Full Title: High resolution epitope binning informs antibody drug discovery and enhances next generation antibody workflows
Event: The Antibody Series, 2022
Speaker: Dan Bedinger, PhD, Carterra
Abstract: Several recent high-profile examples have been published highlighting the utility of high-resolution competition-based epitope binning in the rapid characterization of diverse monoclonal antibody panels. Detailed competition-based epitope binning can be used to cluster related antibodies into binding classes which inform variant resistance, avidity, and activity. Furthermore, this information can enable a more detailed understanding of mAb sequence sets which are generated from diverse panels of putative binders from next generation sequencing-based discovery approaches. The Carterra LSA and Epitope software enable this analysis at an unrivaled scale and level of detail.