Does Wellbutrin Make Anxiety Worse? Wellbutrin For Anxiety Disorders (Bupropion And Anxiety)

Does Wellbutrin make anxiety worse? We'll also explore its role in treating anxiety disorders, specifically looking at Bupropion and anxiety.
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Does Wellbutrin Make Anxiety Worse? The video discusses the effects of Wellbutrin for Anxiety Disorders and anxious depression. It challenges the common belief that bupropion worsens anxiety, as this notion is an oversimplification of the complex relationship between neurotransmitters and mental health conditions.
The video cites a meta-analysis of 10 studies that found no significant difference between bupropion and SSRIs (selective serotonin reuptake inhibitors) in treating non-anxious depression. In cases of anxious depression, SSRIs showed a slight advantage over bupropion, but the clinical relevance of this difference was minimal. Bupropion and anxiety has been a question for a while.
For generalized anxiety disorder, a small study suggested no differences between bupropion and Lexapro. Preliminary evidence also indicates that bupropion may be effective in treating social anxiety disorder, but larger studies are needed.
The video acknowledges that a small subset of patients may experience treatment-emergent anxiety with bupropion or SSRIs, but the rates are comparable. It suggests starting with a low dose of bupropion and slowly titrating up to minimize anxiety side effects.
In conclusion, while SSRIs may have a slight edge in treating anxiety disorders, bupropion should not be dismissed as a viable option, particularly for patients concerned about SSRI side effects.
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#depression #bupropion #psychopharmacology
Chapters:
00:00 Psychos Will Farm
00:09 Bupropion & Anxiety
00:34 Why do we assume Wellbutrin is bad for anxiety?
04:00 What is anxiety?
06:33 Anxious Depression (Bupropion effect)
08:40 Generalized Anxiety Disorder
10:12 Social Anxiety Disorder, OCD, Panic
12:30 Summary
14:36 Dosing: Low and Slow
15:51 Outro

Пікірлер: 95

  • @Gloriaglo0502
    @Gloriaglo050210 ай бұрын

    What a legend you are. Hey your videos are soo easy to understand nothing complicated. Thank You soo much you are very much appreciated ❤

  • @bretgallihugh4723
    @bretgallihugh4723 Жыл бұрын

    Another good video. The studies for different diagnoses are appreciated. I see bupropion got it’s second R back in it’s pronunciation though ;). I do personally like to reach for bupropion first if anxiety isn’t significant, due to less weight gain and sexual side effects, as well as possible help with decreasing food cravings, nicotine/illicit drug use that a large amount of my population tends to have at least one of these cooccurring issues. Thanks again for great content!

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Much appreciated! The R comes and goes like the tides.

  • @hermanlindqvist7238
    @hermanlindqvist7238 Жыл бұрын

    fantastic content mate thank you for putting in the time!

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Much appreciated my friend

  • @a.littleblue2890
    @a.littleblue2890Ай бұрын

    Thank you, so helpful

  • @czanderrr
    @czanderrr2 ай бұрын

    Great video. I just started wellbutrin a few days ago, my doctor added it on to Lexapro. Lexapro has been great for my anxiety but made me more sluggish and depressed. In the initial days Wellbutrin definitely has affected my anxiety in a negative way, but I'm sticking with it. Really want this combo to work

  • @idontkare20011
    @idontkare20011 Жыл бұрын

    I’m on 150XL and it is helping me a lot with my anxiety and depression. It’s really helpful for me. It have only been on it for two weeks. I hope it sustains

  • @drenlacasa

    @drenlacasa

    11 ай бұрын

    How's it going so far? I'm about to start taking it tomorrow

  • @PsychoFarm

    @PsychoFarm

    11 ай бұрын

    I hope it sustains too!

  • @wesleydevries7415

    @wesleydevries7415

    10 ай бұрын

    Got an update? :)

  • @UniqueYoutubeHandle13
    @UniqueYoutubeHandle138 ай бұрын

    Would love a Buspar breakdown video.

  • @JohnnyScumbagg
    @JohnnyScumbagg11 ай бұрын

    Wellbutrin has been absolutely **terrible** for my anxiety. It makes me into a live wire, constantly fidgety, can’t sit still, constantly humming or growling to self soothe and makes me make weird faces. I’m getting tf off this.

  • @nenadcubric2663

    @nenadcubric2663

    7 ай бұрын

    I had the same with Citalopram

  • @jpie78
    @jpie78 Жыл бұрын

    Another amazing video!!!

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Thank you!

  • @tbear9353
    @tbear9353 Жыл бұрын

    Good video. 👍 Have you thought about maybe shooting in a room with less reverberation, or maybe putting the mic closer to you? I think it would help the audio quality. Just my opinion. Keep up the great content. Thanks.

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Good call, appreciate the feedback and will incorporate it!

  • @suns1457
    @suns1457 Жыл бұрын

    please do a video on all the different methylphenidate meds and when to use which one! Thank you! keep up the good work!

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Thanks! Will be a while but will get around to it eventually.

  • @specialist-in-tech
    @specialist-in-tech8 ай бұрын

    Wellbutrin in directly helped my anxiety.

  • @ashuvijay7031

    @ashuvijay7031

    7 ай бұрын

    R u still taking it ? How many days have been so far ?

  • @evabarvitskiemarshall7999
    @evabarvitskiemarshall79996 ай бұрын

    Love your teaching

  • @SamanthaParker-ir2gq
    @SamanthaParker-ir2gq9 күн бұрын

    it's saved my life. I know its cliché and there was once a time i read similar comments and thought "they're so lucky". I had tried everything under the sun and not seen a difference or felt numb. This medicine helped me straight away turn my depression and anxiety dials down. I still feel emotions though, still have bad days. But i am always ok, always able to cope with what's going on, compared to before when every min was painful. I have ADHD though and also take stimulants. Both have been such a turning point for me.

  • @SamanthaParker-ir2gq

    @SamanthaParker-ir2gq

    9 күн бұрын

    Interesting because I also have OCD but it helped me anyway.

  • @Iris_Crypts
    @Iris_Crypts Жыл бұрын

    Downregulation and desensitisation combined with increased availability in the synapse is probably going to have a stabilising effect. SSRIs have emotional and physical numbing properties essentially acting as minor tranquilisers. Cutting out the lows but also removing the highs. The same idea can arch to the properties of reuptake inhibitors in general. I do think this would be dosage dependant with less 'stabilising' and different effects at higher dosages. Long term and chronic use is different from the short term and treatment emergent effects. I think it can increase extroversion so it could potentially change the dynamics of the flight, fight, freeze response. Since depression correlates with anxiety, if you can treat depression it could also be the case that you correlate to treating the anxiety by virtue and irrespective of the mechanism of action

  • @pipp972

    @pipp972

    3 ай бұрын

    "I think it can increase extroversion so it could potentially change the dynamics of the flight, fight, freeze response. " Anecdotally I see it prescribed a lot for social anxiety with mostly good reviews from patients.

  • @davidbohanonbohao3604
    @davidbohanonbohao3604 Жыл бұрын

    Have been hesitant to tx. Sexual side effects of SSRI in anxious pt. With Bupropion augmentation based on previous training. Might me worth a revisit as we have more blinds feeling the elephant and communicating 😊.

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    🐘

  • @orion10x10
    @orion10x10 Жыл бұрын

    Thank you so much for making this

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    You are very welcome

  • @kenhaze5230
    @kenhaze5230 Жыл бұрын

    The mechanisms is different despite the PEA skeleton, but amph is basically the flagship for "causing anxiety," and yet withdrawal is noted for increased anxiety. Maybe it could do by different mechs. Or in some persons but not others. Or anxiety is too loosely defined to differentiate iatrogenic vs withdrawal "types" of anxiety. Or, it's amph lore that it causes anxiety at therapeutic dose and researchers are biased or afraid to talk nice about a SII chem. Extremely low motivation can also cause distress or even dread in demanding situations, and D2 antagonists have those kinds of effects. It's caveman-like to just impute the same effect to SNDRI/SNDRA w/drawal, but cavemen weren't always wrong about all things. So likely to me it seems over-"activation" anxiety and irritable, short attention span fatigue anxiety are distinct phenomena but are called the same thing.

  • @jonathanberry9502
    @jonathanberry95025 ай бұрын

    🎯 Key Takeaways for quick navigation: 00:20 🧠 *Complexity of Bupropion and Anxiety Theories* - Understanding bupropion's effect on anxiety is not straightforward. - Psychiatric theories often provide varying perspectives on mental health treatments. - Not all established beliefs about bupropion and anxiety hold up to nuanced examination. 02:21 🐘 *Parable of the Elephant and Psychiatric Theories* - The parable highlights the limitations of viewing truths from a single perspective. - Multiple psychiatric theories exist, each offering insights but also limitations. - Understanding mental health requires considering various perspectives and theories. 04:02 🎭 *Definition and Understanding of Anxiety* - Anxiety is a universal human experience characterized by various symptoms. - Differentiating between typical anxiety and clinical anxiety disorders is crucial. - Anxiety can serve as a communication tool, signaling when something is out of balance. 05:52 🌡️ *Bupropion's Impact on Anxious Depression* - Anxious depression refers to heightened anxiety during depressive episodes. - Studies suggest comparable efficacy between bupropion and SSRIs for treating anxious depression. - Bupropion does not inherently worsen anxiety in depressive patients. 08:49 📊 *Studies on Bupropion and Generalized Anxiety Disorder* - Limited data suggests bupropion's efficacy in treating generalized anxiety disorder is comparable to other medications. - Some patients experience treatment-emergent anxiety with bupropion, similar to other antidepressants. - Further research is necessary to conclusively determine bupropion's effectiveness for generalized anxiety disorder. 10:24 🚫 *Bupropion's Effectiveness in Other Anxiety-Related Disorders* - Limited studies indicate mixed results for bupropion's efficacy in disorders like OCD and social anxiety disorder. - Some patients may experience worsened symptoms with bupropion in certain anxiety-related disorders. - The response to bupropion varies among individuals with different anxiety-related diagnoses. 14:49 💡 *Clinical Strategies for Minimizing Treatment-Emergent Anxiety* - Starting bupropion at a low dose and gradually increasing can help minimize treatment-emergent anxiety. - Different formulations of bupropion (IR, SR, XL) allow for tailored dosing strategies. - Clinicians can use a "start low and go slow" approach to mitigate potential side effects. Made with HARPA AI

  • @PsychoFarm

    @PsychoFarm

    5 ай бұрын

    Jonathan this is awesome! Thanks sir much. Can you teach me how to do it for other vids.

  • @BereichAllgemein
    @BereichAllgemein3 ай бұрын

    I have diagnosed SAD and GAD, Bupropion helps with my anxiety, it actually gives me a little bit more self esteem. Was on Sertraline before and it felt terrible, it just blunted my emotions. It helps with anxiety in a different way than SSRIs - at least in my own subjective experiance.

  • @IAmLegend9291

    @IAmLegend9291

    2 ай бұрын

    I have bad anxiety and was prescribed this , I’m terrified to start but I think if I want to change something I need it at least try ..

  • @lordnoiado
    @lordnoiado2 ай бұрын

    It absolutely killed me. Anxiety and manic depressive episodes quite regularly

  • @DontLookBehindYou1
    @DontLookBehindYou12 ай бұрын

    It's been amazing for me so far... But I'm waiting to see if the edginess wears off after I've been in it for a while. The energy is great, but the edginess not so much. I'm sure it's manageable and it's certainly better than where i was... Which was very bad, even with my lithium and lamictal... It's overall been a great trio treatment... Just some nuances to get used to.

  • @taaayll
    @taaayll8 ай бұрын

    Content wildly good. Audio quality wildly bad.

  • @brandonm8131
    @brandonm813110 ай бұрын

    Iv only been on it for 2 days but im feeling well. I have anxiety and this medication keeps my heart from racing.

  • @nenadcubric2663

    @nenadcubric2663

    6 ай бұрын

    Thats no good

  • @Lydiam777
    @Lydiam7772 ай бұрын

    Omg Wellbutrin saved my life. At my peak depression/kinda anxiety I was in the hospital for suicidal ideation. They gave me this med after trying so many other meds. After like 3ish days I felt so much better. I stopped taking it about a month and a half ago because I was doing really good. But I’m now going through a REALLY BAD anxiety patch panic attacks, constant thoughts. My parents, psychiatrist and me think that Wellbutrin really did help my anxiety. I’m starting it again today but this really is like a last hope for me. This med saved my life before and I hope it saves me again. I DEFINITELY do believe this med helps with anxiety but it also can cause it❤❤

  • @brettkorenak3721

    @brettkorenak3721

    2 ай бұрын

    I just got put on it today , I’m hoping to get similar results as you because I’m feeling the same way. I hope it’s helped and you’re doing well since you’ve restarted taking it

  • @Lydiam777

    @Lydiam777

    2 ай бұрын

    @@brettkorenak3721 I’m still re adjusting to it! I’m noticing lights are really bothering me and my vision has been a bit blurry and I’ve been more irritable. I’ve only been on it for a week though! I do remember sorta feeling this way when I first started it. Just know your anxiety MIGHT get way worse before it gets better. Give it at least a couple weeks. This is the only med I truly trust I’ve been on so many others! Goodluck and you can always ask me questions when I was on it before it helped me so so much!

  • @IAmLegend9291

    @IAmLegend9291

    2 ай бұрын

    How it’s going ?

  • @Lydiam777

    @Lydiam777

    2 ай бұрын

    @@IAmLegend9291 It’s going. I’m 2 weeks on the medication and I feel a bit better but I’m still adjusting, it’s my second time on the medication so it will take longer. I’m definitely irritable and I like can never sit still and my senses are heightened which is common starting meds. Gonna give it 2 more weeks and see where we are at. Don’t let this scare you Wellbutrin saved my life before and it’s the only med I have EVER tolerated. If you need anything else just ask me and I’ll respond as so soon as possible ❤️❤️

  • @Lydiam777

    @Lydiam777

    Ай бұрын

    @@IAmLegend9291 okay! I’m quite irritable but waiting to see if that goes away! I started Buspar to target my anxiety and so far it’s working! I actually want to get out of my house sometimes now lol I’m just tired and dizzy but I’m still adjusting! Hope you’re doing well if you have anything questions feel free to ask! < 3

  • @vikashk11
    @vikashk11 Жыл бұрын

    Thanks so much for this great information. On a separate note has anyone experienced a difference in hair loss or hair thinning whilst on bupropion?

  • @dominicle7123
    @dominicle7123 Жыл бұрын

    babe hurry psychofarm just psoted

  • @EsotericResearcher666

    @EsotericResearcher666

    Ай бұрын

    Shut up

  • @itspeache
    @itspeache9 ай бұрын

    Great video but please get a better microphone. It’s hard to understand you with the bad sound recording.

  • @minepolz320
    @minepolz3206 ай бұрын

    Please do vid MAOI, they are very underrated, there is little quality information about them and there are many misconceptions about them

  • @PsychoFarm

    @PsychoFarm

    5 ай бұрын

    I finished an entire series on them. It should be out next month 😇

  • @minepolz320

    @minepolz320

    5 ай бұрын

    @@PsychoFarm thank you for this

  • @minepolz320

    @minepolz320

    5 ай бұрын

    @@PsychoFarm ♥️♥️♥️♥️

  • @Michelle-bl8sz
    @Michelle-bl8sz Жыл бұрын

    Jw what are your credentials- your content is 💯

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    I’m a rodeo clown

  • @ashuagarwal8674

    @ashuagarwal8674

    Жыл бұрын

    Legend

  • @felixmakume5856
    @felixmakume585610 ай бұрын

    So can I use both wellbruitin and serdep???

  • @paulflur4519
    @paulflur45193 ай бұрын

    I take it with vraylar and it works wonders for my anxiety.

  • @fpsroxie
    @fpsroxie7 ай бұрын

    wellbutrin made me not sleep for 2 days when i took it i had anxiety attacks every few hours

  • @BigYellow1500
    @BigYellow15006 ай бұрын

    I give up I can’t finish this video

  • @DB78888
    @DB78888 Жыл бұрын

    I take 150mg Zoloft and Wellbutrin XL long term for post-treated OCD, MDD, GAD. It’s great. When I was on lower Zoloft dosing Wellbutrin was too much for me. Now at higher dosing it balances out so well.

  • @jeremyclarkson3409

    @jeremyclarkson3409

    11 ай бұрын

    Have you noticed any side-effects?

  • @JohnPatersonAu
    @JohnPatersonAu11 ай бұрын

    Can't get Wellbutrin here in Australia. I have to get Zyban instead. It's crazy, Bupropion is sooo much better than SSRI's. I felt like a zombie on SSRI's. Bupropion is a much cleaner drug.

  • @richdude8150

    @richdude8150

    10 ай бұрын

    Definitely better than SSRI

  • @mgscindy
    @mgscindy2 ай бұрын

    Se puede tomar estando embarazada?

  • @gtVel
    @gtVel Жыл бұрын

    Hey man, I gotta ask some questions and throw out unsolicited advice. I stream for a living and know how to have it all configured. What's your audio and recording setup? Microphone, recording software, etc? It's REALLY hard to listen to this video, especially on anything beyond x1 speed. I'd love to see you get it sorted out and make the quality better overall, it helps immensely having this kind of content available online.

  • @gtVel

    @gtVel

    Жыл бұрын

    I'll correct myself ahead of time, your video on the rapid review of different amphetamines had it perfect. Not trying to tell you how to do your thing, but whatever you were doing with that video, (potentially sitting closer to the microphone?), it made it CONSIDERABLY more legible.

  • @PsychoFarm

    @PsychoFarm

    11 ай бұрын

    Always appreciate constructive feedback! I reached out on twitter for more advice. As for audio: temporary living in a sublet where I don't have my normal set up including mic (Yeti blue). Moving to my new place in 1 week and audio problems should resolve then 😇

  • @tubo1812
    @tubo1812 Жыл бұрын

    The video quality is good but the sound isn't. I hope you can improve it so it is easier to understand for non native speakers

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    Will be fixed for next video!

  • @tuffymcfukleby
    @tuffymcfukleby10 ай бұрын

    The audio keeps fading in and out throughout the video. :/ Otherwise solid content.

  • @nenadcubric2663
    @nenadcubric26636 ай бұрын

    If anxiety/Panic is part of a Chronic Depression, then Buprinion will help

  • @Scrazelope
    @Scrazelope11 ай бұрын

    Your mic is much quieter than your videos where you don't use a camera. You should look into getting a mic closer to your mouth.

  • @dmtdreamz7706
    @dmtdreamz77065 ай бұрын

    🐬

  • @thebeatles9
    @thebeatles9 Жыл бұрын

    Why is every doc on KZread hot. I'm never gonna get in to med school

  • @PsychoFarm

    @PsychoFarm

    Жыл бұрын

    You Is Smart, You Is Kind, You Is Hot

  • @maestro9765
    @maestro9765 Жыл бұрын

    For me, caffeine reduces anxiety. Can bupropion lower anxiety for me?

  • @jldouglas1985

    @jldouglas1985

    11 ай бұрын

    Caffeine increases my anxiety, so frustrating

  • @PsychoFarm

    @PsychoFarm

    11 ай бұрын

    Different folks different strokes

  • @wesleydevries7415

    @wesleydevries7415

    10 ай бұрын

    Caffeine does nothing for me apart from making my armpits wet when taking adderall

  • @maestro9765

    @maestro9765

    2 ай бұрын

    @@jldouglas1985 I know this is normal for everyone but somehow not for me. I've never had anxiety from caffeine, not even the time that I drank 12 red bulls in one day. In fact, the day I drank 12 red bulls I slept like a rock.

  • @squashbrowns
    @squashbrowns Жыл бұрын

    daddy

  • @goldeternal
    @goldeternal7 ай бұрын

    i hate psychiatrist

  • @Mental_Patient

    @Mental_Patient

    7 ай бұрын

    I'd see a therapist for this anger 😂

  • @jarkiro
    @jarkiro3 ай бұрын

    I've been on the escitalopram (lexapro) + buproprion combo. 150mg slow release buproprion and 10mg escitalopram, the buproprion has helped a lot with reducing some side effects of the lexapro.

  • @jarkiro

    @jarkiro

    3 ай бұрын

    I should note, only to treat GAD and SAD, not for depression.

  • @belencita9526

    @belencita9526

    2 ай бұрын

    I took this exact combo for GAD but Lexapro made me gain like 10 pounds. Wondering if I should try Wellbutrin only

  • @jarkiro

    @jarkiro

    2 ай бұрын

    @@belencita9526 yeah Lexapro definitely made me gain a little bit. I've swapped to Lexapro 10mg at Night and the 150mg Slow release Buproprion in the morning. Helps slightly more with appetite suppressing and sexual side effects imo.

  • @nick8670
    @nick867011 ай бұрын

    I watched your video on anti-psychotics and I was wondering what medication you would recommend for direct insomnia instead of quetiapine

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