ай бұрын

The tests make a healthy person into a patient who now needs procedures or drugs.

*14:30** i suspect ket wont work unless pts are drug naïve (as in all dissociative / PDel "wkends & raves included" naïve.) especially at the kid doses ive seen offered (in most cases.)* but im equally sure thr are real benefits otherwise - & so long as ECT is still on the table, im all for whatever. just maybe more things require a shaman on staff. (we can lose the chaplins if need be) _JC

It might be that for the benefits of Ketamine to be realized the patient has to be fully conscious and attempting to correct thought distortions, practice re-framing, etc. in real-time during an infusion.

First!!!

Please address the lack of true placebos in childhood v.

With the over-prescription of certain antibiotics, imagine if for a brief period, an algorithm randomized their unsuspecting patients to the script or a placebo. And imagine doing this to blinded docs, NPs, & PAs & then comparing across practitioner type. (Just a thought exercise, not meant to be real.)

Never ever heard angina pronounced that way...

I’ve learned so much about studies and bs trails from Dr Vinay! 26:58 my question is even if these effects are placebo, if the placebo effect is outweighing any side effects, isn’t that still a win? Even if 80% of available prescription medications are proven to have zero scientific benefit vs a placebo, should we have people stop taking them if they’re getting actual results through the idea that their medication helps? If we do studies that prove they don’t work, the people who take them see these studies and the placebo benefit is eliminated… I know that’s the right thing to do, but should we?

I have sometimes wondered if a lot of studies in medicine and health have looked for control variables to weigh causality not just correlation. The last example were reported studies that middle aged people with moderately elevated BMIs have longer life expectancy on average than those with rcommended BMI. There seems to be a correlation, but have they undertaken the statistical, econometric studies to weigh causal variables? I am not in expert in all of this, but often times I have the impression quite a few studies do not live up to higher standards.

Does the placebo effect have same/similar duration to that of the tested substance, procedure or device? Maybe also investigating if placebo effect lasts equivalent to or longer lasting than the tested substance or device and whether the difference is statistically significant....also better understanding of the mechanisms of the placebo effect seems valuable. If we can undestand the mechanisms of fooling ourselves, that could be a treatment in some cases. Always enjoy you content and presentations.

I have long covid-19 and have multiple positive physical testing , including small fiber neuropathy biopsy, elevated interlukins, insane elevated crp/esr. I have very abnormal autonomic testing. Many of us do with proper testing. I have low igg/igm. I have gi dysmotility and gp seen on physilogical testing. Many of us when we get proper testing it is coming down to autoimmune/autoinflammatory, small fiber neuropathy, and autonomic dysfunction. The issue is getting proper testing. Also dysautonomia/autonomic dysfunction symptoms often mimic psychiatrc disease process. Recently started ivig really hoping one day to be back to previous life.

@kimfleury

5 ай бұрын

But the question is whether it's any more common than with other viral infections, because those effects are known to occur post-infection from other viruses.

@Amethyst_fairy81

5 ай бұрын

​@@kimfleury I can agree with that and that is definitely a question that needs to be answered

Hello Dr. Prasad. Longtime viewer/supporter here. Thank you so much for your critical analysis of our medical, pharmaceutical, research and regulatory systems. Could you please do an analysis on the EMPEROR REDUCED TRIAL (Empagliflozin) with respect to patients with HFrEF? I am a 69 yo female with heart failure and afib since late 2018. I was put on Entresto as well as carvedilol, digoxin, warfarin, furosemide. Currently only warfarin and carvedilol. I believe I hit a toxicity wall with Entresto in early 2022 when I got very ill (not cardiac). To my knowledge Novartis has never released post marketing data. Why is this allowed? Three ablations over 5 years, numerous ineffective cardioversions. One aborted ablation occured because of a surgical error where a hole was punctured in my heart requiring transfusions and cardiac ICU). The afib has been controlled for 13 months so far. My normally wonderful GP is pushing Jardiance now. I have had pre-diabetes in the 6.0-6.4 range for decades. Not treated. Each time I get a UTI (from meds) and require antibiotic my afib returns immediately. I have chemical sensitivities which are well reported to all my doctors. Some drugs must be compounded. As our health system is in fast freefall here in Ontario Canada why would I take a drug that would have such a high risk to me with little access to timely surgery? Can you do an analysis of absolute risk,relative risk and NNT with this trial? I have a feeling this is another drug, not targeted to cardiac issues originally, whose benefits have been overblown and side effects/QOL under emphasized or ignored. I am suspicious of the skewed gender representation as it isnt reflective of women’s experience with heart failure. Many thanks in advance.

I would love to see you provide education on how cancer is detected, what tests are run, what proves it’s cancer, are there false positive results and if yes, at what level?

I've been on a placebo and was told ahead of time that that's what it was. It was affordable, it worked, and I was grateful but it was weird that it worked, and I wonder if people fear being stigmatized as mentally weak for a placebo working for them. Maybe placebos should be a routine starting place.

The problem with masking psychoactive drugs like ketamine with anesthesia is that anesthetic agents are also psychoactive drugs. You have to be very certain that the pharmacological mechanisms of your anesthetic agents don't interfere with ketamine's mechanism of action, and that they do not have their own antidepressant effects. In that ketamine+anesthesia paper, the authors were surprised by the robust antidepressant response in both of the groups and were unable to disentangle these possibilities.

there might be several non-pharmacological things worth comparing with hypnosis. talk therapy & meditation are two that i think of quickly

I fully support healthy kids as unrestricted hospital visitors. The problem lies in determining who is healthy. Statistically, a kid has 8 colds per year. That's a ton of contagious days. Maybe post covid everyone is more skilled and honest about who has a cold and who doesn't. BUT, precovid, it WAS usually called "allergies" if the parents haD limited other children care options for these times.

@denofpigs2575

5 ай бұрын

Seriously? Eight colds a year? Average? That means that 50% of kids have MORE than that. I wonder how many of those colds were "I can't go to school mom I'm sick"

@nancienordwick4169

5 ай бұрын

@denofpigs2575 for daycare attendees thru grade schoolers, yes. But that was precovid. The viral mileau of communities may have changed.

@nancienordwick4169

5 ай бұрын

@denofpigs2575 most kids won't complain about colds because it's their normal. It's adults that have the complaints mostly.

keep charging. windmills abound. thanks

If you dont put this in med journals as must read Most of us are under those who do not really care and or have no common sense clueless to discrenment

Love that ketamine study...

A single dose of Ketamine did not lift my depression. A course of Ketamine brought long-lasting remission. Only a quarter of participants in the research I was involved in improved through a course of unmasked Ketamine treatment. How anyone felt after immediately after the treatment was irrelevant. I found it pretty horrible, but the acute effects were short-lived. There is an assumption that a given treatment will be effective for the majority, but some treatments will not benefit the most of patients. Maybe medicine is close to the ceiling in treatments that, like vitamin C for scurvy, will bring near, or universal benefit for a given condition.

How about a talk on the vagaries of depression diagnosis?

Maybe it's the material that dust mites are attracted to? What if they like regular sheets, but something about the rubber sheets is offputting to them. Thus, the holes in the rubber sheets are of no effect.

Regarding "long covid", I keep mentioning this in the hopes somebody studies it: Mg deficiency is associated with all of these negative mental health signals. Covid recovery requires a lot of Mg. Long covid symptoms read like a Mg deficiency checklist. Other illnesses require a lot of Mg in recovery as well. For the love of all that's holy, will somebody please check if this is all explained parsimoniously by Mg deficiency instead of floating the psychiatric diagnosis? Especially since many psychiatric diagnoses have malnutritional roots. Word to the wise, a clever study design is necessary because blood tests check only movement of Mg within the system, not its availability within the organs that rely on it.

A sham surgery is really scary. There is really a potential for harm.

Supportive comment

I wish the doctor gave my dad a placebo. rather than antibiotics, for what was most likely a viral infection. I think doctors should hand out vitamin D, as there's some evidence it works and it's definitely not harmful at the recommended dose.

Not errors. It is simple greed.

So I would propose that neither arm of the ketamine study had active treatment. Just like with psychedelics the treatment is the conscious experience. With general anesthesia there is no conscious experience thus no treatment.

Using antipsychotic drugs for depression makes no sense mechanistically. Any effects of quetiapine with SSRI probably due to sedation, which may help with depression associated insomnia.

Vinay, from a psychiatric perspective, recommending SSRIs for individuals with long COVID may not be the most prudent course of action. Such an approach could potentially aggravate their symptoms, including significant impacts on sexual health and the capacity for orgasm, potentially paving the way for PSSD.

It wasn't but 60/70 years ago lobotomies were the newest miracle cure all, migraines, depression, we'll cut your brain in half, fix you right up. Medicine can get it wrong, the problem is doctors are put on a pedestal and is very hard for them to swallow their ego and admit it. Thats why disastrous practicies can continue for decades. The doctors of today who are denying adverse vaccine reactions and saying all the side effects are caused by covid I call lobotomy doctors, because they are the same ones who would have been perscribing a lobotomy for your headache 70 years ago.

VP, if you are concerned about placebo effects, don't look at hypnosis as if it's a message from the flat earth society. Suggestions can be subtle, delivered unknowingly, yet have a powerful effect. All doctors I've talked to dismiss it.