Coagulation Cascade | Part 1/12

#drnajeeb #medicines #pharmacology #physiology #coagulation
Coagulation Cascade | Part 1/12
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Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.
Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation (clotting) factors beyond factor VII respond in a cascade to form fibrin strands, which strengthen the platelet plug.
Disorders of coagulation are disease states which can result in problems with hemorrhage, bruising, or thrombosis.
Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the most extensively researched and is the best understood.
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Пікірлер: 150

  • @dpledford1
    @dpledford110 жыл бұрын

    As a teacher who can honestly say that far too many of the concepts I should have learned as an undergrad, and grad student were not taught for understanding. I can say that though I made A's I took very little from cell biology, cell physiology, etc. So rarely do you see a teacher who both knows the material, and can explain it. I truly mean it when I say that your teaching helps me to be a better teacher. I now feel that I understand the concepts I should have learned 10 years ago. Thank you!

  • @drhamdaankhan3691

    @drhamdaankhan3691

    5 жыл бұрын

    so lovely from you sir👍

  • @Stonefalconetti

    @Stonefalconetti

    3 жыл бұрын

    Totally. I watched most of Dr Najeeb's video at the end of my internship and start of my residency.... I wished i understood these concepts in a much more explicit, comprehensive and effable manner way back when I was a young student...

  • @Stonefalconetti
    @Stonefalconetti12 жыл бұрын

    Every time I watch your videos (even for just a few minutes), the expression "you've made my day" takes ALL its sense! :) If all teachers could teach clear concepts as CLEARLY as you do, there wouldn't be any failures!!

  • @kulsumnoorain8088
    @kulsumnoorain80888 ай бұрын

    This video is from 2010 when I was in 1st class.. And now I'm watching this lecture in my mbbs 1st year😄

  • @DoctorNajeeb

    @DoctorNajeeb

    8 ай бұрын

    Thank you for your Love. Keep watching Keep Learning!

  • @Achiri81
    @Achiri8112 жыл бұрын

    Thank you Sir, I have watched most of your youtube video toward an exam and thanks to those videos, I passed the exam. Also I learnt a lot from them. I'm very thankful for your gift of transmitting knowledge. This is a classical way of teaching without borders and hence accept my greetings from Cameroon!

  • @rosaliarodrigues
    @rosaliarodrigues13 жыл бұрын

    Thumbs up if every time u have a lecture that u dont understand u secretly pray that DoctorNajeeb has a video about it =)

  • @faithforme2
    @faithforme213 жыл бұрын

    I am appreciative of the clear and concise explanations you provide along with the background and examples given to reinforce the concepts!

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    This guy is a legend!!! proper interactive!

  • @sreekanth6919
    @sreekanth69197 жыл бұрын

    sir ur teaching was fantastic...I became a huge fan of ur teaching...I just love it...plz upload more vedios on every topic of pathology....ThnQ sir very much...u makes d subject more interesting😍

  • @nystagmus
    @nystagmus13 жыл бұрын

    WOW Dr Najeeb. You are excellent. When I was in med school had to read this stuff in a pictureless text book. Now students can learn this same material on youtube. You really made the coagulation cascade much more clearer.

  • @Tabishhh381

    @Tabishhh381

    7 ай бұрын

    Hy

  • @18-tanvirahsan74
    @18-tanvirahsan746 жыл бұрын

    Long live my beloved Dr. Najeeb sir

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    @AR-fy2qo2 жыл бұрын

    Superb teaching...never taught like that at university. Beats any book.

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Glad you loved my teaching methodology! ❤️

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    @SaharAleeKoloukani10 жыл бұрын

    You are the very best master! i adore you teacher.

  • @kalyanichakrawar2449
    @kalyanichakrawar24497 жыл бұрын

    you are awesomr sir..... I suddenly regained my interest in physiology....thanks a ton...

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always.

  • @brycecream007
    @brycecream00712 жыл бұрын

    absolutely love them...very helpful thank you

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    @MrOussamatube12 жыл бұрын

    Wonderful Doctor!..I really like your videos and the method of teaching :)

  • @danechrist5607
    @danechrist560710 жыл бұрын

    Fantastic teaching methods- engage students through an expectation of acknowledgement of deficits in knowledge AND an obvious passion to help students obtain what is missing.

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always.

  • @dvdshaya
    @dvdshaya13 жыл бұрын

    Indians have always been the best lecturers, Sir you could finally change my destiny, Thank God i found you, Now those A's are finally in the distance

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    @ayushvinesh12 жыл бұрын

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  • @pank4music
    @pank4music12 жыл бұрын

    Thank you for the wonderful lecture!

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    @shitalgaikwad13195 жыл бұрын

    Happy doctor's day dr.Nazeeb

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    @yousuffsm9 жыл бұрын

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    @fathybakr91646 жыл бұрын

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    @alifinagideon94996 жыл бұрын

    thanks a lot sir ur the best lecture have ever seen

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    @roshangupta75596 жыл бұрын

    I don’t have words to express my respect ..really amazing ..feel like attending ur lectures in person ..much much appreciated sir thank u

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    @meenasharma9609

    2 жыл бұрын

    Really? But he is a pakistani muslim

  • @xyzu1509

    @xyzu1509

    2 жыл бұрын

    @@meenasharma9609 what has that to do with it....there are gems of med sci in Pakistan......

  • @nikunthapa3924
    @nikunthapa39244 жыл бұрын

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    @hurabhaseeb4 жыл бұрын

    Love you, your teaching and explanations

  • @aswineentennakoon5482
    @aswineentennakoon54826 жыл бұрын

    A cascade of knowledge flow

  • @muhammadyaseenmahtaab7820
    @muhammadyaseenmahtaab78206 жыл бұрын

    Assalamu Alaykum Sir, I enjoy your teaching, May Allah reward you with the Good....Shukriya :)

  • @samarasimham9643
    @samarasimham96436 жыл бұрын

    Sir u excellent teacher I'm seeing your videos and become a fan of you sir and please give lecture on wound healing and lymphatic system and pathology

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    @joaooliveira4114 жыл бұрын

    you're the best man keep going teaching

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    @1ahmeduddin12 жыл бұрын

    I have never seen such a beautiful way of teaching

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    @karishmarawat6510 Жыл бұрын

    Respect and love from India You are a genius...😊

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    @wakarooooo13 жыл бұрын

    Em not a medical student, but i can even stand hiz 90% of lecture. :D He z really a gr8 man.

  • @MegaAlfies
    @MegaAlfies12 жыл бұрын

    this really is the best explanation!!!

  • @Nadzieja103
    @Nadzieja10312 жыл бұрын

    I have never understood completely the Coagulation process. It seemed complicated and not that logic. But thanks to you, doctor Najeeb, I took a ten today at Physiopathology. Thank you so much, you're a fantastic teacher! :)

  • @zakirehman9023

    @zakirehman9023

    2 жыл бұрын

    isn't it "pathophysiology"?

  • @shreyashreya1328

    @shreyashreya1328

    Жыл бұрын

    @@zakirehman9023 yes of course

  • @RameshBabu-vd9dj
    @RameshBabu-vd9dj7 жыл бұрын

    No words sir appreciate you.....

  • @shakeelalvi2182
    @shakeelalvi21828 жыл бұрын

    God father of medical world

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    @blackyrocky7438

    3 жыл бұрын

    Godfather👍👍😁

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    @fatimaqureshi70158 жыл бұрын

    simply best teacher who clears all concepts and misconceptions.

  • @smhasanuzzamanjumman1170
    @smhasanuzzamanjumman117012 жыл бұрын

    wow!!! najeeb sir is genious!!!!!

  • @641rider
    @641rider12 жыл бұрын

    love ur way of teaching,,

  • @princeraj8935
    @princeraj893510 жыл бұрын

    thank you sir for such a good lecture

  • @tajshah155
    @tajshah15512 жыл бұрын

    dr najeeb u are d blessing on earth u deserve endless prayers endless happinesssssssssssssssss love u sir so much and respect u endless

  • @MR-gv8df
    @MR-gv8df12 жыл бұрын

    SIR YOU ARE ''ALLAHS'' ANGEL WHO SERVES MANKIND,AN EYE FOR BLIND DOCTERS........................AFTER YOUR LEACTURES I HAVE GAINED SO MUCH OF LOGIC CONCEPTS WHICH HELPED ME CLEAR MY EXAM.............THANK YOU SO MUCH SIR....I AM IN NEW DELHI AND HAVE ATTENDED CLASSES OF ALL TOP TEACHERS IN INDIA WHO WRITES TEXT BOOKS.....BUT YOUR CONCEPTS MADE ME WORK HARD AND I HAVE CLEARD MY EXAMS.....THANK YOU SIR...

  • @darrylportelli
    @darrylportelli12 жыл бұрын

    @Boxy5773 Talking to yourself and going over cascades and making funny noises really gets medical stuff in your head!!!

  • @mahimadc6592
    @mahimadc65926 жыл бұрын

    a normal teacher comes and delivers his lecture, a good teacher really teaches you and a best teacher makes sure that u understand, and sir u are the best, u inspire me a lot. thank u. your u tube student from nepal

  • @hifzurrahman621
    @hifzurrahman6216 жыл бұрын

    You are the best best best teacher...

  • @drguruprasadn
    @drguruprasadn7 жыл бұрын

    Thank you Sir for an excellent lecture on coagulation. You are a passionate teacher and make the subject so understandable.

  • @drguruprasadn

    @drguruprasadn

    7 жыл бұрын

    I have already subscribed for your lectures Sir and enjoying it too. Hope I can share it with my daughter who is doing her medicine.

  • @sanjibmahanty1745
    @sanjibmahanty17456 жыл бұрын

    Excellent

  • @maimunabano9873
    @maimunabano98734 жыл бұрын

    Taught in excellence

  • @estedrawn
    @estedrawn12 жыл бұрын

    Najeeb is da man.

  • @abbylim7512
    @abbylim751211 жыл бұрын

    Thank you very much sir!!!

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    @shazz03793 жыл бұрын

    Sir, you are amazing. I just got into medical college going to take my first internal exam and I was totally upset with my studies until I found out about you. You're the best, sir. May Allah bless you with lots of happiness and peace. Love and respect from Pakistan. 🇵🇰✌🏼🙏🏻🙏🏻🙏🏻😇

  • @santoshmallick382
    @santoshmallick3824 жыл бұрын

    Powerful teaching

  • @user-iq4yi9cs9v
    @user-iq4yi9cs9v5 жыл бұрын

    sir you are amazing ! non of the teacher in medical school taught us like the way you teach !

  • @samiahmad9831
    @samiahmad983111 жыл бұрын

    amazing

  • @temeyoya3389
    @temeyoya3389 Жыл бұрын

    what a lecture.wonderful l like it

  • @TheDonadoni1985
    @TheDonadoni198510 жыл бұрын

    Hi Dr najeeb, u r just wow, what a way u have to transfer information wow wow wow funny and easy to memorise. I like u so much. Do u have any lecture about HLA typing? thx heaps and regards from australia. By the way where r u? all the best.

  • @prettyjasmine2008
    @prettyjasmine200813 жыл бұрын

    God bless you Doctor Najeeb! :-) thank u very very much..:-)

  • @007rapture
    @007rapture12 жыл бұрын

    thank you teacher

  • @joopakaavinash6632
    @joopakaavinash66323 жыл бұрын

    Ohh he is trying to confuse me😂😂 really supurb sir 🙏🙏

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always.

  • @NY11
    @NY1112 жыл бұрын

    Dr. Najeeb I want to thank you so much for your time to help many students easily understand concepts which was so difficult.Also I found the lecture fun & very interesting.Anyways best wishes to you always & wish more professors had your gift in teaching.

  • @user-jv4mv9ov7d
    @user-jv4mv9ov7d3 жыл бұрын

    Very good

  • @kunjalkundu2059
    @kunjalkundu20595 жыл бұрын

    Sir a big big salute to you You make students understand the real meaning of biology

  • @meenasharma9609

    @meenasharma9609

    2 жыл бұрын

    Sure?? But he is a pakistani muslim.

  • @nadiyabhatt6248
    @nadiyabhatt62488 жыл бұрын

    simply best

  • @shabnamstarr
    @shabnamstarr12 жыл бұрын

    i wish i was in his class!!

  • @dawson203
    @dawson20311 жыл бұрын

    now if you can teach at my university as well that will be great

  • @avikamathur1154
    @avikamathur11546 жыл бұрын

    sir i need ur all vieodes..sir ur the best teacher in this world ...sir i want ur viedio on antianginal drugs..thank u sir .....i like ur alll lecture..u r idol teacher...god for us...

  • @mbbsdr8378

    @mbbsdr8378

    4 жыл бұрын

    U musttake his subscription

  • @musc2escape
    @musc2escape8 жыл бұрын

    the best!! thank you a million times!

  • @DrArjunKataria
    @DrArjunKataria10 жыл бұрын

    you are LEGEND......

  • @DrArjunKataria

    @DrArjunKataria

    7 жыл бұрын

    Dr. Najeeb Lectures our group of friends is already having your subscription

  • @colors7559
    @colors75593 жыл бұрын

    Thank you thank you for clearing my concept like water

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    You're most welcome :)

  • @shasha.v1
    @shasha.v13 жыл бұрын

    Great teacher , make learning fun

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always.

  • @Abhishek_das007
    @Abhishek_das0074 жыл бұрын

    I'm watching this video in 2019 & it is still helpful for me though it was published in 2010. Thank you sir

  • @biologylover7248
    @biologylover72482 ай бұрын

    Great one ❤

  • @DoctorNajeeb

    @DoctorNajeeb

    2 ай бұрын

    Glad you like it ❤

  • @fragan01
    @fragan0114 жыл бұрын

    In short.. Coagulation is a serious of cascade reactions that ultimately produce fibrinogen that produces fibrin fibers that are for clots.

  • @drsainiprakash
    @drsainiprakash7 жыл бұрын

    Thank You so Much , i really enjoyed this

  • @kirankumari05
    @kirankumari052 жыл бұрын

    Thank you sir for this great lecture ♥️🌸

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome. Keep watching and supporting 💖💖

  • @patient3841
    @patient38415 жыл бұрын

    Good

  • @DrMehakZaheer
    @DrMehakZaheer8 ай бұрын

    Masterpiece 🎉lectures❤❤❤❤

  • @DoctorNajeeb

    @DoctorNajeeb

    8 ай бұрын

    Thank you❤

  • @gurralamohankumar5838
    @gurralamohankumar58384 жыл бұрын

    Thank u sir 😀🙂♥️

  • @munnahossain2704
    @munnahossain27042 жыл бұрын

    I am not only impressed but also in love with your lectures!! ❤️❤️❤️❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Glad you loved it. Stay tuned ❤️

  • @asmaaelabbar3533
    @asmaaelabbar353311 жыл бұрын

    thank so muh due to helpe me in my studey

  • @medicodoctors7936
    @medicodoctors7936 Жыл бұрын

    Sir I am so impress form ur lecture GOD bless u sir alway

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Thanks a lot❤️ Stay blessed ❤️

  • @jasonroy9292
    @jasonroy92923 жыл бұрын

    Nice sir

  • @tovinoadmirer3622
    @tovinoadmirer36222 ай бұрын

    Thankyou sir ❤

  • @DoctorNajeeb

    @DoctorNajeeb

    2 ай бұрын

    Most welcome❤

  • @fahadahmad9262
    @fahadahmad92622 жыл бұрын

    sir May Allah Almighty give u good health

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Ameen. Stay blessed ❤️

  • @aksh5454
    @aksh54542 жыл бұрын

    Thank you sir.

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome❤️

  • @sushiroast
    @sushiroast3 жыл бұрын

    Ur teaching is very good please upload more videos

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Glad to know that. Keep sharing your feedback. Thank you for your love and support. :)

  • @amalothman1743
    @amalothman17432 жыл бұрын

    ما شااء الله ، ربنا يبارك في علمك و ينفعنا فيه ..

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Jazakallah Khairan! ❤️

  • @sserunkuumabruno1943
    @sserunkuumabruno19434 жыл бұрын

    He is indeed nice

  • @ritupremnagore4192

    @ritupremnagore4192

    3 жыл бұрын

    Sir have u any lecture on Hemophilia

  • @muhammadyaseenmahtaab7820
    @muhammadyaseenmahtaab78206 жыл бұрын

    I Love You and I respect you :)

  • @fizzasafdar2048
    @fizzasafdar20482 жыл бұрын

    Thank you soo much sir

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome. Keep supporting ❤️

  • @animalsdrugsandequipmentus1818
    @animalsdrugsandequipmentus1818 Жыл бұрын

    Thanks my lecture.( Successful!)

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    You are welcome!❤️

  • @superinga1000
    @superinga100013 жыл бұрын

    i love!!

  • @kalembaashabahebwa3471
    @kalembaashabahebwa34715 жыл бұрын

    Hlo....thanks.....what is the cause of ischemia

  • @neiamulkarim934
    @neiamulkarim9342 жыл бұрын

    Awesome❤️❤️❤️❤️❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you for your love and support! ❤️

  • @Vaibhav-bb6is
    @Vaibhav-bb6is4 жыл бұрын

    sir, we need notes of everthing you teach.

  • @animalsdrugsandequipmentus1818
    @animalsdrugsandequipmentus1818 Жыл бұрын

    Very well

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Thanks 🙏

  • @osamakhan8684
    @osamakhan86842 жыл бұрын

    Zaberdast

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you ❤️

  • @rusteez8099
    @rusteez80993 жыл бұрын

    I love u sir ♥

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Love you too. Stay blessed :)

  • @jasonroy9292
    @jasonroy92923 жыл бұрын

    Sir I'm not understanding how can I purchase your lectures

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Please visit the link members.drnajeeblectures.com/#!/video-library