Thanks for this! My mother was diagnosed with Stage IV Type-A lung cancer a little over a month ago. She started chemotherapy a couple of weeks ago, so this information is very relevant to me and definitely simplifies the concept enough for me to adequately understand it.

@darkscienceyt

5 жыл бұрын

I'm sorry to hear about your mother, I hope she responds well to the treatments and gets rid of that nasty cancer. I also want to say that your response to the video is exactly what my goal was for this channel. Helping people understand things even just a little bit better so they're less uncomfortable and little more confident in how things work. Knowledge is power. I hope your mother beats her cancer. Excelsior!

@ultralaggerREV1

3 жыл бұрын

It’s been a year, what happened then?

@TheOfficialCzex

3 жыл бұрын

@@ultralaggerREV1 She's doing great! The cancer hasn't spread since.

@ultralaggerREV1

3 жыл бұрын

@@TheOfficialCzex i’m glad to read this... Out of topic: I noticed your profile pic is a GIF, how do you do that?

@TheOfficialCzex

3 жыл бұрын

@@ultralaggerREV1 Just upload a GIF instead of an image.

questions for science: teaching me the answers to questions i didn't know i have & am now fascinated by.

I remember in the h3 podcast in where totalbiscuit (may the emperor bless his soul) said that chemo was basically about hoping that you kill the cancer faster than you kill the patient. Those words have stuck with me for a long time.

@marguskiis7711

3 жыл бұрын

Basically its true.

@weirdpuzzledude1876

3 жыл бұрын

@@NinoCristianini i miss him too I wish that he stuck around long enough to play doom eternal he would have loved it.

@nanobotsaviour3733

2 жыл бұрын

@@weirdpuzzledude1876 At least he didn't have to witness Diablo Immortal announcement and recent Blizzard direction, he would have hated it.

My old school friend didn't survive the blood cancer despite hard battle....he was just 17....10 years of togetherness...may God give his soul eternal peace.

@LightForxes

2 жыл бұрын

:(

Our doctor also told us that the chemo drugs, in addition to directly destroying cancer cells as you mentioned, "mark" them in some way for radiation to target and destroy them. Interesting stuff!

serious love your stuff, I always find it really educational on things i have always wanted to know about.

We learn more here on this channel than a full 4 years of science in high school

@darkscienceyt

5 жыл бұрын

:D thanks!

@TheReck12

5 жыл бұрын

Why the fuck would you need to know how chemotherapy works in general education

@praimchandplays3257

3 жыл бұрын

No cappity

@5falltv895

3 жыл бұрын

@@TheReck12 if you ever reincarnate as a cancer cell

@birdies8397

3 жыл бұрын

Do you still learn about the cell cycle in high school? That’s extremely relevant to how chemotherapy works. Certain chemo drugs target different parts of the cell cycle. So, in a way, you do kinda learn some of the basics.

I love your channel man and I'm glad your still making videos after you lost your videos, keep it up and pursue for more knowledge

@darkscienceyt

5 жыл бұрын

Thank you! It means alot right now

You never fail to amaze me with your videos, keep up the good work! Also please consider using a gray backdrop since white can feel like too much sometimes

It's like dropping nuke on a city and hoping the good guys survive and are able to rebuild the population

@ulick1692

3 жыл бұрын

No it’s not

@hectorsandoval1976

3 жыл бұрын

@@ulick1692 how he explained it. Yes it is lol

@Convertscafe

3 жыл бұрын

@@ulick1692 yea it is lmao

@mikep11218

3 жыл бұрын

Exactly. Chemotherapy is a murderous scam. Tremendous shame how easy it is to fool people. But then again, many people want to be fooled.

@jessepinkman1471

2 жыл бұрын

@@mikep11218 nice satire you got there

Yet again great video!

Crisp and clean information. Beautiful video!

i always wondered this exact thing...thanks for the great explanation!!

Great to see a video from you

I'm really grateful for your sophisticated explanation

My grandma recently died after a long battle with cancer in the uterus...

Been under chemo for two years .... it has helped quite a bit !!

@chucky7285

3 жыл бұрын

Been a year since you wrote that.. How are you doing? You still with us?

@ice-mm6em

3 жыл бұрын

@@chucky7285 his name - “obvious troll”

@chucky7285

3 жыл бұрын

@@ice-mm6em I can't stand fictitious accounts

Great general info - FYI, medical typist here for oncology and haematology patients. Knowledge is Power

damn, I learned a lot in 4 minutes. thank you

My buddy friend who had been diagnosed with breast cancer in year of 2020. I am so worried and nervous about my best buddy friend because my grandfather passed away from esophagus cancer on October 30,2018.

@jakeg3126

3 жыл бұрын

Wish him/her luck for me.

@mr.boostang2064

2 жыл бұрын

Hope all is well 🙏

@maxcovfefe

2 жыл бұрын

If it makes you feel any better... breast cancer has way more advancements, research, and funding than esophagus cancer. I hope your friend is okay.

Jesus the older I get the better a gun looks I can’t imagine going through chemotherapy it’s aweful my moms best friend of 15 years our neighbor just passed and this is really hitting home 😢

@cr34t_

Жыл бұрын

I've gone through very tough chemotherapy myself. Even though I felt awful I wasn't sad. Us humans are really good at adopting to situations.

thanks for the video, i really had no idea how chemo therapy worked ^^

My grandpa was crazy, now he's dead. Get more than just the surgery

I took an immunotherapy for stage 4 melanoma in 2018 and haven't even had a cold since.

@maxcovfefe

2 жыл бұрын

That's HUGE! CONGRATULATIONS!!! Fantastic news!!

P.S Lysosomes are organelles which contain cell digesting enzymes.If cell is not working well,they burst and digest the cell.Therefore the Cell commits suicide....

Question: what exactly is heart disease Or what types of heart disease are there?

I saw the word "chemotherapy " and automatically thought of Walter White's Lung Cancer

Sir, i have understaned.

I used to always think it was radiation

I'm 6 months in and it is Hell!

@marguskiis7711

3 жыл бұрын

Yes it is. But it can save you.

@GunsNGames1

3 жыл бұрын

My father passed away in 2010 5 months in treatment for lung and throat cancer

@xxrapidfirexx08

2 жыл бұрын

My mom went through 3 bouts of lung cancer and 1 of brain cancer, she's in remission now thanks to chemo so keep at it! I wish you all the best 👍👍

@maxcovfefe

2 жыл бұрын

I've been on chemo for nearly 2 years, but it's not like yours. Mine is a more gentle kind, I think because it hasn't been "hell" so far, thank goodness! Nevertheless, I know I'm fortunate, and I'm aware that others may be on way more toxic types of chemo than me. I hope it's helping you the way mine has helped me! I wish you all the best!!!

Would you make a video about how low dose chemo is used to treat rheumatoid arthritis.

2:49 - Thank you for explaining this. Also, not mentioned here, it's not just vomiting that can occur. It's unfair that I went into this without any warning that chemo can also cause GI tract issues down on the other end. Although, I think the most common side effect I get is tired. I was told a few months ago at the local cancer center than by 2025, most chemo will be oral.

@jakeg3126

2 жыл бұрын

I was told when I was in middle school things were going to be flying out all ends until I got adjusted or if i ever got adjusted by doctors and the people that were going to stab me when I was at the clinic. I had an I think an LGL leukemia. You might've had something else. I thought they left out a lot, that's why I mentioned the radiation part. I didn't notice they left out the GI stuff. Did they add all the emotional stuff that sometimes happens too?

@maxcovfefe

2 жыл бұрын

@@jakeg3126 I think maybe different types of chemo do different things(?). The emotional stuff is probably due to the illness and feeling sick or being afraid than the actual chemo itself. Sorry to hear you had to deal with it so young! That would be awful. I hope you feel better now.

@jakeg3126

2 жыл бұрын

@@maxcovfefe Thanks, I didn't think of age. I'm sorry you, or anyone has to go through that. I would assume different drugs to different things, but I think i know what you mean by I'm guessing side effects and what each poison(drug) does what effect. It's like concentration camp bad for some people, you probably saw them, but people hives all over the body, any symptoms/rashes are worse on someone else. I have to say though I was lucky I cancer and went through chemo when I was young, because as a kid I was somewhat clueless to how dangerous it was, what was going on, and the like 100+ things that could or might happen. Also, it was pre- everyone googles everything just to see stuff that can/probably will happen. Good being clueless.

@maxcovfefe

2 жыл бұрын

@@jakeg3126 LOL, you reminded me of the Google lesson I learned very early in my diagnosis. (It's not that Google is wrong; it's that Google is too right, and I was wrong. They thought my cancer had moved to my liver, so I looked it up and got all sorts of scared only to find out it wasn't in my liver; it had spread to my lungs instead. I unnecessarily put myself through that crap TWICE!) Now I let the docs tell me what's up BEFORE Googling anything. YES, I think age is a huge factor. I feel so badly for cancer kids. It sucks as an adult, but at least I under5stand all the poking and prodding. As a kid, I think it woulda been scarier, but the way you put it actually made me feel better even as a grownup. Not thinking about the risks is what got me through a lot of it. Being clueless for the win!

@jakeg3126

2 жыл бұрын

@@maxcovfefe yea, No one was really complaining it was watching the small tv, for your chair, maybe a movie, but mainly play with the brand-new PlayStation 2 that some people didn't even have at home. Not the old crabby ladies bitching and moaning about everything, and everyone being impatient. I'm 32 and I know I'm a worse patient.

my mom had cancer when i was a kid and until now i always thought chemotherapy and radiation were the same thing. i feel pretty dumb now

@kiemi5437

2 жыл бұрын

i also didnt know what it entailed other than "laying down inside a big tube for hours"

@maxcovfefe

2 жыл бұрын

Don't feel dumb! I'm a cancer patient, and the things I had to learn when I got my diagnosis...! It felt like a semester of college.

@rexjabay2727

Жыл бұрын

​@@maxcovfefehow are you now?

This is 3am in the morning,i had exam this morning and i watched a cemotheraphy video

Pharmacology mechanisms ♥️

@darkscienceyt

5 жыл бұрын

Glad to see you're still around. How's med school going?

@thestandardcouture

5 жыл бұрын

Questions for Science It is grueling! But I got through the first year and have a small summer break now :) I think my brain tripled in size 😂 So thoughtful of you to check in!!!! Hope you are well!

@missyb9526

3 жыл бұрын

My nightmare 😓😂🤷‍♀️

I love the term 'suicide mechanism'

The pie chart at 0:15 - Should be PROSTATE: 8%

Thanks, never quite knew what chemo was

@darkscienceyt

3 жыл бұрын

no problem

I think that the video will be better without music 👍

What a nice day to not have cancer

So your telling me these healing crystals I bought on ebay don't work.

Can the normal cells still replicate? (When effected by chemo-therapy)

@maxcovfefe

2 жыл бұрын

Chemo patient here... Good question! The answer is YES, my hair and fingernails/toenails, for example, are still growing even after being on chemo for 2 years.

@rexjabay2727

Жыл бұрын

​@@maxcovfefehow are you now?

I have heard from one woman who knew a female cancer patient in chemotherapy, particularly intereinteresting thing she said was that the woman carried a bottle of frozen water with her and as the water melted during her chemo she drank it and this is how she saved her hair from falling of. Is there any science in this?

@DarkZerol

Жыл бұрын

Cooling will cause the blood vessels to narrow, which results in less chemotherapy reaching the hair follicle save her hair from falling out however medical professionals use a specific cooling device that sits on your scalp specifically targeting your hair follicles during chemotherapy. Just drinking ice cold water alone will do very little to nothing as the water you drank goes directly to your stomach and digestive system not the scalp thus it wouldn't have any noticeable impact in preventing the chemo drug from specifically reaching the follicles in your scalp.

@cr34t_

Жыл бұрын

There is a thing called cold caps, that many cancer patients use. It's just a cold helmet that works because blood vessels contract when cold.

Sir infom us quickly =Breast cancer stage 4. Are this possible to cure this cancer by chemotherapy

@marguskiis7711

3 жыл бұрын

Radical surgery + the strongest chem + total etc abandoning of ALL meat, eggs, milk, sugar until end of your life

@maxcovfefe

2 жыл бұрын

No, not that I know of. My cancer is Stage 4, and I've been on chemotherapy for 2 years. That's not gonna change unless it quits working, and if/when that happens my oncology crew has more ideas. Also, certain kinds of breast cancer can be managed for years, even decades for some people. It just depends what kind and how aggressive it is. I wish you all the best! Take care.

Can you redo the alkaline water video?? Please!

@darkscienceyt

5 жыл бұрын

Working on it. Sorry to be delaying all the old videos. At any one instant I'm writing, recording, or editing 2-3 videos a week. Thank you, It'll be out

You should debunk German New Medicine.

@darkscienceyt

5 жыл бұрын

Never heard of it. I'll look into it, I can't promise I'll get to it soon or even the next few months as I'm way backed up editing old content and producing new as well. Thanks for the suggestion

I lost my mom this year after 5 years of battle

1:38 How do the drugs "recognise" damaged DNA?

@darkscienceyt

5 жыл бұрын

The drugs don't recognize DNA damage, they cause it. I think you may be asking, how do the drugs recognize the specific DNA in a cancer cell, and not just any regular cell. Well it's important to note that mitosis plays a huge role in drug induced DNA damaged. When cells aren't in mitosis, the DNA is tightly wound around proteins called histones, much like a spool of yarn. When DNA is wrapped up like this its difficult for the drugs to interact with it. When cells enter into mitosis, the DNA unwinds, also like unwinding a spool of yarn. The unwound DNA is easier for the chemo drugs to access, and so they do. Hope this helps

@adeleaviv8058

5 жыл бұрын

@@darkscienceyt what about the drugs that inhibit the DNA-replicating proteins? Why do they attack the cancer cells more often?

@darkscienceyt

5 жыл бұрын

Speaking strictly on mitotic inhibitors (not sure about other chemo drugs), the enzymes that are inhibited are present, because again, the cells are in mitosis. Theoretically, if you treat a cell with a mitotic inhibitor drug that will inhibit mitotic enzymes and the cell is NOT in mitosis, the cell would be unaffected, because the enzymes aren't present and can't be inhibited. Remember, cancer cells are higher in probability of being in mitosis, and therefore are more likely to be targeted. Think of it like this: You have two garbage shoots in which you throw out scrap metal. On any other day, you throw the scrap metal down the shoot and it goes into the garbage. The metal is going through the shoot without any different effect. Then one day, you line the shoot with magnets. Now when you throw the scrap metal down the shoot, it's attracted to the magnets and stays in the shoot. This is because the conditions of the shoot permitted the scrap metal to behave differently. It's the same with mitotic inhibitors. Mitotic inhibitors passed through a cell with no mitotic enzymes simply pass through without effecting anything or being effected. Now you have a cell in mitosis with the enzymes present (think of the magnets in the shoot), now the mitotic drugs are going to interact with the enzymes because they're present. Hope this helps!

@adeleaviv8058

5 жыл бұрын

@@darkscienceyt Thank you!! It's a little question I've always been curious about :) keep up the good work!

Jada smith is really going through it huh.

Ah, I see.

i am confused. then why all chemo patience drop dead?

Immunotherapy. That's where it's at.

Wait I'm perplexed so if the cancer drug is slowing or stopping the cell cycle to prompt apoptosis why would the cell even care if it's a tumor suppressor gene that's busted and that was the gene responsible for telling the cell to undergo apoptosis would the cell not just kind of float around in a suspended state with no working genes to tell it to die or alternatively couldn't it just not care and keep cranking out janky DNA it seems like this type of process could be more damaging to cells that have functioning apoptosis pathways rather than cancer cells

Yep, this just helps prove the earth is flat-I mean c'mon, don't be a sheeple; open your eyes!

Cancer feeds on (eats) sugar.

I'm guessing vitamin B17 is not good then?

@maxcovfefe

2 жыл бұрын

Chemo zaps all the D outta me. I'm on a somewhat high dose of 3000 IU per day.

Should be titled ‘How chemotherapy DOESN’T work!

Okay with this video ..... Nerds find a cure

U should do a video on how a healthier diet with fasting can heal cancer

@maxcovfefe

2 жыл бұрын

I've done quite a lot of reading since my diagnosis, and I have yet to read any credible source claiming that there's any kind of diet or exercise that will prevent or cure cancer with any measurable efficacy. Be careful what you advise. I think diet and exercise have a HUGE part in prevention and recovery, but these aren't foolproof, and they alone aren't enough to take out cancer.

@aquilescastro1335

Жыл бұрын

It only works if the diet kills you

Thc oil helps more than chemo

@marguskiis7711

3 жыл бұрын

No

@birdies8397

3 жыл бұрын

No, it doesn’t.

Youre saying "apohtosis" it's cellular "Apoptosis"

So here's the question for you, if you were diagnosed with a quick growing cancer would you get chemotherapy? I looked into this 6 years ago after my father was diagnosed and shortly thereafter died from pancreatic cancer. Most of the information I found pointed to chemo not being a good idea for cancer since the statistics for a "successful" treatment ended shortly after chemo and there was a high mortality rate several years later. I read that even if the cancer is gone and then comes back that chemo was considered successful. I understand there are many many variables here, but I guess I'm just looking for your personal opinion on cancer if you were diagnosed

@maxcovfefe

2 жыл бұрын

It always depends on the type of cancer and the type of chemo. There are lots of different kinds of chemotherapeutic drugs. The one I take is daily (3 weeks on, 1 week off to recover lost t-cells and white blood cells, blood work is done to confirm cell counts, then repeat), and my chemo is 100% oral. Local pharmacies don't carry it, so my oncologist orders it shipped from a specialty oncology pharmacy from out of state, and it comes right to my house. The rumor at our local cancer center is "most chemo will be oral by 2025." Each year more new research adds to the mounting number of cures they're finding for cancers if caught early enough. My own cancer IS CURABLE, but not for me - if only I'd been less stubborn and just had it checked out sooner. (Cancer doesn't hurt. If it hurts, you might've waited too long, which is another factor in your question! I put up with really minor, easily ignored pain in my side for over a year before having it checked.) Mine was stage 4 when they found it, and it's slow-growing (Grade 2). I feel fine BECAUSE OF my chemotherapy; it hasn't made me sick, but it shrank my tumors FAST! (Within weeks me and my oncologist could no longer feel my main tumor just with our hands like it kinda was before! Within months, the scans show such TINY tumors that you need a medical degree just to see them!) It's been almost 2 years on the chemo, and I still feel mostly healthy, and I still have hair! Toward the 3rd week of each round I get kinda tired, but that's mainly the most common side effect I've encountered. I don't share this to get sympathy! Like I said, I feel great! But I share it as word to the wise for people like me who might be too stubborn to actually get checked out. That and DON'T freak out if you ever hear the C-word. HEAR out all the options BEFORE you let your imagination run wild! Chances are fairly good that you may hear about recent developments for that disease. That said, ultimately I hop[e you don't have to deal with it at all anymore. Sounds like you've already endured enough cancer in your lifetime. Sorry about your dad!!

@joelmcgee2280

2 жыл бұрын

@@maxcovfefe this is actually great news to hear and an encouraging story! The great news being the new medical approach and research towards cancer of course. Thank you for sharing, have you considered promoting your story on a bigger platform? Many people especially here in the US with the healthcare system we have will not go to the doctor unless it's severe, me included. Hearing this type of a story definitely inspires others to take better care of themselves and simply get things checked out. I'm sorry to hear you've got cancer, I truly hope your quality of life continues being great for as many years as possible.

@maxcovfefe

2 жыл бұрын

@@joelmcgee2280 Thanks! I'm glad if it helps you feel more hopeful about the advancements they've made and will keep making. I considered filming the diagnostic process, but Covid, so it didn't seem like the right time because they were limiting appointments, guests, and general exposure at the cancer center. Covid has created a lot of change in oncology, but they're still managing to keep most of us healthy.

Luckily we think more about the patient than the promises on paper. Also how many times did he say "and the cell commits suicide"

I don’t mind the idea of ten more hours, compared to lots of hours of chemotherapy.

Chemo absolutely sucks. Don't try it. It did make me piss all the different kool-aid colors though. So that's cool.

@cr34t_

Жыл бұрын

Chemo>Dying of cancer

@223rockmaster

Жыл бұрын

@@cr34t_ Ok you can try it.

EXPLAIN crystal healing

@wokeil

5 жыл бұрын

Not real

@MrMerve-tl9my

5 жыл бұрын

Its fake

@darkscienceyt

5 жыл бұрын

I'm on it

It doesn't

How chemotherapy works: It doesn't.

@mikep11218

2 жыл бұрын

@@maxcovfefe All the studies which exist have proven that it simply does not work. Chemo actually causes cancer. It doesn't cure it. Chemo cannot distinguish between healthy cells and cancer cells. The rate at which it destroys healthy cells is the same rate at which it could target any cancer cell. If you're on it, you'll only get weaker and weaker, until eventually meeting your maker. I do not wish that for you. It would be great, if at the very least, you researched the true history of cancer "treatment". Also while you're at it, look up the history of AIDS. There is a documentary called House of Numbers. You will learn a lot. AIDS and cancer "treatment" are strongly connected. Watch House of Numbers. You will be stunned to learn the truth.

@mikep11218

2 жыл бұрын

@@maxcovfefe My father was a medical scientist, and I myself have in-depth knowledge on this subject matter. In fact, more than you do. I am aware of what is being taught, as well as what happens in the real world. But it's not in my best interest whether you watch the film or not. It might only have been in yours. I cannot beg you, nor will I attempt to convince you. Take care, and be safe.

@maxcovfefe

2 жыл бұрын

@@mikep11218 I deleted my other comments in this conversation. After what I told you, you ignored everything I said and replied to me with this HOAX stuff?? Are you even a human being? I'm beyond insulted. Anyway, I reported that KZread video for disinformation (at least one good thing came of this), and I don't think I want to continue any conversation with you or anyone who'd treat me with such disdain without provocation. I was just trying to be nice.

where's gun related deaths?

Worst idea for a cure ever

@maxcovfefe

2 жыл бұрын

As far as I know, chemotherapy isn't a cure by itself. It may be part of a cure, but mostly it's just a treatment to keep cancer patients alive. The chemotherapy I'm on is fairly gentle, it's oral, and I still have hair even after taking it for almost 2 yrs.

How Chemotherapy Works??? Duh..... It doesn't!!!

@maxcovfefe

2 жыл бұрын

It does work on many people. Me, for example.

More likely to be cancer in your toes is what? You never finished the sentence.