Combined Effect of Drug | Synergistic Effect | Additive Effect | Superaadditive Effect of Drugs

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Synergism comes from the Greek word "synergies" meaning working together. It refers to the interaction between two or more "things" when the combined effect is greater than if you added the "things" on their own
In toxicology, synergism refers to the effect caused when exposure to two or more chemicals at as time results in health effects that are greater than the sum of the effects of the individual chemicals.
Additive Effect - This action occurs when the combined effect of two or more chemicals is equal to the sum of the effect of each agent given alone, they do not interact in a direct way for example:
2 + 2 = 4
This effect is the most common when two chemicals are given together.
Potentiation - This effect results when one substance that does not normally have a toxic effect is added to another chemical, it makes the second chemical much more toxic; for example:
Antagonism - Antagonism is the opposite of synergism. It is the situation where the combined effect of two or more compounds is less toxic than the individual effects; for example:
Antagonistic effects are the basis of many antidotes for poisonings or for medical treatments. For example, ethyl alcohol (ethanol) can antagonize the toxic effects of methyl alcohol (methanol) by displacing it from the enzyme that oxidizes the methanol
In comparison, a synergistic effect is a situation where the combined effect of two chemicals is much greater than the sum of the effects of each agent given alone, for example:
There are various examples including:
(a) Carbon tetrachloride and ethanol (ethyl alcohol) are individually toxic to the liver, but together they produce much liver injury than the sum of their individual effects on the liver.
(b) The much higher incidence of lung cancer resulting from occupational exposure to asbestos in smokers (compared to exposed non-smokers).
(c) The toxicity of some insecticides notably pyrethrin (from chrysanthemums) and synthetic pyrethrins (pyrethroids) can be increased many times by the addition of compounds which themselves are not insecticides.
(d) Barbiturate drugs have a greater effect on the central nervous system (CNS) by causing CNS depression when taken with general anaesthetics, alcohol (acute consumption) narcotic analgesic (pain reliever) and other sedative-hypnotic drugs.
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Пікірлер: 349

  • @mudassirkhan1938
    @mudassirkhan19384 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

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    @muskanrai9567

    4 жыл бұрын

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    @sanketramteke42723 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

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  • @utkarshwankhade1392
    @utkarshwankhade13923 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

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    @tradetalks014 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

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    @hukams143

    Жыл бұрын

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    @ahemadriaz3 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you

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    @shubhamsemwal61385 жыл бұрын

    Pharmacology bhut simple lgri h apke lecture study krne ke baad 😊 thank u sir

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Thank you so much. Meri kosis hi yahi hai ki is tough subject ko easy banaya jaae

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    @MazharHussain-jn1zx

    4 жыл бұрын

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  • @soumyaagrawal2023
    @soumyaagrawal20234 жыл бұрын

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  • @MuhammadAkbar-ci9cm
    @MuhammadAkbar-ci9cm Жыл бұрын

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  • @Siddat143
    @Siddat1433 жыл бұрын

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    @gaganpreet86893 жыл бұрын

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    @Salar12378Ай бұрын

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    @poonamgundrajiya82155 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Purnima Gupta My pleasure

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    @iramjahan74884 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Iram jahan Thank you so much

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    @rizz4life Жыл бұрын

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    @mohammadrahis19994 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Mujhe to aap sabke dil me hi rahna hai

  • @AbhishekKumar-yc8ni
    @AbhishekKumar-yc8ni Жыл бұрын

    Thank you dewta aese hi continue bnaese video

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    @aqibawanawan77752 жыл бұрын

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  • @Mr.common7033
    @Mr.common7033 Жыл бұрын

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    @nidajamil12302 жыл бұрын

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    @alihasan-pf7uf8 ай бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    8 ай бұрын

    Thanks and welcome

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    @SachinKumar-fo6dd3 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Most welcome. Its my pleasure

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    @muzahidshaikh87605 жыл бұрын

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    @solutionpharmacy

    5 жыл бұрын

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    @jasleenkaur81403 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    My pleasure. Thank you for your valuable feedback

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    @sudhirsingh9279 Жыл бұрын

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    @shanezamariyam1824 жыл бұрын

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    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @akashmishra5434
    @akashmishra54344 жыл бұрын

    Sir before that mujhe pharmacology tuff lagti thi but aapke lecture dekhne ke baad sb acche se samajh aata hai Thankyou sir..

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Akash Mishra Great. Meri kosis yahi rahti hai ki sab achhe se samjh sake

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    @akashmishra5434

    4 жыл бұрын

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    @ManojKumar-tv7xo2 жыл бұрын

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    @suyashpalhappy1479 Жыл бұрын

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    @MazharHussain-jn1zx4 жыл бұрын

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    @vishwajeetdubey13575 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

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    @vishwajeetdubey1357

    5 жыл бұрын

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    @kurranagalakshmi90323 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Mybpleasure. Thank you

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    @devanshsharma62444 жыл бұрын

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    @solutionpharmacy

    4 жыл бұрын

    Thank you

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    @ashuhooda10123 жыл бұрын

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    @pratikshagaikwad12984 жыл бұрын

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    @solutionpharmacy

    4 жыл бұрын

    Thank you

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    @suneelsingh1626 Жыл бұрын

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    @rashmisinha2234 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thanks alot for your support and motivation.

  • @rashmisinha223

    @rashmisinha223

    4 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Sorry we can not send via mail. You can take help of your friends

  • @tradetalks01
    @tradetalks014 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    You can find animation in playlist and diagram on facebook group

  • @dhurvendragaur9143
    @dhurvendragaur91435 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    dhurvendra gaur its my pleasure. I love to do somthing for my students and all others.

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    @sandipchaudhari38744 жыл бұрын

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    @solutionpharmacy

    4 жыл бұрын

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    @sakshitomar10214 жыл бұрын

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    @solutionpharmacy

    4 жыл бұрын

    Thank you

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    @iramjahan74884 жыл бұрын

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    @ramsubhag86054 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you so much

  • @tahirkhan97
    @tahirkhan973 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you

  • @ilyasahmad8153
    @ilyasahmad81533 жыл бұрын

    Thank you very much ...

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Most welcome

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    @pinky96095 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Amisha Pandey Thanks alot. Yes i wil upload many more video. You may support us by sharing with your friends. Thanks.

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    @pinky9609

    5 жыл бұрын

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    @ganpatpatel3343

    5 жыл бұрын

    I am also preparing for gpat 2020... Best of luck for upcoming exam gpat 2020

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    @dvijenjagirdar98414 жыл бұрын

    Excellent sir...thanks

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    My pleasure.

  • @muskanrai9567
    @muskanrai95674 жыл бұрын

    Aap achche se smjate h thanks sir iam waiting for next video

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Muskan Rai thank you. I have already uploaded all videos

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    @rajaazhar69613 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you so much

  • @pmportantonlygodgreat
    @pmportantonlygodgreat2 жыл бұрын

    Sir ,you are doing great.Sir can you add practice of those questions in your pharmacology lectures that is important for next exam mbbs

  • @nilidutta4759
    @nilidutta47594 жыл бұрын

    Thanks a lot sir....I was really worried about pharmacology but your explaination makes me understand Pharmacology...I m followin K D Tripathi..plzzz sir make more videos In pharmacolgy..Always be greaful to you...🙏🙏🙏🙏🙏

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Nilanjana Dutta Thanks alot dor your feedback. We have more than 650 videos. I have already finished cology -1 and 2. Please have a look.

  • @nilidutta4759

    @nilidutta4759

    4 жыл бұрын

    @@solutionpharmacy sure sir i will see all your videos....I am looking for the Topics which are covered in my class..day by day all the topics will cover and ur videos will help me to understand..🙏🙏🙏

  • @reetikaraj2169
    @reetikaraj21693 жыл бұрын

    Your way of teaching is amazing sir

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you so much

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    @itspiyushnagar98104 жыл бұрын

    Thankyou sir love you 😘😘😍

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    @user-wk2gp3tu8h3 жыл бұрын

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  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    My pleasure

  • @Gajanan585
    @Gajanan5853 жыл бұрын

    Very good teaching sir thank you so much sir 🙏🙏

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    My pleasure. Thank you

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    @arzoosanjwal43365 жыл бұрын

    Great work sir

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Arzoo Sanjwal thank you so much

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    @rutikchaudhari44653 жыл бұрын

    Thank you sir for making such wonderful video and I hope u will make some other subject videos too

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you. Completed cology, started micro then will start another

  • @mohnishgautam3327
    @mohnishgautam33274 жыл бұрын

    Thanks sir, i wish it could be more simple with more diagrams and signs...... Its just an opinion, your work is great

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thanks alot. I too love diagrams. In my vidoes 70% are having diagram.

  • @priyankaislam4514
    @priyankaislam45144 жыл бұрын

    Thank you so much sir!

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Most welcome

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    @mohammadasif37194 жыл бұрын

    Nice

  • @priyamarydas1696
    @priyamarydas16964 жыл бұрын

    Thank you sir 👍

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Welcome

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    @pratixapatel65402 жыл бұрын

    Very useful for me sir,👍

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    @solutionpharmacy

    2 жыл бұрын

    Thank you. Please download our app from play store - play.google.com/store/apps/details?id=co.bolton.nqilv

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    @vishaljadhav-ur6ye4 жыл бұрын

    It is very helpful sir tqu

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @rajivdas8185
    @rajivdas81853 жыл бұрын

    Good

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    @kausarriaz45313 жыл бұрын

    Your teaching is very good 🙂

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you

  • @inayatkhanafridi3344
    @inayatkhanafridi33442 жыл бұрын

    Great job sir you teaching method is awesome ♥

  • @solutionpharmacy

    @solutionpharmacy

    2 жыл бұрын

    Thank you so much

  • @inayatkhanafridi3344

    @inayatkhanafridi3344

    2 жыл бұрын

    You are welcome sir ♥

  • @avinashverma2736
    @avinashverma27364 жыл бұрын

    Very useful video ....

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @girishyt8207
    @girishyt82073 жыл бұрын

    Great gob sir ji 👍👍🤗🤗🤗🤗❤️❤️

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you

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    @MazharHussain-jc9bm4 жыл бұрын

    You are great sir

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Mazhar Hussain Thank you for your love and support

  • @azrabatool7235
    @azrabatool72353 жыл бұрын

    Thank you sir..Allah bless

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Shukriya

  • @kedarjadhav1396
    @kedarjadhav13963 жыл бұрын

    Great work 👏

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you

  • @drxgarimasahu3072
    @drxgarimasahu30724 жыл бұрын

    Tq sir

  • @KrishKumar-to8tg
    @KrishKumar-to8tg4 жыл бұрын

    Thanku sir for easily language 🙏

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Welcome

  • @sohanyadav1788
    @sohanyadav17884 ай бұрын

    Sir aap ka Jo samjha ne ka trika very good morning ❤❤

  • @solutionpharmacy

    @solutionpharmacy

    4 ай бұрын

    Thank you so much

  • @mddilkash3617
    @mddilkash36172 жыл бұрын

    Outstanding

  • @solutionpharmacy

    @solutionpharmacy

    2 жыл бұрын

    Thank you

  • @MuhammadimranMLT-hw5cf
    @MuhammadimranMLT-hw5cf2 жыл бұрын

    very good Sir !

  • @solutionpharmacy

    @solutionpharmacy

    2 жыл бұрын

    Thank you

  • @drx.ramkumar872
    @drx.ramkumar8725 жыл бұрын

    Sir apne mera dil jeet Liya esa understanding kiya

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Thank you so much.

  • @drx.ramkumar872

    @drx.ramkumar872

    5 жыл бұрын

    Solution- Pharmacy sir pdf or send kardo

  • @drx.ramkumar872

    @drx.ramkumar872

    5 жыл бұрын

    Pci syllabus 2,3,4,5 unit send kar do please pharmacology ki pdf

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    RAM KUMAR Sorry but not available at the moment. All notes are available in our group only. Sare notes wahi hai uske alawa nahi hai abhi.

  • @hrishikeshgawali3388
    @hrishikeshgawali33883 жыл бұрын

    Wonderful lecture sir 🔥🔥🔥

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thank you so much

  • @nehasiddique2383
    @nehasiddique23833 жыл бұрын

    Thankuu so much sir

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    My pleasure

  • @RxDharmendra22
    @RxDharmendra225 жыл бұрын

    Thanks Sir 🇮🇳🇮🇳🇮🇳🇮🇳🇮🇳🙏🙏🙏🙏🙏

  • @chauhanchauhan2443
    @chauhanchauhan24435 жыл бұрын

    Great Sr

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Thank you

  • @guptapooja8233
    @guptapooja82334 жыл бұрын

    Nice information sir

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @j.sbhandari8813
    @j.sbhandari88133 жыл бұрын

    Good presentation sir

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    jinesh bhandari Thank you

  • @swarnalatamohapatra2044
    @swarnalatamohapatra20443 жыл бұрын

    Thank u so much sir ❤️❤️

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    My pleasure

  • @neelkanthpant2115
    @neelkanthpant21154 жыл бұрын

    Awesome

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @masroorali9773
    @masroorali9773 Жыл бұрын

    Good information sir

  • @solutionpharmacy

    @solutionpharmacy

    Жыл бұрын

    Thank you

  • @mediconsyncracy1745
    @mediconsyncracy17453 жыл бұрын

    Best explain ❤❤

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Thanks

  • @tenzinlhagyal2028
    @tenzinlhagyal20284 жыл бұрын

    Great sir ..

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @shreeshyampareek5154
    @shreeshyampareek51543 жыл бұрын

    Sir there is a statement in kdt that in super addition one drug is individually produce no effect . And in example we have cotrimaxozole in which both component are active individually.

  • @kunal5178
    @kunal51782 жыл бұрын

    Sir please explain treatment of Overdigitalization

  • @rohitpatil2757
    @rohitpatil27575 жыл бұрын

    Very nice sir

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Rohit Patil Thank you

  • @mudassirmudassirkhan5239
    @mudassirmudassirkhan52393 жыл бұрын

    Good Job And Thanks For Awareness Hii I Am Dr. Mudassir Khan Consultant Psychiatrist From Pakistan (Islamabad)

  • @NaeemKhan-iu6gb
    @NaeemKhan-iu6gb Жыл бұрын

    Plz why we can gave the piracetamol and disprin to gather it must by devid does

  • @user-sc9rz2jp5v
    @user-sc9rz2jp5v5 ай бұрын

    Thank you sir much sir

  • @solutionpharmacy

    @solutionpharmacy

    5 ай бұрын

    My pleasure

  • @chandanchaudhary3010
    @chandanchaudhary30104 жыл бұрын

    Nice sir..

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @utkarshsrivastava6776
    @utkarshsrivastava67763 жыл бұрын

    amazing sir, but one suggestion can u plz give those animations or reference videos u tell about in the I button during leacture

  • @solutionpharmacy

    @solutionpharmacy

    3 жыл бұрын

    Those are available as playlist in our channel

  • @sohanyadav1788
    @sohanyadav17884 ай бұрын

    Super sir

  • @solutionpharmacy

    @solutionpharmacy

    4 ай бұрын

    Thank you

  • @ShoaibKhan-fk7vi
    @ShoaibKhan-fk7vi Жыл бұрын

    Masha Allah ❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️

  • @vaidyaabhay
    @vaidyaabhay4 жыл бұрын

    nice sir g,👌👌

  • @solutionpharmacy

    @solutionpharmacy

    4 жыл бұрын

    Thank you

  • @ayisha1943
    @ayisha1943 Жыл бұрын

    If in additive effect the total effect will be same as the individual effect of drugs so does it means it is okay if we prescribe any one of the drug to patient?? E.g. both aspirin and paracetamol don't need to be prescribed but just any one of them?? Kindly clear my confusion. Thank you

  • @bangashkpk6310
    @bangashkpk63105 жыл бұрын

    Thnx sir g

  • @solutionpharmacy

    @solutionpharmacy

    5 жыл бұрын

    Most welcome

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