Hi Nathan, you point out that there is an higher chance of IRRs when the mAb has lower human structure. However, these two sources say otherwise: Lenz HJ: Management and preparedness for infusion and hypersensitivity reactions. Oncologist 12(5): 601-609, 2007. PMID: 17522249. DOI: 10.1634/theoncologist.12-5-601 & Vogel WH: Infusion reactions: Diagnosis, assessment, and management. Clin J Oncol Nurs 14(2): E10-21, 2010. PMID: 20350882. DOI: 10.1188/10.cjon.e10-e21
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Hi Nathan, you point out that there is an higher chance of IRRs when the mAb has lower human structure. However, these two sources say otherwise: Lenz HJ: Management and preparedness for infusion and hypersensitivity reactions. Oncologist 12(5): 601-609, 2007. PMID: 17522249. DOI: 10.1634/theoncologist.12-5-601 & Vogel WH: Infusion reactions: Diagnosis, assessment, and management. Clin J Oncol Nurs 14(2): E10-21, 2010. PMID: 20350882. DOI: 10.1188/10.cjon.e10-e21