I have a good question. What happens to the cells that produced the spike proteins? Are they killed? how many cells are affected and produce them? Does the body start attacking it's own cells as a result? thanks!

@varyolla435

8 ай бұрын

Yes. They are subsequently eliminated and replaced by new normal cells following activation of your immune system. As to how many that depends upon the level of exposure - meaning how many viruses/protein spikes circulate in your bloodstream.

What mechanisms would explain the rare possible reported side effects such as myocarditis, clotting, and thrombosis? Would this come from the spike protein itself or is it the result of the immune system destroying the cells that have been instructed by the mRNA to produce spike proteins?

@ThuyTran-sm4by

2 жыл бұрын

Good questions!

@andrewdl6824

2 жыл бұрын

These complications can occur after viral and bacterial infections as well. It is likely an autoimmune response, which means immune cells attack other tissue/protein during and/or after the battle with the infected cells. These people would likely have the same response to a Covid infection, possible more likely and more severe. I could be wrong but autoimmune conditions run in my family. Autoimmune responses more typically occur when chains of animal protein pass through a leaky gut into the bloodstream... and the immune system is tasked with removing it. Because mammal meats (complete proteins) resemble our own tissue our immune system learns to attack our tissue. This is just theoretical currently, but many people have sent all types of autoimmune conditions into remission on plant-based diets... so we'll likely see enough proof to confirm these mechanisms soon.

@martymcfly5423

2 жыл бұрын

Good questions!

Question: if we don't know how long natural immunity from having covid lasts, do we know how long immunity granted by the vaccine lasts? How often will we need a new jab, every 6 months, every year?

@JohnWSaundersIII

2 жыл бұрын

We can't know yet. It's a new virus.

@earthboundangel2926

2 жыл бұрын

The virus is constantly mutating, so we may well need another booster shot--especially if too many people refuse the vaccine, which allows the pandemic to continue and makes the appearance of mutations more likely.

@nickhurley2472

2 жыл бұрын

Who cares. As long as we’re safe

@TheRykpaalt

2 жыл бұрын

@@earthboundangel2926 And likely to be less virulent- look at Ebola, killed so fast it would not spread as well. IMO, viruses become so that they can infect more. Kinda like "not killing the golden goose (host".

@DrZoonotics

2 жыл бұрын

@@DupageDragonsFan94 "too many people get the vaccine and the virus adapts" ???? Where did you get that idea from?

Why have mRNA vaccines never been used before, although they’ve been studied for 20 years?

@DannildaCorrea

3 жыл бұрын

If you look it up, medicines of all type take between 15 and 35 years to be created, developed..etc. We know much more now so maybe it will take less, but that is how long, or even more, it takes of studies, doing it over and over again. This is necessary to ensure it works and that there are not side effects that should not be there.

@tmorelli1982

2 жыл бұрын

It's actually been waiting in the wings for quite some time

@JohnWSaundersIII

2 жыл бұрын

These vaccines were in the right place at the right time. Example: a Phase III clinical trial can end when "enough" people from the placebo group get sick. Because we're in a pandemic, that doesn't take long. Imagine how much longer it would take if there were 1/1000000 as many cases.

@dallysinghson5569

2 жыл бұрын

mRNA vaccines are more difficult to store and we haven't needed a vaccine in such a rush before- mRNA vaccine production is massively scalable.

So, mrna delivers the instructions "to the cell" to make the spike protein. What part of the cell, exactly, makes the spike protein? What stops the mRNA from entering the nucleus? How do we know the spike protein doesn't break off and go AWOL? How do we know that we should not be concerned that the toll-like receptor #4 has been down-regulated to reduce the immune response to the mrna? Why won't that impact how our immune system acts against other pathogens? Natural immunity is almost inarguably more robust and durable than induced immunity. Why would we still want further risks from the pathogenic spike protein, when there is likely to be almost zero benefit, and only risk? Natural lasts longer, and operates on more levels, and does not have just a narrow focus solely on the spike protein. That means there is less chance for virus to mutate in ways that evade the immune response.

Question: So it states that this mRNA is 'NEW', but not unknown -in development for decades... Why is it that mRNA vaccines have only been introduced now for Covid and not previously utilised for other viruses & diseases? If it is safe & given that it is emphasized, how much suffering we are saved by not having to suffer with the actual illness (from weakened strains used in (all?) the other type of vaccine)?? There must be a good reason why mRNA vaccines have been developed & worked with for "decades".... but NOT made it to mainstream use/the preferred choice of vaccine type... until now???!

I am for vaccine but I have a question: If you say as per the video that even if you recovered from covid 19 you still need the vaccine because the protection will not last what make you believe the vaccine protection will last? Otherwise why vaccinate or at least why vaccinate the ones who have antibodies??

@taraakins8273

2 жыл бұрын

I've wondered that as well. I had covid in 2020. My entire household did (first time we've ever all been sick at once. Ever.) And it took me 4 months to heal. Honestly I should have at the very least gotten on some oxygen because I wasn't thinking clearly at all due to a lack of it. I gasped and gasped and gasped for 2 weeks then it went to a little more bearable each week but at 3 months I was still tired and still had random but strong heart palpitations (I was born with asthma and a heart murmur maybe that's why I was hit so hard in the lungs and heart) after all that and the cdc warnings of heart related issues for some who take the vaccine I'm honestly afraid to even try and since I had covid so badly already why should I risk it... Unless the antibodies don't stay then we'd need a constant stream of boosters I suppose ... Its just very concerning. I've never not received a vaccine that was available. Even the flu vaccine I get every year. I even had the h1n1 vaccine back in 2009. But something about this scares me and my gut says don't do it. But I don't worry about my family having got it. I just worry ill end up sick heart wise and need care and I don't want them to have to deal with that if possible.

@petebaldwin6361

2 жыл бұрын

There isn't enough data yet, but the theory is that getting the COVID vaccine strengthens the immune response and T-Cell memory just like getting the 2nd dose of the vaccine.

@GovnaBuckingham

2 жыл бұрын

Both natural immunity and vaccine immunity go down over time. The body will produce less antibodies each month regardless of if you have natural immunity from an infection or if you got the vaccine.

I understand this process almost completely. There's just one thing I want to know: what cells of mine does my immune system attack and kill because those cells absorbed the mRNA and are producing this spike protein? Phagocites? Muscle cells? Dendritic cells? How many? I'm imagining I'm sacrificing billions of my own cells to train my body how to fight the virus. How long does it take my body to recover these sacrificed cells?

are most of the spike proteins expressed at the muscle cells at the injection site or do they travel around? Do the mrna only express the spike protiein at muscle cells or can it go in to other cells ? thanks

Once the cell expresses the spike protein on its surface, our body recognizes it as not normal (not a proper self) and then what happens? All the videos stop at the same place, clearly more happens and we don't want a bunch of spikey cells hanging out in our body. Does a phagocyte come along, destroy the cell and present it to B cells and then we make antibodies and then the body cleans up all these spikey cells? What happens if one of these cells is a neuron?

@teehee4096

3 жыл бұрын

the spike protein cells are all epithelial cells inside of the muscle tissue right at the point of injection. once the body has produced its necessary antibodies, phagocytes destroy all of the spike protein cells, which are very low in number. after this the memory B cells remain in your lymph nodes until you are exposed to COVID-19 later on, which is when they will immediately flood the body with antibodies to eliminate the virus before it becomes noticeable. hope this helps you visualize the whole thing.

@Jinryuushi

3 жыл бұрын

Thank you both for the question and the answer.

@mblackops2

3 жыл бұрын

@@8genmilitaryfamusa671 Basic information on how a vaccine works

how does the MRNA vaccine work against the Variants (isn't the RNA of the variant different?) if the RNA sequence of the vaccine is based on the original COVID virus?

great info but the music is horrendously distracting (too loud)

How long does the MRNA remain in the body, instructing our cells to produce these fragments?

@nomi253

2 жыл бұрын

mRNA itself is rather unstable (will degrade rather quickly, especially compared to other types of RNA), thus it will only be present for a few days before it gets broken up into protein fragments.

One question that doesn't seem to be addressed in these types of videos/articles: What is the likelihood that an mRNA vaccine could either create an autoimmune disorder or trigger/bring out an underlying autoimmune disorder? It seems the vaccine teaches your body to destroy something that was created by your own cells. That sounds an awful lot like an autoimmune disorder. And it's very disturbing to think about the body creating a permanent immune response to something that it shouldn't be attacking. Up to this point the only reassurance we have is that it seems this hasn't happened in the millions of people who have already been vaccinated. Is there anything else that anyone can point to that could answer this concern?

@MrRastafl

3 жыл бұрын

To clarify, your body actually creates and replicates the actual virus if you get it, this is not exclusive to the vaccine. This is the way viruses work, they highjack your body and use it to make itself. All the vaccine is doing is showing your body how to recognize the virus and not get highjacked...

@jehanne5865

2 жыл бұрын

@@MrRastafl are the organs repartition of cells infected by the virus and cells 'hacked' by the mRNA the same?

@EmInMI80

2 жыл бұрын

@@MrRastafl is right about this. If you haven’t had the delightful opportunity of watching an educational video about how viruses infect cells, and then use those cells to replicate themselves, go look it up on KZread. It is pretty freaky.

so if you were infected by the Whole Virus which aside from the spike protien present a slew of othet prptien that can stimulate an immunr response. you are say that exposure to the spike protien along is bettet than exposure to a whole virus and confers a longer immunr protection?

@imanahmed7278

3 жыл бұрын

When you get an infection, or whatever it is that needs an immune response, there are two waves of immunoglobulins that are made to respond: an initial small wave of IgM and then a much bigger and sustained response with IgG. The worrying thing about corona is that it suppresses the IgG response, which is the principal immunoglobulin needed for the immune response+ immunity. That being said, the vaccine doesn’t cause an infection, it simply introduces the markers needed to identify corona (spike proteins) to the body. This way, we know the immunity is conferred and there’s not the worry of the suppressed IgG response like if you were to actually be infected

@MrRastafl

3 жыл бұрын

No. The spike protein is the only part of the actual virus that would ever enter your cell anyway, so that is why this is all that needs to be made! The response above is way too complicated! :)

@portarican82

3 жыл бұрын

There are many other proteins, but the spike protein signature is unique to Coronavirus. (That is why it gets the name corona which is Spanish for crown) By letting the body identify the spike protein you allow it to be able to find and identify Coronavirus as the enemy and mount an immune response.

@DrZoonotics

2 жыл бұрын

@@MrRastafl Basically, it's like giving a picture of a suspect and saying "If you see this guy, zap him."

@julievalerie2198

2 жыл бұрын

The spike protein does not confer longer immune protection than other proteins on the viral cell. But it was chosen because it is the protein that lets the virus enter and infect our cells, so it is important that our cells recognise this specific protein. Also exposure to whole virus is more dangerous than exposure to only the grabby arm of the virus.

Are dendritic cells the intended and the only recipients of the synthetic RNA? Do I understand this correctly that dendritic cells are unique in their ability to internalize exogenous RNAs (or get infected by a virus), express it, and then present the new antigens on the surface for other cells of the immune system? Thanks!

@julievalerie2198

2 жыл бұрын

Hello, you've pretty much got the process correct although dendritic cells are not the only cells that are able to do this. Dendritic cells are what we call an Antigen Presenting Cell (APC) and there are quite a few of them (E.g. macrophages), dendritic cells are just the main ones as they are the most effective at processing and presenting antigen from foreign bodies, since it is their main job.

Will this reduce the transmission rate and by how much? Cheers

Good to see an informative video. Why on Earth was such loud background music added to something people need to concentrate on what's being said though? 🤷‍♂️🎶

What would happen if someone's body didn't make any antibodies when the spike proteins entered their cells? Is that a possibility for people with compromised immune systems?

@mleecthulhu

2 жыл бұрын

Yea, and what about ppl w autoimmune disorders??!!

@earthboundangel2926

2 жыл бұрын

Good question. Possibly the level of antibodies should be tested--I think this is called a titer test--to determine whether an adequate level of Covid-19 antibodies are present in the blood.

@billycrunches8117

2 жыл бұрын

Then you would get blood clots and all symptoms youd get if you had covid

@chrisscheri9566

2 жыл бұрын

@@mleecthulhu Those people could respond to the vaccine with a cytocine storm... over production of T cells that start to attack the body.

@julievalerie2198

2 жыл бұрын

Hello, I wouldn't say it is a possibility for someone to not produce any antibodies, but some people might produce a lower titre (amount) of the antibody. For immunocompromised individuals, some might not be recommended the vaccine but some might. It all depends on their specific immunodeficiency, for example if someone is deficient in B cells, then the vaccine might not be very effective at protecting them because they don't have the capacity to make enough antibodies. Other cells of your immune system such as T cells could still help clear away the spike protein, the individual just won't have the lasting protection vaccine are designed to give.

What is the mechanism used to introduce the mRNA into the cell?

How is the mRNA teaching the cell to recreate the spike protein if it doesn't enter the nucleus?

Please explain how exactly does the cell start expressing the spike protein?

What happens to all the ingredients used to transport the mRNA into cells once it connects with a cell? Do the sugar, lipids, PEG molecules stay within the cell and repopulate, or end up staying in the body for a prolonged period? How does the body get rid of them?

@thapelomotsabi2742

2 жыл бұрын

Well from the little knowledge I have, they are simply degraded by the enzymes

A simplification: The vaccine produces safe antigens that then allow the immune system's NORMAL RESPONSE of detection and antibody (both short and long term) production. In this case, the immune system has detected the antigens and has produced the memory cells so future encounters will be dealt with quicker. Right? 3 QUESTIONS: 1) If memory cells are produced, why the question about immunity longevity? 2) How do the vaccines guard against the fast antibody autoimmune behavior? 3) My concern is that when we "help" the immune system, do we make it weaker? Do we become more and more dependent on vaccines?

@noname-kx4cu

2 жыл бұрын

1) immune system is pretty random when it comes to how long it keeps the memory. For chicken pox it's keeps it for basically your whole life. For the flu it's like a year.

@0RiCeBuBbLeZ0

2 жыл бұрын

@@noname-kx4cu because flu is different strain each year

@kimblejest4290

2 жыл бұрын

@@noname-kx4cu flu also changes it's structure every year.

So how does the vaccine produce a better immunity than an infection and recovery of covid? (which is the assumption in that you should be vaccinated even if you've had it)

@darkale658

2 жыл бұрын

studies suggest that being vaccinated offers a more consistent degree of protection than getting covid and recovering, to the degree that you are less likely to be reinfected again if you are vaccinated. there is also a recent paper by Greaney et. al. in Science Translational Medicine that suggests that the antibodies you get from the mrna vaccine are more broadly binding, which confers better protection.

@todo870

2 жыл бұрын

I would think that the vaccine will have a greater variety of synthetic mRNA thus teaching your body to produce a greater variety of spike proteins. This may not be true, but it seems logical to me.

Since there is still a small possibility that a fully vaccinated person can become infected with COVID-19, albeit a mild course of illness, does the vaccine prevent against long COVID? The data suggests that most long haulers had mild illness. Thanks!

I just got my second mRNA vaccine and feel sore and achy. I was wondering why there is such a strong reaction in the body with this vaccine but not others? (Please answer if your knowledgeable)

@Cerulean0987

3 жыл бұрын

I'm no expert, but I am curious about your normal reaction to flu vaccines. I can't speak for others, but for me flu vaccines have no side-effect. No aches, no soreness, no chills, no headache, nothing. The most I experience is a teeny bit of soreness at the injection site which to me is certainly understandable since the injection is directly into the deltoid muscle, but that quickly goes away. Similarly I haven't experienced any reactions with the COVID vaccine.

@renatamanowitz116

2 жыл бұрын

I didn't have any reaction to the vaccine. Maybe your body developed more antibodies than mine

Why use our body to make fragments instead of manufacturing them by more conventional means?

Which cells in the human body are used by the MRNA vaccines to make the fragments?

Here are some questions. I don't expect all the answers, but maybe people and or researchers need to ask themselves. 1. Does the lymphatic system absorb some of the vaccine material and disperse it into the circulatory system? If so how much? 2. If this mRNA material is in your circulatory system what effect will it have? 3. If your vascular endothelium (arterial/blood vessel/capillary) walls absorb the mRNA material, will the cells composing these walls develop spike proteins on them? If so what effect will that have? 4. If the cells making up the vascular endothelium (arterial/blood vessel/capillary) walls develop the spike proteins on their membranes, will blood platelets form clots because of these spikes?

What happens after our own cells are able to produce the spike protein? Will they be less versatile to other unknown viruses or variant of Covid-19

The reactions to the vaccine seem to have a wide range. Are the vaccine reactions any indication of how your body would or would have reacted to contracting COVID?

So why did it start with 1 shot, then 2 now boosters. Israel is the most vaccinated country in the world and they now having outbreaks.

Im happy to finally see someone recommending guidance for hand washing along side the vaccines. Its concerning that hand washing is not promoted during the pandemic

Which cells produce the spike protein? Are they then destroyed by the antibodies? How many cells produce the protein? For how long?

@edwardvillano9547

3 жыл бұрын

@@danieldebruijn2107 Isn't it the T cells that first stick to the spike protein and then alarm other immune cells?

@mblackops2

3 жыл бұрын

@@edwardvillano9547 Yes T Cells are the first to respond in Adaptive Immunity

if the cell puts that protein on it's surface will the immune system attack that cell?

@imanahmed7278

3 жыл бұрын

Yeah! That’s the basic idea. Essentially, an antigen is just a word for a marker. All our cells have “self antigen” markers, which we refer to as MHC 1. Any other type of presentation of proteins or foreign types of antigens become a red flag for immune cells to destroy. That’s why the spike proteins presenting on self cells flags immune cells to destroy it, teaching them to recognize and fight anything with those same spike proteins it encounters again

sir can i use your video for seminar and translate it into other language?

How does a long molecule like mRNA enter cells after vaccination?

Where are they getting Mrna from

The video says people who have already been infected with COVID should get the vaccine because one one knows how long the natural antibodies last. Do we know how long the mRNA vaccine stays in someone's system? Seems unprecedented in medicine to vaccinate someone who already has the disease (e.g., no one suggests I get the flu or measles vaccine after I've had the disease and recovered).

@ch2nda

3 жыл бұрын

Your physician better be suggesting you get the flu vaccine every year whether you have had it or not. The flu changes yearly as do the vaccines. Flu spikes in the Southern Hemisphere so we in the Northern Hemisphere use that info from that flu season to make our vaccine. And just like the Covid vaccine, the vaccines don't always mean that you won't get the virus that year, but what it does absolutely do, is weaken the virus a lot because you have antibodies and Memory B and T cells ready to fight it. The end result being you get the flu or Covid, but you don't get hospitalized for it, die from it, have long term complications from it. It's a much milder version of CV19 or influenza, and I don't know about you, but I would far rather have a mild illness for a few days vs. a catastrophic illness that either kills me or leaves me with lifelong complications such as stroke, brain damage, clotting disorders, kidney failure requiring dialysis, extremely decreased lung capacity sometimes requiring lung transplants, same with damage to the heart, etc. I'm an RN for 22 years and work in pediatric ICU, Neonatal ICU and general pediatrics. I have seen young kids die from flu every year. Flu is very bad for the vulnerable populations of the very old and very young. I've seen some bad long term effects from CV19 already, too. My best friend had several strokes in April 2020 and she is going to be effected for the rest of her life. GET THE VACCINES!! Both Flu and CV19. MMR too since measles is now on the rise because of antivaxxers. My husband is an ER doctor and has patients die from preventable diseases every day. It's stupid to play around with your life like that.

@earthboundangel2926

2 жыл бұрын

It is absolutely recommended to get the vaccine even if you had a previous infection because the length of time that your immunity will last is unknown and second infections are often much more serious than first infections. Additionally, new variants are continually evolving and some are more adept at defeating the immune cells produced by infections from other variants.

Does anyone know any other vaccine that uses mRNA technology?

@earthboundangel2926

2 жыл бұрын

mRNA technology was in research and development for many (37?) years with hopes of creating a vaccine for HIV/AIDS. Then Covid appeared and all that already completed R&D was appropriated to create the Covid-19 mRNA vaccines. The HIV/AIDS vax is not yet licensed.

How does an mRNA vaccine interact with other vaccines? E.g. Gardasil (HPV) vaccine? How much time should one wait after receiving an mRNA before administering another type of vaccine?

@earthboundangel2926

2 жыл бұрын

Ask a doctor or pharmacist.

@JB-dv7ew

2 жыл бұрын

I'm no doctor so don't actually take my advice but some vaccines can be taken with others and other vaccines you have to get 8 weeks apart

How long does the vaccine last after 2 doses and will we need new shot if new variant shows up

Should i get a shot for my newborn?

Why doesn't the immune cell destroy the human cell that is now presenting the synthesized spike protein?

@mblackops2

3 жыл бұрын

What do you mean?

Good video but, please ditch the ANNOYING music in the background. It serves no purpose and distracts from the message in the video.

Thank you for adding pictures so my ape brain can understand

One thing I don’t quite understand is, when these so-called spike proteins are produced by our cells and get presented on the cell surface, hence leading to our intrinsic antibody production, will these antibodies neutralize/kill off the cells that make the spike proteins in the first place?

@MrRastafl

3 жыл бұрын

Yes, they will! And your B cells will be left to remember in case the virus shows up!

How long does the spike protein stay in body?

@EddyA1337

3 жыл бұрын

it's not the not the spike protein that stays but B cells and memory T cells that recognize and attack the virus as it's covered in spike proteins that the mRNA in the shot you got told your cells how to make. You don't even need a live or "activated" version of the virus to make an mRNA vaccine, just it's genome. Pfizer and BioNtech had the version of the vaccine created, the one that was put in your arm, in about 2 months after the Chinese published the virus's genome online. For instance, when the Trump and other VIP people like senators and congressmen got sick they got the vaccine, as well as monoclonal antibodies and convalescent plasma packed with covid antibodies, I'm talking way back a little under a year ago. The only challenge was encasing the mRNA instructions in to a robust lipid nanocapsid that could push itself through the lipid bilayer of your cells. Then your mitochondria and ribosomes simply make the spike protein, your body remembers what it is like and creates antibodies for it. The Johnson and Johnson vaccine uses a modified adenovirus (harmless to humans) but they're modified to have the spike protein that Sars-CoV-2 has on their outer shell, which normally they wouldn't. The Johnson and Johnson vaccine is literally a harmless virus created in a lab, something that is completely artificial and doesn't exist in nature, to teach your body to resist Sars-Cov-2. People talk about how they think maybe coronavirus is man made "do we have the technology though?" people say. We've had the tech for decades, it's now we make live attenuated viral vector vaccines. In the past for other vaccines the reason it took ten years was because they had to culture the virus generation after generation and allow it go through enough mutations that it would be in a weakened, or non active state, but still similar enough to the real deal to be able to provide a sufficient immune response. IDK about y'all, but I'd rather have a vaccine that programs my cells to make what it needs instead of a modified virus, hypothetically a vaccine could mutate if it is live. mRNA vaccines can't mutate because they're not even a dead virus. Just a nanoscopic droplet of fat with an mRNA payload.

@jerryplumb7028

3 жыл бұрын

I thought you all were going to answer questions from the comment section? This question is 2 months old.

Will you be making this video in other languages? :D

@scamp9360

3 жыл бұрын

Spanish please!!!

as advertised, antibodies are produced to the spike protein. None are made to the vcapsular portion, which may, IMO, prove to eb a major shortcoming of this method, not that it does not work, but the capsid may be a better target. Time will tell.

@jehanne5865

2 жыл бұрын

that's interesting. Is it really possible to create vaccines that target the capsid? Would that make new vaccines more efficient against new variants (assuming the mutations of virus tend to change the spike proteins but not the capsid's)?

I've been looking for a short video that explains this from a reputable source. Perfect!

If this has been studied for years, why is it just getting approval now? Were any successful animal studies completed prior to this being rolled out?

@EmInMI80

2 жыл бұрын

You can’t just get a blanket approval for any mRNA vaccine. You have to get approval for the specific vaccine that’s developed by a specific company for a specific disease. Hence, why each vaccine needed to go through its own approval process even though mRNA vaccines have been well studied over several decades.

How long does the infiltrated redblood cell produce said spike protein? Is it there always and are new cells born with the same spike proteins from there on till the body dies? Also is every red blood cell infiltrated or just some?

Do the synthetic spike proteins remain on the surface of the cells that have been "hacked" by the mRNA or are they "released" by the cell?

@renatamanowitz116

2 жыл бұрын

They video says they are eliminated by our antibodied

@jehanne5865

2 жыл бұрын

@@renatamanowitz116 that does not answer my question.

@julievalerie2198

2 жыл бұрын

They are either processed by a dendritic cell (APC) and presented on their surface (it is a dendritic cell's job to engulf, process then present antigens for immune cell recognition) or are produced and released by other cells.

@nomi253

2 жыл бұрын

Good question! So for the spike protein itself, it will typically remain in the body for a few weeks in the body. The immune system recognizes it as foreign material and will eradicate it, even if attached to a cell. However, if by chance the immune system were to miss it, because it is a protein it will naturally degrade over time. Hope this answers your question!

I would love to know the answer: Once inside the patient, will this mRNA machine be working in perpetuity? I see no turn off mechanism.

@earthboundangel2926

2 жыл бұрын

The cells that display the spike protein will be destroyed by the immune system and their remains disposed of in the same way that cells that die a natural death are disposed of. The antibodies, however, remain to fight any future infection. For how long they remain is unknown at this time. Some vaccines confer lifelong immunity, but this is a new virus and a new vaccine, so we just don't yet know.

@jehanne5865

2 жыл бұрын

@@earthboundangel2926 which cells in which organs? are the cells 'hacked' by the virus to produce the spike protein the same in quantity and repartition into organs as those infected by the virus?

Thank you for educating the public.

Great info - thank you, we're grateful. But, pleeeease, no meaningless beat under the audio - it adds NOTHING and degrades comprehension.

When will the J&J vaccine be available for LAUSD employees ?

@MrRastafl

3 жыл бұрын

Don't discriminate! Get any vax that is available!

Can mRNA vaccine make my muscle cells healthy by making them repair?

Excellent video - explained succinctly while discussing misconceptions.

Are our cells that express the spike protein destroyed by our immune response?

@Gaiagirl85

3 жыл бұрын

I'd like to know this too. And the potential for autoimmune response by attacking our own muscle cells. (In a natural infection the same thing happens, but the virus doesn't normally get into the muscle cells... it's an unnatural place for a respiratory virus to be).

@MarleeM-M

3 жыл бұрын

If I understand what I've read about this topic correctly, the cells that express the spike protein are normal body cells that are basically displaying the spike protein like waving a red flag to get our immune system in gear against that protein, so they shouldn't be destroyed in the immune response. Your immune system can discriminate between an actual pathogen (e.g. coronavirus w/the spike protein) and a normal body cell displaying the spike protein to activate the immune system.

@mikeketterman7720

3 жыл бұрын

@@MarleeM-M I’ve been looking for the same answer, all the video seem to be skipping over it… I’d like a better explanation of how your antibodies know the difference between a human cells with the right spikes and a foreign cell with the right spikes.

@darkale658

2 жыл бұрын

It is worth pointing out here that traditional vaccines work the exact same way of eliciting our cells to make spike proteins... the only difference is that traditional vaccines use attenuated viruses and mrna vaccines do not use viruses at all, just snippets of mrna.

Is the vaccine recommended for women who are pregnant or actively trying to get pregnant?

@EddyA1337

3 жыл бұрын

I feel like you could have asked google that and gotten your answer from a much more reputable source than a randomer on youtube.

Highly informative and clearly stated. This Respiratory Therapist thanks you very much for this video. I have done extensive research into both DNA and mRNA vaccines, but people always like to have some literature or accompanying information to further inform them. This will help very much.

how does the mrna teach our immune system what the spike is without any traces of it. is mrna just a simple stimulant?

@earthboundangel2926

2 жыл бұрын

mRNA is just a set of instructions that ribosomes inside the cell use to produce the protein which is then displayed on the cell's surface for immune cells to find and identify. Once identified, an army of antibodies is produced that will be standing by if you become infected. Vaccines don't prevent infection; they prevent disease through preparing the immune system to fight off a specific pathogen.

Slow down !

Good video. But, ditch the music.

Daeeemn the music is a bop

@MinecraftSemlan4

2 жыл бұрын

Still vibing to it

@MinecraftSemlan4

2 жыл бұрын

Stil be wildin to it

Thank you! Great simple video.

@jackiepmorgan114

2 жыл бұрын

yes much to simple

Great video! My cousin’s wife was just asking this morning if the vaccine impedes fertility. Any credible sources for her are greatly appreciated, this will be her first pregnancy.

@JohnsHopkinsSPH

3 жыл бұрын

Hi, thanks for your interest! Getting the COVID-19 vaccine will not affect fertility. You can read more information on Johns Hopkins Medicine's website: www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/the-covid19-vaccine-and-pregnancy-what-you-need-to-know

This is way too difficult for many KZreadrs to understand---I mean, many people on KZread dislike videos that say the earth is spherical, and you guys want them to understand this? LOL.

@blaireofhylia1572

2 жыл бұрын

It had to be made.

PLEASE GET RID OF THE BACKGROUND MUSIC!!

how does the mRNA actually get into each cell? what is the method it enters a human cell? is it injected into each cell somehow?

@jakmageson2050

2 жыл бұрын

research how RNA works, it's quite interesting

@MrAgentCandy

2 жыл бұрын

its wrapped in lipids, which make it easier to enter the cell

Why did they choose to use mRNA vaccines instead of traditional method of vaccines for Covid-19?

@xx-rr3ug

2 жыл бұрын

Yes this is my question too.

@jaredstrapp6623

2 жыл бұрын

Because they are quicker to produce and can be manufactured in large quantities much faster.

@kanayo8816

2 жыл бұрын

Good question

Question: Can you have too much? what is the line or cap on the amount. So when is a third shot booster coming in law? and when is a fourth? (concerning, as death is a hard malady to treat ----- "Trying to Vaccinate Against Latest Chinese Virus", thanks!

why are side effects not uncommon? why are there side effects at all? what is causing those side effects?

What happens to the mRNA? Cell eats it, produces the spike proteins but what happens to the mRNA then and/or to the cells containing it? Do the cells continuously produce these spikes and immune system continuously has to attack it, please?

@TonyPerryOfficial

2 жыл бұрын

It gets filtered out by the liver and you pee it out.

@nomi253

2 жыл бұрын

Great Question! So a common misconception is that mRNA will stay in your body for a long time, this is untrue. mRNA is unstable, which means it will degrade rather quickly (especially compared to the other types of RNA). This is one of the reasons the vaccine must be kept in frigid temperatures, to slow the rate at which the mRNA will degrade. After a few days of being replicated in the cell, the mRNA will be naturally be broken down. After it is degraded, no more spike proteins will be produced, thus the immune system will no longer need to eliminate them, but the cool thing is it will still have the antibodies needed in case you do get sick from the real virus. Hope this helps!

So no toxic adjuvants? Nothing that can trigger a bad adverse reaction?

Hard to hear the content over the music

Why do people think it will modify their DNA?

@noname-kx4cu

2 жыл бұрын

Because of misinformation.

Still censoring inoffensive science-based comments I see......... Ergo = still a useless clickbait channel rather than an educational academic one.......... 🤨

How long mRNA vaccine remain on the body...