Great host. He interjects just enough but not too much and has a sense of humor. I like Neil D Tyson, but he is like a steam roller.

Sean Carroll, this is my new favorite podcast. I love your way of explaining things that are difficult to think about. My hat is off to you Sir! Thank you.

Thank you for the knowledge. I look forward to learning more Mr. Carroll.

Awesome podcast. Thanks Sean for this jewel of knowledge..!

Been a fan for a long time. Glad to hear your branching out. Also glad you decided to share your podcast on JRE lol

Fantastic job on the series so far. You couldn't possibly put these up fast enough.

This podcast really kills it, thanks so much

Very interesting discussion about DNA and the like! Sean, you have the best guests! Keep these coming, sir!

Listened to the audiobook a month or so ago. Excellent read, recommended.

Fantastic! Archetype of a great podcast: Great host + Great Guest + Great Content. Loved it!

I'm happy this podcast exists.

Along the lines on how hard it is to imagine the time before we knew about DNA, there was a great Innovation Hub segment on 'Where Babies Come From' that talks about the interesting theories that people had before it was understood! Regarding how some of the non-protein-coding sections of dna is used to make RNA and to silence genes.. or how there is constant genetic negotiation happening, like when the sperm kills off it's own mitochondria (mitosis) upon fertilization.. on the Radiolab episode X&Y (and 'The Primordial Journey') they talk about how the gonads and how the presence of the DMRT1 gene continuously prevents the cell from changing sex! There was also a study mentioned on TWIS #680, that talked about how the father's genetic contribution silences the Phlda2 gene in the fetus, which then results in hormone signaling to make the mother more nurturing towards its offspring! Regarding the use of a bacteria's immune system (1h17m), the Atlantic had a great story ("You May Already Be Immune to CRISPR") that describes one of the bigger CRISPR challenges, namely the body kills off the bacteria before it's had a chance to do it' thing! Finally, on the AfterOn podcast "Ancient DNA", David Reich mentions how there are ~30 nuclear-dna mutations per generation, but since most will land in the 99% 'junk dna', the entire human evolution can be traced to just very few nuclear dna changes! It's also mentioned how most diseases, are either inherited via the mitochondria (maternal dna), or arise somatically in mtDNA due to nuclear gene disorders (since most mtDNA functions are coded using nuclear DNA).

Thank you, Sean, great podcast, as always😊

Yay! Another great podcast!

Awesome podcast. Re: Caesarians, I’ve read crapsules / faecal transplants can be used to introduce the microbiome from someone else. Map my gut and all that!

i feel like so much of the problems in all branches of science is that we have 7 billion people on the planet... about 13,700 of them are actually investigating the universe and the rest are bickering and/or poor trying to stay alive... i cant wait until everyone is focused enough to explore and see how amazing this universe really is #atheism #Universe

Have you seen the movie Gattaca ? It wonderfully captures the essence of a world in which designer babies are commonplace and its natural repercussions. It is very insightful.

You’re good talking man you’re funny and it’s interesting thank you

The first 3 minutes felt like a course introduction, 2 weeks until next semester start 😂

Getting better!

Good episode.

If you listen to cognitive scientist Daniel Dennett, among others, you might think you are discounting the 30 trillion stowaways in our microbiome that impact digestion, the immune system, disease, metabolism and reproduction not even mentioning their effect on cognitive behavior, feelings and emotion. Lastly, so much in this area is impacted by the great strides in increased computational power and reduced costs. The Moore's Law equivalent in gene sequencing and knowledge paces so much of the ongoing innovative science.

I understand RNA, DNA but what puzzles me is understanding ETA "EVOLUTIONARY TRANSFORMATIONAL AGENTS" Can you shed some light in this very important matter, thank you.

21:25 The Celestials reference for mutants?

This would be so much better if it was a video, and if you could provide images to better describe some of the complex ideas that you guys talk about!

Great podcast Sean. Can you please have someone on to discuss the physics of: 1. how artificial limbs are controlled by brain signals. 2. how Psychedelics convince recipients that their visions are real.

@mrEofPlanetEarth

5 жыл бұрын

Zachary Hlavinka ..I like your first question, however I can tell you unfortunately we don't have experimental experience or evidence to answer your second question objectively. The answer for it however is that those visions are real. If they're seen, they're real to the person who saw them. What they mean is a different question.

Quantum epigentic yoga... im on it.

Carl Zimmer sounds like a teenager. I'm amazed, really.

Response to 1:13:30-2: The reluctance to allow gene editing of humans is not just being uncomfortable about it but deep ethical issues. I was born with congenital nystagmus. It like so many other congenital aspects is pathologized. In a world of fine-tuning of genes, eugenics would unquestionably be implemented. People like myself, people with Downs Syndrome, and so on, would be routinely eliminated in utero. It is already happening now via abortion although I wholeheartedly support the right to choose. I do so in spite of the fact that so many arguments about quality of life assume my life is not worth living. I do not contend the issues are insurmountable. They aren't. Yet they do exist.

Mr. Carroll, this doesnt have to do with the topics discussed on this podcast but Im curious if you would be interested in reviewing Dr. Judy Woods work? Its subject matter warrants a scientific review, im not trolling you and very curious if this is something you could do, if it doesnt intrest you I understand, Thank you and good luck with your future endeavors.

@CONTACTLIGHTTOMMY

5 жыл бұрын

You must be kidding. Wood is batshit crazy...at best.

Always great stuff in your podcast. Suggestion: why you don't bring more physicists on your podcast, some with different views from yours and have debates...and not only physicists. As for now, most of your podcasts have people "laying" down their view about a subject. I think a debate/clash of ideas, will be more interesting and also more crowd pleasing.

@dawddawds8019

5 жыл бұрын

Battle Royale

@vitaly2432

5 жыл бұрын

Yohan Scoobuko the winner gets quantum dinner

@grievous6614

5 жыл бұрын

Yeah..exactly. We've all seen Sean participating in a couple of debates already, and I think would be beneficial to his podcast to grow, having more polemic disputes about different, let's call them "unsolved" subjects in science, politics etc, having maybe even 2 other guests who can have a dispute over a subject. There are so many informal channels out there, where if one is seeking some info about a subject, can easily find it. For his channel to grow more, will be so hard without a "spark" of something more intriguing/controversial. It will manly be visited by ppl who know a bit about him, while in the mean time any schmuck with charisma and conversation skills can just collect some info, put it together into a flashy vid with a appealing name, and get lots and lots of views, while in the mean time the real scientists struggles to get their views out there (that in case they want to do that).

@pezit

5 жыл бұрын

Wouldn't two physicists going at it go over the heads of like 99.9% of the viewers?

I think that caution is well-warranted in regard to intentional intervention in our heredity processes. A cautionary tale can be found in eugenics policies which were responsible for the forced sterilization of from 300,000 to 400,000 people in the 1930s to 1940s.

Vinome Ill try it

Non-Mendelian inheritance has been reported to eventuate in heritable metabolic and psychological traits following, apropos of the former, the "Dutch Hunger Winter of 1944" and as heritable anxiety spectrum disorder and traits under conditions of high maternal stress during pregnancy (by dint of developmental inhibition of amygdala and hypothalamus during fetal development by hypersecretion of ACTH and corticosteroids in their mothers during pregnancy). This too has been reported to appear in the second generation (whose own fetal exposures were associated with hypersecretion of ACTH and corticosteroids." Perhaps the issue of heritable traits or disorders associated with maternal exposures during pregnancy will not be as peremptorily dealt with in the next podcast on genetics. It looks like it may prove influential to normal variation of trait heritability as well as that of heritability of symptom or syndrome in psychiatry. Jack E. Rosenblatt, MD

Everybody's talking about designer baby's, I just want to know if we can still enhance ourselves

@0113Naruto

5 жыл бұрын

Same

@madvillain2675

5 жыл бұрын

I don't know much of anything about the subject but the impression I get is that we can still enhance ourselves just not to the dramatic extent we can enhance babies, as embryos have less cells than fully grown adults and are easier to work with

Sean, I'm a huge fan thanks for the podcast. I think you are the most effective advocate for atheism on the planet. You should debate creationist Kent Hovind on an episode. I can get in touch with him, I know he would jump at the chance! I've spoken to him once briefly but I have his cell #. Let me know if your interested.

I have no doubt that the next level in heredity would see us as food if chimps and colobus monkeys are any guide

Great incite, thank you. Just praise today. And wonderful work by those three (I think) individuals that brought us Crispr. Jennifer Doudna being one. Cas 9 protein for the win, so far...

I am already in my lab creating monsters, be afraid be very afraid wahahahahahahahahahaha.

the steaks were enormous lmao

Software,Vision

a Youknow drinking game, any1? even with DROPS of wine, it would be devastating

Too short

*tldr;* IQ raising technology inevitable. Enemy nations churn out Von Neumann's. Rich people fly to Caiman Islands to get it done, as you said; normal people 50 years behind. [US must democratize CRISPR for all citizens and lead the world with a genetic bill of rights once the tech is mature enough.]

@credman

5 жыл бұрын

Rolling Rock I agree, except I think technological breakthroughs that render this moot will happen within 2-4 generations. (E.g., the ability to directly augment intelligence, biological immortality, AGI.) These breakthroughs (accelerated by the application of genetically enhanced brainpower) will happen long before inequality of access to genetic engineering can cause significant genetic separation between groups of human beings.

@jesperburns

5 жыл бұрын

The US must be the first? The US is one of the most corrupt countries of "the west". Don't you have any better ideas?

@rollingrock3480

5 жыл бұрын

"But how in the hell will we pay for this?" Taxes.

@jesperburns

5 жыл бұрын

Taxation is theft.

@noahway13

5 жыл бұрын

Develop it yourself, Mr know it all. @@jesperburns

Hey sean im from the Joe Rogan podcast can you go back again please :)

@Young.Supernovas

4 жыл бұрын

Carl Zimmer should, too.

Noam Chomsky please!!!!!

@mrEofPlanetEarth

5 жыл бұрын

No please don't!!!!!!

@dorotakel3720

5 жыл бұрын

Yes! And hurry up!

You are going to really confuse lay people by continuosly stating that there are more than two sexes. Disease states are not additonal sexes. Chromosomal abnormalities are not additional sexes. You are letting politics influence scientific fact here. If i have a heart defect that isnt an additional type of human heart. Chromosomal abnormalities are rare because they have serious drawbacks. Same for malformed sex organs.

@budesmatpicu3992

5 жыл бұрын

don't worry, neomarxists will take a lesson - and will use any destructive element (biological or memetic) for their ultimate goal set by their "frankfurt school" prophets (google cultural marxism), disruption of the "bad bad burgeoise" western society (and family is THE number one target)

@adamdalgleish8769

5 жыл бұрын

robot hand love... lol

Editing of the DNA hmmmmmm don’t know why evil Doctor Menguele comes to my mind...

Shyful islambhuyan 90146 Palermo

Oh no! no visuals at all! please add something, you and guests sitting in opposing chairs overlooking a golf course. Maybe even an anthill with the ants eating something you can comment on every so often for comedic relief. It doesn't take much, anything but what should be your intro visual. :)

@ameremortal

4 жыл бұрын

Steven Inge Close your eyes and try to train your mind to make models out of these ideas. You’ll gain a much deeper understanding that way.

Can you find another intro tune? This one is cringe lol

@tyrred

5 жыл бұрын

Damn, and the rest of us were hoping that you could come up with other words than cringe and lol to describe your distaste in music. Drat.

@Loftipixels

5 жыл бұрын

tyrred and you are relevant why?

@mrEofPlanetEarth

5 жыл бұрын

A Lofty Place ...because he's got a point.

@ameremortal

4 жыл бұрын

The intro tune is great! I hope it has grown on you by now.

8:10 Darwin is Brilliant. He calls them #Gemmules. Not Proteins, the things that bend and shape the proteins.

@neilcidial-masrysandagesid7796

5 жыл бұрын

8:18 we always knew would come out wrong. Giant Egg, little sperm = men still taught they were the purest raCE to embody the family fame. So the woman was naturally fatter than man, and the sperm egg was male penis in thunder pair shaped inflatable raft things. Pure sperm, chubby egg. = 50:50. Or my DNA 300lb dad 120lb mom, and mom #J1C2 is 69~71% while dad at 200~300lbs #M253 is 24%(x3)~44%(x1) percent of my DNA mass.

Pamphlet VolunTeer, Here. Appreciate learning inter-marriage of a better USA adapted species is a #SteamDream. Concerned about the center of the population charges toward two directions killing all the ph 5.5 Races, in homes of a ph 13 muck free Future. #BoringCompany can so Ph 11. Ph Futura, ph Past: #1GlobalDesert = see an #EqualArea Satellite Projection. Azimuthal Maps, or later Gall-Peters Projection.

Eat your heart out Sam Harris. This is how you have a real discussion about heredity without being racist.

@vaultsjan

5 жыл бұрын

Damn Richard Haier and Eric Turkheimer

@llaauuddrruupp

5 жыл бұрын

Sam Harris wasn't and isn't racist. If you know anything about him, you know that.

@the4xeeffect

5 жыл бұрын

This discussion, albeit very interesting and worth having, had little overlap with the Harris-Murray podcast. The latter was a discussion of intelligence and specifically intelligence and "race". That simply wasn't the topic here.

@thezzach

5 жыл бұрын

Please forgive “JE MOODY”. He got the DUMBASS gene.

@C05597641

5 жыл бұрын

What a stupid comment.