How a Medical Mystery in Guam Led to a New Approach to Alzheimer’s Disease
As part of his reporting for “The Last Alzheimer’s Patient” documentary, CNN Chief Medical Correspondent Dr. Sanjay Gupta travels to Jackson Hole, Wyoming, to learn more about an ethnobotanist’s audacious theory on treating Alzheimer’s disease. After Dr. Paul Cox, founder of the nonprofit Brain Chemistry Labs, discovered the source of a mysterious neurodegenerative disease afflicting people in Guam, those clues led him to a novel way of thinking about Alzheimer’s and a simple amino acid called L-serine. His novel theory and possible treatment are now being tested in Mild Cognitive Impairment patients at Houston Methodist. Watch the full documentary on CNN’s “The Whole Story” premiering on May 19 at 8p ET/PT and streaming on MAX on June 18. #cnn #News #health
Пікірлер: 470
Listen to how the true scientist answers questions. He doesn’t make overly enthusiastic claims. He didn’t just endorse L-Sering, he was is specific speaking to what the question was, what they did to investigate, what they tried and simply what the result was. THIS is doing your research looks like and why trusting actual trained and practicing experts is so important.
@roundtwo3321
Ай бұрын
That's right.
@ErikBongers
Ай бұрын
Yes! Exactly what I was thinking! To go even further, this way of assessing information is, in my opinion, the best way to deal with misinformation. In fact, the term misinformation is problematic as it's a subjective label that suggests that it's objective, but it's not. Galileo Galilei was thought to be spreading misinformation in his time. So the best way to protect yourself against misinformation is to assess it. Assessing information is becoming the new Darwinian filter.
@skicreature
Ай бұрын
Exactly I was very impressed by the scientific ethic of his responses. This is how scientists I know talk but so frequently what we hear on TV are salesman instead of scientists. This was excellent.
@AndreaCrisp
Ай бұрын
Great comment. For the record, it is L-Serine. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. But given the prevalence of neuro cognitive disorders in the world now and all of the toxins we are exposed to these days may be humans need more than we used to in order to stay healthy.
@seedye
Ай бұрын
@@ErikBongers Importantly, Galileo was persecuted by ignorant religious leaders who did no work to replicate or invalidate his work. Cranks and their fans like to drag Galileo out whenever they get criticized for spreading misinformation by claiming they’re challenging “scientific dogma” (which is not a thing) just like Galileo challenged religious dogma. Or “just asking questions” - which they pose to laypeople and journalists, rather than the experts. The best way to deal with misinformation, IMO, is say “don’t try to convince me - I’m not an expert. Wake me when you’ve convinced the experts.”
As someone who was born into a family with a high rate of this disease, this is a breath of fresh air and I hope more advances like this will save millions. Thank you so much for your work Dr. Paul
@jkgermany2182
Ай бұрын
Me too. So worried for my husband and kids 😳
@i.ehrenfest349
Ай бұрын
@@jkgermany2182look into the books of the neurologists Perlemutter and Bredesen. It doesn’t have to happen and you don’t need a pill.
@paulcox880
Ай бұрын
Thank you for your kind response. Our clinical trial for Mild Cognitive Impairment has not yet concluded, but your encouragement is appreciated.. Dr. Paul Cox
@simulationkoyo
Ай бұрын
old rich people can now live longer. hooray.
@smallpeople172
Ай бұрын
Stop eating toxins bruh
It won’t help my mom, who is too far gone. But it might save my sisters … and me
5:20- L. Serine is found in: - Eggs - soy tofu - edamame - sweet potatoes - turkey - pork
@saratemp790
29 күн бұрын
All of what Asians eat.
@ws7001
29 күн бұрын
100grams of top round beef has 1.52 grams. 5.2% on dry basis.
@fswatyahoocom
29 күн бұрын
in all our proteins = what life is.
@000_x9
28 күн бұрын
My mom has dementia and does not like meat and no longer eats eggs. I do not know if I can get her to eat tofu products but will try. She cannot eat sweet potatoes due to she has ckd and has to watch potassium intake. If I could buy a pill I would, anything to help her.
@Cineenvenordquist
26 күн бұрын
@@000_x9edamame salads, slaws, " mayo salads, maybe related beans will have the l-serine and be effective, roll in cooked ginger bits or wedges, get y'r mirin and rice wine vinegar and salt substitutes, lots o fun.
Great "Human interest story" CNN....we need more good news like this.....Kudos.
HAFA ADAI from Guam...The study of "Lytico-bodig" disease, aka Guam disease, or amyotrophic lateral sclerosis-parkinsonism-dementia (ALS-PDC)[ has been ongoing for many years. I knew of many elders who met their demise with this horrible affliction. I look forward to the findings. Si Yu'os Maåse (Thank you).
Being half Japanese and half Okinawan, some day I will visit my ancestors islands. Hoping a long healthy life forALL ! Aloha from Hawaii
I am 67, was widowed in 1998. I am totally alone now. I do live a very healthy life style, but I am concerned since my grandmother died, so slowly from this horrific disease. I just don’t want to be a burden to my kids. Praying and following!
@LaBamba690
Ай бұрын
If praying to an imaginary deity works, why follow a scientist's advice? Or is your deity not as powerful as you'd like to believe? lol
@enough1494
Ай бұрын
@@LaBamba690 oh I so sorry I offended your tickle bone! What deity? Again? Praying, for me is an active participation in my life. Gratitude for the most part. Religions are for others and for tickle bones. Blessings dear. My imaginary creator said you and I are one! Hugs! 🥰
@jenkem4464
29 күн бұрын
@@LaBamba690 Context is key. Sounds like it was just a turn of phrase so maybe lay off a bit?
@Ms2cents
28 күн бұрын
@@jenkem4464probably just a smartass atheist. Tends to be their mo. Their claws comes out whenever God or some type of religion or religious belief is mentioned! 😂
@ThiagoSilva-gb2iv
28 күн бұрын
@@LaBamba690 as a scientist i also pray many times, please don't be ignorant
This is a Nobel Prize worthy
@flashgordon6510
9 күн бұрын
If it works. Which I really hope it does, but let's see what further studies show.
Wow! Thank you, Drs. Gupta and Paul!!!
I really hope they find the cause of Alzhemiers and the cure. I really hope next they try to find the cause and cure for ME/CFS. I was stuck down with this disease at 55. I had a good life. I have a friend whose son was diagnosed at age 15. He is now in his 30s, and mostly bedbound. His life was cut short by this awful disease.
@hillsofwi
Ай бұрын
I can't think of an illness more neglected in terms of severity and number of victims in regard to its severity. It's destroyed my life.
@Gina-dn6xm
Ай бұрын
@@hillsofwi Yes, people really don't understand what it is like to basically be flat in your bed most of the day and night. Alive but not...
@roundtwo3321
Ай бұрын
2:57 This video said that in this case, the cause was blue-green algae, also known as the cyano bacteria, from the sea. "It contains toxins, such as BMAA."
Bats can't catch a break. Stop eating them. Eat foods with L-Serine, such as Sweet potatoes, Edible seaweed, Nuts, especially peanuts, almonds, and walnuts, Chickpeas, and Lentils.
@DSAK55
Ай бұрын
Bats have the best immune system of all mammals, that's why they're carriers of diseases
@danielmartin7838
Ай бұрын
Peanuts are legumes, not nuts
@fontfroide1
Ай бұрын
Completely wrong, these vegetables contain many poisons and sugars, plants do not want to be eaten and people do not know what damage they will cause over years of eating them. There are now a number of houses in America that treat people simply by letting them eat meat and heal people or improve them at a distant stage.
@manolingz
Ай бұрын
@@danielmartin7838 so are chickpeas and lentils, he was just enumerating food rich in L-serine.
@user-xu7vq1fr2o
Ай бұрын
Chamorros don't eat bats like our relatives did decades ago. This film is somewhat inaccurate and the pics they show are definitely from decades ago. So to say, "now we can save our children", is somewhat misleading. FYI
Good luck to the researchers and thank you. Is it possible to donate to support them?
@paulcox880
13 күн бұрын
The Brain Chemistry Labs is a 501 (c) 3 not-for-profit organization.
I hope you Americans are proud of this man.
@pamgrimm8850
29 күн бұрын
EXTREMELY PROUD. Thanks.
@triciac1019
24 күн бұрын
How kind of you you to say that! While I had no part in any of this and the credit goes completely to him, I am so proud of him. He is pursuing his talents.
Well presented by not saying it's a 'magic pull' but waiting for results. Thank you for your work
@richardgrier8968
Ай бұрын
Yes, indeed. Atypical for science reporting.
@paulcox880
Ай бұрын
Yes, please keep your fingers crossed that our clinical trial will demonstrate efficacy! Paul Cox
@richardgrier8968
Ай бұрын
@@paulcox880 Fingers and toes crossed!
I appreciate the real responses from actual people. There is also a ton of troll bots in today's comments.
@Lee-jh6cr
Ай бұрын
@RandyWatson-xx5fmThank you. I rip on YT via feedback weekly, for what it's worth. They need to screen. Last winter Meta shut down 5,000.
@lauchlanguddy1004
Ай бұрын
@RandyWatson-xx5fm fool tube is a snake, takes other sites down claiming bots boost numbers, its all political.
So pleasing to hear some actual news that's not part of the dog and pony show.😁 Thanks
II am so PROUD a wonderful brilliant scientist friend of mine works here. Also she is a fabulous photographer, she is in love with the beauty of where she works.
@paulcox880
Ай бұрын
Dr. Dunlop is a brilliant scientist and we are lucky to have her with us. She played a key role in identifying BMAA as the neurotoxin.
I heard about this research years ago but they’ve made progress!!
Wow, I wonder if this might apply to other mental conditions like schizophrenia and anxiety. I keep hoping we can find answers in things we can control like diet.
@marieslabbert6009
Ай бұрын
If you read up a bit about it, you will see that it is also for those conditions and help you to sleep better too.
@Danielle_1234
Ай бұрын
There's a kind of schizophrenia where a part of the brain pushes up against the skull. I don't know if all forms of schizophrenia are like that. Anxiety is correlated to the gut microbiome and there is a lot of study into it right now. I believe there are even diets that reduce anxiety due to after a handful of months they change the gut biome. Anxiety is interesting because it's also psychological, a blend of both the gut and the mind. Usually both aspects need to be addressed. On the psychological side both CBT and DBT both are proven in studies to work, and both of them I believe are 12 sessions, 1 session a week. A lot of progress can be done quite quickly thankfully. Good luck with everything.
@osilva2367
Ай бұрын
The one thing missing in most research about different cognitive diseases is that alzheimers is much like heart disease in that it is plaque build up in the brain that is preventable by diet. So, it's encouraging to see one about an amino acid that you get in food.
Wow!!!!! What a breakthrough in medicine !! I see a possible Nobel prize in his future ! I was born into this potential threat. I hope this study becomes a realty for prevention and treatment !!
@paulcox880
Ай бұрын
Thank you, Leslie.
Please keep us updated. If it can be prevented, I would be willing to do whatever can help prevent it.
Thank you! Looking forward for successful research. I hope this Dr receives an extraordinary support for this extensive research.
I’m listening either way Sir! I’ve lost loved ones to Alzheimer maternal grandmother and Parkinson’s disease maternal grandfather. Cancer paternal side of my family. I’m blessed to still have my parents and fear I will lose them to it.
This researcher helps to restore my faith in humanity. This man is a true ambassador for science and I’m thankful for his and his teammates efforts!
The man is an impressive scientist. Thank you for your work.^
Wonderfully exciting! Hopefully it results in an effective fight against a really horrid disease. Thank you so much!
@paulcox880
Ай бұрын
Thank you for your encouragement. We also hope that it works, but won't know for sure until next year. Dr. Paul Cox
@JillKnapp
Ай бұрын
@@paulcox880Thank you, thank you, thank you! Is there a way we can support your work?
Thank you for this report - I am looking forward to the results of the trials .
Foods high in serine are eggs, soybeans and shellfish.
Anytime there is hope. I am all in.
This is so great, thank you.
This story reminds me of how the root cause of Kuru was discovered. I’m so thankful for unorthodox thinkers and the intellectual excellence of scientists like this. ❤ (this was also cool because I live in the WY mountains!)
@paulcox880
Ай бұрын
Many thanks. Dr. Carleton Gajdusek, who studied Kuru, was very interested in our early work in Guam. Come see our lab in Jackson! Dr. Paul Cox
@Lee-jh6cr
Ай бұрын
Lytico-bodig (ALS-PDC), which so many of our service people based in Guam developed, my father included.
@brooklynnchick
Ай бұрын
@@Lee-jh6cr I am unfamiliar with this but will be researching it now! I too have vets in my family who have paid a high price for their service to our country. They are truly the best of us. Best wishes to you and yours.
@MeMeDaVinci
27 күн бұрын
My dad was stationed on Guam during WWII. He thought it was beautiful there but there is no way he would have eaten a flying bat, or something like that, of any kind. He died of Non-Hodgkins lymphoma. It was my mother that had vascular dementia, similar symptoms to Alzheimer's but not the same. My best wishes go out to all the scientists working so diligently to make the world 🌎🌍 a better place.
Amazing research and reporting
Very Interesting and I hope the results show a favorable response.
@ClaudiaMaestes
Ай бұрын
Hello
Good work, there, on Guam, and thank you, Sanjay, for your great reporting. I am still plant based after seeing your broadcast about preventing heart disease. I recommend playing it again.
How very interesting!!! Keep us informed.
Wow - great story indeed 👍🏼👏🏼
Great interview, God speed to these scientists!
Really interesting research. Hopefully they get some good results
Awesome story! One question though-what made them decide to test the l-serine as a means to offset the effects of the cyan bacteria?
My heartfelt thanks to those scientists who work tirelessly to find a glimmer of hope in retreating all diseases, Alzheimer's especially. If they can cure/treat ALS, wow. They've made strides with the lymphoma diseases, too. All i can say is support your local science teachers and classrooms. Those kids will carry on the work and save more lives. The Nobel prize would help tremendously pay for more research...
Great scientific divergent thinking by DR Cox
The story ended on a cliffhanger 😮
Yes SYMPTOMS (plaques & tangles) This alone to get thru to the AMA is huge!
Impressive! I'm curious why and how the Dr. zeroed in on L-serine as a possible treatment.
With these great doctors there’s hope for everyone
Awesome!
Sounds very promising🙏
Was there any follow up that eliminating bats from the diet reduced the incidence of cognitive impairment? Seems a giant leap from bats and Cyanobacteria to L-serine.
I have a hearing Impairment and this background music makes it impossible for me to hear the dialogue.
@y0nd3r
Ай бұрын
I do also. Use the CC and read along.
Interesting 🤔 If safe, why not add it to your diet? I would have asked the researcher, has this changed your diet?
HOW WONDERFUL GREAT REPORT THANKS
This is incredible. Thanks for your perspective, Dr. Cox.
@paulcox880
Ай бұрын
Many thanks! Paul Cox www.brainchemistrylabs.org
Did no one watch a recent "60 Minutes" episode where one of the top neurosurgeons in the world says he has cured/halted dementia/alzheimer's, with ultra sound? However, I am excited to hear this discovery too.
It’s good to have hope.
Hello. Will Phosphatidyl Serine accomplish the same results?
Great info. Another great endorsement to japanese okinawa diet?
Wonder what Dr. Paul Cox found to be the diet of the Okinawans. I do know they do eat alot of the L-Serin menu shown except turkey but the islanders also eat alot of fish/seafood variety and local vegetables. Can't wait to see the results of Dr.Roman's trial on L-Serin that may help with mild cognitive symptoms.👍
My Great grandma and grandma had it. Last child out of 21 kids. Part Cherokee Black. (Alabama)
CNN has NO captions?
@saudigold50
6 күн бұрын
Use the CC and read along ✌🏼
Too bad the full documentary is only available on CNN and MAX.
@triciac1019
24 күн бұрын
It's wonderful it's available! Doesn't matter where.
Blue green algae worked very well on my symptoms. Maybe it depends on where it comes from.
This is great news!
Love it I hope dr Gupta follows up with clinical results . I pray they get this through and it’s affordable to everyone ! Like insulin is not!!!
@elaexplorer
Ай бұрын
Since it's in every day foods a pill won't be necessary. Just a diet change.
Explains why Ozzy Osbourne lost his marbles.
Even without the algae, isn't cycad already toxic by itself?
He mentioned a mix of ALS and Alzheimer's symptoms. Neurodegenerative symptoms. I never knew those could be related.
@BowenUSA
Ай бұрын
Neurological conditions are all toxin related and often have pathogenic activity involved. Clearing the metals and toxins from the brain and improving the body's immune system are crucial to recovery. Sweet potatoes clear metals out while boosting the immune system. Bananas and citrus are plentiful in tropical regions. Papaya, mango, coconut, jackfruit, etc. are also big healers. Yes, food is good medicine. But laughter, supportive family and friends, movement, spiritual growth, a sense of purpose, positive affirmations, play, love, and creativity all play important roles in healing and staying well.
@MeMeDaVinci
27 күн бұрын
Motor Neuron Diseases (MND)...of which both you mentioned are included.
You could offer my Dad with Alzheimer’s a cure that would make him 40 years younger. And he’ll probably curse you out and remove you from his Will. Then he’ll get mad that you don’t call everyday.
@vintagelady1
Ай бұрын
Keep in mind that it's not him speaking, it's the disease. Not his fault, try to remember him as he was before the Alzheimer's. So sorry you are going through this.
@Lisargarza
Ай бұрын
@@vintagelady1Wise words, my friend. Best wishes to those dealing with this awful disease.
@simulationkoyo
Ай бұрын
just what we need, ways to make old people live longer.
@mal74
29 күн бұрын
@@simulationkoyo You'll get old too, I suppose you want Alzheimer's when you get there.
@Cineenvenordquist
26 күн бұрын
Hey, he can still tell you didn't sauce it up and start eating it all the time yourself!? Like the stories about pocket packs of extra ham from Alinea.
I wish that it hadn't been necessary to test on animals. We do have other ways of finding this information. But thank you for showing that if we pay attention to our diet we can find both the causes and the cures of our diseases.
@MeMeDaVinci
27 күн бұрын
As he said, it wasn't ready to be used by humans yet. Unfortunately, people who have the disease are in no state to be aware of the legalities of being a test project. You can become an organ donor upon death with a preference and a signature; maybe if a person is of sound mind and body they can decide to be part of testing if and when that time comes before it happens. All it would take is a preference and a signature...
I remember reading about lydigo bodig disease in The Pacific Daily News back in the 1980s. Then the theory was that flour made from the kernel of the fadang palm (cycad) was the cause. So the cycad is still considered the source, but the route of ingestion has been more specifically identified.
Fun fact Bat in Chamorro is "fani'hi" Fah-knee-hee That's crazy to hear. Grew up there for 20 years. Kind of Mercury exponentially growing in fish.
@randyevermore9323
Ай бұрын
Yikes. Google "Minamata disease."
Good luck!
I, for one, will definitely stay tuned. And it certainly can’t hurt to eat more of those foods in the meantime, especially the plant-based sources.
So I should probably not use my fish/turtle pond water to water my vegetable plants?
What are the current results??
Very significant findings for Florida, where blue-green algae in polluted water is a major problem.
Amazing.
If its a treatment, perhaps you are close to understanding a cure!!🎉🎉 thank you for your dedication, Dr!🎉🎉
Magnetic density and direction ..if we reduce magnetic below weber then people and computer lose most data
Why did he not use pictures instead of words, in his tests on alzheimers patients?
Wow 👏🏼👏🏼
You're looking at my yard
I think it would be wise to look at the long term study done out of Mayo Clinic...nearly 50 years. You will present a more scientific point of view. This didn't begin in 2003; I worked with the people in Guam in 1996. A ton of information that should be added here; this is quite incomplete.
@MeMeDaVinci
27 күн бұрын
It's only part of the documentary apparently. Don't get your undies in a bundle; research that is being done now, it's implied that it's built on what came before.
The music makes this impossible to listen to, probably good info, but lost in the annoying sounds
There are many toxins that can contribute to one getting Alzheimer. The principal creator of some of these Toxins is the Fructose in our diet which has several downstream effects from Obesity, Insulin Resistance, high blood pressure, arteriolosclerosis and Alzh to name a few. The brain itself gets little direct Fructose, but its downstream effect of Insulin Resistance results in neuron mitochondria being full of glucose causing the creation of ROS (Reactive Oxidative Stress) substances. With the excess glucose and use of ATPs Fructose is created in the mitochondria. With a lack of ATPs (the energy of the cell/Neron), essentially starvation, it starts to protect itself in a manner by the creation of amyloid and tau as there are insufficient ATPs to keep the proteins from misfolding. It is very complex, but the main factors, first was the increase consumption of Sugar from sugar cane (1 Glucose + 1 Fructose) and then in 1965 with the development of high Fructose Corn Syrup which is cheaper to manufacture than Sugar. - Now 80% of folk are overweight, 60% higher Uric Acid levels than in blood of a person from 1890, (Uric Acid directly causes higher blood pressure) and the development of Alzh later in life. KZread has many videos with Dr. Johnston and Dr. Lustig discussing this topic. Do a search Ford and Fructose or Lustig and Fructose. (Eat an apple, don't drink Apple Juice or Soda.) An average person can eat 10 to 12 grams of Fructose a day which is equivalent to 24 grams of Sugar. Less than a can of coke cola. Beyond that it has a cascading effect on the body's metabolism including increase appetite and the signaling of the body to convert glucose to fat in the liver (similar to the effect of over drinking which causes fatty liver disease).
@luisostasuc8135
Ай бұрын
Not to mention, a regular pop is around 40-45 grams (8-9teaspoons) of hfcs per 12! ounces. Meaning a 20 oz bottle of pop is 13-15 teaspoons of high fructose corn syrup. I'm getting nauseated just thinking about it.
@edl653
Ай бұрын
When I would eat at Burger King I always ordered a Large Coke 40oz (they recently downsized) which was larger than the McDonalds large at 32oz. If I only knew how much damage I was doing. Thank goodness for lots of Ice.
This should have CC enabled.
The body can already produce its own L-serine with the help of vitamin b6 (pyridoxal phosphate). This just demonstrates the necessity for balanced nutrition status.
@saratemp790
29 күн бұрын
I believe Vit B6 is also good for PCOS.
Important.
Why are captions not available for this?
Dr Gupta, please search more angels like Dr Paul and tell us about them
This is a bit confusing. Yes, Okinawans live unusually long lives. But does that mean they have a low rate of Alzheimer's disease or dementia in general?
CNN should discover closed caption options.
@TaLeng2023
Ай бұрын
I was actually looking for it coz some parts I can't understand what they're saying without having to raise the volume and realized there's no sub option, not even autogenerated
Alzheimer’s is not a fun thing to experience
@Muttinchopsforeverandalways
Ай бұрын
And heartbreaking to watch
@olerius1235
Ай бұрын
@@Muttinchopsforeverandalways it sucks ive seen people go from being a rly talented person drawing amazing art to not being able to pick up a pen
@FishFace1776-ur9qw
Ай бұрын
Neither is anything else. 🤷🤷🤷
@executionerofthedeepstate
Ай бұрын
Imagine where you must be on the IQ scale when you get your information from CNN 🤣
@Muttinchopsforeverandalways
Ай бұрын
@@executionerofthedeepstate anything beats your zero
I love this kind of story. Bat drumsticks point to source, source provides remedy. Hope gramma does not die extra crispy. Too late for our gramma and grampa. Future hope of extra sides. ❤
I lived in Guam in the early 70s, and remember that there was alot of ALS. cases.
@DSAK55
Ай бұрын
was that when RFK Jr was around?
@Lee-jh6cr
Ай бұрын
Lytico-bodig (ALS-PDC). My father died of it in 1996. Many of our US vets based in Guam developed it. I found out about it in 1991 from an army medic pre-med student who had just finished researching it in Guam with WHO. Until then, my father had been diagnosed with atypical Parkinsonism dementia - an umbrella term for we don't know what he has.
@Lee-jh6cr
Ай бұрын
@@DSAK55Early onset?
6:16 researcher: “do you still eat a lot of everyday?” Japanese person: 🙄
Amazing 😀🇨🇦
I hope Bruce Willis is in this treatment research treatment.....❤
The body can adapt to any food and its quantity, to treatment, to lifestyle and habits. But... the owner of the organism may not like this adaptation. Be content with little. What doesn't kill us makes us weaker.
A How much L-Serene are the using in the trial dose?
@poethammer
Ай бұрын
30 grams a day, according to the video