Perrysburg is a city located in Wood County, Ohio, United States, along the south side of the Maumee River. The population was 25,041 at the 2020 census. It was founded before and is part of the Toledo Metropolitan area, a large port city located about 12 miles (19 km) further down the Maumee River. It is the second largest city in Wood County, after the county seat of Bowling Green. It is the most rapidly growing community in Northwest Ohio.
The town soon became a center for shipbuilding and commerce on Lake Erie. It was named after Commodore Oliver Hazard Perry, naval commander during the War of 1812 and hero of the Battle of Lake Erie.
In 1833, Perrysburg contained a courthouse, jail, schoolhouse, two stores, two taverns, two physicians, two lawyers, about 60 houses, and 250 inhabitants.
In 1854, an epidemic of cholera decimated the population. The town closed down for two months in that summer, trying to contain the epidemic at a time when people did not understand how it was transmitted. More than 100 people died. Other towns along the Maumee also suffered high losses from the epidemic, and Providence, Ohio was abandoned. It had suffered a disastrous fire less than a decade before.