Coagulation Cascade | Intrinsic and Extrinsic Pathway
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Coagulation, also known as clotting, is the process by which bl00d changes from a liquid to a gel, forming a bl00d clot. It potentially results in hemostasis, the cessation of bl00d loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis).
Coagulation begins almost instantly after an injury to the bl00d vessel has damaged the endothelium lining the bl00d vessel. Exposure of bl00d to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma Factor VII, which ultimately leads to fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII (listed below) respond in a complex cascade to form fibrin strands, which strengthen the platelet plug.
Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component.The system in humans has been the most extensively researched and is the best understood.
The coagulation cascade of secondary hemostasis has two initial pathways which lead to fibrin formation. These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway), which both lead to the same fundamental reactions that produce fibrin. It was previously thought that the two pathways of coagulation cascade were of equal importance, but it is now known that the primary pathway for the initiation of bl00d coagulation is the tissue factor (extrinsic) pathway. The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade, ultimately resulting in cross-linked fibrin. Coagulation factors are generally indicated by Roman numerals, with a lowercase a appended to indicate an active form.
The coagulation factors are generally serine proteases (enzymes), which act by cleaving downstream proteins. The exceptions are tissue factor, FV, FVIII, FXIII. Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase.[7] The coagulation factors circulate as inactive zymogens. The coagulation cascade is therefore classically divided into three pathways. The tissue factor and contact activation pathways both activate the "final common pathway" of factor X, thrombin and fibrin.
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Пікірлер: 136
I loved it, this is exactly wha it was looking for without the extra fluff - thank you my dude
This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!
@hussainbiology
3 жыл бұрын
thanks for appreciation..Glad it helps ✌️
Thanks for saving me I was planning to drop this question
@hussainbiology
3 жыл бұрын
thanks for appreciation..Glad to know that it helps ✌️
@avanikilledar11
9 ай бұрын
Omg same physio test is tomorrow🤯
@hussainbiology
9 ай бұрын
@@avanikilledar11 all the best
Thank you for going straight to the point, i was beginning to get even more confused with some videos i watched earlier
شكرا اخي تحياتي من مصر ❤ جزاك الله خير
This is a fantastic overview of the intrinsic and extrinsic pathways, thank you bro i try it to understand from long time i did it now thanks
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps ✌️
Within very short time...u gives enough information required..so thnks
clearly explained thankyou so much
Literally fantastic 💥
4 yrs after uploading this video is still doing wonders🎉
@hussainbiology
9 ай бұрын
that is ur kindness and love towards me.... ❤️❤️
Finally a simplified vedio..Thanks a lot
How to easily remeber in what order which clotting factor activates the next? Fantastic video, thank you!
Awesome.. Time saving ❤
thank you for such amazing explanation
Thankss for the video!!!
Simple and to the point👌👌 thanks..
@hussainbiology
4 жыл бұрын
thanks for appreciation
Owoo YOU JUST....🔥🔥 Thank you for this explanation ✨
Man you made me understand thanks man
Guys save time and watch this ! Thank you man
Means a lot thank you so much love you love you love you helping me a lot
man that saved a lot of time tysm
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps....✌️
Awesome,,you have made it simple
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps ✌️
Thank you so much sir Nice explanation
God bless you ❤
Amazing
Masha Allah dr Thanks keep giong.
@hussainbiology
5 жыл бұрын
Thanks Shamis for appreciation
Thnks for understanding us in simple way .....
@hussainbiology
3 жыл бұрын
Thanks for appreciation
Sooo much helpful!! Thank u soo soo much
@hussainbiology
10 ай бұрын
thanks for appreciation..Glad it helps ❤️
Thank you 💞
@hussainbiology
2 жыл бұрын
You’re welcome 😊
Super cool
genious Dr Hussain
Thank you very much.. .. I really need it for my exams preparation.. Good job...
@hussainbiology
4 жыл бұрын
Thanks Sana for appreciation..Glad to know that it helps. All the best for exams
@sanaansari8224
4 жыл бұрын
@@hussainbiology Thank you very much sir...
@hussainbiology
4 жыл бұрын
You are welcome
Too excellent.
@hussainbiology
3 жыл бұрын
thanks for appreciation
Thanks sir after watching this video I feel it is very easy question ..
@hussainbiology
Жыл бұрын
thanks for appreciation.. Glad it helps ✌️
Super clear! Thanks😫
@hussainbiology
3 жыл бұрын
Thanks for appreciation....✌️
@mithila3556
3 жыл бұрын
@@hussainbiology I have an exam tomorrow and really thought of skipping the topic.. but this vid helped me☺
@hussainbiology
3 жыл бұрын
@@mithila3556 All the best Mithila.... do well
@mithila3556
3 жыл бұрын
@@hussainbiology 😊✌🏻
Thank you soo much 🙏🙏🙏❤️
@hussainbiology
3 жыл бұрын
Thanks for appreciation..Glad to know that it helps ✌️
Thanks
Amazing I understood at one's
@hussainbiology
3 жыл бұрын
thanks for appreciation
simple and helpful thanks
@hussainbiology
2 жыл бұрын
most welcome
Best explanation
Simply the best explanation , thank you so much.
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps....✌️
Thank you so much sir ☺️
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps ✌️
Thanku sir 🙏
@hussainbiology
2 жыл бұрын
most welcome
Sir were does the tenase complex come in
Straight forward
@hussainbiology
Жыл бұрын
thanks
If it is not acting in sequence, why do we need to remember in sequence 1 to 13
life saver
Thanks!
@hussainbiology
3 жыл бұрын
most welcome
Thank you so much 😭♥️
@hussainbiology
Жыл бұрын
You're so welcome!
Hello Sir, May I ask what kind of markers/pens are you using, if you dont mind? I like them.
@hussainbiology
Ай бұрын
hi Omar....Yes why not... ask anything.... I am using simple markers....like Luxor... DOMS....Artline etc
Informative
@hussainbiology
5 жыл бұрын
Thanks brother for appreciation...Keep sharing and supporting
Thanks bro you save me in my exam....
@hussainbiology
4 жыл бұрын
thanks for appreciation..Glad to know that it helps...
Great!
@hussainbiology
4 жыл бұрын
thanks for appreciation
Nice
Great 😍
So thrombin activates factor V and factor Va helps in activation of more thrombin? So can we consider this a cycle?
@hussainbiology
3 жыл бұрын
Yes.. a Positive Feedback cycle .. 👍
Tysm sir♥️
Tq so much sir
I hate to slow down his speed upto 0.25x so that my brain can start his Cascade 😂
@hussainbiology
3 жыл бұрын
✌️✌️
👌 wow
Last moment saviour
I love this 💖 bro.... ماشاءاللہ۔۔۔
Sir .... Is coagulation cascade and coagulation of blood same?
@hussainbiology
2 жыл бұрын
yes
This is amazing 😅 I was read it 10 time but I don't understand .
@hussainbiology
Жыл бұрын
thanks for appreciation..Glad it helps ✌️
Pls tell me which are intrinsic factor and which are extrinsic factor
@hussainbiology
3 жыл бұрын
It is actually Intrinsic and Extrinsic Mediated pathway.... Intrinsic includes factors like IX ,X ,XI ,XII........ Extrinsic includes factor VIII
Saved my 5 marks bro thank you 😂
@hussainbiology
Жыл бұрын
thanks for appreciation...Glad it helps ✌️
Good👍👍👍
@hussainbiology
5 жыл бұрын
Thanks for appreciation...Keep sharing and supporting
what is factor 12? you should have explained that for a beginner first. what are factors? where these come from?
Wao Amazing 🙈🙈🙊
@hussainbiology
4 жыл бұрын
thanks for appreciation...Glad to know that it helps.
A+
👍👍
Oo today was our zoology 3rd sem home examination and what else thank u
@hussainbiology
3 жыл бұрын
Oh great.. ✌️✌️✌️ Most welcome
Excuse me sir, i have a question in mind... Can you please explain how does factor VIII help in the activation of X when it is "to be" activated by thrombin which is "after" the activation of X??? Thanks in advance.....
@hussainbiology
4 жыл бұрын
Since both mechanisms occur simultaneously .....
Love u
@hussainbiology
2 жыл бұрын
❤️..Lots of love....
I think factor X is common not factor 2
Sir where are you from
@hussainbiology
3 жыл бұрын
Kashmir ✌️✌️
@hsbmk
3 жыл бұрын
@@hussainbiology 👏 👏 mai basyav godnethi
@hussainbiology
3 жыл бұрын
@@hsbmk 😊 Jaan gov....
👍
@hussainbiology
5 жыл бұрын
Thanks brother for appreciation
☺☺☺☺
Noo
Hindi me sir please
Pathetic....please review and then explain properly
This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!
@hussainbiology
9 ай бұрын
Glad you enjoyed it!
Amazing
This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!
@hussainbiology
9 ай бұрын
Glad you enjoyed it!