I entirely agree with your assessment. As a biomedical scientist I measured thousands of serum cholesterol levels, and the low levels were very often in very sick people, often elderly and malnourished. I'm reminded of those claiming that excess acidity is the cause of all illness, whereas the truth is that acidosis, like a very low cholesterol, is the RESULT of illness, not the CAUSE.

@larryc1616

Жыл бұрын

It can be both just like high cholesterol can be due to diet/genetics or disease

@soniashapiro4827

Жыл бұрын

I'm so delighted that you posted this. I've been so confused by people talking about acidifying and alkalinizing foods. The only good grain is millet. Etc. This has made no sense to me. I get it now, because of your clarity. Thank you.

@ScottLane-ud9tj

28 күн бұрын

Dr. Atkins had a heart attack and a history of heart disease and he was overweight.

I find it chilling knowing that your videos NOW will probably wind up saving my life when I turn 60.

Epic Gil. Because of science communicators like you, faith is being restored in the clinical guidelines and your viewers are leading healthier lives

@donwinston

Жыл бұрын

You are more optimistic than me. We've got an anti science kook running for President in the USA who's polling in double figures and getting applauded by people like Musk, Maher, an ex Twitter CEO, ..etc

@Joop3000

Жыл бұрын

It is frightening that it is so easy to restore your faith. He used association of other U-curve graphs to disprove the association in an other u-curve graph. & had one half-baked argument that the reason why lower cholesterol has a high hazard is because people with disease have lower cholesterol by coincidence of being sick. So unfortunate that they have this really great and healthy cholesterol score, but still are dying from cancer and such. When dismissing the U-curve. What should the graph look like then? linear? Would you argue that it is best to have 0 cholesterol?

@888jucu

Жыл бұрын

@@Joop3000 I think you miss the point, if certain diseases naturally drop your cholesterol then this becomes a symptom and the lower cholesterol shouldn’t be read as a cause. To have the correct correlation then those cofounders would need to be filtered out for it to be truly representative of whether or not the cholesterol level of a certain individual represents their risk of getting sick and not related to them already being sick

@Joop3000

Жыл бұрын

@@888jucu That is exactly what I got out of it. So, let me ask you then, if we ''filter'' (I don't think this is realistic and based in logic and evidence, but just for the sake of argument) those confounding factors out, what do we end up with then? A linear line going back to 0 cholesterol which is healthiest?

@888jucu

Жыл бұрын

@@Joop3000 I don’t believe zero is realistic nor advisable for the general populace but probably a number significantly less than 230. That said for people with real advanced ASCVD then lowering cholesterol either with lifestyle, drugs or both has proven to be the best for their immediate health outcomes. For the general population what is the best cholesterol target seems to still be of some debate but high cholesterol certainly is well documented to be problematic regardless what certain carnivore advocates may preach. True carnivores in nature do not develop ASCVD so humans being “omnivore” means we are not fully developed to handle large quantities of saturated fats as can been seen by the fact our species develops ASCVD the more we are exposed to saturated fat be it through direct diet or internally produced by “excessive” carb intake etc

Similar issue with a recent paper on weight loss being associated with increased mortality where the confounding of disease driven weight loss was so obvious and yet it still hit the headlines that “weight loss can kill you“. Reverse causality. Another good video, Gil. Keep up the good work.

@Engrave.Danger

8 ай бұрын

To be fair weight loss is often unhealthy. What people should be focusing on is fat loss and a scale is a poor way of measuring that. People start reducing calories, hydration and protein which results in an unsustainable loss of weight that includes lean mass and reduced basal metabolic rate.

I just came across your channel. This is cool. Your logic is flawless

@blademan4043

5 ай бұрын

He must be Vulcan 😂.

@williamwightman8409

4 ай бұрын

It is not the logic that gets us in trouble, it is the low probability premises. Doing the expensive research and data analysis for accurate premises is the hard work.

Excellent video. Very helpful in understanding so many KZread channels that state there's little wrong with high cholesterol. Thank you.

This is becoming my favorite nutrition channel.

As a physician for 35 years, this presentation is eye opening. Medical disease prevention criteria now seem backwards!

Thank you for another straightforward explanation that even a high school dropout could understand. If I had only seen these graphs w/o your explanation, I probably would've thought "oh, I guess they found new evidence." Keep the good work going, a lot of us depend on you.

Hi Gil.I just came across your channel.I am very impressed.We need more people like you to cut through the confusion.We should connect.

Interesting point in your video is that if your cholesterol is lower than expected, while you never tried to actively lower it,.... it means you probably have a disease you may not even be aware of. I know some people like that, though they are aware of the diseases. But their doctors tell them it's great. They don't tell them that their cholesterol is low because of their other diseases.

@JoeS97756

Жыл бұрын

Many people for genetic reasons have low cholesterol and that is a healthy marker. It's when your cholesterol declines over time without a reason that it is cause for concern.

I appreciate your dedication to digging into this important issue.

Great video with lots of easy to understand information. You have a really great ability at explaining a complicated subject, and making it easy to understand.

This is a good explanation and a reminder that correlation is not the same as causation. My 84 YO father died 3 months ago and we had just seen his lung doctor 4 days earlier. His weight was the lowest it had ever been as an adult and his blood pressure was also very low and his cholesterol thanks to taking vytorin was around 150 and frankly, better than mine. An uneducated person (ie. people who listen to "Bro" podcasts) might then conclude that low cholesterol, losing weight, and having low BP is unhealthy but in his case, when he WAS "healthy", he had very high blood pressure. He was in denial about it and I didn't find out about it until 15 years ago when he cut his finger and it would not stop bleeding and the urgent care center saw that his BP was 215 and they had to put him on an IV med to bring it down before letting us leave. After that, I became active in his care and got him a primary care doctor who managed his BP, cholesterol but the damage was done as 6 years later he needed a stent put in and 6 years after that, he had heart failure that thanks in part due to all the COVID lockdowns and in part due to the cardiologist not being aggressive with the water pills and/or wanting to do a valve replacement surgery, he had so much fluid build up in his lungs that by the time they admitted him to the hospital, the damage was done to his lungs and so at that point, surgery was completely off the table and he pretty much had to suffer for 2 1/2 years with home oxygen and being homebound and mostly just getting comfort care which led to him losing weight and his heart getting weaker. If I had a time machine, I would have made sure he got to his doctor sooner.

@sandrabentley8111

5 ай бұрын

Probably ate many carbs

I am at 30, but I am mostly muscle. I have about 12% body fat. I always thought that BMI completely ignores athletes!

@DrAJ_LatinAmerica

10 ай бұрын

Correct. However, the higher performing the athlete, the less healthy. For example great to lift weights, but unhealthy to be Mr. Olympia bodybuilders. Great to ride a bike, very unhealthy to be a Tour de France rider. Same with many sports. All on a similar curve. Couch potato bad, sweet spot in the middle, pro level generally too much.

Thank you for what you do. There’s so much misinformation about nutrition floating around on KZread. It’s a shame cause people are trying to better their health but getting misinformed by non experts or outright grifters. We need more professionals to do this kind of thing. 👍

@ianstuart5660

Жыл бұрын

Outright grifters is very accurate. Won't mention any names though!

This is truly fascinating and such a great explanation! Just goes to show, we shouldn’t take research data at face value out of context!

Great video! You see the same sort of curve for level of alcohol use and mortality, where it appears that people who don't drink at all have higher mortality. However, when you control for why a significant proportion of those people aren't drinking (due to health problems), the relationship becomes linear, with healthy people who don't drink having the lowest risk of mortality.

@7x779

7 ай бұрын

That's good information to share thank you

I love information. And your study of studies (meta-analysis) is the cream of the crop. Thank you for helping me on my health journey.

Doctor , THIS IS REAL AND QUALITY MEDICAL SCIENCE you present for your You tube public. Thank you again ! All the best and keep the standards up.

You make some of the best health related videos out there Gil! Huge thumbs up for this well put together presentation of the facts. Thank you!

Thank you so much for empowering your audience and letting us decide on what to do based on the science. It's such a refreshing change from KZreadrs that use click bait, criticise a persons character that they don't agree with and let their emotions get involved in their efforts to ultimately deliver an otherwise well intentioned message. Great work and thank you again.

So these u curves can be read as an indication of how uncommon being healthy actually is.

@NutritionMadeSimple

Жыл бұрын

excellent realization

@bobbenoit8470

5 ай бұрын

That's exactly what I thought. The paradox might be caused by a lack of healthy people!

@yoso585

4 ай бұрын

@@bobbenoit8470 wouldn’t have to be unhealthy. It’s all dependent on when these measurements are taken: at death, 1 year out, and so on.

You nailed it, Dr Carvalho! Thanks for going the extra mile to dig into the data and explain it so clearly. I wonder if the numbers of people with a given level of a blood marker factors into it those graphs, as well. For example: fewer people have an A1c under 5 (than 5.5) so perhaps a larger proportion have subclinical disease?

This video would be helped by showing graphs from some of the better, double-blind studies that factor out the people with illness and show the curves where they "should" be. I'm skeptical without seeing those graphs. No dog in this fight, just want to actually see the better evidence.

@kevinmurphy4649

Жыл бұрын

I can't point to the exact video, but I think he shows one where he puts dot plots of all the studies on a graph and it shows pretty clearly the affect of LDL cholesterol on mortality. If you have time to check out some of his older videos on cholesterol, you will run into it.

@SuperOptiman

Жыл бұрын

You are correct. He needs to do better. My friend was even more confused. I think your suggestion would make it clearer.

@ioodyssey3740

Жыл бұрын

The links to the studies are all in the description. The Korean cholestrol study is exceptionally thorough and HUGE. Read the details of it and see. (first link I believe)

Thanks for this! I remember when I first got my cholesterol taken. It was at a company heath screening. A couple friends had slightly high readings. Mine? In the low 130s. When everyone commented the nurse there immediately jumped in an made a comment that cholesterol can be too low. I blew it off at the time because I was in my twenties. Fast forward to today when I’m 56, I’m still getting low readings. As a vegan it dropped again to 126 which is my lowest and has happened a couple years ago as well. When was this a problem for me? Well, prior to adopting a vegan diet, I was on a low carb diet called GAPS. After that, I experimented with Keto. In BOTH of those communities I started hearing how I needed to raise my cholesterol because of research about low cholesterol. A functional medicine practitioner talked to me about the same thing. My efforts yielded a total of 162. I am thankful that I found a channel where someone actually discusses the actual studies (and posts them!). Thanks again!

@birdgirl1516

Жыл бұрын

I just found this channel and wondered if he has shared this fact with the audience yet; Did you know that Cholesterol is a required precursor to essential hormones: estrogen, testosterone and vitamin D?

@tomgoff7887

Жыл бұрын

@@birdgirl1516 It's the dose that makes the poison.

@paulmaxwell8851

11 ай бұрын

@@birdgirl1516 Yes, it is. But today's adults (and many children) have cholesterol levels that are far beyond that necessary for basic bodily functions. No healthy person needs to worry about 'having enough' cholesterol.

I like your cholesterol paradox resolution from the epidemiological point of view. Very well explained Gil, with your excellent structured multimedia presentation.

So crystal clear and to the point and brilliantly put! Thank you for this!

Excellently presented and very interesting! All I can do is repeat the famous words of Dr. John McDougall that "People Love to hear good things about their bad habits", and the internet hugely rewards those claims with tons of hits. Keep doing what you are doing!

@johnsonpaul1914

Жыл бұрын

McDougall?? rofl, A diet of white rice, fruit, fruit juice and table sugar -- cures diabetes, heart disease, arthritis, obesity, and just about everything, is the claim of Mcdougall

love the explanation, I wish you make a series on how to understand and interpret data pulled from studies, but on a side note, what kind of chronic disease that would lower HbA1c or blood pressure ?

Thank you! I'm so glad I found you, because you are able to explain to lay people. And you illustrate how important it is to be discerning about nutrition/health info that comes out, and not just swallow everyone/everything blindly. I appreciate you!

man, you nailed it. Beautiful, thank you. Love clear explanations of scientific realities.

Always great content Gil! I'm so happy that your channel is flourishing as more people discover this gem.

@marcdaniels9079

10 ай бұрын

I wouldn’t get so fixated on micro biological mechanisms. Outcome studies are what matter.

I also can imagine that some 'experts' use this intentionally to mislead people to promote certain diets and for their own popularity.

@ZsuzsaKarolySmith

Жыл бұрын

It would be criminal if they knowingly misinterpreted the data - it’s more likely they are just ignorant. Still, it’s no excuse for misleading people.

Bravo - Love how you explain complicated issues in a way that makes them easy to understand.

that was very informative and easy to understand. Thank you!

I saw this mentioned recently by a couple of other youtube "doctors" as a reason why you don't need to worry about cholesterol ... glad you made this video to clear that up, thank you!

@tzenophile

Жыл бұрын

chiropractic "doctors" no doubt

@DrummerDucky

Жыл бұрын

It's always painful to listen to professionals speak on things they don't have a clear grasp.

@dms8504

Жыл бұрын

I admit i was sucked in by dr berg and his chiropractic cronies for a while too, until the likes of gil, brad stanfield, and lately physionic, brought me back from the dark side. Watching dr berg et al now is almost cringeworthy.

@JonathanBennett84

Жыл бұрын

@@James-zr1lu Right, especially considering the vast amount of evidence showing the positive effects of lowering LDL. One can't claim to be scientific and just ignore dozens/hundreds of other quality studies.

@SET12DSP

Жыл бұрын

@@DrummerDucky Even more painful when you have to heal yourself...

Oh my goodness thank you so much for making this video. The dangerous messaging out there is getting out of hand. We need actual doctors like you to set the record straight.

Nice! Always looking for good evidence to continue taking care of myself!

Excellent explanations. Finally, some proper medical interpretation of this phenomenon.

Just popping in to say thanks for the great video!

From what I’ve learned cholesterol is extremely nuanced. There are many factors involved. lots to know and I’m still learning to help make the best decisions along with my doctor but it’s a team effort.

You deserve an award. Your fact-checking is as valuable as anything issued by the Surgeon General.

As always, your videos are a great asset for understanding complex medical findings. Obrigado!

Excellent explanation! 🎉 thank you!

"I wanted to take a moment to express my appreciation for this fantastic KZread channel and the informative content that it provides. This topic is incredibly insightful and well-presented. Thank you for taking the time to share this valuable information with your viewers."

Thank u Sir. In depth understanding leaves no confusiom.

Great vid!! Well explained! Reverse causation. People generally have trouble understanding this concept. Is a bit tricky at first.

Not understanding how 5.5 and a disasterous 10.0 A1c has the same rate. What disease is associated with a good A1c?

I would think if disease is lowering the cholesterol, it would also lower the BMI? But the BMI is up for longevity. How can you have disease lower cholesterol but you gain weight?

@starrynight8007

4 ай бұрын

Yup, I hear ya..

Have recently encountered this in conversations with friends, thank you for information that will be helpful in those conversations.

Excellent presentation. Thank you.

Gil, Can you please expound on your understanding of the physiologic mechanism by which the cholesterol molecule gets itself positioned beneath the endothelial layer of the systemic artery? In other words, is the endothelial cell actively, or passively, transporting it from the LDL in the bloodstream, through the cell and then expelling it on the other side, or is the cholesterol molecule somehow disrupting the tight junctions between the endothelium and working their way back behind them? If so, how? And if so, why does this never happen in veins and almost never happen in the pulmonary arteries?

Dr. Gil, Thanks again for your easy to understand explanation of such a heated topic. Your dedication is truly appreciated and has taught me so much.

@rubygreta1

Жыл бұрын

I understand low BMI (you could be wasting away). I don't understand an A1c under 6. What fatal disease is associated with low A1c?

@AndyMorrisArt

Жыл бұрын

@@rubygreta1 plug the question into google

@garyloewenthal

Жыл бұрын

@@rubygreta1 Just taking a guess here, but I wonder if it could be a side effect of lack of appetite.

You're very smart This may be the most informative video I've ever seen. Thank you.

Wow, yet another wonderful video!

It's like losing weight. That happening for no reason (diet, exercise) is usually mentioned as a cancer symptom.

People love good news about their bad habits. Probably the most generally accurate statement I've heard in the health space. I imagine it could be credited for the "cholesterol skeptic" movement.

@JonathanBennett84

Жыл бұрын

"People love good news about their bad habits." -- great point and well said.

@matthewg5792

Жыл бұрын

@@JonathanBennett84 credit to John A. McDougall

You and Dr. Seheult are the only MDs on KZread I trust.

Helpful as always. Well presented.

Great explanation of a complicated issue. Thank you!!

Thank you! This video is useful

Pleased I saw this episode, I have been puzzled by the association between low cholesterol and death, Thank you for the clear explanation.

Quality information and delivery!

Wow, Gil, this was absolutely fantastic. You really put my mind at ease. Thank you so much for this clear, concise, reasonable, rational, scientifically correct explanation. You are doing so much good in this world, and you can tell your mother I said so. (I'm a mom, too, so my guess is she is super proud of you.)

If you have untreated hyperlipidemia, you can have all of those markers (total cholesterol, LDL-C, triglyceride) dropping to nice levels during an acute infection, things like tooth infection, kidney infection etc.

I remember the confusion it caused me when I first saw these U curves few years ago. Thank you for your good work.

Great video packed with important information. Thanks

For those that are worried about high cholesterol, it might be good to get a CAC score to see if there's any blockages. There is also Life Line screening that will do the same thing if you don't want to go to the doctors to get a referral for CAC. I will be doing the Life Line screening since I have high cholesterol.

@amyntas97jones29

Жыл бұрын

In Wales this will cost around £700. This is too much for many people.

@broccoli7263

Жыл бұрын

A CAC score won't tell you about blockages caused by soft plaque. It will only reveal old, calcified plaque. Your arteries can be nearly fully clogged with a low CAC score.

@angelalaskodi3459

Жыл бұрын

@@amyntas97jones29 I live in Southern California and it costs $159.

@Fearzero

Жыл бұрын

About one-fourth to one-third of the total incident cardiovascular disease events occur in those with a CAC of zero. - AHA

@someguy4967

Жыл бұрын

CAC only detects calcium. Not all of the build up will be calcified, may work in very old people or people who have been developing cholesterol build-up from a young age and gave it years to calcify

Oh boy does this answer a question I formed yesterday after watching one of the "Doctors" vids, where he put up a chart that shocked me! It showed cholesterol number ranges and associated them with good, ok, and bad, colored in Green, Yellow, and Red. This was a very odd chart to me because the "good" range was in fact from about 200-260, ok from 260 to about 340, and over 340 RED. He said however even 350 could be ok for some people! More surprising was the ranges below 200. That started yellow, and when it dropped to under about 100, there was a BIG RED. And yes, he emphasized that was the major risk of death area. I've just stopped watching any of these vids now, but now I know where their data is coming from. Thanks.

Wonderful explanation and clears up a lot of confusion.

That was really an exceptional video.

In a recent interview with Simon Hill - Walter Willet claimed that aggressive lowering of cholesterol may increase risk of hemorrhagic stroke (according to Mendelian Randomisation data) I’ve never heard this claim before - could you make a video exploring this claim?

@alane3983

Жыл бұрын

I heard that too and was surprised. Thanks for mentioning it here.

@raithneach

Жыл бұрын

I had the same thought, had meant to put it up on Simon Hills video as a query but had forgotten. Would be great to understand this with a bit more context.

@helenryan2848

Жыл бұрын

Dr Aseem Mulhotra has a lot of interesting information also.

@ItsJordaninnit

Жыл бұрын

@@helenryan2848 I personally haven’t heard much from Mulhotra outside of his cholesterol denialism claims. There’s a great article by Dr Alan Flanagan of Sigma Nutrition explaining the errors in his arguments - look up: *Sigma Nutrition - Low Cholesterol & Increased Mortality Risk?: Clarifying the Confusion*

@flagmichael

Жыл бұрын

Googling, I see an article from late 2020 in the Journal of Diabetes Investigation about it. As the article put it: "...all meta‐analyses have shown a net benefit of lowering LDL‐C with statins in reducing atherosclerotic cardiovascular disease (including ischemic stroke), which far outweighs the small risk of hemorrhagic strokes."

Great explanation, thanks! I've seen people saying on social media that you need to eat plenty of dietary cholesterol to maintain high testosterone levels, even recommending pure butter for gains. Others say pretty much the opposite, that fatty foods are associated with lower testosterone. Could you please clarify?

@yoraul5157

Жыл бұрын

All sexual hormones in both male and female are made from cholesterol, taken it from food is essential for a normal level. Just look at statistics on the age women get to menopause, 30 years ago it was 50+, today when we eat a lot less cholesterol together with other factors of course, many women see signs of menopause at early '40. It's that just a coincidence?

Beautifully conveyed. 💯

Great video again @Gil well explained

Thank You for explaining this complex issue.

Just to confuse matters,I remember reading that a small number of people have an extremely negative reaction,in terms of greatly increased risk of suicide,to having their cholesterol lowered.I think I read it in 'Genome,' by Matt Ridley.

@beemrmem3

Жыл бұрын

Maybe it lowered testosterone levels?

@dmanwainright2132

6 ай бұрын

​@@beemrmem3 I bet that's right

Gil, thank you, a really interesting and enlightening video.

I've watched this video three times and read a lot of the comments, and I"m still not persuaded that optimums on cholesterol aren't actually the high levels. Remove the people with cancers and other non-cardiovascular diseases, and we should see a linear effect, with those at relatively high levels still near the optimum. The comparison to the BMI, BP, and HbA1c are not persuasive as two of them are not quadratic, and the other shows a tiny risk change across a wide range of BMIs.

Great video.

Makes a video with such bold claims and fails to mention the study's limitations: "First, the use of lipid-lowering medication was unaccounted for. The risk associated with high cholesterol might have been underestimated. Additionally, this study could not determine whether statin-induced low cholesterol increases mortality." "Second, other lipid measures, such as low-density lipoprotein and high-density lipoprotein cholesterol levels, were unavailable. Recent dyslipidemia management guidelines are more closely focused on these sub-fractions of cholesterol, so the direct application of our findings to individual patient care might be somewhat limited."

Can you please start writing a book on nutrition and these related topics… We need a voice like yours out there.

Great Video!!! Thanks Dr Gil!!

Great video! Statins helped me but I stopped after 3 months. From there, diet and walking. Not so much diet as a lifestyle change. Meat was causing belly pain where my gallbladder area is and in my colon. Screw anymore surgeries, I went vegetarian 🥗. Best decision of my life.

So what about the 200 total cholesterol being the max? I've seen where several doctors say 250 is a better limit and the curve demonstrates that. Who set the 200 and on what data? Let's please talk about both sides of this observation.

@kevinmurphy2751

Жыл бұрын

Both reference articles state optimum range of 210-240 Total, the Denmark says 190 is the high end for LDL, but with HDL of 50, 240 still looks reasonable, vs 200 TC in this video. Is it time to challenge this old guidance?.

Great info as always, Doc! Thanks!

Excellently explained, like always!

How much of this data was done on populations of those practicing low carb diets or those that remained in ketosis for a considerable length of time? The problem is that when I follow a anything but high fat, red meat heavy diet, I am practically bedridden and can not hold down a job. If I eat high fat/low carb/lots of red meat I have my life back. I have to choose between preventing a heart attack and have no quality of life, or have a true quality of life and risk a heart attack. I take these studies and cholesterol seriously, but it seems like diet of the test population isn’t a recorded factor.

@NutritionMadeSimple

Жыл бұрын

hi. obviously there's some severe intolerance issue (unrelated to cholesterol or the topic of this video). this is something that has to be investigated. are the symptoms GI-centered? have your doctors ruled out things like IBD, IBS? celiac? those are just some initial ideas, it will depend on the symptoms. clearly there's an underlying condition and/or imbalance that needs to be identified/diagnosed

Your explanation regarding the higher mortality rate of people with low cholesterol due to other underlying conditions (cancer, infections) that lower cholesterol sounds reasonable, although there should be data available on the cause of death and hence the curve can be re-drawn by excluding those. What is missing from all your videos explaining this paradox is the fact that the lowest risk (hazard ratio of 1.0) is among people having higher cholesterol than the recommended limit? For that, which is the key take away from this chart, you provide no explanation! Do you have one?

@kennethyuman1940

Жыл бұрын

The mystery remains. He didn't show that the low mortality point at total cholesterol 230 was bad. We need longitudinal data: people with cholesterol of 200 live longer than those of 230 starting at age 70.

@ioodyssey3740

Жыл бұрын

@@kennethyuman1940 look up framingham study. it's all there in the original graphs. also, all his source studies are linked in the description.

Great video - perfect way to teach this topic

This is awesome, thanks Gil. Doesn’t this U curve also happen for alcohol consumption?

@Engrave.Danger

8 ай бұрын

The only case I can think of where alcohol legitimately has a u shaped curve is blood clot prevention during a long flight but there are other healthier alternatives.

Ironically, self-proclaimed "sceptics" are somehow incredibly sceptical when it comes to peer-reviewed science and medicine, yet will believe anything they hear from a guest on their podcast of choice, without doing any double-checking to see if said guest is considered a fraud or a madman...

Look at the level of cholesterol and mental illness and suicide. Under 160 seems to be a problem on this side. Despite these reasonable suppositions, many studies over decades have (for the most part) consistently linked low total serum cholesterol with suicide, violence, and depression. Total cholesterol levels below 160, and especially below 130, correlate with a higher risk of mental problems.

@Max-nu1sc

Жыл бұрын

"correlate". Is there any evidence that points to causation?

@victorycall

Жыл бұрын

The curves would seem to suggest that cholesterol of 240 is just fine... as long as it's not an upward trend. And BMI of 28 is just fine, even if it's considered overweight. And systolic blood pressure of 140 is just fine. And even that an A1C of 7 is just fine! And that the danger is when these values trend upward over time, which unfortunately they tend to do, into the frank danger zones. I appreciate Dr. Gil's point that the lower end values correspond with chronic disease, and that's different from "higher is healthier;" yet it does seem to me that if strictly following the data, a *little* bit higher is actually, truly healthier! Also, some of these things are not like the others. I've got low (healthy range) blood pressure, 21 BMI, low (healthy range) blood glucose from my low carb, high fat way of eating. I don't have inflammation problems, aches and pains, energy deficits like so many other 50 year olds do, and I'm simply not concerned about my cholesterol. I've got a low resting pulse rate, even, when I tested it at the pharmacy kiosk along with my blood pressure recently. I searched it up and it suggested it could be because a person is old, or an elite athlete. I'm not quite either, so who knows! I feel great and I don't think worrying is going to improve my health OR my disposition.

@-TheRealThing-

Жыл бұрын

It's so funny watching you grasping at straws

Dr. C I really enjoy your videos! I think you honestly try to follow data. I’ve seen a similar idea about alcohol consumption.

Fantastic explanation. Thank you.

Berg and Ekberg and consorts will completely ignore and discard this explanation.

@heathensein6582

Жыл бұрын

Just as you people do with high cholesterol

@BasedChadman

Жыл бұрын

Unfortunately true. I've taken away some decent advice from them, but the total lack of regard for the data made me unsub from both about a year ago. I despise statins and refuse to touch one ever again, but the claims about how they "help no one and only cause harm" are too extreme. It's also absurd to claim a carnivore diet is healthier than a vegan one when fiber intake is directly associated with mortality. (And I friggin love meat.)

@donewittit6607

Жыл бұрын

@@heathensein6582 layne norton has a doctorate in biochemistry the cattlemens association paid for his degree, he eats meat and has no hangups about it he clears says that the mandellian randomized trials showed high cholesterol is a independent marker for heart disease, even when low triglycerides were accounted for and high hdl it didn't matter so whose ignoring who

@LinusBerglund

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​@@heathensein6582well, if you have followed Gil you know what he says: it is a marker, but not always associated with higher risk. It often correlates with ApoB which is much much better associated with risk.

@Fearzero

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​@@BasedChadmanGo volunteer at an animal sanctuary and get to know some pigs, chickens and cows. Hang out with them and pet them. You won't love meat anymore.

Well presented doc.

Great video ! Thank you!

Interesting ... I am wondering about the size of the risk increase at the lower end. Your argument is interesting, but is it enough to explain the size of the effect. In your opinion does this mean that a) there is a lot more undiagnosed illness than people are aware of, and that is sitting there as a large pool of potential problems representing a large proportion of the population . This is the moderate risk, high population option. b) That the risks of those in this position are very high, so that a limited number of cases are going to be driving the curve up steeply because the risk of mortality is very high. This is the high risk, moderate population option. Or c) something else ?

@shiftgood

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You nailed it. There is no way it would be that steep... also... what if you have low cholesterol and then get that disease? etc. etc. This assosication to other graphs doesn't prove anything.