Dmitry Korkin: Computational Biology of Coronavirus | Lex Fridman Podcast #90
Ғылым және технология
Dmitry Korkin is a professor of bioinformatics and computational biology at Worcester Polytechnic Institute, where he specializes in bioinformatics of complex disease, computational genomics, systems biology, and biomedical data analytics. I came across Dmitry's work when in February his group used the viral genome of the COVID-19 to reconstruct the 3D structure of its major viral proteins and their interactions with human proteins, in effect creating a structural genomics map of the coronavirus and making this data open and available to researchers everywhere. We talked about the biology of COVID-19, SARS, and viruses in general, and how computational methods can help us understand their structure and function in order to develop antiviral drugs and vaccines.
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EPISODE LINKS:
Dmitry's Website: korkinlab.org/
Dmitry's Twitter: / dmkorkin
Dmitry's Paper that we discuss: bit.ly/3eKghEM
PODCAST INFO:
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lexfridman.com/podcast
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OUTLINE:
0:00 - Introduction
2:33 - Viruses are terrifying and fascinating
6:02 - How hard is it to engineer a virus?
10:48 - What makes a virus contagious?
29:52 - Figuring out the function of a protein
53:27 - Functional regions of viral proteins
1:19:09 - Biology of a coronavirus treatment
1:34:46 - Is a virus alive?
1:37:05 - Epidemiological modeling
1:55:27 - Russia
2:02:31 - Science bobbleheads
2:06:31 - Meaning of life
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Пікірлер: 117
I really enjoyed this conversation with Dmitry. Here's the outline: 0:00 - Introduction 2:33 - Viruses are terrifying and fascinating 6:02 - How hard is it to engineer a virus? 10:48 - What makes a virus contagious? 29:52 - Figuring out the function of a protein 53:27 - Functional regions of viral proteins 1:19:09 - Biology of a coronavirus treatment 1:34:46 - Is a virus alive? 1:37:05 - Epidemiological modeling 1:55:27 - Russia 2:02:31 - Science bobbleheads 2:06:31 - Meaning of life
@jessicavanvugt5937
4 жыл бұрын
Thanks Alex ! We will spread some of your video's in and around, The Netherlands.
I am so impressed by the content of this podcast, which widely covers different domains of science, allowing outsiders to understand the challenges of so many cutting edge science topics, with an approachable fashion! I just supported you on Patreon, please keep doing the amazing work!
Lex is something else. A man who truly cares.
@blackguard93
4 жыл бұрын
who cares?)
@sapito169
4 жыл бұрын
lex is robot
I fall asleep to these videos. I swear I wake up smarter everyday.
@LIHPIT
4 жыл бұрын
Many people wake up stupid than they were before repeating information they have no idea is true or not
@yoavsnake
4 жыл бұрын
Is it because autoplay is on and it plays SmarterEveryDay?
@IsaacRodman
4 жыл бұрын
This is hilarious, because this is exactly what I've done for months. I think it only results in more significant but stressful sleep patterns
@queball685
4 жыл бұрын
I discovered this channel a few days ago and this exactly what i've been using it for. Perfect podcast to fall asleep to
Excellent guest! Definitely broadened my understanding of what is going on. Solid 2 hours.
wow! One of the best Interviews i have ever seen. Dmitry is amazingly lucid communicator, his own admission of "thick accent notwithstanding. I would love to sit in one of his classes. Thank you Lex for bringing such brilliant people to illuminate our understanding of things.
I love that you label the sections by subject. I wish more people would, or knew how, to do that. Great interview!
My two favorite Russians in the same place? What more could I want?! I'm excited that the greater AI community can benefit from hearing Dr. Korkin's words. I've been lucky enough to be in his classes; he is the only lecturer I've had that I have recruited classmates to record if I had to miss class (his classes are of a very few I didn't skip just because).
I love this particular podcast. Open discussion about so many aspects of science. No melodrama. Lots of facts, conjecture and calm, probing curiosity. It's the anti-Eric Weinstein interview.
big fan of the podcasts, I'm wondering are there transcripts available for the podcasts? would love to share with a deaf friend
@gerardwalsh4724
4 жыл бұрын
You can turn on captions - they're pretty good at transcribing the video.
This has come at the best time for me, bioinformatics is all I'm doing at the minute with lockdown. Great guest and podcast.
Thanks for the discussion. I think Dmitry was thinking of Foldit when he answered the Folding@home question. Folding@home runs simulations on its own, while Foldit is an interactive game.
I appreciate how Lex comes prepared with notes. One of my new favourite podcasts!
@Arcticwhir
4 жыл бұрын
On the other hand, letting the guest ramble on brings out interesting discussions, sometimes I dont like when the host interrupts too many times
@Adreno23421
4 жыл бұрын
True. However, Lex could have read the guest's paper before having him over. It would not take that long and he would have been better informed, making the conversation perhaps more interesting (because it could be easier to go deeper into the subject).
From one Dmitry to another, well done. Informative and thought provoking.
Thank you so much. Fascinating. I really enjoyed the topic about Dmitry's bobblehead collection, as well as his opinion on the question of life.
I'm really grateful for your work Lex, thank you!
Hi Lex, Great and inspiring video as always! In the context of bioinformatics I would like to see you interviewing professor Pavel Pevzner. Peace and love :)
That was really cool Lex, thanks. He answered a lot of questions I had and inspired new ones. The folded proteins look a lot like Wolfram's 3D rendered cellular automata structures.
Every podcast my appreciation for the human machine(lex) increases
You should do a podcast with Ken Thompson and talk to him about c and c++
Loving the accents on this episode! Great episodes lately lex! Keep it up :)
Thank you for letting us hear information from the professionals
Again another interesting guest.!! Thx Lex.
This is interesting to watch !!! Epidemicological mondeling. Wow wow wow. It.s all in the details. Video of the year !!!
Thanks for this one Lex!
Keep it up Lex! I watch every second of your amazing conversations. Also when I go for running as podcast. You do a wonderful job.
awesome video
A most interesting and informative presentation. He should be sought out and consulted..This man I could trust
This is fascinating - but best viewed at x3.
Thank you to Lex for another fascinating video, full of great questions. And thank you to Dmitry for doing very useful work.
That was a great conversation, thank so much, as a biologist can I please request some more biologists
Thank you for interviewing a computational (computer) scientist who knows the details of viral physiology.. this is similar to you interviewing an AI (computer) scientists who actually knows the details of the Python, LISP, C++ languages. 💪
@andreybashkin9030
4 жыл бұрын
Or, those who actually created Python, C++ languages.
Amazing ❤️
Lex: Hi. Dmitry: Both.
You are amazing at doing your job, Lex! Thank you!
his eyes .. his question about hope at ~7:50 .. I think I saw someone ask a question who knows (or fears) the answer (really smart conversation, thanks)
How do you have no accent talking to him you are a very impressive human if you are in fact human love your work thank you for expanding my narrow mind
As a medical student I appreciate this!
Best podcast on youtube!!
I wish there was more depth in the discussion of his scientific research, such as how is agent-based modeling done? what were the results of his cruise ship study? how would potential drugs work, such as remdesivir, chloroquine for covid19?
I'm really curious to know the reliability of the covid-19 tests in the hypothetical case of a person infected with another member of the coronavirus family. Can't find the answer for that anywhere Congrats for another great podcast, Lex. You're the best.
Lex, Your pod cast is great! I'm very interested in animal intelligence and what this means for AI. Keep asking the hard questions.
Came from Discord
@finalform6667
4 жыл бұрын
What Discord?
Really enjoyed the deep discussion. The breadth of knowledge is so vast that we are still learning and we have only just begun. It was also nice to see Lex so interested in Biology. I wonder if he will start a collaboration and direct AI and deep learning towards COVID and beyond. Cellular intelligence would be a cool topic too.
Another great interview (didn't need "Coronavirus" in the title to be captivating)!. I believe Dr. Eric Lander would be fantastic material for another one on similar subjects.
Sounds like we need hologram video conferencing, of the above desk body.
I love your podcast, though I can't support you financially as I myself am a student, but would really like it if you stopped putting midroll ads, instead, you can put them at the beginning or the end.
We are truly multitudes. #PhilosophyOfTimeTravel
Would you say the time period of 10 years could be great speed up, with brain natural interface, providing much faster ways to interact, explorer and interrogate the data and manipulate it?
Fucking great podcast Lex. Keep it up!
I watch for Hedgy fandom, the topics go over my head :-p
He says you know a lot
I would expect generally the virus to be more transmissible during the asymptomatic phase, and very early symptomatic phase. Note that the asymptomatic phase means your body is not yet responding to the virus and it is replicating rather freely. Symptoms are the response of the body fighting the virus so we might expect transmissibility to start falling.
I like this nasty smile of Dmitry, when he says something funny.
03:43 how Unix-y of it😂
Wanted to ask if blood type makes a difference. The reason Mac operating software is less susceptible to viruses is because of the percentage it has in market share. By analogy, are rare blood types less susceptible to the Corona virus?
Lex is the AI Cyborg. Otherwise how he maintains that voice and broadcasts love.
As Lex struggled with the genome ideas, I suddenly realized he doesn't know everything. That was a shock.
My wife would like to know: out of everyone who has gotten sick with COVID-19 or died, what is the average percentage that already had chronic disease, and/or compromised immune systems?
Было бы еще круче, если интервью было на русском)) Спасибо!
@singularonaut
4 жыл бұрын
Учите английский) либо ждите нейронку подражающую голосам людей в видео на лету переводящее по смыслу сказанное ими на выбранный язык) лет через 10 будет не важно на каком языке в оригинале произведён контент 😏
@andreybashkin9030
4 жыл бұрын
Такое интервью собрало бы меньшую аудиторию. Было бы хуже и для обоих в кадре, и для 95% аудитории. Вот реально, что было бы здорово - это хорошие субтитры на русском. Но это трудозатратно. Если есть у кого-нибудь время, желание этим заняться - предложите Лексу помощь. Я думаю, он оценит.
Get manolis kellis next
🖤
Honestly an educational video but with very monotone voices 😭😭
Why is he talking about statist regulations?
Viruses have Swarm Intelligence!? cool stuff.. :) thx!
you should ask people about their education and let them talk about their research
I think it's time you expand the variety of content and start giving your opinions on other things such as books, music etc. (I'm not saying you should stop doing these podcasts but I'd definitely love to see what your thoughts are on other things/events as well.)
Hey lex , your podcast's are amazing It would be great if you could interview neil de grasse tyson
Lex you are wrong about Russian AI. It’s pretty big. You should visit ods.ai, the biggest Russian data science community.
@Anton_Sh.
4 жыл бұрын
Is it really that big with regard to conferences ?
Throughout vastly most of human history, there was a smaller, relatively immobile human population, and that is what humans evolved to live in. I am afraid humans are not biologically equipped -- yet -- for today's large, mobile populations. Evolution will eventually equip us the hard way, sadly, but good science and good political policy together can be the way out of this difficulty. Humans have to improve both or else we will fail, as we have already seen. A boolean AND gate is connecting our political and scientific outputs.
Сэнкс а лот Лекс! Зис кайнд оф видео инспайер ас то би стэинг эт хоум 😏 анд ауэр хоуп фор креатинг а вакцин агейнст ковид ис гроуниг ин экспоненшиал рейт)
@andreybashkin9030
4 жыл бұрын
*ваКцин Александр, Вы забыли проверку правописания включить.
@singularonaut
3 жыл бұрын
@@andreybashkin9030 сэнкс комрад, ай фиксед ит 😏
@monopatilog
2 жыл бұрын
Найс вей ту спик интранслятабл рашн))
Ёжик! :)
@likorice_swiss
Жыл бұрын
Расскажите, почему у Лекса стоит Ежик?
First.
a host can't spread if they're dead. Why did he act like it was a mystery why more deadly viruses are less contagious?
Lex - the thinking person's cuddly toy. . . .
sik vid
If you ever want to make an evolutionary biologist laugh at you or punch you in the face is to tell then humans descend from apes. 😂😂😂
You know.
Is it just me , or does Lex sound like a smackhead between nods ? No offense , most of my mates are on heroin .
Did Lex pluck some random dude off the street to talk about viruses?? The guest is slow & under-informed.
Lex is something else. A man who truly cares.