Meredith Baxter as Elyse Keaton
Michael Gross as Steven Keaton
Michael J. Fox as Alex P. Keaton
Justine Bateman as Mallory Keaton
Tina Yothers as Jennifer Keaton
Brian Bonsall as Andrew 'Andy' Keaton
Marc Price as Irwin 'Skippy' Handelman
Scott Valentine as Nick Moore
Courteney Cox as Lauren Miller
Tracy Pollan as Ellen Reed
John Hancock as Gus Thompson
Terry Wills as Dr. Schulte
Robert Schanche as Robert
Alan Blumenfeld as George Bellack
Enid Kent as Phyllis Evans
Robert Costanzo as Andrew the Waiter
John Petlock as Ted Waterman
Norman Parker as Robert Keaton
John Dukakis as Jeff Wakefield
David Wohl as Oscar - 'Peter Good Vibes'
Michael David Wright as Young Steven Keaton
Ben Piazza as Mr. Wertz
Bunny Summers as Barbara
Denise D'Amico as Customer #2
Tom Hanks as Ned Donnelly
John Putch as Neil
Melinda Culea as Rebecca Ryan
Timothy Busfield as Doug
Matthew Faison as Dr. Skip Williamson
James N. Hamilton as Bellhop
Margaret Marx as Young Elyse Donnelly
Jane Adams as Marty Brodie
Philip Baker Hall as Dr. Harrison
Raymond Singer as Buffaloed Bill
Walter Olkewicz as Bill Channing
Sal Viscuso as Richard Grasso
Priscilla Morrill as Kate
Belita Moreno as Bernice
Mary Farrell as Carol Mannings
Richard Venture as Agent Bert Carlyle
Jason Naylor as Simon Wickerson
Tammy Lauren as Marilyn Keaton
Julie Cobb as Maureen Keaton
Dan Hedaya as Joe Moore
Philip Sterling as Mr. Winkler
Jay Tarses as Ron Davis
Brooke Alderson as Suzanne Davis
Daphne Zuniga as Rachel Miller
Sam Whipple as Bill
Suzanne Snyder as Tricia Armstrong
Music by the great Kevin MacLeod